β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice

Bahi, Amine; Al Mansouri, Shamma; Al Memari, Elyazia; Al Ameri, Mouza; Nurulain, Syed M; Ojha, Shreesh

doi:10.1016/j.physbeh.2014.06.003

Cited by 291Cannabis and Cannabinoid ResearchMedicinal Plant Extracts EffectsTreatment of Major Depression

β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice

Bahi, Amine, Al Mansouri, Shamma, Al Memari, Elyazia, Al Ameri, Mouza, Nurulain, Syed M, Ojha, Shreesh·2014·Physiology & Behavior

DOI 10.1016/j.physbeh.2014.06.003

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Abstract

Recent evidence suggests that the cannabinoid receptor subtype 2 (CB2) is implicated in anxiety and depression disorders, although few systematic studies in laboratory animals have been reported. The aim of the current experiments was to test the effects of the CB2 receptor potent-selective agonist β-caryophyllene (BCP) in animals subjected to models of anxiolytic- and antidepressant-like effects. Therefore effects of BCP (50mg/kg) on anxiety were assessed using the elevated plus maze (EPM), open field (OF), and marble burying test (MBT). However for depression, the novelty-suppressed feeding (NSF), tail suspension test (TST), and forced swim tests (FST) were used. Results indicated that adult mice receiving BCP showed amelioration of all the parameters observed in the EPM test. Also, BCP significantly increased the time spent in the center of the arena without altering the general motor activity in the OF test. This dose was also able to decrease the number of buried marbles and time spent digging in the MBT, suggesting an anti-compulsive-like effect. In addition, the systemic administration of BCP reduced immobility time in the TST and the FST. Finally, BCP treatment decreased feeding latency in the NSF test. Most importantly, pre-administration of the CB2 receptor antagonist AM630, fully abrogated the anxiolytic and the anti-depressant effects of BCP. Taken together, these preclinical results suggest that CB2 receptors may provide alternative therapeutic targets for the treatment of anxiety and depression. The possibility that BCP may ameliorate the symptoms of these mood disorders offers exciting prospects for future studies.

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“CB2 activation reduces VTA dopamine neuron firing [39] and immobility in forced-swim and tail-suspension tests [40].”
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Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders
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Beta-Caryophyllene, a Cannabinoid Receptor Type 2 Selective Agonist, in Emotional and Cognitive Disorders
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Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases
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Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development
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Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice
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Anthriscus nemorosa essential oil inhalation prevents memory impairment, anxiety and depression in scopolamine-treated rats
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A functional variant of CB2 receptor gene interacts with childhood trauma and FAAH gene on anxious and depressive phenotypes
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Early life stress and development of the endocannabinoid system: A bidirectional process in programming future coping
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β‐Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents
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Lemon balm (Melissa officinalis L.) essential oil and citronellal modulate anxiety-related symptoms – In vitro and in vivo studies
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Characterization of bark, needles and cones from silver fir (Abies alba mill.) towards valorization of biomass forestry residues
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Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention
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Decreased anxiety, voluntary ethanol intake and ethanol-induced CPP acquisition following activation of the metabotropic glutamate receptor 8 “mGluR8”
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Assessment of phytochemicals, nutritional compositions and metabolite profiling using GCMS– from annual edible flowers
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Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems
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Behavioral and neurochemical effects of beta-caryophyllene in experimental models of anxiety and depression in mice
Cardoso, N. A. (2018) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems
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Acute or Chronic β‐Caryophyllene Systemic Administration in Healthy Adult Male Mice Does Not Modulate Anxiety‐Like Extinction Behavior Induced by Subsequent Re‐Exposure to 3D Maze
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Depression‐resistant endophenotype in mice overexpressing cannabinoid CB 2 receptors
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Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression
Hwang, E., Kim, H.-B., Lee, S., Kim, M. J., Kim, K.-J., Han, G., Han, S.-Y., Lee, E.-A., Yoon, J.-H., Kim, D., et al. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112439 · Cited by 67 · see citing works

Authors: Bahi, A., Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M., & Ojha, S.
Affiliations: United Arab Emirates University (AE)
ORCID: Nurulain, Syed M
Ojha, Shreesh
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2014-08
Volume: 135
Pages: 119-124
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/j.physbeh.2014.06.003
OpenAlex: W2026710536
Cited by: 291
References: 61
Citations by year: 2026: 25 · 2025: 24 · 2024: 27 · 2023: 28 · 2022: 27 · 2021: 31 · 2020: 25 · 2019: 35 · 2018: 17 · 2017: 22 · 2016: 20 · 2015: 10
FWCI: 12.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: β-caryophyllene, CB2 receptor agonist, CB2 receptor, anxiety, depression, anxiolytic-like effects, antidepressant-like effects, AM630, elevated plus maze, marble burying test, tail suspension test, forced swim test, novelty-suppressed feeding, mood disorders
MeSH terms: Polycyclic Sesquiterpenes, Animals, Anxiety, Behavior, Animal, Depression, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Sesquiterpenes, Receptor, Cannabinoid, CB2, Mice

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β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice

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