New insecticides with ecdysteroidal and juvenile hormone activity

Dhadialla, Tarlochan S.; Carlson, Glenn R.; Le, Dat P.

doi:10.1146/annurev.ento.43.1.545

Cited by 914Insect Pest Control StrategiesInsect Resistance and GeneticsInsect-Plant Interactions and Control

New insecticides with ecdysteroidal and juvenile hormone activity

Dhadialla, Tarlochan S., Carlson, Glenn R., Le, Dat P.·1998·Annual Review of Entomology

DOI 10.1146/annurev.ento.43.1.545

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Abstract

Agrochemical research over the last two decades has resulted in the discovery of chemically novel insecticides that mimic the action of the two insect growth and developmental hormones, the steroidal 20-hydroxyecdysone (20E) and the sesquiterpenoid juvenile hormone (JH). Bisacylhydrazines are non-steroidal agonists of 20E and exhibit their insecticidal activity via interaction with the ecdysteroid receptor proteins. Interestingly, two of the bisacylhydrazine (tebufenozide and RH-2485) insecticides are very selectively toxic to lepidopteran pests. These insecticides are safe to beneficial insects and have a benign ecotoxicological profile. Aromatic non-terpenoidal insecticides (fenoxycarb and pyriproxyfen) mimic the action of JHs. However, like the JHs, their exact mode of action is not well understood. These insecticides are toxic to a broad spectrum of insects during their embryonic, last larval, or reproductive stages. The insecticidal, ecotoxicological properties and the mode of action of the two groups of insecticides are reviewed in this article.

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One alternative strategy that has been successfully commercially developed is the use of non-steroidal ecdysteroid analogues as insecticidal compounds (bisacylhydrazines), since these chemicals are easy to synthesise, non-polar and resistant to metabolism.
“One alternative strategy that has been successfully commercially developed is the use of non-steroidal ecdysteroid analogues as insecticidal compounds (bisacylhydrazines; [90]) since these chemicals are easy to synthesise, non-polar and resistant to metabolism.”
From Ecdysteroids (2021) · cites this paper as [90]

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Field evaluation of an insect growth regulator, pyriproxyfen, against Anopheles punctulatus on north Guadalcanal, Solomon Islands.
Okazawa, T., Bakote'e, B., Suzuki, H., Kawada, H., & Kere, N. (1991) · PubMed · Cited by 28 · see citing works
Effects of a nonsteroidal ecdysone agonist, tebufenozide, on host/parasitoid interactions
Brown, J. J. (1994) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.940260212 · Cited by 27 · see citing works
Juvenile hormone action on locust fat body
Wyatt, G. R., Cook, K. E., Firko, H., & Dhadialla, T. S. (1987) · Insect Biochemistry · doi:10.1016/0020-1790(87)90122-3 · Cited by 26 · see citing works
The Compatibility of Tebufenozide with a Laboratory Lepidopteran Host/Hymenopteran Parasitoid Population
Brown, J. J. (1996) · Biological Control · doi:10.1006/bcon.1996.0012 · Cited by 25 · see citing works
Comparative Sterilizing and Ovicidal Activity of Fenoxyearb and Hydroprene in Adults and Oothecae of the German Cockroach (Dictyoptera: Blattellidae)
King, J. E., & Bennett, G. W. (1990) · Journal of Medical Entomology · doi:10.1093/jmedent/27.4.642 · Cited by 24 · see citing works
Laboratory evaluation of two insect juvenile hormone analogues against Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae)
Edwards, J., & Abraham, L. (1985) · Journal of Stored Products Research · doi:10.1016/0022-474x(85)90014-1 · Cited by 24 · see citing works
Effects of a juvenile hormone mimetic, fenoxycarb, on post-embryonic development of the European corn borer,Ostrinia nubilalis Hbn.
Gadenne, C., Grenier, S., Plantevin, G., & Mauchamp, B. (1990) · Cellular and Molecular Life Sciences · doi:10.1007/bf01939954 · Cited by 22 · see citing works
Tebufenozide (Mimic®), a non-ecdysteroidal ecdysone agonist, induces spermatogenesis reinitiation in isolated abdomens of diapausing codling moth larvae (Cydia pomonella)
Friedlander, M. J., & Brown, J. J. (1995) · Journal of Insect Physiology · doi:10.1016/0022-1910(94)00125-z · Cited by 21 · see citing works
8-O-Acetylharpagide is a nonsteroidal ecdysteroid agonist
Elbrecht, A., Chen, Y., Jurgens, T. M., Hensens, O. D., Zink, D. L., Beck, H. T., Balick, M. J., & Borris, R. P. (1996) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(95)00103-4 · Cited by 21 · see citing works
New Cuticle Formation and Molt Inhibition by RH-5849 in the Common Cutworm, Spodoptera litura(Lepidoptera:Noctuidae)
Tateishi, K., Kiuchi, M., & Takeda, S. (1993) · Applied Entomology and Zoology · doi:10.1303/aez.28.177 · Cited by 20 · see citing works
Efficacy of the insect growth regulators tebufenozide and fenoxycarb for lepidopteran pest control in apples, and their compatibility with biological control for integrated pest management
Valentine, B., Gurr, G. M., & Thwaite, W. G. (1996) · Australian Journal of Experimental Agriculture · doi:10.1071/ea9960501 · Cited by 20 · see citing works
Fenoxycarb, a selective insecticide for inclusion in integrated pest management systems for pear in the UK
Solomon, M. G., & Fitzgerald, J. (1990) · Journal of Horticultural Science · doi:10.1080/00221589.1990.11516090 · Cited by 19 · see citing works
Host Range of the Argentine Root Borer Carmenta haematica (Ureta) (Lepidoptera: Sesiidae), a Potential Biocontrol Agent for Snakeweeds (Gutierrezia spp) in the United States
Cordo, H. A., DeLoach, C. J., & Ferrer, R. (1995) · Biological Control · doi:10.1006/bcon.1995.1001 · Cited by 19 · see citing works
Mechanism of action and cloning of epoxide hydrolase from the cabbage looper,Trichoplusia ni
Roe, R. M., Kallapur, V. L., Linderman, R. J., Viviani, F., Harris, S. V., Walker, E. A., & Thompson, D. M. (1996) · Archives of Insect Biochemistry and Physiology · doi:10.1002/(sici)1520-6327(1996)32:3/4 · Cited by 18 · see citing works
Biological effects and metabolism of fenoxycarb after treatment of the fourth and the fifth instars of the tobacco budworm, Heliothis virescens F.
Mauchamp, B., Malosse, C., & Saroglia, P. (1989) · Pesticide Science · doi:10.1002/ps.2780260308 · Cited by 18 · see citing works
Effect of the Insect Growth Regulator Fenoxycarb on the Ovaries of Queens of the Red Imported Fire Ant (Hymenoptera: Formicidae)1
Glancey, B. M., & Banks, W. A. (1988) · Annals of the Entomological Society of America · doi:10.1093/aesa/81.4.642 · Cited by 18 · see citing works
Juvenile hormone binding components of locust fat body
Braun, R. P., Edwards, G. C., Yagi, K. J., Tobe, S. S., & Wyatt, G. R. (1995) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.940280309 · Cited by 18 · see citing works
Effects of anti‐ecdysteroid azole analogues of metyrapone on the larval development of the fleshfly, Neobellieria bullata
Bélai, I., Darvas, B., Bauer, K., & El‐Din, M. H. T. (1995) · Pesticide Science · doi:10.1002/ps.2780440304 · Cited by 17 · see citing works
Integrated pest management in Swiss apple orchards: Stability and risks
Wildbolz, T. (1988) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.1988.tb02478.x · Cited by 15 · see citing works
The juvenile hormone receptor of the cockroach Leucophaea maderae
Engelmann, F. (1995) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(95)00011-j · Cited by 14 · see citing works
EFFECTS OF SELECTED JUVENILE HORMONE ANALOGS ON SIXTH-INSTAR LARVAE OF THE EASTERN SPRUCE BUDWORM, CHORISTONEURA FUMIFERANA CLEMENS (LEPIDOPTERA: TORTRICIDAE)
Mulye, H., & Gordon, R. (1989) · The Canadian Entomologist · doi:10.4039/ent1211111-12 · Cited by 14 · see citing works
Fenoxycarb as a Long-Term Protectant for Stored Rough Rice1
Cogburn, R. R. (1988) · Journal of Economic Entomology · doi:10.1093/jee/81.2.722 · Cited by 14 · see citing works
EFFECTS OF THE JUVENILE HORMONE ANALOG FENOXYCARB ON VARIOUS DEVELOPMENTAL STAGES OF THE EASTERN SPRUCE BUDWORM, CHORISTONEURA FUMIFERANA (CLEMENS) (LEPIDOPTERA: TORTRICIDAE)
Hicks, B. J., & Gordon, R. (1992) · The Canadian Entomologist · doi:10.4039/ent124117-1 · Cited by 14 · see citing works
Trials to Control Matsucoccus josephi (Homoptera: Margarodidae) with Fenoxycarb
Mendel, Z., & Rosenberg, U. (1988) · Journal of Economic Entomology · doi:10.1093/jee/81.4.1143 · Cited by 13 · see citing works
Les régulateurs de croissance d'insectes (RCI), mimiques de l'hormone juvénile, en tant que moyen de lutte morphogénétique et ovicide contre les tordeuses des vergers
Charmillot, P. J. (1989) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.1989.tb01214.x · Cited by 13 · see citing works
Other hormonal agents: ecdysone agonists.
Kd, W., & Ramsay (1989) · Europe PMC (PubMed Central) · Cited by 12 · see citing works
Evaluation of Fenoxycarb, Bacillus thuringiensis, and Malathion as Grain Protectants in Small Bins1
Kramer, K. J., Hendricks, L. H., Wojciak, J. H., & Fylers, J. (1985) · Journal of Economic Entomology · doi:10.1093/jee/78.3.632 · Cited by 11 · see citing works
Nonsteroidal ecdysteroid agonists : biological activity and insect specificity
Smagghe, G. J. (1995) · Ghent University Academic Bibliography (Ghent University) · Cited by 11 · see citing works
Ecdysteroid receptor binding activity and ecdysteroid agonist activity at the level of gene expression are correlated with the activity of dibenzoyl hydrazines in larvae of Bombyx mori
Mikitani, K. (1996) · Journal of Insect Physiology · doi:10.1016/0022-1910(96)00056-x · Cited by 10 · see citing works
ADVERSE EFFECT OF FENOXYCARB ON REPRODUCTION BY THE CALIFORNIA FIVESPINED IPS,IPS PARACONFUSUSLANIER (COLEOPTERA: SCOLYTIDAE)
Chen, N. M., & Borden, J. H. (1989) · The Canadian Entomologist · doi:10.4039/ent1211059-12 · Cited by 10 · see citing works
The use of the Insect Growth Regulators fenoxycarb and epofenonane against leafrollers in Integrated Pest Management in apple orchards
de Reede, R. H., Alkema, P., & Blommers, L. H. M. (1985) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.1985.tb00469.x · Cited by 10 · see citing works
Arylpyridyl-thiosemicarbazones: A new class of anti-juvenile hormones active against Lepidoptera
Barton, A., Wing, K. D., Le, D. P., Slawecki, R. A., & Feyereisen, R. (1989) · Cellular and Molecular Life Sciences · doi:10.1007/bf01990513 · Cited by 9 · see citing works
In vitro effect of nonsteroidal ecdysone agonist RH 5849 on fat body acid phosphatase activity in rice moth, Corcyra cephalonica (Insecta).
ASHOK, M., & Dutta‐Gupta, A. (1991) · PubMed · Cited by 9 · see citing works
Foliar Persistence and Effect of Fenoxycarb on Platynota idaeusalis (Lepidoptera: Tortricidae) on Apple
Hull, L. A., Barrett, B. A., & Rajotte, E. G. (1991) · Journal of Economic Entomology · doi:10.1093/jee/84.3.965 · Cited by 8 · see citing works
Impact of fenoxycarb, a carbamate insect growth regulator, on some aquatic invertebrates abundant in mosquito breeding habitats.
Miura, T., & Rm, T. (1987) · PubMed · Cited by 7 · see citing works
Diofenolan - a new insect growth regulator for the control of scale insects and important lepidopterous pests in deciduous fruit and citrus
Streibert, H. P., Frischknecht, M. L., & Karrer, F. (1994) · Cited by 5 · see citing works
The Insect Moulting Hormone System as a Possible Target Site for Insecticidal Action
Watkinson, I. A., & Clarke, B. (1973) · PANS Pest Articles & News Summaries · doi:10.1080/09670877309411827 · Cited by 5 · see citing works
An insect growth regulator for controlling leafrollers on kiwifruit
Stevens, P. S., & Steven, D. (1994) · Proceedings of the New Zealand Weed Control Conference · doi:10.30843/nzpp.1994.47.11044 · Cited by 4 · see citing works
Apple, Tufted Apple BUD Moth Management Tactics, 1994
Hull, L. A. (1995) · Arthropod management tests · doi:10.1093/amt/20.1.20 · Cited by 3 · see citing works
Laboratory evaluations of insect growth regulators against lightbrown apple moth
McGhie, R. A., & Tomkins, A. R. (1988) · Proceedings of the New Zealand Weed Control Conference · doi:10.30843/nzpp.1988.41.9866 · Cited by 3 · see citing works
Evaluation of Rh0345 and Turcam 76Wp for Management of Japanese Beetle Grubs on a Golf Course Rough in Carbon County, Pennsylvania, 1995
Heller, P. R., & WALKER, R. R. (1996) · Arthropod management tests · doi:10.1093/amt/21.1.339 · Cited by 2 · see citing works
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Influence of Application Time on the Efficacy of Insect Growth Regulators and Insecticides for Control of Japanese Beetle and Northern Masked Chafer Larvae on a Golf Course, 1994
Power, K. T., Shetlar, D. J., Niemczyk, H. D., & Belcher, M. G. (1995) · Arthropod management tests · doi:10.1093/amt/20.1.274 · Cited by 1 · see citing works
Black Cutworm and Sod Webworm Larval Control on Golf Course Putting Green Turf, Oh, 1994
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Small Plot Insecticide Trial Against SCB, 1994
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10.1007/BF00343444
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Flagged first, then by citations

2 of the 131 references couldn’t be matched to a known paper.

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The Sublethal Effects of Pesticides on Beneficial Arthropods
Desneux, N., Decourtye, A., & Delpuech, J. (2006) · Annual Review of Entomology · doi:10.1146/annurev.ento.52.110405.091440 · Cited by 3,576 · see citing works
Chitin metabolism in insects: structure, function and regulation of chitin synthases and chitinases
Merzendorfer, H., & Zimoch, L. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00709 · Cited by 1,251 · see citing works
“…and pyriproxyfen mimic the hormone action, and the juvenile hormone antagonists precocene I and II act via their cytotoxicities on the corpora allata (Schooneveld, 1979; Mulla et al., 1985; Dhadialla et al., 1998; Hoffmann and Lorenz, 1998; Kostyukovsky et al., 2000; Retnakaran et al., 2001).”
Background
Ecdysone receptors and their biological actions
Riddiford, L. M., Cherbas, P., & Truman, J. W. (2000) · Vitamins & Hormones · doi:10.1016/s0083-6729(00)60016-x · Cited by 605 · see citing works
Insecticidal control and resistance management for Bemisia tabaci
Palumbo, J. C., Horowitz, A. R., & Prabhaker, N. (2001) · Crop Protection · doi:10.1016/s0261-2194(01)00117-x · Cited by 471 · see citing works
Synthetic methodology for alkyl substituted hydrazines
Ragnarsson, U. (2001) · Chemical Society Reviews · doi:10.1039/b010091a · Cited by 454 · see citing works
The Evolution of Insect Metamorphosis
Truman, J. W. (2019) · Current Biology · doi:10.1016/j.cub.2019.10.009 · Cited by 420 · see citing works
Phytoecdysteroids: Biological aspects
Dinan, L. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00078-4 · Cited by 392 · see citing works
Insecticide use: Contexts and ecological consequences
Devine, G. J., & Furlong, M. J. (2007) · Agriculture and Human Values · doi:10.1007/s10460-007-9067-z · Cited by 332 · see citing works
“Tebufenozide and methoxyfenozide [dibenzoylhydrazine insect growth regulators (IGRs)] disrupt the molting process in Lepidoptera but do not affect beneficial insects (Dhadialla et al., 1998; HewaKapuge et al., 2003).”
Background
Rapid, Nongenomic Responses to Ecdysteroids and Catecholamines Mediated by a Novel<i>Drosophila</i>G-Protein-Coupled Receptor
Srivastava, D. P., Yu, E. J., Kennedy, K., Chatwin, H., Reale, V., Hamon, M., Smith, T., & Evans, P. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1005-05.2005 · Cited by 272 · see citing works
“In addition, the bisacylhydrazine ecdysteroid agonists RH5849 and RH-0345 (halofenozide), which bind effectively to EcRs from Lepidoptera (Dhadialla et al., 1998; Nakagawa et al., 2000) and Drosophila (Nakagawa et al.”
BackgroundInfluential
Arthropod nuclear receptors and their role in molting
Nakagawa, Y., & Henrich, V. C. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07347.x · Cited by 255 · see citing works
Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
Billas, I. M. L., Iwema, T., Garnier, J., Mitschler, A., Rochel, N., & Moras, D. (2003) · Nature · doi:10.1038/nature02112 · Cited by 254 · see citing works
The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry
Shao, C., Bao, B., Xie, Z., Chen, X., Li, B., Jia, X., Yao, Q., Ortı́, G., Li, W., Li, X., et al. (2016) · Nature Genetics · doi:10.1038/ng.3732 · Cited by 248 · see citing works
Conventional agrochemicals towards nano-biopesticides: an overview on recent advances
Abdollahdokht, D., Gao, Y., Faramarz, S., Poustforoosh, A., Abbasi, M., Asadikaram, G., & Nematollahi, M. H. (2022) · Chemical and Biological Technologies in Agriculture · doi:10.1186/s40538-021-00281-0 · Cited by 226 · see citing works
“Selective insecticides, such as juvenile hormone mimics (fenoxycarb and pyriproxyfen) [34], ecdysone agonists, and chitin synthesis inhibitors (diflubenzuron), impede insect reproduction and growth by acting on insect-specific targets [35].”
Background
Chemically regulated gene expression in plants.
Padidam, M. (2003) · Current opinion in plant biology · doi:10.1016/s1369-5266(03)00005-0 · Cited by 228 · see citing works
The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist
Carlson, G. R., Dhadialla, T. S., Hunter, R., Jansson, R. K., Jany, C. S., Lidert, Z., & Slawecki, R. A. (2001) · Pest Management Science · doi:10.1002/1526-4998(200102)57:2 · Cited by 210 · see citing works
Practical uses for ecdysteroids in mammals including humans: and update
Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1093/jis/3.1.7 · Cited by 196 · see citing works
“In the context of this review, the identification of bisacylhydrazines as non-steroidal ecdysteroid agonists (Wing, 1988; Dhadialla et al., 1998) is particularly worth mentioning as, in addition to several of these molecules being commercialised as insecticides, other analogues appear appropriate as gene switching eli…”
BackgroundInfluential
Practical uses for ecdysteroids in mammals including humans: And update
Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1673/031.003.0701 · Cited by 196 · see citing works
“In the context of this review, the identification of bisacylhydrazines as non-steroidal ecdysteroid agonists (Wing, 1988; Dhadialla et al., 1998) is particularly worth mentioning as, in addition to several of these molecules being commercialised as insecticides, other analogues appear appropriate as gene switching eli…”
Influential
Insecticides Mode of Action in Relation to Their Toxicity to Non-Target Organisms
Blacquière, T., Smagghe, G., van Gestel, C., & Mommaerts, V. (2012) · Journal of Environmental & Analytical Toxicology · doi:10.4172/2161-0525.s4-002 · Cited by 187 · see citing works
Fifty years of the integrated control concept: moving the model and implementation forward in Arizona
Naranjo, S. E., & Ellsworth, P. C. (2009) · Pest Management Science · doi:10.1002/ps.1861 · Cited by 183 · see citing works
New modes of action of insecticides
Nauen, R., & Bretschneider, T. (2002) · Pesticide Outlook · doi:10.1039/b211171n · Cited by 181 · see citing works
“Insect growth regulators are often very species-specific insecticides (Dhadialla et al., 1998), and in general are not active as aphicides, but rather against other pest insects, e.g. whiteflies (buprofezin and pyriproxyfen), Lepidoptera (methoprene, fenoxycarb, and benzoylphenyl ureas),…”
Background
Recent Developments in Ectoparasiticides
Taylor, M. A. (2001) · The Veterinary Journal · doi:10.1053/tvjl.2000.0549 · Cited by 179 · see citing works
Eat to reproduce: a key role for the insulin signaling pathway in adult insects
Badisco, L., Van Wielendaele, P., & Vanden Broeck, J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00202 · Cited by 173 · see citing works
“In addition, although the early stages of oogenesis, as well as initiation of vitellogenesis in B. mori require the presence of ecdysteroids, their absence seems to be necessary for completion of vitellogenesis and choriogenesis (Dhadialla et al., 1998; Swevers and Iatrou, 2009).”
Background
Insecticides with Novel Modes of Action
Ishaaya, I., & Degheele, D. (1998) · Springer eBooks · doi:10.1007/978-3-662-03565-8 · Cited by 167 · see citing works
Biological activities of lignans and stilbenoids associated with plant-insect chemical interactions
Harmatha, J., & Dinan, L. N. (2003) · Phytochemistry Reviews · doi:10.1023/b:phyt.0000045494.98645.a3 · Cited by 160 · see citing works
“The activity of synthetic non-ecdysteroidal agonists of the phenolic bisacylhydrazine type (Dhadialla et al., 1998), as well as antagonistic stilbenes (e.g. cisresveratrol) or simple phenylpropanoids (e.g. apiol), reported by Dinan et al. (1999b; 2001a, b), encouraged us to assess lignans, which…”
Background
Ecdysone Receptors: From the Ashburner Model to Structural Biology
Hill, R. J., Billas, I. M. L., Bonneton, F., Graham, L. D., & Lawrence, M. C. (2012) · Annual Review of Entomology · doi:10.1146/annurev-ento-120811-153610 · Cited by 160 · see citing works
“The lepidopteran-selective DBH insecticides bind with high affinity to lepidopteran ecdysone receptors, with lower affinity to coleopteran and dipteran receptors, and with low or negligible affinity to the receptors of most other insect orders (26, 36, 121).”
Background
Evidence for Endocrine Disruption in Invertebrates
Oetken, M., Bachmann, J., Schulte‐Oehlmann, U., & Oehlmann, J. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)36001-8 · Cited by 159 · see citing works
“Additionally to the publications on ED effects in chironomids one paper was dedicated to Lepidoptera as test organisms.”
Background
Environmental fate and properties of pyriproxyfen
Sullivan, J. J., & Goh, K. S. (2008) · Journal of Pesticide Science · doi:10.1584/jpestics.r08-02 · Cited by 157 · see citing works
Action of insect growth regulator insecticides and spinosad on life history parameters and absorption in third-instar larvae of the endoparasitoid Hyposoter didymator
Schneider, M. I., Smagghe, G. J., Pineda, S., & Viñuela, E. (2004) · Biological Control · doi:10.1016/j.biocontrol.2004.04.013 · Cited by 149 · see citing works
“The ecdysone agonists, MET and TEB are highly selective against lepidopteran larvae (Dhadialla et al., 1998; Pineda et al., 2000; Smagghe and Degheele, 1994a).”
Background
Insect Nuclear Receptors
Fahrbach, S. E., Smagghe, G. J., & Velarde, R. A. (2011) · Annual Review of Entomology · doi:10.1146/annurev-ento-120710-100607 · Cited by 147 · see citing works
The molecular site of action of juvenile hormone and juvenile hormone insecticides during metamorphosis: how these compounds kill insects
Wilson, T. G. (2004) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2003.12.004 · Cited by 146 · see citing works
Conservation of natural enemies in cotton: role of insect growth regulators in management of Bemisia tabaci
Naranjo, S. E., Ellsworth, P. C., & Hagler, J. R. (2003) · Biological Control · doi:10.1016/j.biocontrol.2003.09.010 · Cited by 142 · see citing works
“, 1988) and both materials have low vertebrate toxicity and other qualities that make them relatively safe for the environment (Dhadialla et al., 1998; Pener, 2002).”
Background
Lethal and Sublethal Effects of Methoxyfenozide and Spinosad on Spodoptera littoralis (Lepidoptera: Noctuidae)
Pineda, S., Schneider, M. I., Smagghe, G. J., Martı́nez, A.-M., del Estal, P., Viñuela, E., Valle, J. F., & Budia, F. (2007) · Journal of Economic Entomology · doi:10.1093/jee/100.3.773 · Cited by 142 · see citing works
Pesticide selectivity for the insect egg parasitoid Telenomus remus
do Carmo, E. L., Bueno, A. F., & Bueno, R. C. O. F. (2010) · BioControl · doi:10.1007/s10526-010-9269-y · Cited by 139 · see citing works
“It accelerates the molting process by acting as an ecdysone agonist or ecdysonoid, substituting for the natural 20-hydroxyecdysone insectmolting hormone (Dhadialla et al. 1998).”
Background
Insect Growth- and Development-Disrupting Insecticides
Dhadialla, T. S., Retnakaran, A., & Smagghe, G. J. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00076-4 · Cited by 139 · see citing works
An extensive ecdysteroid CoMFA
Dinan, L. N., Hormann, R. E., & Fujimoto, T. T. (1999) · Journal of Computer-Aided Molecular Design · doi:10.1023/a:1008052320014 · Cited by 137 · see citing works
Tebufenozide resistance selected in Plutella xylostella and its cross‐resistance and fitness cost
Cao, G., & Han, Z. (2006) · Pest Management Science · doi:10.1002/ps.1234 · Cited by 136 · see citing works
Insecticide resistance resulting from an absence of target-site gene product
Wilson, T. G., & Ashok, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14040 · Cited by 136 · see citing works
The ecdysone regulatory cascade and ovarian development in lepidopteran insects: insights from the silkmoth paradigm
Swevers, L., & Iatrou, K. (2003) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2003.06.012 · Cited by 134 · see citing works
Silencing the HaHR3 Gene by Transgenic Plant-mediated RNAi to Disrupt Helicoverpa armigera Development
Xiong, Y., Zeng, H., Zhang, Y., Xu, D., & Qiu, D. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.5929 · Cited by 130 · see citing works
“Field applications show that diverse insecticides that target molting are safe to beneficial insects and are selectively toxic to lepidopteran pests [30].”
Background
Edysone receptor isoforms play distinct roles in controlling molting and metamorphosis in the red flour beetle, Tribolium castaneum
Tan, A., & Palli, S. R. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.05.006 · Cited by 124 · see citing works
miR-71 and miR-263 Jointly Regulate Target Genes Chitin synthase and Chitinase to Control Locust Molting
Yang, M., Wang, Y., Jiang, F., Song, T., Wang, H., Liu, Q. F., Zhang, J., Zhang, J., & Kang, L. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006257 · Cited by 124 · see citing works
“In addition, 20-hydroxyecdysone (20E), as a key steroid hormone, coordinates multiple developmental events involving insect molting and metamorphosis [40].”
Background
Monitoring of resistance in Spodoptera exigua (Lepidoptera: Noctuidae) from four districts of the Southern Punjab, Pakistan to four conventional and six new chemistry insecticides
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Background
Compatibility of Spinosad, Tebufenozide and Azadirachtin with Eggs and Pupae of the Predator Chrysoperla carnea (Stephens) Under Laboratory Conditions
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Effects of pesticides used in soybean crops to the egg parasitoid Trichogramma pretiosum
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The Insect Ecdysone Receptor is a Good Potential Target for RNAi-based Pest Control
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Toxicity and biochemical study of two insect growth regulators, buprofezin and pyriproxyfen, on cotton leafworm Spodoptera littoralis
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Insect growth regulatory effects of some extracts and sterols from Myrtillocactus geometrizans (Cactaceae) against Spodoptera frugiperda and Tenebrio molitor
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Background
The genus Sida L. – A traditional medicine: Its ethnopharmacological, phytochemical and pharmacological data for commercial exploitation in herbal drugs industry
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“These ecdysteroids may be useful candidates for successful insect control agents (Dhadialla et al., 1998).”
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An Overview of Insect Growth Disruptors; Applied Aspects
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Genomic and proteomic studies on the effects of the insect growth regulator diflubenzuron in the model beetle species Tribolium castaneum
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“Ecdysone agonists such as tebufenozide or methoxyfenozide, and juvenile hormone mimics such as fenoxycarb, methoprene or pyriproxyfen interfere with the hormonal control of molting and metamorphosis (Dhadialla et al., 1998).”
Background
Effects of endocrine-active chemicals on the development of sex characteristics of Daphnia magna
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“An analog, tebufenozide (RH-5992), proved to be extremely potent against and selective toward larval Lepidoptera (Carlson et al. 1994, Dhadialla et al. 1998) and is now widely used against lepidopteranpestson several crops throughout the world.”
Background
Chemical-Inducible, Ecdysone Receptor-Based Gene Expression System for Plants
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“Methoxyfenozide, a non-steroidal agonist of EcR, binds to EcR with nanomolar affinity and is safe to many organisms (Dhadialla et al., 1998).”
Background
Impact of Halofenozide, Imidacloprid, and Bendiocarb on Beneficial Invertebrates and Predatory Activity in Turfgrass
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BackgroundInfluential
Organization and repression by juvenile hormone of a vitellogenin gene cluster in the crustacean, Daphnia magna
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Dynamics of insecticide resistance in Bemisia tabaci: a case study with the insect growth regulator pyriproxyfen
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“Insecticides of this group are responsible for the regulation of molting, metamorphosis, caste determination, and yolk synthesis (Hartfelder, 2000), as well as extending the development period and affecting the reproductive stages (Dhadialla et al., 1998).”
Background
Comparative toxicity and sublethal effects of emamectin benzoate, lufenuron and spinosad on Spodoptera littoralis Boisd. (Lepidoptera: Noctuidae)
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Impact of pesticides on non-target invertebrates in agricultural ecosystems
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“Bees were fed sucrose solution containing methoprene, a well known JH agonist (4 mg/ml, Wellmark International, reviewed in Dhadialla et al. 1998) or octopamine (2 mg/ml, Sigma).”
Method
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Authors: Dhadialla, T. S., Carlson, G. R., & Le, D. P.
Affiliations: Insecticide Research Laboratories, Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania 19477;
Venue: Annual Review of Entomology
Publisher: Annual Reviews
Published: 1998-01
Volume: 43
Issue: 1
Pages: 545-569
ISSN: 0066-4170 (ISSN-L)
1545-4487
DOI: 10.1146/annurev.ento.43.1.545
OpenAlex: W2149662691
Cited by: 912
References: 131
Citations by year: 2026: 12 · 2025: 29 · 2024: 29 · 2023: 22 · 2022: 23 · 2021: 44 · 2020: 22 · 2019: 30 · 2018: 23 · 2017: 34 · 2016: 32 · 2015: 28 · 2014: 21 · 2013: 32 · 2012: 49
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Entomology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
Keywords: insect growth regulators, ecdysteroid agonists, juvenile hormone agonists, tebufenozide, fenoxycarb, pyriproxyfen, 20-hydroxyecdysone, ecdysteroid receptor, insecticide mode of action, ecotoxicology, lepidopteran pests
MeSH terms: Animals, Forecasting, Hydrazines, Insecticides, Insecta, Juvenile Hormones, Steroids, Molecular Structure, Molecular Mimicry, Ecdysteroids

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New insecticides with ecdysteroidal and juvenile hormone activity

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