Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia

Maynard, T. M.; Sikich, L.; Lieberman, J. A.; LaMantia, A.-S.

doi:10.1093/oxfordjournals.schbul.a006887

Cited by 383Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorMental Health and Psychiatry

Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia

Maynard, T. M., Sikich, L., Lieberman, J. A., LaMantia, A.-S.·2001·Schizophrenia Bulletin

DOI 10.1093/oxfordjournals.schbul.a006887

Open this paper in CoChat — free account

Abstract

To account for the complex genetics, the developmental biology, and the late adolescent/early adulthood onset of schizophrenia, the "two-hit" hypothesis has gained increasing attention. In this model, genetic or environmental factors disrupt early central nervous system (CNS) development. These early disruptions produce long-term vulnerability to a "second hit" that then leads to the onset of schizophrenia symptoms. The cell-cell signaling pathways involved in nonaxial induction, morphogenesis, and differentiation in the brain, as well as in the limbs and face, could be targets for a "first hit" during early development. These same pathways, redeployed for neuronal maintenance rather than morphogenesis, may be targets for a "second hit" in the adolescent or adult brain. Furthermore, dysregulation of cell-cell signaling by a "first hit" may prime the CNS for a pathologic response to a "second hit" via the same signaling pathway. Thus, parallel disruption of cell-cell signaling in both the developing and the mature CNS provides a plausible way of integrating genetic, developmental, and environmental factors that contribute to vulnerability and pathogenesis in schizophrenia.

Integrity signals

Registry

Crossref · 10.1093/oxfordjournals.schbul.a006887

Cites

163 of 163 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

These findings support a two-hit model in which early life stress confers vulnerability to psychiatric symptoms, but symptom onset occurs only after a subsequent stressor.
“These studies support a “two hit” model in which ELS, such as maternal separation, confers vulnerability to symptoms of psychiatric illness, but with symptom onset only occurring after exposure to a subsequent stressor (Bayer et al., 1999; Maynard et al., 2001).”
From The effects of early life stress on reward processing (2018) · cites this paper as Maynard et al., 2001

Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909 · see citing works
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898 · see citing works
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works
Physiology and Behavior
Falk, J. L. (1973) · Contemporary Psychology · doi:10.1037/0011818 · Cited by 2,288 · see citing works
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220 · see citing works
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
Jonjić, S., Mutter, W., Weiland, F., Reddehase, M. J., & Koszinowski, U. H. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1199 · Cited by 2,106 · see citing works
Retinoic acid embryopathy
Lammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., Curry, C. J., Fernhoff, P. M., Grix, A. W., Lott, I. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510033131401 · Cited by 1,942 · see citing works
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685 · see citing works
Meta-analysis of regional brain volumes in schizophrenia
Wright, I. C., Rabe-Hesketh, S., Woodruff, P. W. R., David, A. S., Murray, R. M., & Bullmore, E. T. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.16 · Cited by 1,662 · see citing works
Predictors of Relapse Following Response From a First Episode of Schizophrenia or Schizoaffective Disorder
Robinson, D., Woerner, M. G., Alvir, J. M. J., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.241 · Cited by 1,327 · see citing works
Self-citation
Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis
Weiss, S., Dunne, C., Hewson, J., Wohl, C. A., Wheatley, M., Peterson, A. C., & Reynolds, B. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07599.1996 · Cited by 1,219 · see citing works
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.Preprint
Mangelsdorf, D. J., Borgmeyer, U., Heyman, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A., & Evans, R. M. (1992) · Genes & Development · doi:10.1101/gad.6.3.329 · Cited by 1,193 · see citing works
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,111 · see citing works
Notch signaling is essential for vascular morphogenesis in micePreprint
Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., et al. (2000) · Genes & Development · doi:10.1101/gad.14.11.1343 · Cited by 1,065 · see citing works
Molecular Basis of Visual Excitation
Wald, G. (1968) · Science · doi:10.1126/science.162.3850.230 · Cited by 1,028 · see citing works
High rates of schizophrenia in adults with velo-cardio-facial syndrome
Murphy, K. C., Jones, L. A., & Owen, M. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.940 · Cited by 1,024 · see citing works
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
The reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909 · see citing works
Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients
Benes, F. M. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350036005 · Cited by 894 · see citing works
The Dopamine Hypothesis of Schizophrenia: A Review*
Meltzer, H. Y., & Stahl, S. M. (1976) · Schizophrenia Bulletin · doi:10.1093/schbul/2.1.19 · Cited by 883 · see citing works
Duration of psychosis and outcome in first-episode schizophrenia
Loebel, A. D., Lieberman, J. A., Alvir, J. M., Mayerhoff, D. I., Geisler, S. H., & Szymanski, S. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1183 · Cited by 880 · see citing works
Self-citation
Schizophrenia genesis: the origins of madness
(1991) · Choice Reviews Online · doi:10.5860/choice.28-6500 · Cited by 832 · see citing works
The Molecular Basis of Visual Excitation
WALD, G. (1968) · Nature · doi:10.1038/219800a0 · Cited by 824 · see citing works
Neurotransmitters as growth regulatory signals: role of receptors and second messengers
Lauder, J. M. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90162-f · Cited by 806 · see citing works
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
Allenby, G., Bocquel, M. T., Saunders, M., Kazmer, S., Speck, J., Rosenberger, M., Lovey, A. J., Kastner, P., Grippo, J. F., & Chambon, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.30 · Cited by 755 · see citing works
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 753 · see citing works
Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain
Gaiano, N., Nye, J. S., & Fishell, G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81172-1 · Cited by 727 · see citing works
Inductive interactions direct early regionalization of the mouse forebrain
Shimamura, K., & Rubenstein, J. L. R. (1997) · Development · doi:10.1242/dev.124.14.2709 · Cited by 659 · see citing works
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
Belloni, E., Muenke, M., Roessler, E., Traverse, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C. A., Hing, A. V., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-353 · Cited by 643 · see citing works
Positional signalling and specification of digits in chick limb morphogenesis
Tickle, C. A., Summerbell, D., & Wolpert, L. (1975) · Nature · doi:10.1038/254199a0 · Cited by 588 · see citing works
Molecular Models for Vertebrate Limb Development
Johnson, R. L., & Tabin, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80364-5 · Cited by 584 · see citing works
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
Šestan, N., Artavanis‐Tsakonas, S., & RAKIC, P. T. (1999) · Science · doi:10.1126/science.286.5440.741 · Cited by 573 · see citing works
From neuropathology to neurodevelopment
Weinberger, D. R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91386-6 · Cited by 568 · see citing works
Provocative tests with psychostimulant drugs in schizophrenia
Lieberman, J. A., Kane, J. M., & Alvir, J. (1987) · Psychopharmacology · doi:10.1007/bf00216006 · Cited by 535 · see citing works
Self-citation
Emerging principles of altered neural circuitry in schizophrenia
Benes, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00041-7 · Cited by 513 · see citing works
Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment.
Shenefelt, R. (1972) · Teratology · doi:10.1002/tera.1420050115 · Cited by 512 · see citing works
Attention, Memory, and Motor Skills as Childhood Predictors of Schizophrenia-Related Psychoses: The New York High-Risk Project
Erlenmeyer‐Kimling, L., Rock, D., Roberts, S. A., Janal, M. N., Kestenbaum, C. J., Cornblatt, B. A., Adamo, U. H., & Gottesman, I. I. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.9.1416 · Cited by 511 · see citing works
Catecholamines in the Brain as Mediators of Amphetamine Psychosis
Snyder, S. H. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750260021004 · Cited by 432 · see citing works
Congenital heart disease in mice deficient for the DiGeorge syndrome region
Lindsay, E. A., Botta, A., Jurecic, V., Carattini-Rivera, S., Cheah, Y.-C., Rosenblatt, H. M., Bradley, A., & Baldini, A. (1999) · Nature · doi:10.1038/43900 · Cited by 426 · see citing works
Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
BEASLEY, C., & REYNOLDS, G. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00122-3 · Cited by 426 · see citing works
Velo‐cardio‐facial syndrome: A review of 120 patients
Goldberg, R. B., Motzkin, B., Marion, R., Scambler, P. J., & Shprintzen, R. J. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320450307 · Cited by 422 · see citing works
Defects in limb, craniofacial, and thymic development in Jagged2 mutant micePreprint
Jiang, R., Lan, Y., Chapman, H. D., Shawber, C. J., Norton, C. R., SERREZE, D. V., Weinmaster, G., & Gridley, T. (1998) · Genes & Development · doi:10.1101/gad.12.7.1046 · Cited by 418 · see citing works
Physiological Evidence for Habenula as Major Link Between Forebrain and Midbrain Raphe
Wang, R. Y., & Aghajanian, G. K. (1977) · Science · doi:10.1126/science.194312 · Cited by 411 · see citing works
Late‐Onset psychosis in the velo‐cardio‐facial syndrome
Shprintzen, R. J., Goldberg, R. B., Golding‐Kushner, K. J., & Marion, R. W. (1992) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320420131 · Cited by 402 · see citing works
THE BIOLOGICAL FUNCTION OF VITAMIN A ACID.
Dowling, J., & Wald, G. (1960) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.46.5.587 · Cited by 393 · see citing works
Motor Neuron–Derived Retinoid Signaling Specifies the Subtype Identity of Spinal Motor Neurons
Sockanathan, S., & Jessell, T. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81591-3 · Cited by 389 · see citing works
The Ins and Outs of Notch Signaling
Weinmaster, G. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0612 · Cited by 382 · see citing works
Establishing the onset of psychotic illness
Beiser, M., Erickson, D., Fleming, J. A. E., & Iacono, W. G. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.9.1349 · Cited by 373 · see citing works
Viruses, schizophrenia, and bipolar disorder
Yolken, R. H., & Torrey, Ε. F. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.1.131 · Cited by 356 · see citing works
Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice
Krężel, W., Ghyselinck, N. B., Samad, T. A., Dupé, V., Kastner, P., Borrelli, E., & Chambon, P. (1998) · Science · doi:10.1126/science.279.5352.863 · Cited by 349 · see citing works
Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “Two hit hypothesis.”
Bayer, T. A., Falkai, P., & Maier, W. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00039-4 · Cited by 346 · see citing works
Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics
Joyce, J. N., Shane, A. L., Lexow, N., Winokur, A., Casanova, M. F., & Kleinman, J. E. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.32 · Cited by 340 · see citing works
Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients
Takahashi, M., Shirakawa, O., Toyooka, K., Kitamura, N., Hashimoto, T., Maeda, K., Koizumi, S., Wakabayashi, K., Takahashi, H., Someya, T., et al. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000718 · Cited by 340 · see citing works
Comparison of Amphetamine Psychosis and Schizophrenia
Bell, D. S. (1965) · The British Journal of Psychiatry · doi:10.1192/bjp.111.477.701 · Cited by 328 · see citing works
An Essential Role for Retinoid Receptors RARβ and RXRγ In Long-Term Potentiation and Depression
Chiang, M.-Y., Misner, D., Kempermann, G., Schikorski, T., Giguère, V., Sucov, H. M., Gage, F. H., Stevens, C. F., & Evans, R. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80654-6 · Cited by 323 · see citing works
Olfactory Dysfunction in Schizophrenia A Qualitative and Quantitative Review
Moberg, P. J. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00019-6 · Cited by 317 · see citing works
Cocaine, kindling, and psychosis
Post, R. M., & Kopanda, R. T. (1976) · American Journal of Psychiatry · doi:10.1176/ajp.133.6.627 · Cited by 308 · see citing works
Imaging dopamine transmission in schizophrenia. A review and meta-analysis.
Laruelle, M. (1998) · PubMed · Cited by 280 · see citing works
Velo-cardio-facial syndrome: language and psychological profiles.
Golding‐Kushner, K. J., Weller, G. M., & Shprintzen, R. J. (1985) · PubMed · Cited by 266 · see citing works
NUMB Localizes in the Basal Cortex of Mitotic Avian Neuroepithelial Cells and Modulates Neuronal Differentiation by Binding to NOTCH-1
Wakamatsu, Y., Maynard, T. M., Jones, S. U., & Weston, J. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80754-0 · Cited by 256 · see citing works
Self-citation
Arbiter of differentiation and death: Notch signaling meets apoptosis
Miele, L., & Osborne, B. A. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199912)181:3 · Cited by 253 · see citing works
Children and Adolescents With Velocardiofacial Syndrome: A Volumetric MRI Study
D, S. E. M., Schmitt, J. E., White, C. D., & Reiss, A. L. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.3.409 · Cited by 251 · see citing works
Cocaine-Induced Psychosis
Brady, K. T., Lydiard, R. B., Malcolm, R. J., & Ballenger, J. C. (1992) · PsycEXTRA Dataset · doi:10.1037/e324222004-013 · Cited by 247 · see citing works
Differential expression of retinoid receptors in the adult mouse central nervous system
Krężel, W., Kastner, P., & Chambon, P. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00342-x · Cited by 238 · see citing works
Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia.
Arnold, S. E., Lee, V. M., Gur, R. E., & Trojanowski, J. Q. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10850 · Cited by 236 · see citing works
RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.
Krężel, W., Dupé, V., Mark, M., Dierich, A., Kastner, P., & Chambon, P. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.17.9010 · Cited by 231 · see citing works
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Siris, S. G. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800350089019 · Cited by 224 · see citing works
E2F-6, a member of the E2F family that can behave as a transcriptional repressor
Trimarchi, J. M., Fairchild, B., Verona, R. I., Moberg, K. H., Andon, N. L., & Lees, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2850 · Cited by 223 · see citing works
Prenatal Exposure to Famine and Brain Morphology in Schizophrenia
Pol, H. E. H., Hoek, H. W., Susser, E., Brown, A. S., Dingemans, A. E., Schnack, H. G., van Haren, N. E. M., Ramos, L. M. P., Wied, C. C. G., & Kahn, R. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1170 · Cited by 215 · see citing works
Factors influencing treatment response and outcome of first-episode schizophrenia: implications for understanding the pathophysiology of schizophrenia.
Lieberman, J. A., Koreen, A., Chakos, M., Sheitman, B., Woerner, M. G., Alvir, J. M. J., & Bilder, R. M. (1996) · PubMed · Cited by 211 · see citing works
Self-citation
The behavioural phenotype in velo-cardio-facial syndrome (VCFS): from infancy to adolescence.
Swillen, A., Devriendt, K., Legius, E., Prinzie, P., Vogels, A., Ghesquière, P., & Fryns, J. (1999) · PubMed · Cited by 208 · see citing works
Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluRl and GluR2 in medial temporal lobe neurons in schizophrenia
Eastwood, S. L., McDonald, B., Burnet, P. W. J., Beckwith, J. P., Kerwin, R. W., & Harrison, P. J. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00247-c · Cited by 207 · see citing works
MINOR PHYSICAL ANOMALIES AND BEHAVIOR IN PRESCHOOL CHILDREN
Waldrop, M. F., Pedersen, F. A., & Bell, R. Q. (1968) · Child Development · doi:10.1111/j.1467-8624.1968.tb04433.x · Cited by 206 · see citing works
Minor Physical Anomalies and Behavior in Preschool Children
Waldrop, M. F., Pedersen, F. A., & Bell, R. Q. (1968) · Child Development · doi:10.2307/1126953 · Cited by 203 · see citing works
Reduced Olfactory Bulb Volume in Patients With Schizophrenia
Turetsky, B. I., Moberg, P. J., Yousem, D. M., Doty, R. L., Arnold, S. E., & Gur, R. E. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.828 · Cited by 197 · see citing works
Premorbid and Onset Features of First-Episode Schizophrenia
Haas, G. L., & Sweeney, J. A. (1992) · Schizophrenia Bulletin · doi:10.1093/schbul/18.3.373 · Cited by 196 · see citing works
Three independent lines of evidence suggest retinoids as causal to schizophrenia
Goodman, A. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7240 · Cited by 190 · see citing works
Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula
Ellison, G. D. (1994) · Brain Research Reviews · doi:10.1016/0165-0173(94)90012-4 · Cited by 182 · see citing works
The NOTCH4 locus is associated with susceptibility to schizophrenia
Wei, J., & Hemmings, G. P. (2000) · Nature Genetics · doi:10.1038/78044 · Cited by 180 · see citing works
Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6
Gaubatz, S., Wood, J. G., & Livingston, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9190 · Cited by 180 · see citing works
Drugs and Aging
McKim, W. A., & Mishara, B. L. (1987) · Medical Entomology and Zoology · Cited by 177 · see citing works
The initiation of the limb bud: Growth factors, Hox genes, and retinoids
Tabin, C. (1995) · Cell · doi:10.1016/0092-8674(95)90343-7 · Cited by 171 · see citing works
Schizoid personality disorder after prenatal exposure to famine
Hoek, H. W., Susser, E., Buck, K. A., Lumey, L. H., Lin, S. P., & Gorman, J. M. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.12.1637 · Cited by 168 · see citing works
Transgenic indicator mice for studying activated retinoic acid receptors during development.
Balkan, W., Colbert, M., Bock, C., & Linney, E. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3347 · Cited by 166 · see citing works
Mesenchymal/Epithelial Induction Mediates Olfactory Pathway Formation
LaMantia, A., Bhasin, N., Rhodes, K., & Heemskerk, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00121-5 · Cited by 164 · see citing works
Self-citation
Minor Physical Anomalies in Schizophrenic Patients and Their Siblings
Ismail, B., Cantor‐Graae, E., & McNeil, T. F. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.12.1695 · Cited by 164 · see citing works
Increased expression of Wnt-1 in schizophrenic brains
Miyaoka, T., Seno, H., & Ishino, H. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00179-0 · Cited by 161 · see citing works
Ectodermal-mesodermal interactions in the growth of limb buds in the chick embryo: Constancy and temporal limits of the ectodermal induction
Rubin, L., & Saunders, J. W. (1972) · Developmental Biology · doi:10.1016/0012-1606(72)90129-7 · Cited by 160 · see citing works
Altered levels of the synaptosomal associated protein SNAP-25 in schizophrenia
Thompson, P. M., Sower, A. C., & Perrone‐Bizzozero, N. I. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00204-7 · Cited by 158 · see citing works
The Incidence of Minor Physical Anomalies in Adult Male Schizophrenics
Guy, J. D., Majorski, L. V., Wallace, C. J., & Guy, M. P. (1983) · Schizophrenia Bulletin · doi:10.1093/schbul/9.4.571 · Cited by 154 · see citing works
Abnormalities of Wnt signalling in schizophrenia – evidence for neurodevelopmental abnormality
Cotter, D., Kerwin, R. W., Al-Sarraji, S., Brion, J., Chadwich, A., Lovestone, S., Anderton, B. H., & Everall, I. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00024 · Cited by 152 · see citing works
Notch Is Expressed in Adult Brain, Is Coexpressed with Presenilin-1, and Is Altered in Alzheimer Disease
Berezovska, O., Xia, M., & Hyman, B. T. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199808000-00003 · Cited by 150 · see citing works
Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain
LaMantia, A., Colbert, M. C., & Linney, E. A. (1993) · Neuron · doi:10.1016/0896-6273(93)90052-s · Cited by 146 · see citing works
Self-citation
The natural history and pathophysiology of treatment resistant schizophrenia
Sheitman, B. B., & Lieberman, J. A. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(97)00052-6 · Cited by 140 · see citing works
Self-citation
Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders.
Carlson, C., Papolos, D. F., PANDITA, R. K., Faedda, G. L., Veit, S., Goldberg, R. B., Shprintzen, R. J., Kucherlapati, R., & Morrow, B. E. (1997) · PubMed · Cited by 138 · see citing works
Retinoic acid and retinoic acid receptors in development
Sucov, H. M., & Evans, R. M. (1995) · Molecular Neurobiology · doi:10.1007/bf02740674 · Cited by 136 · see citing works
Minor physical anomalies in alcoholic and schizophrenic adults and hyperactive and autistic children
Gualtieri, C. T., Adams, A., Shen, C., & Loiselle, D. L. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.5.640 · Cited by 134 · see citing works
No evidence for astrogliosis in brains of schizophrenic patients. A post‐mortem study
Falkai, P., Honer, David, Bogerts, Majtenyi, & Bayer (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00162.x · Cited by 132 · see citing works
The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients
Haracz, J. L. (1982) · Schizophrenia Bulletin · doi:10.1093/schbul/8.3.438 · Cited by 128 · see citing works
Localization of cellular retinoid-binding proteins suggests specific roles for retinoids in the adult central nervous system
Zetterström, R. H., Simon, A., Giacobini, M., Eriksson, U., & Olson, L. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90482-0 · Cited by 121 · see citing works
Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogenesis.
Perez-Castro, A. V., Toth, L. E., Wei, L., & Nguyen-Huu, M. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8813 · Cited by 121 · see citing works
Newborn Minor Physical Anomalies Predict Short Attention Span, Peer Aggression, and Impulsivity at Age 3
Waldrop, M. F., Bell, R. Q., McLaughlin, B., & Halverson, C. F. (1978) · Science · doi:10.1126/science.622559 · Cited by 119 · see citing works
Prenatal Development of Monozygotic Twins and Concordance for Schizophrenia
Davis, J. O., Phelps, J. A., & Bracha, H. S. (1995) · Schizophrenia Bulletin · doi:10.1093/schbul/21.3.357 · Cited by 118 · see citing works
Ventricular volume and asymmetry in schizotypal personality disorder and schizophrenia assessed with magnetic resonance imaging
Buchsbaum, M. S., Yang, S., Hazlett, E. A., Siegel, B. V., Germans, M. K., Haznedar, M. M., O'Flaithbheartaigh, S., Wei, T.-C., Silverman, J. M., & Siever, L. J. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00087-x · Cited by 115 · see citing works
Deletion of 150 kb in the Minimal Digeorge/Velocardiofacial Syndrome Critical Region in Mouse
Kimber, W. L., Hsieh, P., Hirotsune, S., Yuva‐Paylor, L. A., Sutherland, H. F., Chen, A., Ruiz‐Lozano, P., Hoogstraten-Miller, S. L., Chien, K. R., Paylor, R. E., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.12.2229 · Cited by 113 · see citing works
Central amygdala lesions affect behavioral and autonomic balance during stress in rats
Roozendaal, B., Koolhaas, J. M., & Bohus, B. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90017-i · Cited by 110 · see citing works
Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.
Yang, N., Schüle, R., Mangelsdorf, D. J., & Evans, R. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3559 · Cited by 109 · see citing works
Forebrain induction, retinoic acid, and vulnerability to schizophrenia: insights from molecular and genetic analysis in developing mice
LaMantia, A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00002-5 · Cited by 106 · see citing works
Self-citation
Potential behavioral modification of glucocorticoid damage to the hippocampus
Sapolsky, R. M. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90133-b · Cited by 103 · see citing works
Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development.
Colbert, M. C., Linney, E. A., & LaMantia, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6572 · Cited by 103 · see citing works
Self-citation
Childhood behavioral characteristics and adult brain morphology in schizophrenia
Walker, E. F., Lewine, R. R. J., & Neumann, C. S. (1996) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00070-9 · Cited by 91 · see citing works
Cerebral ventricle dimensions as risk factors for schizophrenia and affective psychosis: an epidemiological approach to analysis
Jones, P. B., Harvey, I., Lewis, S. W., Toone, B., van Os, J., Williams, M., & Murray, R. M. (1994) · Psychological Medicine · doi:10.1017/s0033291700029081 · Cited by 91 · see citing works
Stress Pathway Activation Induces Phosphorylation of Retinoid X Receptor
Lee, H., Suh, Y., Robinson, M. J., Clifford, J. L., Hong, W. K., Woodgett, J. R., Cobb, M. H., Mangelsdorf, D. J., & Kurie, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005490200 · Cited by 91 · see citing works
Influence of the choroid plexus on cerebellar development: analysis of retinoic acid synthesis
Yamamoto, M., McCaffery, P. J. A., & Dräger, U. C. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00038-7 · Cited by 85 · see citing works
Benign Intracranial Hypertension Associated With Hypervitaminosis A
Feldman, M. H., & Schlezinger, N. S. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480190005001 · Cited by 85 · see citing works
Abnormal Expression of Cell Recognition Molecules in Schizophrenia
Vawter, M. P., Cannon-Spoor, H. E., Hemperly, J. J., Hyde, T. M., VanderPutten, D. M., Kleinman, J. E., & Freed, W. J. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6721 · Cited by 84 · see citing works
Effort and stress influence the effect of lesion of the habenula complex in one-way active avoidance learning
Thornton, E. W., & Bradbury, G. E. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90217-5 · Cited by 83 · see citing works
Neuropsychiatric Adverse Effects of Antiparkinsonian Drugs
Young, B. K., Camicioli, R. M., & Ganzini, L. K. (1997) · Drugs & Aging · doi:10.2165/00002512-199710050-00005 · Cited by 81 · see citing works
Velo‐cardio‐facial syndrome and psychotic disorders: Implications for psychiatric genetics
Chow, E. W. C., Bassett, A. S., & Weksberg, R. (1994) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320540205 · Cited by 79 · see citing works
Newly-generated cells from the rostral migratory stream in the accessory olfactory bulb of the adult rat
Bonfanti, L., Peretto, P., Merighi, A., & Fasolo, A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00090-0 · Cited by 76 · see citing works
Transmitters contained in the efferents of the habenula
Vincent, S. R., Staines, W. A., McGeer, E. G., & Fibiger, H. C. (1980) · Brain Research · doi:10.1016/0006-8993(80)90084-0 · Cited by 74 · see citing works
Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo
Gustafson, A.-L., Dencker, L., & Eriksson, U. (1993) · Development · doi:10.1242/dev.117.2.451 · Cited by 71 · see citing works
Retinoic Acid Embryopathy
Harada, M. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150416 · Cited by 70 · see citing works
Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/ DiGeorge syndrome region
Puech, A., Saint-Jore, B., Merscher, S., Russell, R. G., Chérif, D., Sirotkin, H. I., Xu, H., Factor, S. M., Kucherlapati, R., & Skoultchi, A. I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.10090 · Cited by 68 · see citing works
Differential expression of Notch1 and Notch2 in developing and adult mouse brain
Higuchi, M., Kiyama, H., Hayakawa, T., Hamada, Y., & Tsujimoto, Y. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00257-f · Cited by 67 · see citing works
Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone
Kurosaki, M., Demontis, S., Barzago, M. M., Garattini, E., & Terao, M. (1999) · Biochemical Journal · doi:10.1042/bj3410071 · Cited by 66 · see citing works
Advances in developmental biology
Wassarman, P. M. (1992) · JAI Press Inc. eBooks · Cited by 65 · see citing works
Psychotic complications of long-term levodopa treatment of Parkinson's disease
Friedman, A., & Sienkiewicz, J. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04918.x · Cited by 65 · see citing works
Retinoid‐binding proteins in the cerebellum and choroid plexus and their relationship to regionalized retinoic acid synthesis and degradation
Yamamoto, M., Dräger, U. C., Ong, D. E., & McCaffery, P. J. A. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2570344.x · Cited by 65 · see citing works
Retinoid receptors in transcriptional regulation
Minucci, S., & Ozato, K. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80085-2 · Cited by 62 · see citing works
The usual suspects: GABA and glutamate may regulate proliferation in the neocortex
LaMantia, A. (1995) · Neuron · doi:10.1016/0896-6273(95)90002-0 · Cited by 61 · see citing works
Self-citation
Attenuation of positional signalling in the chick limb by high doses of γ-radiation
Smith, J. C., Tickle, C. A., & Wolpert, L. (1978) · Nature · doi:10.1038/272612a0 · Cited by 58 · see citing works
Neurobehavioral teratology of isotretinoin
Adams, J., & Lammer, E. J. (1993) · Reproductive Toxicology · doi:10.1016/0890-6238(93)90273-a · Cited by 57 · see citing works
Factors affecting the development and regeneration of visual purple in the mammalian retina
Tansley, K. (1933) · Proceedings of the Royal Society of London Series B Containing Papers of a Biological Character · doi:10.1098/rspb.1933.0072 · Cited by 56 · see citing works
Adult rabbit brain synthesizes retinoic acid
Dev, S., Adler, A. J., & Edwards, R. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)91170-w · Cited by 56 · see citing works
Genetic basis of DiGeorge and velocardiofacial syndromes
Driscoll, D. A. (1994) · Current Opinion in Pediatrics · doi:10.1097/00008480-199412000-00016 · Cited by 55 · see citing works
Chromosomal locations and modes of action of genes of the retinoid (vitamin A) system support their involvement in the etiology of schizophrenia
Goodman, A. B. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600415 · Cited by 52 · see citing works
Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene.
Li, L.-H., Huang, G., Banta, A., Deng, Y., Smith, T., Dong, P. N., Friedman, C., Chen, L., Trask, B., Spies, T., et al. (1998) · Genomics · doi:10.1006/geno.1998.5330 · Cited by 49 · see citing works
Vitamin A Deficiency and Its Effects on the Eye
Harris, E. W., Loewenstein, J. I., & Azar, D. T. (1998) · International Ophthalmology Clinics · doi:10.1097/00004397-199803810-00013 · Cited by 49 · see citing works
Two Different Enzymes Are Primarily Responsible for Retinoic Acid Synthesis in Rabbit Liver Cytosol
Huang, D., & Ichikawa, Y. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2803 · Cited by 46 · see citing works
Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors
Maynard, T. M., Wakamatsu, Y., & Weston, J. A. (2000) · Development · doi:10.1242/dev.127.21.4561 · Cited by 39 · see citing works
Self-citation
Effect of retinol and retinoic acid on testosterone production by rat Leydig cells in primary culture
Chaudhary, L. R., Hutson, J. C., & Stocco, D. M. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(89)80061-0 · Cited by 38 · see citing works
Effects of small amygdala lesions on fear, but not aggression, in the rat
Oakes, M. E., & Coover, G. D. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00348-4 · Cited by 36 · see citing works
Is schizophrenia a neurodevelopmental disorder?
Waddington, J. L., & Youssef, H. A. (1987) · BMJ · doi:10.1136/bmj.295.6604.997-b · Cited by 33 · see citing works
Involvement of the entopeduncular nucleus and the habenula in methamphetamine-induced inhibition of dopamine neurons in the substantia nigra of rats
Sasaki, K., Suda, H., Watanabe, H., & Yagi, H. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90262-x · Cited by 32 · see citing works
Viruses, schizophrenia, and bipolar disorder.
Yolken, R. H., & Torrey, Ε. F. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.1.131-145.1995 · Cited by 28 · see citing works
Neurological Disturbances in Rats Reared on Diets Deficient in Vitamin A
Aberle, S. B. D. (1934) · Journal of Nutrition · doi:10.1093/jn/7.4.445 · Cited by 27 · see citing works
Increased immobility in an automated forced swimming test following lesion of the habenula in rats: Absence of evidence for a contribution from motor impairment.
Thornton, E. W., Bradbury, G. E., & Davies, C. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.1.37 · Cited by 27 · see citing works
The Neurotoxic Effects of Continuous Cocaine and Amphetamine in Habenula: Implications for the Substrates of Psychosis
Ellison, G. D., Irwin, S. A., Noguchi, K., Sulur, G., & Keys, A. S. (1996) · PsycEXTRA Dataset · doi:10.1037/e495672006-007 · Cited by 24 · see citing works
Seasonality of births in schizophrenia and bipolar disorder: A review of the literature
Torrey, Ε. F., Miller, J., Rawlings, R. R., & Yolken, R. H. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)82751-x · Cited by 24 · see citing works
Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons
Bendotti, C., Prosperini, E., Kurosaki, M., Garattini, E., & Terao, M. (1997) · Neuroreport · doi:10.1097/00001756-199707070-00048 · Cited by 23 · see citing works
Effects of Habenular Lesions upon Two-Way Active Avoidance Conditioning in Rats
Vale-Martı́nez, A., Martí‐Nicolovius, M., Guillazo‐Blanch, G., Coll-Andreu, M., & Morgado-Bernal, I. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3777 · Cited by 22 · see citing works
Increased immobility in an automated forced swimming test following lesion of the habenula in rats: Absence of evidence for a contribution from motor impairment.
Thornton, E. W., Bradbury, G. E., & Davies, C. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.1.37 · Cited by 22 · see citing works
m2 muscarinic acetylcholine receptor-immunoreactive neurons are not reduced within the nucleus basalis in Alzheimer's disease: Relationship with cholinergic and galaninergic perikarya
Mufson, E. J., Jaffar, S., & Levey, A. I. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980316)392:3 · Cited by 20 · see citing works
Chronic hypervitaminosis A in an adult
Benedetto, R. J. D. (1967) · JAMA · doi:10.1001/jama.201.9.700 · Cited by 19 · see citing works
Retinoid Signaling in Mouse Embryos
Linney, E. A., & LaMantia, A. (1994) · Advances in developmental biology · doi:10.1016/s1566-3116(08)60007-9 · Cited by 18 · see citing works
Self-citation
Habenular lesion attenuates methamphetamine-induced inhibition of dopamine neuronal activity in the substantia nigra pars compacta of rats
Sasaki, K., Suda, H., Watanabe, H., Kaneko, S., Nomura, Y., Nishino, H., & Ono, T. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90184-x · Cited by 18 · see citing works
Chronic Hypervitaminosis A in an Adult
Benedetto, R. J. D. (1967) · JAMA · doi:10.1001/jama.1967.03130090064022 · Cited by 17 · see citing works
Effect of Vitamin A Deficiency on the Retina of the Experimental Rabbit
Sorsby, A., Reading, H. W., & Bunyan, J. (1966) · Nature · doi:10.1038/2101011a0 · Cited by 11 · see citing works
Prenatal exposure to famine and brain morphology in schizophrenia
Pol, H. E. H., Hoek, H. W., Susser, E., Brown, A., Dingemans, A. E., Schnack, H. G., van Haren, N. E. M., Ramos, L. M. P., Wied, C. C. G., & Kahn, R. S. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(00)90321-9 · Cited by 10 · see citing works
Untitled work
Kritzer (1997) · doi:10.1002/(sici)1096-9861(19970310)379:2
Self-citation
Twin studies of schizophrenia: From bow-and-arrow concordances to Star Wars Mx and functional genomics
Cardno, A. G., & Gottesman, I. I. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(200021)97:1
Untitled work
(2000) · doi:10.1002/1098-2779(2000)6:2

Flagged first, then by citations

Sorted by citations

Brain volume in first-episode schizophrenia: Systematic review and meta-analysis of magnetic resonance imaging studies
Steen, R. G., Mull, C., Mcclure, R., Hamer, R. M., & Lieberman, J. A. (2006) · British Journal of Psychiatry · doi:10.1192/bjp.188.6.510 · Cited by 832 · see citing works
Self-citation
Early-life programming of later-life brain and behavior: a critical role for the immune system
Bilbo, S. D. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.014.2009 · Cited by 652 · see citing works
Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems
Meyer, U. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.011 · Cited by 626 · see citing works
The immune system and developmental programming of brain and behavior
Bilbo, S. D., & Schwarz, J. M. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.08.006 · Cited by 579 · see citing works
Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice
Giovanoli, S., Engler, H., Engler, A., Richetto, J., Voget, M., Willi, R., Winter, C., Riva, M. A., Mortensen, P. B., Feldon, J., et al. (2013) · Science · doi:10.1126/science.1228261 · Cited by 459 · see citing works
Functional resting-state networks are differentially affected in schizophrenia
Woodward, N. D., Rogers, B. P., & Heckers, S. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.03.010 · Cited by 342 · see citing works
Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions
Roceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G., & Riva, M. A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.011 · Cited by 317 · see citing works
Prenatal Stress or High-Fat Diet Increases Susceptibility to Diet-Induced Obesity in Rat Offspring
Tamashiro, K. L., Terrillion, C. E., Hyun, J., Koenig, J. I., & Moran, T. H. (2009) · Diabetes · doi:10.2337/db08-1129 · Cited by 291 · see citing works
Autoimmunity, Inflammation, and Psychosis: A Search for Peripheral Markers
Bergink, V., Gibney, S. M., & Drexhage, H. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.037 · Cited by 277 · see citing works
Childhood infection and adult schizophrenia: A meta-analysis of population-based studies
Khandaker, G. M., Zimbron, J., Dalman, C., Lewis, G., & Jones, P. B. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.05.023 · Cited by 257 · see citing works
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
Disorder, A. S., Disorder, B., Disorder, M. D., Disorder, O.-C., Groups, A. S. E. W., Patel, Y., Parker, N., Shin, J., Howard, D., French, L., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.2694 · Cited by 246 · see citing works
A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health
Beaulieu, J. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110011 · Cited by 237 · see citing works
A Two-Hit Model of Autism
Picci, G., & Scherf, K. S. (2014) · Clinical Psychological Science · doi:10.1177/2167702614540646 · Cited by 251 · see citing works
Moving Ahead with the Schizophrenia Concept: From the Elephant to the Mouse
Keshavan, M., Nasrallah, H., & Tandon, R. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.01.011 · Cited by 243 · see citing works
Early life stress as a risk factor for mental health: Role of neurotrophins from rodents to non-human primates
Cirulli, F., Francia, N., Berry, A., Aloe, L., Alleva, E., & Suomi, S. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.001 · Cited by 225 · see citing works
Perinatal environment and its influences on metabolic programming of offspring
Tamashiro, K. L., & Moran, T. H. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.04.008 · Cited by 195 · see citing works
MicroRNA and Posttranscriptional Dysregulation in Psychiatry
Geaghan, M. P., & Cairns, M. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.009 · Cited by 193 · see citing works
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“maternal separation, confers vulnerability to symptoms of psychiatric illness, but with symptom onset only occurring after exposure to a subsequent stressor (Bayer et al., 1999; Maynard et al., 2001).”
Background
The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models
Rubino, T., & Parolaro, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.024 · Cited by 183 · see citing works
Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions
Robinson, N., & Bergen, S. E. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.686666 · Cited by 189 · see citing works
Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence
French, L., Gray, C., Leonard, G. T., Perron, M., Pike, G. B., Richer, L., Séguin, J. R., Veillette, S., Evans, J., Eric Artiges, A., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1131 · Cited by 175 · see citing works
The Synaptic Hypothesis of Schizophrenia
Frankle, W. G., Lerma, J., & Laruelle, M. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00423-9 · Cited by 167 · see citing works
A vitamin for the brain
Shearer, K. D., Stoney, P. N., Morgan, P. J., & McCaffery, P. J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.005 · Cited by 152 · see citing works
The NGF saga: From animal models of psychosocial stress to stress-related psychopathology
Cirulli, F., & Alleva, E. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.002 · Cited by 160 · see citing works
A comprehensive analysis of 22q11 gene expression in the developing and adult brain
Maynard, T. M., Haskell, G., Peters, A. Z., Sikich, L., Lieberman, J. A., & LaMantia, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235651100 · Cited by 154 · see citing works
Self-citation
Neonatal lipopolysaccharide and adult stress exposure predisposes rats to anxiety-like behaviour and blunted corticosterone responses: Implications for the double-hit hypothesis
Walker, A. K., Nakamura, T., Byrne, R. J., Naicker, S., Tynan, R. J., Hunter, M., & Hodgson, D. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.010 · Cited by 150 · see citing works
Role of cannabis and endocannabinoids in the genesis of schizophrenia
Fernández‐Espejo, E., Viveros, M., Núñez, L., Ellenbroek, B. A., & de Fonseca, F. R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1612-6 · Cited by 155 · see citing works
Susceptibility genes for schizophrenia: Characterisation of mutant mouse models at the level of phenotypic behaviour
O’Tuathaigh, C. M. P., Babovic, D., O’Meara, G. F., Clifford, J. J., Croke, D. T., & Waddington, J. L. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.04.002 · Cited by 151 · see citing works
Schizophrenia and Other Psychotic Disorders
Jibson, M. D., Glick, I. D., & Tandon, R. (2004) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.2.1.17 · Cited by 140 · see citing works
Combined neonatal stress and young‐adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: Effects on learning and memory
Choy, K. H. C., de Visser, Y. P., Nichols, N. R., & van den Buuse, M. (2008) · Hippocampus · doi:10.1002/hipo.20425 · Cited by 137 · see citing works
Scents and Nonsense: Olfactory Dysfunction in Schizophrenia
Turetsky, B. I., Hahn, C.-G., Borgmann‐Winter, K. E., & Moberg, P. J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp111 · Cited by 135 · see citing works
Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences
Fitzgerald, E., Hor, K., & Drake, A. J. (2020) · Early Human Development · doi:10.1016/j.earlhumdev.2020.105190 · Cited by 136 · see citing works
Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner
Rincel, M., Aubert, P., Chevalier, J., Grohard, P. ‐., Basso, L., de Oliveira, C. M., Helbling, J., Lévy, É., Chevalier, G., Leboyer, M., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.006 · Cited by 138 · see citing works
The proteome of schizophrenia
Nascimento, J. M., & Martins‐de‐Souza, D. (2015) · Schizophrenia · doi:10.1038/npjschz.2014.3 · Cited by 125 · see citing works
Major Histocompatibility Complex I in Brain Development and Schizophrenia
McAllister, A. K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.003 · Cited by 123 · see citing works
Evidences for a progressive microglial activation and increase in iNOS expression in rats submitted to a neurodevelopmental model of schizophrenia: Reversal by clozapine
Ribeiro, B. M. M., do Carmo, M. R. S., Freire, R. S., Rocha, N. F. M., Borella, V., Menezes, A. T., Monte, A. S., Gomes, P. X. L., de Sousa, F. C. F., Vale, M. L., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.10.040 · Cited by 123 · see citing works
Neurodevelopmental pathways in bipolar disorder
Kloiber, S., Rosenblat, J. D., Husain, M. I., Ortiz, A., Berk, M., Quevedo, J., Vieta, E., Maes, M., Birmaher, B., Soares, J. C., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.005 · Cited by 122 · see citing works
Differential Neurodevelopmental Trajectories in Patients With Early-Onset Bipolar and Schizophrenia Disorders
Arango, C., Fraguas, D., & Parellada, M. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt198 · Cited by 119 · see citing works
Associations Between Maternal Infection During Pregnancy, Childhood Infections and the Risk of Subsequent Psychotic Disorder—A Swedish Cohort Study of Nearly 2 Million Individuals
Blomström, Å., Karlsson, H., Gardner, R. M., Jörgensen, L., Magnusson, C., & Dalman, C. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv112 · Cited by 119 · see citing works
MicroRNA: Small RNA mediators of the brains genomic response to environmental stress
Hollins, S. L., & Cairns, M. J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.005 · Cited by 117 · see citing works
Cellular signalling mechanisms of neural cell adhesion molecules Anitha K Panicker Mona Buhusi
Maness, P. F. (2003) · Frontiers in bioscience · doi:10.2741/1014 · Cited by 116 · see citing works
Stress load during childhood affects psychopathology in psychiatric patients
Weber, K., Rockstroh, B. S., Borgelt, J., Awiszus, B., Popov, T. G., Hoffmann, K. K. P., Schonauer, K., Watzl, H., & Pröpster, K. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-63 · Cited by 112 · see citing works
Peripubertal Diazepam Administration Prevents the Emergence of Dopamine System Hyperresponsivity in the MAM Developmental Disruption Model of Schizophrenia
Du, Y., & Grace, A. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.101 · Cited by 105 · see citing works
Importance of Animal Models in Schizophrenia Research
van den Buuse, M., Garner, B., Gogos, A., & Kusljic, S. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01626.x · Cited by 105 · see citing works
Long Term Sex-Dependent Psychoneuroendocrine Effects of Maternal Deprivation and Juvenile Unpredictable Stress in Rats
Llorente, R., Miguel-Blanco, C., Aisa, B., Lachize, S., Borcel, É., Meijer, O. C., Ramírez, M. J., de Kloet, E. R., & Viveros, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02109.x · Cited by 101 · see citing works
Electrical Excitability of Early Neurons in the Human Cerebral Cortex during the Second Trimester of Gestation
Moore, A. R., Filipovic, R., Mo, Z., Rasband, M. N., Zečević, N., & Antic, S. D. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn206 · Cited by 101 · see citing works
LPS Exposure Increases Maternal Corticosterone Levels, Causes Placental Injury and Increases IL-1Β Levels in Adult Rat Offspring: Relevance to Autism
Kirsten, T. B., Lippi, L. L., Bevilacqua, E. M. A. F., & Bernardi, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082244 · Cited by 103 · see citing works
Sex-specific disruptions in spatial memory and anhedonia in a “two hit” rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling
Hill, R. A., Klug, M., Kiss Von Soly, S., Binder, M. D., Hannan, A. J., & van den Buuse, M. (2014) · Hippocampus · doi:10.1002/hipo.22302 · Cited by 99 · see citing works
Von Economo neuron density in the anterior cingulate cortex is reduced in early onset schizophrenia
Brüne, M., Schöbel, A., Karau, R., Benali, A., Faustmann, P. M., Juckel, G., & Petrasch‐Parwez, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0673-2 · Cited by 94 · see citing works
The connection between microbiome and schizophrenia
Golofast, B., & Vales, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.011 · Cited by 92 · see citing works
Sex‐dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour
Llorente‐Berzal, A., Fuentes, S., Gagliano, H., López‐Gallardo, M., Armario, A., Viveros, M., & Nadal, R. A. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00318.x · Cited by 88 · see citing works
Fetal programming of schizophrenia: Select mechanisms
Debnath, M., Venkatasubramanian, G., & Berk, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.003 · Cited by 84 · see citing works
The dual hit hypothesis of schizophrenia: Evidence from animal models
Guerrin, C. G. J., Doorduin, J., Sommer, I. E., & de Vries, E. F. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.025 · Cited by 81 · see citing works
Animal models of gene–environment interaction in schizophrenia: A dimensional perspective
Ayhan, Y., McFarland, R., & Pletnikov, M. V. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.002 · Cited by 81 · see citing works
Single and combined effects of prenatal immune activation and peripubertal stress on parvalbumin and reelin expression in the hippocampal formation
Giovanoli, S., Weber, L., & Meyer, U. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.005 · Cited by 81 · see citing works
The Long and the Short of it: Gene and Environment Interactions During Early Cortical Development and Consequences for Long-Term Neurological Disease
Stolp, H. B., Neuhaus, A. A., Sundramoorthi, R., & Molnár, Z. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00050 · Cited by 91 · see citing works
A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia
Pérez‐Santiago, J., Dı́ez-Alarcia, R., Callado, L. F., Zhang, J. X., Chana, G., White, C., Glatt, S. J., Tsuang, M. T., Everall, I., Meana, J. J., et al. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.08.005 · Cited by 80 · see citing works
Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure
Hollins, S. L., Zavitsanou, K., Walker, F. R., & Cairns, M. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.99 · Cited by 78 · see citing works
Two-hit model of schizophrenia induced by neonatal immune activation and peripubertal stress in rats: Study of sex differences and brain oxidative alterations
Monte, A. S., Mello, B. S. F., Borella, V., Araújo, T. D. S., da Silva, F. E. R., de Sousa, F. C. F., de Oliveira, A. C. P., Gama, C. S., Seeman, M. V., Vasconcelos, S. M. M., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.057 · Cited by 76 · see citing works
The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex
Pietropaolo, S., Singer, P., Feldon, J., & Yee, B. K. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1081-3 · Cited by 77 · see citing works
Retinal nerve fiber layer thickness measured by optical coherence tomography in patients with schizophrenia: A short report
Ascaso, F. J., CABEZON, L., Quintanilla, M. Á., Gutiérrez-Galve, L., López‐Antón, R., Cristóbal, J. Á., & Lobo, A. (2010) · The European Journal of Psychiatry · doi:10.4321/s0213-61632010000400005 · Cited by 75 · see citing works
Altered Cell Cycle Dynamics in Schizophrenia
Fan, Y., Abrahamsen, G., McGrath, J. J., & Mackay‐Sim, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.004 · Cited by 75 · see citing works
Consequences of early life MK-801 administration: Long-term behavioural effects and relevance to schizophrenia research
Lim, A. L., TAYLOR, D. A. H. B., & Malone, D. T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.052 · Cited by 74 · see citing works
Early motor developmental milestones and schizophrenia: A systematic review and meta-analysis
Filatova, S., Koivumaa-Honkanen, H. T., Hirvonen, N., Freeman, A., Ivandić, I., Hurtig, T. M., Khandaker, G. M., Jones, P. B., Moilanen, K., & Miettunen, J. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.01.029 · Cited by 71 · see citing works
Maternal Type-I interferon signaling adversely affects the microglia and the behavior of the offspring accompanied by increased sensitivity to stress
Ben-Yehuda, H., Matcovitch-Natan, O., Kertser, A., Spinrad, A., Prinz, M., Amit, I., & Schwartz, M. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0604-0 · Cited by 71 · see citing works
Source distribution of neuromagnetic slow wave activity in schizophrenic and depressive patients
Wienbruch, C., Moratti, S., Elbert, T. R., Vogel, U., Fehr, T., Kissler, J. M., Schiller, A., & Rockstroh, B. S. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00210-4 · Cited by 71 · see citing works
Neonatal lipopolysaccharide exposure alters central cytokine responses to stress in adulthood in Wistar rats
Walker, A. K., Nakamura, T., & Hodgson, D. M. (2010) · Stress · doi:10.3109/10253890.2010.489977 · Cited by 69 · see citing works
Reelin as a putative vulnerability factor for depression: Examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice
Lussier, A. L., Romay-Tallón, R., Kalynchuk, L. E., & Caruncho, H. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.007 · Cited by 68 · see citing works
Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress
Øines, E., Murison, R., Mrdalj, J., Grønli, J., & Milde, A. M. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.024 · Cited by 66 · see citing works
Progressive brain changes in children and adolescents with early-onset psychosis: A meta-analysis of longitudinal MRI studies
Fraguas, D., Díaz‐Caneja, C. M., Pina‐Camacho, L., Janssen, J., & Arango, C. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.022 · Cited by 68 · see citing works
Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice
Klug, M., Hill, R., Choy, K. H. C., Kyrios, M., Hannan, A. J., & van den Buuse, M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.015 · Cited by 67 · see citing works
Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis
Heurich, M., Föcking, M., Mongan, D., Cagney, G., & Cotter, D. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01197-9 · Cited by 66 · see citing works
Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective
Quednow, B. B., Brzózka, M. M., & Rossner, M. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1553-4 · Cited by 66 · see citing works
Differential effects of maternal immune activation and juvenile stress on anxiety-like behaviour and physiology in adult rats: No evidence for the “double-hit hypothesis”
Yee, N., Ribic, A., de Roo, C. C., & Fuchs, E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.040 · Cited by 64 · see citing works
Selectively Bred Rodents as Models of Depression and Anxiety
Wegener, G., Mathé, A. A., & Neumann, I. D. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_192 · Cited by 64 · see citing works
Neonatal and juvenile stress induces changes in adult social behavior without affecting cognitive function
Tóth, E., Avital, A., Leshem, M., Richter‐Levin, G., & Braun, K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.012 · Cited by 60 · see citing works
Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers
Deslauriers, J., Larouche, A., Sarret, P., & Grignon, S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.006 · Cited by 61 · see citing works
MicroRNAs in the Onset of Schizophrenia
Thomas, K. T., & Zakharenko, S. S. (2021) · Cells · doi:10.3390/cells10102679 · Cited by 59 · see citing works
Dysbindin-1 and Its Protein Family
Talbot, K., Ong, W., Blake, D., Tang, J.-X. X., Louneva, N., Carlson, G., & Arnold, S. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_5 · Cited by 72 · see citing works
Noses and neurons: Induction, morphogenesis, and neuronal differentiation in the peripheral olfactory pathway
Balmer, C. W., & LaMantia, A. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20582 · Cited by 56 · see citing works
Self-citation
Adolescence, schizophrenia and drug abuse: a window of vulnerability
Nimwegen, L., Haan, L., Beveren, N., Brink, W., & Linszen, D. (2005) · Acta Psychiatrica Scandinavica Supplementum · doi:10.1111/j.1600-0447.2005.00543.x · Cited by 45 · see citing works
Combined effect of BCG vaccination and enriched environment promote neurogenesis and spatial cognition via a shift in meningeal macrophage M2 polarization
Qi, F., Zuo, Z., Yang, J., Hu, S., Yang, Y., Yuan, Q., Zou, J., Guo, K., & Yao, Z. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0808-7 · Cited by 51 · see citing works
Aluminum-Induced Entropy in Biological Systems: Implications for Neurological Disease
Shaw, C. A., Seneff, S., Kette, S. D., Tomljenovic, L., Oller, J. W., & Davidson, R. M. (2014) · Journal of Toxicology · doi:10.1155/2014/491316 · Cited by 55 · see citing works
Maternal Immune Activation and Schizophrenia–Evidence for an Immune Priming Disorder
Choudhury, Z., & Lennox, B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.585742 · Cited by 52 · see citing works
Social and psychological contributions to the co-occurrence of sub-threshold psychotic experiences and suicidal behavior
DeVylder, J., Jahn, D. R., Doherty, T., Wilson, C. S., Wilcox, H. C., Schiffman, J. E., & Hilimire, M. R. (2015) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-015-1139-6 · Cited by 52 · see citing works
Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia
Wonodi, I., McMahon, R. P., Krishna, N., Mitchell, B. D., Liu, J., Glassman, M., Hong, L. E., & Gold, J. M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.10.026 · Cited by 51 · see citing works
Resting-state cerebellar-cerebral networks are differently affected in first-episode, drug-naive schizophrenia patients and unaffected siblings
Guo, W., Liu, F., Chen, J., Wu, R., Zhang, Z., Yu, M., Xiao, C., & Zhao, J. (2015) · Scientific Reports · doi:10.1038/srep17275 · Cited by 51 · see citing works
The expression of retinoic acid receptor alpha is increased in the granule cells of the dentate gyrus in schizophrenia
Rioux, L., & Arnold, S. E. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2004.11.003 · Cited by 51 · see citing works
Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood
Clark, S. M., Notarangelo, F. M., Li, X., Chen, S., Schwarcz, R. M., & Tonelli, L. H. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.011 · Cited by 50 · see citing works
Viral respiratory infections and psychosis: A review of the literature and the implications of COVID-19
Kulaga, S. S., & Miller, C. W. T. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.008 · Cited by 51 · see citing works
Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia
Geddes, A. E., Huang, X., & Newell, K. A. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.017 · Cited by 48 · see citing works
Copy Number Variation Distribution in Six Monozygotic Twin Pairs Discordant for Schizophrenia
Castellani, C. A., Awamleh, Z., Melka, M. G., O’Reilly, R. L., & Singh, S. M. (2014) · Twin Research and Human Genetics · doi:10.1017/thg.2014.6 · Cited by 47 · see citing works
The neurobehavioral teratology of retinoids: A 50‐year history
Adams, J. (2010) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20721 · Cited by 47 · see citing works
Alterations in Postnatal Neurogenesis and Dopamine Dysregulation in Schizophrenia: A Hypothesis
Inta, D., Meyer‐Lindenberg, A., & Gass, P. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq134 · Cited by 47 · see citing works
22q11 DS: genomic mechanisms and gene function in DiGeorge/velocardiofacial syndrome
Maynard, T. M., Haskell, G., Lieberman, J. A., & LaMantia, A. (2002) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(02)00050-3 · Cited by 47 · see citing works
Self-citation
White matter changes in early phase schizophrenia and cannabis use: An update and systematic review of diffusion tensor imaging studies
Cookey, J., Bernier, D. C., & Tibbo, P. G. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.04.026 · Cited by 45 · see citing works
Depth of the olfactory sulcus: A marker of early embryonic disruption in schizophrenia?
Turetsky, B. I., Crutchley, P., Walker, J., Gur, R. E., & Moberg, P. J. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.09.005 · Cited by 45 · see citing works
Does cannabidiol have a role in the treatment of schizophrenia?
Gururajan, A., & Malone, D. T. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.06.022 · Cited by 45 · see citing works
Maternal Diabetes and Fetal Programming Toward Neurological Diseases: Beyond Neural Tube Defects
Márquez-Valadez, B., Valle-Bautista, R., García-López, G., Díaz, N., & Molina-Hernández, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00664 · Cited by 40 · see citing works
Early life stress and psychiatric disorder modulate cortical responses to affective stimuli
Weber, K., Miller, G. A., Schupp, H. T., Borgelt, J., Awiszus, B., Popov, T. G., Elbert, T. R., & Rockstroh, B. S. (2009) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00871.x · Cited by 43 · see citing works

Two hits in one – the neurobiology of schizophrenia
Pocklington, A. J. (2023) · TheScienceBreaker · doi:10.25250/thescbr.brk669
Developmental and Pharmacological Models of Schizophrenia: What Did They Teach Us About Cellular Mechanisms Associated With the Disease?
Grecksch, G., Keilhoff, G., Roskoden, T., Bernstein, H., & Becker, A. (2010) · University of Zagreb University Computing Centre (SRCE)
Development, disease and degeneration in schizophrenia: a unitary pathophysiological model
Keshavan, M. S. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00033-3 · Cited by 272 · see citing works
Lost Their Ways?
Brown, J. A., & Mirnics, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.004
Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia
Roy, C., & Corfas, G. (2007) · Springer eBooks · doi:10.1007/978-0-387-74351-6_4

Authors: Maynard, T. M., Sikich, L., Lieberman, J. A., & LaMantia, A.-S.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: LaMantia, A.-S.
ORCID: Maynard, T. M.
Sikich, L.
LaMantia, A.-S.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 2001-01-01
Volume: 27
Issue: 3
Pages: 457-476
ISSN: 0586-7614 (ISSN-L)
1745-1701
DOI: 10.1093/oxfordjournals.schbul.a006887
OpenAlex: W2056370816
Cited by: 383
References: 160
Citations by year: 2026: 10 · 2025: 18 · 2024: 18 · 2023: 22 · 2022: 22 · 2021: 29 · 2020: 20 · 2019: 16 · 2018: 19 · 2017: 22 · 2016: 18 · 2015: 17 · 2014: 29 · 2013: 24 · 2012: 20
FWCI: 2.80
Type: journal article
Language: en
Open access: closed
Locations: Schizophrenia Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 33127)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-29178)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, two-hit hypothesis
MeSH terms: Brain, Cell Communication, Chromosome Deletion, Chromosomes, Human, Pair 22, Environment, Humans, Neural Pathways, Psychological Theory, Schizophrenia, Tretinoin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks