Ecdysteroids and a sucrose phenylpropanoid ester from Froelichia floridana
Abstract
Phytoecdysteroid glycosides (1-5) and a phenylpropanoid ester of sucrose (6) were isolated from the whole plant of Froelichia floridana, along with eight known compounds including three ecdysteroids (7-9), four flavonoids (10-13), and one phenolic compound (14). Structures were determined using a combination of spectroscopic techniques. Compounds 1, 2 and 6-14 were tested in vitro for their activity against human DNA topoisomerase I. Compound 13 (diosmetin) showed marginal inhibition against topoisomerase I with IC(50) of 130 microM in conjunction with low intercalation ability.
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Compounds 5 and 6 showed no significant human topoisomerase I inhibition in vitro.
“Evaluated human Topo I inhibition and no significant effect have been observed.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [41]
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- Authors
- Wang, P., Li, S., Ownby, S., Zhang, Z., Yuan, W., Zhang, W., & Scott Beasley, R.
- Affiliations
- Stephen F. Austin State University (US)
- Corresponding author
- Li, Shiyou
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 70
- Issue
- 3
- Pages
- 430-436
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2106079359
- Cited by
- 34
- References
- 47
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2017: 1 · 2016: 3 · 2014: 1 · 2013: 2 · 2012: 13
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Index of Texas Archaeology Open Access Grey Literature from the Lone Star State (submittedVersion)
- Funders
- W. M. Keck Foundation
- Stephen F. Austin State University
- Texas A and M University
- Centers for Disease Control and Prevention (R01 CI000315-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Physical Sciences › Materials Science › Biomaterials › Phytochemistry and Bioactive Compounds
- Keywords
- ecdysteroids, flavonoids, diosmetin, topoisomerase I inhibition, DNA intercalation, natural product isolation, structure elucidation
- MeSH terms
- Enzyme Activation, Esters, Flavonoids, Humans, Magnetic Resonance Spectroscopy, Phenols, Molecular Structure, Ecdysteroids, Amaranthaceae, Topoisomerase I Inhibitors
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