Cannabinoids and anxiety

Moreira, Fabrício A.; Wotjak, Carsten T.

doi:10.1007/7854_2009_16

Cited by 177Cannabis and Cannabinoid ResearchMedicinal Plant Extracts EffectsNeuroscience and Neuropharmacology Research

Cannabinoids and anxiety

Moreira, Fabrício A., Wotjak, Carsten T.·2009·Current topics in behavioral neurosciences

DOI 10.1007/7854_2009_16

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Abstract

The term cannabinoids encompasses compounds produced by the plant Cannabis sativa, such as delta9-tetrahydrocannabinol, and synthetic counterparts. Their actions occur mainly through activation of cannabinoid type 1 (CB1) receptors. Arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol (2-AG) serve as major endogenous ligands (endocannabinoids) of CB1 receptors. Hence, the cannabinoid receptors, the endocannabinoids, and their metabolizing enzymes comprise the endocannabinoid system. Cannabinoids induce diverse responses on anxiety- and fear-related behaviors. Generally, low doses tend to induce anxiolytic-like effects, whereas high doses often cause the opposite. Inhibition of endocannabinoid degradation seems to circumvent these biphasic effects by enhancing CB1 receptor signaling in a temporarily and spatially restricted manner, thus reducing anxiety-like behaviors. Pharmacological blockade or genetic deletion of CB1 receptors, in turn, primarily exerts anxiogenic-like effects and impairments in extinction of aversive memories. Interestingly, pharmacological blockade of Transient Receptor Potential Vanilloid Type-1 (TRPV1) channel, which can be activated by anandamide as well, has diametrically opposite consequences. This book chapter summarizes and conceptualizes our current knowledge about the role of (endo)cannabinoids in fear and anxiety and outlines implications for an exploitation of the endocannabinoid system as a target for new anxiolytic drugs.

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From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [9]

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Authors: Moreira, F. A., & Wotjak, C. T.
Affiliations: Universidade Federal de Minas Gerais (BR)
Corresponding author: Moreira, Fabrício A.
ORCID: Moreira, Fabrício A.
Venue: Current topics in behavioral neurosciences
Publisher: Springer Berlin Heidelberg
Published: 2009
Volume: 2
Pages: 429-450
ISSN: 1866-3370 (ISSN-L)
1866-3389
DOI: 10.1007/7854_2009_16
OpenAlex: W1506056832
Cited by: 177
References: 57
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 11 · 2016: 12 · 2015: 21 · 2014: 17 · 2013: 19 · 2012: 17
FWCI: 19.19
Type: book chapter
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current topics in behavioral neurosciences (publishedVersion)
Springer eBooks (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: cannabinoids, anxiety, endocannabinoid system, CB1 receptor, anandamide, 2-arachidonoylglycerol, delta-9-tetrahydrocannabinol, TRPV1, fear, anxiolytics, biphasic effect
MeSH terms: Animals, Anxiety, Cannabinoids, Conditioning, Psychological, Disease Models, Animal, Fear, Humans, Receptor, Cannabinoid, CB1, TRPV Cation Channels, Cannabinoid Receptor Modulators

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Cannabinoids and anxiety

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