Cited by 133Sexual Differentiation and DisordersNeurotransmitter Receptor Influence on BehaviorEvolutionary Psychology and Human Behavior

Testosterone exposure, dopaminergic reward, and sensation-seeking in young men

Campbell, Benjamin C., Dreber, Anna, Apicella, Coren L., Eisenberg, Dan T.A., Gray, Peter B., Little, Anthony C., Garcia, Justin R., Zamore, Richard S. +1 more·2010·Physiology & Behavior

Abstract

To test the relationship between androgen exposure, dopaminergic reward and sensation-seeking, we compared variation in salivary testosterone (T), 2D:4D digit ratio, facial masculinity, Zuckerman's sensation-seeking scale (SSS) and the D4 dopamine receptor (DRD4) genes from 98 young men, between the ages of 18 and 23 years. In univariate analyses, both salivary T and facial masculinity were significantly correlated with the SSS boredom susceptibility subscale, while the presence of the 7-repeat allele (7R+) in the dopamine receptor D4 gene was associated with the SSS thrill and adventure-seeking and overall sensation-seeking. Neither left nor right 2D:4D digit ratio was associated with any sensation-seeking scale. In multivariate models, salivary T and facial masculinity were significant predictors of SSS boredom susceptibility, while 7R+ was a significant predictor of SSS thrill and adventure-seeking. For overall SSS, both 7R+ and salivary T were significant predictors. There was no significant interaction of 7R+ and androgen exposure for SSS or any of the SSS subscales. These results add to earlier reports of an association between T and sensation-seeking. In addition, our results also indicate that genetic variation in DRD4 is independently associated with SSS sensation-seeking.

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Crossref · 10.1016/j.physbeh.2009.12.011

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  • Sensation-Seeking may be specifically associated with hyperactivity-impulsivity and with higher testosterone.

    “Sensation-Seeking (tendency to seek adventure) may be more specifically associated with hyperactivity-impulsivity (Lopez et al., 2015), as well as related to higher T (Campbell et al., 2010; Daitzman & Zuckerman, 1980; Roberti, 2004).”

    From Reproductive steroids and ADHD symptoms across the menstrual cycle (2018) · cites this paper as Campbell et al., 2010

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Authors
Campbell, B. C., Dreber, A., Apicella, C. L., Eisenberg, D. T. A., Gray, P. B., Little, A. C., Garcia, J. R., Zamore, R. S., & Lum, J. K.
Affiliations
  • University of Wisconsin–Milwaukee (US)
  • Harvard University (US)
  • Northwestern University (US)
  • University of Nevada, Las Vegas (US)
  • University of Stirling (GB)
  • Binghamton University (US)
Corresponding author
Campbell, Benjamin C.
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2010-03
Volume
99
Issue
4
Pages
451-456
ISSN
0031-9384 (ISSN-L)
OpenAlex
W2096620721
Cited by
133
References
61
Citations by year
2026: 5 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 12 · 2016: 6 · 2015: 10 · 2014: 15 · 2013: 8 · 2012: 8
FWCI
2.67
Type
journal article
Language
en
Open access
closed
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Stirling Online Research Repository (University of Stirling) (submittedVersion)
Funders
  • Jan Wallanders och Tom Hedelius Stiftelse samt Tore Browaldhs Stiftelse
  • National Science Foundation
  • Royal Society
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
Keywords
testosterone, androgen exposure, sensation seeking, dopaminergic reward, 2D:4D digit ratio, facial masculinity, DRD4 gene, 7-repeat allele, boredom susceptibility, thrill and adventure seeking, young men, salivary testosterone
MeSH terms
Adolescent, Androgens, Dopamine, Face, Fingers, Genotype, Humans, Male, Reward, Risk-Taking, Saliva, Sensation, Testosterone, Minisatellite Repeats, Receptors, Dopamine D4, Young Adult, Masculinity

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