Neonatal tactile stimulation alleviates the negative effects of neonatal isolation on novel object recognition, sociability and neuroendocrine levels in male adult mandarin voles (Microtus mandarinus).
Abstract
Neonatal isolation results in long-lasting negative alterations to the brain and behavior. Some of these changes include effects on non-spatial learning and memory, sociability and neuroendocrine levels. Theoretically, neonatal tactile stimulation should reverse the impacts of neonatal isolation; however, this remains unknown for changes relating to learning, memory, sociability and hormones in social animals. Using socially monogamous mandarin voles (Microtus mandarinus), the long-lasting effects of these early manipulations on anxiety-like behavior, novel object recognition, sociability, and neuroendocrine levels were investigated. Compared with neonatal-isolated males, males subjected to the same manipulation but accompanied with tactile stimulation had heavier body weights across PND4-18 and displayed significantly less anxiety-like behavior in an open field test. In addition, tactile stimulation increased the preference index for novel object recognition reduced by neonatal isolation. Compared with control males, neonatal-isolated males engaged in less body contact with unfamiliar same-sex individuals and this effect was reversed by neonatal tactile stimulation. Tactile stimulation enhanced aggressive behavior in neonatal-isolated males and increased the levels of AVP and OT in the paraventricular nucleus (PVN) which were decreased by neonatal isolation. This early manipulation also reduced serum CORT levels that were significantly up-regulated by neonatal isolation in b…
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3 h of daily maternal separation reduced social interest in both adult male and female mandarin voles and mice.
“It was observed that 3 h of daily maternal separation reduced social interest (i.e., time spent exploring a conspecific) in both adult male and female mandarin voles (Wei et al., 2013; Yu et al., 2013) and mice (Tsuda and Ogawa, 2012; Zoicas and Neumann, 2016).”
From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Wei et al., 2013
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- Authors
- Wei, B., Tai, F., Liu, X., Ma, L., Yang, X., Jia, R., & Zhang, X.
- Affiliations
- Shaanxi Normal University (CN)
- University of Ottawa (CA)
- Corresponding author
- Tai, Fadao
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 112-113
- Pages
- 14-22
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2075163934
- Cited by
- 33
- References
- 7
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30970370, 31170377)
- Fundamental Research Funds for the Central Universities (GK261001)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Keywords
- neonatal isolation, tactile stimulation, mandarin vole, Microtus mandarinus, novel object recognition, sociability, anxiety-like behavior, aggression, vasopressin, oxytocin, paraventricular nucleus, corticosterone, neuroendocrine regulation, early life experience, social behavior development
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Arginine Vasopressin, Body Weight, Corticosterone, Arvicolinae, Exploratory Behavior, Female, Interpersonal Relations, Male, Oxytocin, Paraventricular Hypothalamic Nucleus, Physical Stimulation, Social Isolation, Stress, Psychological, Touch, Recognition, Psychology, Neuroendocrine Cells
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