Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway
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Early adverse experiences often have devastating consequences. However, whether preweaning paternal deprivation (PD) affects emotional and social behaviors and their underlying neural mechanisms remain unexplored. Using monogamous mandarin voles, we found that PD increased anxiety-like behavior and attenuated social preference in adulthood. PD also decreased the number of oxytocin (OT)-positive neurons projecting from the paraventricular nucleus (PVN) and reduced the levels of the medial prefrontal cortex OT receptor protein in females and of the OT receptor and V1a receptor proteins in males. Intra-prelimbic cortical OT injections reversed the PD-induced changes in anxiety-like behavior and social preferences. Optogenetic activation of the prelimbic cortex OT terminals from PVN OT neurons reversed the PD-induced changes in emotion and social preference behaviors, whereas optogenetic inhibition was anxiogenic and impaired social preference in naive voles. These findings demonstrate that PD increases anxiety-like behavior and attenuates social preferences through the involvement of PVN OT neuron projections to the prelimbic cortex.
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Monogamous mandarin voles raised without a father socialize less and have fewer paraventricular oxytocin cells, a behavioral difference that can be reversed by optogenetic stimulation of paraventricular oxytocin terminals within the prelimbic cortex.
“Monogamous mandarin voles raised without a father socialize less and have fewer PVN OXT cells, a behavioral difference that can be reversed by optogenetic stimulation of PVN OXT terminals within the prelimbic cortex (86).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [86]
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Abbreviations Used for Major Brain Regions
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- Authors
- He, Z., Young, L., Ma, X.-M., Guo, Q., Wang, L., Yang, Y., Luo, L., Yuan, W., Li, L., Zhang, J., Hou, W., Qiao, H., Jia, R., & Tai, F.
- Affiliations
- Shaanxi Normal University (CN)
- University of Tsukuba (JP)
- UConn Health (US)
- Corresponding author
- Tai, Fadao
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2019-05-14
- Volume
- 8
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC6516825
- OpenAlex
- W2946185416
- Cited by
- 81
- References
- 80
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 15 · 2023: 14 · 2022: 10 · 2021: 10 · 2020: 23
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundamental Research Funds for Central University of China (GK201903065)
- National Institutes of Health (P50MH100023)
- Yerkes Regional Primate Research Center (P51OD11132)
- National Natural Science Foundation of China (31372213, 31670421)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- paternal deprivation, anxiety-like behavior, social preferences, oxytocin, paraventricular nucleus, prelimbic cortex, oxytocin receptor, V1a receptor, childhood adversity, optogenetic manipulation
- MeSH terms
- Animals, Anxiety, Arvicolinae, Female, Male, Neural Pathways, Neurons, Paraventricular Hypothalamic Nucleus, Paternal Deprivation, Social Behavior, Receptors, Vasopressin, Receptors, Oxytocin
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