Salicylic acid and aspirin stimulate growth of Chlamydomonas and inhibit lipoxygenase and chloroplast desaturase pathways
Open accessAbstract
Chemical stimulants, used to enhance biomass yield, are highly desirable for the commercialisation of algal products for a wide range of applications in the food, pharma and biofuels sectors. In the present study, phenolic compounds, varying in substituents and positional isomers on the arene ring have been evaluated to determine structure-activity relationship and growth. The phenols, catechol, 4-methylcatechol and 2, 4-dimethyl phenol were generally inhibitory to growth as were the compounds containing an aldehyde function. By contrast, the phenolic acids, salicylic acid, aspirin and 4-hydroxybenzoate markedly stimulated cell proliferation enhancing cell numbers by 20-45% at mid-log phase. The order of growth stimulation was ortho > para > meta with respect to the position of the OH group. Both SA and aspirin reduced 16:3 in chloroplast galactolipids. In addition, both compounds inhibited lipoxygenase activity and lowered the levels of lipid hydroperoxides and malondialdehydes in the cells. The present study has demonstrated the possibility of using SA or aspirin to promote algal growth through the manipulation of lipid metabolising enzymes.
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The addition of phenolics (particularly salicylic acid and aspirin) stimulates cell division significantly in Chlamydomomas and may be a useful tool to achieve higher biomass in a shorter time period.
“Recently, the addition of phenolics (particularly salicylic acid and aspirin) have been shown to stimulate cell division significantly in Chlamydomomas and may be a useful tool to achieve higher biomass in a shorter time period [26].”
From Key Targets for Improving Algal Biofuel Production (2021) · cites this paper as [26]
Phenolic compounds control the rate of cell division in Chlamydomonas and are particularly stimulated by salicylic acid.
“Phenolic compounds are known to control the rate of cell division in Chlamydomonas and are particularly stimulated by salicylic acid [26].”
From Key Targets for Improving Algal Biofuel Production (2021) · cites this paper as [26]
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Key Targets for Improving Algal Biofuel Production
Griffiths, G., Hossain, A. K., Sharma, V., & Duraisamy, G. (2021) · Clean Technologies · doi:10.3390/cleantechnol3040043 · Cited by 49 · see citing works
Self-citation
- Authors
- Awad, N., Vega-Estévez, S., & Griffiths, G.
- Affiliations
- Aston University (GB)
- Corresponding author
- Griffiths, Gareth
- Venue
- Plant Physiology and Biochemistry
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 149
- Pages
- 256-265
- ISSN
- 0981-9428 (ISSN-L)
- OpenAlex
- W3005632850
- Cited by
- 20
- References
- 43
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- Locations
- Plant Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- Funders
- Erasmus+
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Growth Enhancement Techniques
- Keywords
- salicylic acid, aspirin, Chlamydomonas reinhardtii, algal growth stimulation, phenolic compounds, structure-activity relationship, lipoxygenase inhibition, lipid hydroperoxides, malondialdehyde, lipid peroxidation, p-hydroxybenzoic acid, 4-methylcatechol, catechol, 2,4-dimethylphenol, algal biomass production
- MeSH terms
- Aspirin, Chlamydomonas, Chloroplasts, Enzyme Activation, Enzyme Inhibitors, Lipoxygenase, Salicylic Acid, Fatty Acid Desaturases
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