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Cited by 195

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Perinatal environment and its influences on metabolic programming of offspring

Open access
Tamashiro, Kellie L.K., Moran, Timothy H.·2010·Physiology & Behavior

Abstract

The intrauterine environment supports the development and health of offspring. Perturbations to this environment can have detrimental effects on the fetus that have persistent pathological consequences through adolescence and adulthood. The developmental origins of health and disease concept, also known as the “Barker Hypothesis”, has been put forth to describe the increased incidence of chronic disease such as cardiovascular disease and diabetes in humans and animals exposed to a less than ideal intrauterine environment. Maternal infection, poor or excess nutrition, and stressful events can negatively influence development of different cell types, tissues and organ systems ultimately predisposing the organism to pathological conditions. Although there are a variety of conditions associated to exposure to altered intrauterine environments, the focus of this review will be on the consequences of stress and high fat diet during the pre- and perinatal periods and associated outcomes related to obesity and other metabolic conditions. We further discuss possible neuroendocrine and epigenetic mechanisms responsible for metabolic programming of offspring.

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Crossref · 10.1016/j.physbeh.2010.04.008

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Metadata

Authors
Tamashiro, K. L. K., & Moran, T. H.
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2010-07
Volume
100
Issue
5
Pages
560-566
ISSN
0031-9384 (ISSN-L)
OpenAlex
W2041778509
Cited by
195
References
10
FWCI
17.38
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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