Vasopressinergic regulation of the hypothalamic pituitary adrenal axis and stress adaptation

Volpi, Simona; Rabadan-Diehl, Cristina; Aguilera, Greti

doi:10.1080/10253890410001733535

Cited by 138Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

Vasopressinergic regulation of the hypothalamic pituitary adrenal axis and stress adaptation

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Volpi, Simona, Rabadan-Diehl, Cristina, Aguilera, Greti·2004·Stress

DOI 10.1080/10253890410001733535

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Abstract

Vasopressin (VP) stimulates pituitary ACTH secretion through interaction with receptors of the V1b subtype (V1bR, V3R), located in the plasma membrane of the pituitary corticotroph, mainly by potentiating the stimulatory effects of corticotropin releasing hormone (CRH). Chronic stress paradigms associated with corticotroph hyperresponsiveness lead to preferential expression of hypothalamic VP over CRH and upregulation of pituitary V1bR, suggesting an important role for VP during adaptation of the hypothalamic-pituitary-adrenal (HPA) axis to stress. Vasopressinergic regulation of ACTH secretion depends on the number of V1bRs as well as coupling of the receptor to phospholipase C (PLC) in the pituitary. Regulation of V1bR gene transcription may involve a number of regulatory elements in the promoter region, of which a GAGA box was shown to be essential. Although V1bR gene transcription is necessary to maintain V1bR mRNA levels, the lack of correlation between VP binding and V1bR mRNA suggests that regulation of mRNA translation is a major regulatory step of the number of V1bRs. V1bR translation appears to be under tonic inhibition by upstream minicistrons and positive regulation through protein kinase C (PKC) activation of an internal ribosome entry site (IRES) in the 5' untranslated region (5'UTR) of the mRNA. The data provide mechanisms by which regulation of hypothalamic VP and pituitary V1bR content contribute to controlling HPA axis activity during chronic stress.

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Both CRH and AVP act on their own receptors on corticotrope cells in the anterior pituitary to stimulate ACTH production and release, with different or even similar potencies.
“Namely, it has been indicated that both CRH and AVP act on their own receptors (28–32) on corticotrope cells in anterior pituitary to stimulate adrenocorticotropic hormone (ACTH) production and release with different (26, 33–41) or even similar potencies (42).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [32]
The ‘Vasopressinergic Regulation of the Pituitary Corticotroph’ section (page unavailable) supports ACTH secretion by both hormones but says VP alone is a weak stimulus that potentiates CRH, not that they have similar potencies. It also says VP inhibits basal and CRH-stimulated POMC gene transcription, so the claim that both stimulate ACTH production is not supported. (LLM, conf=0.88)
Experimental — accuracy not yet measured
CRH and AVP are both required as stimulatory inputs to corticotrope cells for a complete ACTH response in physiologically normal and various stressful conditions.
“In essence, CRH and AVP are both required as stimulatory inputs to corticotrope cells for a complete ACTH response in physiologically normal as well as in various stressful conditions (32, 38, 48–51).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [32]
The Introduction and “Vasopressinergic Regulation of the Pituitary Corticotroph” section (pages unavailable) say that vasopressin potentiates CRH-stimulated ACTH secretion and helps maintain corticotroph responsiveness during chronic stress. They do not establish that both inputs are required for a complete ACTH response under physiologically normal conditions or across various stressful conditions. (LLM, conf=0.85)
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Long-term salt loading impairs pituitary responsiveness to ACTH secretagogues and stress in rats
Dohanics, J., Kovacs, K. J., Folly, G., & Makara, G. B. (1990) · Peptides · doi:10.1016/0196-9781(90)90110-q · Cited by 36 · cited 1× · see citing works
“…ACTH secretion under acute conditions (Holmes et al., 1986; Irvine et al., 1989; Aguilera, 1994) but prolonged activation of magnocellular VP neurons inhibits rather than stimulates the hypothalamic– pituitary–adrenal (HPA) axis (Dohanics et al., 1990; Chowdry et al., 1991; Aguilera, 1994).”
Background
Transcription of the Rat Serine Protease Inhibitor 2.1 Gene in Vivo: Correlation with GAGA Box Promoter Occupancy and Mechanism of Cytokine-Mediated Down-Regulation
Simar‐Blanchet, A., Legraverend, C., Thissen, J., & Cam, A. L. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.3.0080 · Cited by 34 · cited 2× · see citing works
“, 2002), suggests that the GAGA repeats are required for initiation of transcription, similar to observations in the type-1 angiotensin receptor and serine protease inhibitor genes (Simar-Blanchet et al., 1998; Wyse et al., 2000).”
Background
Paracrine communication regulates adrenocorticotropin secretion.
Jia, L.-G., Canny, B. J., & Leong, D. A. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309348 · Cited by 31 · cited 1× · see citing works
“In vitro experiments have shown that VP increases the number of cells responsive to CRH in vitro (Jia et al., 1992), possibly by increasing the number of cells expressing CRH receptors.”
Background
Repression of vasopressin gene expression by glucocorticoids in transgenic mice: evidence of a direct mechanism mediated by proximal 5′ flanking sequence
Burke, Z. D., Ho, M.-Y., Morgan, H. E., Smith, M., Murphy, D., & Carter, D. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00603-3 · Cited by 30 · cited 1× · see citing works
“On the other hand, the VP gene promoter contains an active glucocorticoid response element (GRE; Burke et al., 1997) capable of mediating transcriptional inhibition by glucocorticoids.”
Background
Functional role of a novel cis-acting element (GAGA box) in human type-1 angiotensin II receptor gene transcription
Wyse, B., Linas, S., & Thekkumkara, T. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250097 · Cited by 28 · cited 2× · see citing works
“, 2002), suggests that the GAGA repeats are required for initiation of transcription, similar to observations in the type-1 angiotensin receptor and serine protease inhibitor genes (Simar-Blanchet et al., 1998; Wyse et al., 2000).”
Background
Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene
René, P., Lenne, F., Ventura, M. A., BERTAGNA, X. Y., & de Keyzer, Y. (2000) · Gene · doi:10.1016/s0378-1119(99)00468-0 · Cited by 24 · cited 1× · see citing works
“…et al., 1995) and the more recent identification and characterization of genomic clones and 50flanking region have facilitated the understanding of the molecular mechanisms of regulation of the receptor (De Keyser et al., 1994; Ventura et al., 1999; Rabadan-Diehl et al., 2000; Rene et al., 2000).”
Background
Transcriptional Regulation of the Pituitary Vasopressin V1b Receptor Involves a GAGA-binding Protein
Volpi, S., Rabadan‐Diehl, C., Cawley, N. X., & Aguilera, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201508200 · Cited by 23 · cited 17× · see citing works
“corresponds to a homo- or heterodimer of proteins of about ,70 kDa (Volpi et al., 2002).”
BackgroundMethodResultInfluential
Translational Regulation of Angiotensin II Type 1A Receptor
Mori, Y., Matsubara, H., Murasawa, S., Kijima, K., Maruyama, K., Tsukaguchi, H., Okubo, N., Hamakubo, T., Inagami, T., Iwasaka, T., et al. (1996) · Hypertension · doi:10.1161/01.hyp.28.5.810 · Cited by 22 · cited 2× · see citing works
“of translation of the receptor proteins (Parola and Kobilka, 1994; Mori et al., 1996; Xu et al., 2001).”
Background
Involvement of upstream open reading frames in regulation of rat V1bvasopressin receptor expression
Nomura, A., Iwasaki, Y., Saito, M., Aoki, Y., Yamamori, E., Ozaki, N., Tachikawa, K., Mutsuga, N., Morishita, M., Yoshida, M., et al. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e780 · Cited by 21 · cited 4× · see citing works
“Mutations that inactivate the upstream ORFs in the V1bR mRNA have been shown to increase in vitro translation of a 46 kDa band corresponding to the V1bR (Rabadan-Diehl and Aguilera, 2002), or luciferase activity using reporter gene constructs (Nomura et al., 2001).”
BackgroundMethodInfluential
Isolation and Characterization of the Promoter Region of the Rat Vasopressin V1b Receptor Gene
Rabadan‐Diehl, Lolait, & Aguilera, G. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00473.x · Cited by 20 · cited 7× · see citing works
“Vasopressinergic regulation of ACTH secretion depends on the number of V1bRs as well as coupling of the receptor to phospholipase C (PLC) in the pituitary.”
BackgroundInfluential
Translational Regulation of the Vasopressin V1b Receptor Involves an Internal Ribosome Entry Site
Rabadan‐Diehl, C., Volpi, S., Nikodémová, M., & Aguilera, G. (2003) · Molecular Endocrinology · doi:10.1210/me.2001-0336 · Cited by 15 · cited 2× · see citing works
“Recent studies have focused on the translational regulation of the V1bR, and especially on the role of the 50UTR (Nomura et al., 2001; Rabadan-Diehl and Aguilera, 2002; Rabadan-Diehl et al., 2003).”
Background
Effect of Thyroid Alteration on a Cortical Response Elicited at the Midbrain Level
Thompson, J. W., Barker, S. B., & Chambers, W. F. (2008) · Neuroendocrinology · doi:10.1159/000121576 · Cited by 14 · see citing works

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Sonnenberg, N. (1996) In: Hershey, J.W.B., Mathews, M.B. and Sonenberg, N., eds, Translational Control (Cold Spring Harbor Lab. Press, Plainview, NY), pp 245-269.

Sorted by citations

Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“As such, VP is part of the hypothalamic-pituitaryadrenal (HPA) axis, a system involved in the neuroendocrine stress response (Herman, 1995; Volpi et al., 2004).”
Background
Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
Gjerstad, J. K., Lightman, S. L., & Spiga, F. (2018) · Stress · doi:10.1080/10253890.2018.1470238 · Cited by 437 · see citing works
“Although the role of vasopressin in regulating ACTH secretion in responses to stress is well known (Volpi et al., 2004), current evidence suggests that vasopressin does not regulate basal HPA axis activity.”
Background
The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy
Young, W. S., Li, J., Wersinger, S. R., & Palkovits, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.040 · Cited by 222 · see citing works
“…the role of the Avpr1b in regulating adrenocorticotropin hormone from the anterior pituitary in response to stress, especially chronic, has been extensively studied (for reviews, see (Engelmann et al., 2004; Volpi et al., 2004)) ever since the receptor was first described (Antoni et al., 1984).”
BackgroundResult
Epigenetics of stress adaptations in the brain
Stankiewicz, A. M., Swiergiel, A. H., & Lisowski, P. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.07.003 · Cited by 220 · see citing works
The stress hormone copeptin: a new prognostic biomarker in acute illness
Christ‐Crain, M. (2010) · Swiss Medical Weekly · doi:10.4414/smw.2010.13101 · Cited by 207 · see citing works
Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: Focus on vasopressin and glyoxalase-I
Landgraf, R., Kessler, M. S., Bunck, M., Murgatroyd, C., Spengler, D., Zimbelmann, M., Nußbaumer, M., Czibere, L., Turck, C. W., Singewald, N., et al. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.003 · Cited by 199 · see citing works
Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms
Brown, C. H., Bains, J. S., Ludwig, M., & Stern, J. E. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12051 · Cited by 170 · see citing works
Brain and peripheral angiotensin II play a major role in stress
Saavedra, J. M., & Benický, J. (2007) · Stress · doi:10.1080/10253890701350735 · Cited by 166 · see citing works
“Brain Ang II also stimulates vasopressin (AVP) formation in the PVN and its release from the median eminence (Saavedra 1992) to participate with CRF in enhancing ACTH production (Antoni 1993; Volpi et al. 2004).”
Background
Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome
Saleem, U., Khaleghi, M., Morgenthaler, N. G., Bergmann, A., Struck, J., Mosley, T. H., & Kullo, I. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2278 · Cited by 161 · see citing works
The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress
Aguilera, G., Subburaju, S., YOUNG, S., & CHEN, J. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00403-2 · Cited by 148 · see citing works
The Hypothalamic-Pituitary-Adrenal Axis Response to Stress in Mice Lacking Functional Vasopressin V1b Receptors
Lolait, S. J., Stewart, L. Q., Jessop, D. S., Young, W. S., & O’Carroll, A. (2006) · Endocrinology · doi:10.1210/en.2006-1309 · Cited by 146 · see citing works
“hypothalamic-pituitary-adrenal (HPA) axis (6, 7).”
Exploring the role of neuropeptides in depression and anxiety
Rana, T., Behl, T., Sehgal, A., Singh, S., Sharma, N., Abdeen, A., Ibrahim, S. F., Mani, V., Iqbal, M. S., Bhatia, S., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110478 · Cited by 126 · see citing works
The vasopressin Avpr1b receptor: Molecular and pharmacological studies
Roper, J. A., O'Carroll, A.-M., Young, W. S., & Lolait, S. (2010) · Stress · doi:10.3109/10253890.2010.512376 · Cited by 116 · see citing works
“…Avp and pituitary Avpr1b responsiveness is maintained during stress adaptation suggests the existence of numerous transcriptional and translational regulatory components involved in PVN and pituitary plasticity that dynamically alter Avp and Avpr1b levels according to demand (Volpi et al. 2004a,b).”
Background
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113 · see citing works
Oxytocin and Vasopressin: Genetics and Behavioral Implications
Caldwell, H. K., & Young, W. S. (2006) · Springer eBooks · doi:10.1007/0-387-30395-2_25 · Cited by 113 · see citing works
Rationally designed peptide regulators of protein kinase C
Churchill, E. N., Qvit, N., & Mochly‐Rosen, D. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.10.002 · Cited by 106 · see citing works
Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation
Ellis, B. J., Horn, A. J., Carter, C. S., van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.101985 · Cited by 103 · see citing works
Stress Responsiveness of the Hypothalamic–Pituitary–Adrenal Axis: Age-Related Features of the Vasopressinergic Regulation
Goncharova, N. D. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00026 · Cited by 99 · see citing works
“Nevertheless, AVP is still considered as an important regulator of the HPA axis (Antoni, 1993; Herman, 1995; Volpi et al., 2004; Aguilera, 2011).”
Background
Chronic Stress and Individual Vulnerability
Schmidt, M. V., Sterlemann, V., & Müller, M. B. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.017 · Cited by 97 · see citing works
Sexually dimorphic effects of maternal separation stress on corticotrophin‐releasing factor and vasopressin systems in the adult rat brain
Desbonnet, L., Garrett, L., Daly, E., McDermott, K. W. G., & Dinan, T. G. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.02.004 · Cited by 97 · see citing works
Signs of attenuated depression-like behavior in vasopressin deficient Brattleboro rats
Mlynarik, M., Zelena, D., Bagdy, G., Makara, G. B., & Ježová, D. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.12.007 · Cited by 93 · see citing works
Effects of chronic social defeat on behavioral and neural correlates of sociality: Vasopressin, oxytocin and the vasopressinergic V1b receptor
Litvin, Y., Murakami, G., & Pfaff, D. W. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.007 · Cited by 90 · see citing works
“AVP secreted from parvocellular neurons of the paraventricular nucleus of the hypothalamus (PVN) travels to the anterior pituitary, where it binds V1bRs to both directly control corticotropin release and to exacerbate the effects of corticotropinreleasing factor (CRF) on pituitary corticotrophs [21].”
Influential
Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress
Armando, I., Volpi, S., Aguilera, G., & Saavedra, J. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.037 · Cited by 86 · see citing works
“Ang II also stimulates vasopressin (AVP) formation in the PVN and its release from the median eminence to participate with CRF in enhancing ACTH production (Volpi et al., 2004; Antoni 1993).”
Background
Postnatal Glucocorticoid Excess Due to Pituitary Glucocorticoid Receptor Deficiency: Differential Short- and Long-Term Consequences
Schmidt, M. V., Sterlemann, V., Wagner, K. V., Niederleitner, B., Ganea, K., Liebl, C., Deussing, J. M., Berger, S., Schütz, G., Holsboer, F., et al. (2009) · Endocrinology · doi:10.1210/en.2008-1211 · Cited by 81 · see citing works
“This is intriguing because chronic stress or high glucocorticoid levels in adults also result in a shift from CRH to AVP in regulating HPA axis activity (42).”
Background
Experimental models of stress
Patchev, V. K., & Patchev, A. V. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/vpatchev · Cited by 80 · see citing works
“Extensive research in the past has shown that stress-associated changes in CRH and AVP expression in the PVN follow distinct temporal patterns, with AVP “coming into action” with certain delay or in the course of chronic stress load.(35) Oxytocin and angiotensin also deserve mention as auxiliary peptidergic ACTH secre…”
Background
Copeptin as a Diagnostic and Prognostic Biomarker in Cardiovascular Diseases
Mu, D., Cheng, J. H., Qiu, L., & Cheng, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.901990 · Cited by 69 · see citing works
“Another stimulated hypothalamic hormone is AVP, which can interact with CRH and lead to the secretion of ACTH (211).”
BackgroundInfluential
Mechanisms of rhythmogenesis: insights from hypothalamic vasopressin neurons
Brown, C. H., & Bourque, C. W. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.11.005 · Cited by 66 · see citing works
Vasopressin, Central Autonomic Control and Blood Pressure Regulation
Lozić, M., Šarenac, O., Murphy, D., & Japundžić‐Žigon, N. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0811-0 · Cited by 65 · see citing works
Magnocellular Neurons and Posterior Pituitary Function
Brown, C. H. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150053 · Cited by 77 · see citing works
Central organization of androgen-sensitive pathways to the hypothalamic-pituitary-adrenal axis: Implications for individual differences in responses to homeostatic threat and predisposition to disease
Williamson, M., Bingham, B., & Viau, V. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.009 · Cited by 58 · see citing works
Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat
Overstreet, D. H., & Griebel, G. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.07.021 · Cited by 58 · see citing works
“Evidence indicates that AVP may exist not only in the hypothalamus, where it participates in the hypothalamic–pituitary–adrenal axis (Engelmann et al., 2004; Volpi et al., 2004), but also in other key brain regions such as the medial amygdala (DeVries and Buijs, 1983).”
Background
Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review
Japundžić‐Žigon, N., Lozić, M., Šarenac, O., & Murphy, D. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190717150501 · Cited by 56 · see citing works
Pathogenic involvement of neuropeptides in anxiety and depression
Alldredge, B. (2010) · Neuropeptides · doi:10.1016/j.npep.2009.12.014 · Cited by 55 · see citing works
Sex differences in activation of the hypothalamic–pituitary–adrenal axis by methamphetamine
Zuloaga, D. G., Johnson, L. A., Agam, M. R., & Raber, J. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12651 · Cited by 54 · see citing works
Vasopressin Antagonists as Anxiolytics and Antidepressants: Recent Developments
Simon, N. G., Guillon, C., Fabio, K. M., Heindel, N. D., Lu, S., Miller, M., Ferris, C. F., Brownstein, M., Garippa, C., & KOPPEL, G. A. (2008) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488908784534586 · Cited by 51 · see citing works
Character and temperament in major depressive disorder and a highly anxious-retarded subtype derived from melancholia
de Winter, R. F. P., Wolterbeek, R., Spinhoven, P., Zitman, F. G., & Goekoop, J. G. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2007.04.002 · Cited by 50 · see citing works
The Role of Neuropeptides in Suicidal Behavior: A Systematic Review
Serafini, G., Pompili, M., Lindqvist, D., Dwivedi, Y. K., & Girardi, P. (2013) · BioMed Research International · doi:10.1155/2013/687575 · Cited by 49 · see citing works
“Corticotropin-Releasing Factor (CRF), Oxytocin, andArginine Vasopressin (AVP).”
Influential
Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats
Bayerl, D. S., & Bosch, O. J. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12517 · Cited by 46 · see citing works
Plasma copeptin and long-term outcomes in acute ischemic stroke
Zhang, J.-L., Yin, C., Zhang, Y., Zhao, L., Fu, H.-J., & Feng, J.-C. (2013) · Acta Neurologica Scandinavica · doi:10.1111/ane.12132 · Cited by 46 · see citing works
Attenuated Stress Response to Acute Lipopolysaccharide Challenge and Ethanol Administration in Vasopressin V1b Receptor Knockout Mice
Lolait, S. J., Stewart, L. Q., Roper, J. A., Harrison, G., Jessop, D., Young, W. S., & O’Carroll, A. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01560.x · Cited by 43 · see citing works
Copeptin as a Marker for Severity and Prognosis of Aneurysmal Subarachnoid Hemorrhage
Fung, C., Marchis, G. M. D., Mira, K., Seiler, M., Arnold, M., Gralla, J., Raabe, A., & Beck, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053191 · Cited by 42 · see citing works
“Vasopressin potentiates the action of corticotrophin releasing hormone and leads downstream to a release of adrenocorticotropic hormone (ACTH) and production of cortisol [8].”
Background
Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons
Brown, C. H., Scott, V. M., Ludwig, M., Leng, G., & Bourque, C. W. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351236 · Cited by 41 · see citing works
Relaxin-3 stimulates the neuro-endocrine stress axis via corticotrophin-releasing hormone
McGowan, B. M., MINNION, J. S., Murphy, K. G., Roy, D., Stanley, S. A., Dhillo, W. S., Gardiner, J., Ghatei, M. A., & Bloom, S. R. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0603 · Cited by 41 · see citing works
“CRH stimulates adrenocorticotrophic hormone (ACTH) release from the anterior pituitary, an effect that is potentiated by http://joe.endocrinology-journals.org 2014 Society for Endocrinology DOI: 10.1530/JOE-13-0603 Printed in Great Britain AVP (Volpi et al. 2004).”
BackgroundInfluential
The association of antidiuretic hormone levels with an attack of Meniere's disease
Aoki, M., Ando, K., Kuze, B., Mizuta, K., Hayashi, T., & Ito, Y. (2005) · Clinical Otolaryngology · doi:10.1111/j.1749-4486.2005.01107.x · Cited by 39 · see citing works
The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors
Caldwell, H. K., Stewart, J., Wiedholz, L. M., Millstein, R. A., Iacangelo, A. L., Holmes, A., Young, W. S., & Wersinger, S. R. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.08.001 · Cited by 39 · see citing works
Inflammatory and neuroendocrine biomarkers of prognosis after ischemic stroke
Mira, K., & Elkind, M. S. V. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.200 · Cited by 37 · see citing works
Social dominance in male vasopressin 1b receptor knockout mice
Caldwell, H. K., Dike, O. E., Stevenson, E. L., Storck, K. E., & Young, W. S. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.008 · Cited by 34 · see citing works
“As the Avpr1b gene is important in regulation of the hypothalamic-pituitary-adrenal axis, as it is highly expressed in the anterior pituitary and synergizes the Avp signal with the corticotropinreleasing hormone (Crh) signal to stimulate adrenocorticotropic hormone (ACTH) release (Antoni, 1993), it would be easy to sp…”
Background
Neonatal tactile stimulation alleviates the negative effects of neonatal isolation on novel object recognition, sociability and neuroendocrine levels in male adult mandarin voles (Microtus mandarinus).
Wei, B., Tai, F., Liu, X., Ma, L., Yang, X., Jia, R., & Zhang, X. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.005 · Cited by 33 · see citing works
Oxytocin and Vasopressin Involved in Restraint Water-Immersion Stress Mediated by Oxytocin Receptor and Vasopressin 1b Receptor in Rat Brain
Zhao, D., & Hong-bin, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023362 · Cited by 31 · see citing works
“It is well known that the activation of hypothalamic-pituitary-adrenocortical (HPA) axis by stress is an important regulatory mechanism used by most mammals to maintain homeostasis after multiple types of challenges. Whether the activation of OT- and AVP-containing neurons in the PVN and SON in response to the RWIS is…”
Background
Neuroanatomical distribution and function of the vasopressin V1B receptor in the rat brain deciphered using specific fluorescent ligands
Corbani, M., Marir, R., Trueba, M., Chafaï, M., Vincent, A., Borie, A. M., Desarménien, M. G., Ueta, Y., Corbani, M., Olma, A., et al. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.10.011 · Cited by 31 · see citing works
“…that analogue 3 decoration observed on brain slices corresponded to in vivo rV1B receptor labelling, we performed control experiments on rat corticotroph cells in primary culture known to express high amounts of this vasopressin receptor subtype (Aguilera et al, 2003; Volpi et al, 2004).”
BackgroundMethod
The influence of psychological stress on arginine vasopressin concentration in the human plasma and cerebrospinal fluid
Bao, L.-L., Jiang, W.-Q., Sun, F.-J., Wang, D., Pan, Y.-J., Song, Z., Wang, C., & Yang, J. (2014) · Neuropeptides · doi:10.1016/j.npep.2014.09.006 · Cited by 30 · see citing works
Magnocellular hypothalamic system and its interaction with the hypothalamo-pituitary-adrenal axis
Sivukhina, E. V., & Jirikowski, G. F. (2016) · Steroids · doi:10.1016/j.steroids.2016.01.008 · Cited by 29 · see citing works
Differential effects of central administration of relaxin‐3 on food intake and hypothalamic neuropeptides in male and female rats
Calvez, J., Lenglos, C., de Ávila, C., Guèvremont, G., & Timofeeva, E. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12236 · Cited by 29 · see citing works
Neurobiological aspects of pain in the context of alcohol use disorder
Cucinello‐Ragland, J. A., & Edwards, S. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.001 · Cited by 27 · see citing works
State‐Dependent Plasticity in Vasopressin Neurones: Dehydration‐Induced Changes in Activity Patterning
Scott, V. M., & Brown, C. H. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01961.x · Cited by 27 · see citing works
Is PTSD-Phenotype Associated with HPA-Axis Sensitivity? Feedback Inhibition and Other Modulating Factors of Glucocorticoid Signaling Dynamics
Danan, D., Todder, D., Zohar, J., & Cohen, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116050 · Cited by 26 · see citing works
Effects of vasopressin V1b receptor deficiency on adrenocorticotropin release from anterior pituitary cells in response to oxytocin stimulation
Nakamura, K., Fujiwara, Y., Mizutani, R., Sanbe, A., Miyauchi, N., Hiroyama, M., Yamauchi, J., Yamashita, T., Nakamura, S., Mori, T., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1528 · Cited by 25 · see citing works
Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons
Brown, C. H., RUAN, M., Scott, V. M., Tobin, V. A., & LUDWIG, M. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00419-6 · Cited by 25 · see citing works
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“Other studies also support the prolongation of AVP secretion in male rats (Aguilera et al., 2008; Volpi et al., 2004), and a shift to more than half of CRH neurons coexpressing AVP (Aguilera, Kiss, Liu, & Kamitakahara, 2007; Aguilera et al., 2008; Chowdrey et al., 1995; de Goeij et al., 1991; Ma,…”
Influential
In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone.
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Vasopressinergic regulation of the hypothalamic–pituitary–adrenal axis: implications for stress adaptation
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Authors: Volpi, S., Rabadan-Diehl, C., & Aguilera, G.
Affiliations: National Institutes of Health (US)
Corresponding author: Aguilera, Greti
ORCID: Volpi, Simona
Venue: Stress
Publisher: Informa UK Limited
Published: 2004-06
Volume: 7
Issue: 2
Pages: 75-83
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.1080/10253890410001733535
OpenAlex: W2094450224
Cited by: 136
References: 60
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 10 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 3
FWCI: 0.70
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: public-domain
Locations: Stress (publishedVersion, public-domain)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: vasopressin, V1b receptor, hypothalamic-pituitary-adrenal axis, ACTH secretion, corticotropin-releasing factor, chronic stress, stress adaptation, phospholipase C signaling, mRNA translation regulation, protein kinase C, internal ribosome entry site, 5' untranslated region
MeSH terms: Adaptation, Physiological, Animals, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Physiological, Vasopressins

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Vasopressinergic regulation of the hypothalamic pituitary adrenal axis and stress adaptation

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