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Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): An emerging signaling molecule
Open accessAbstract
Golgi body-mediated signaling has been linked to its fragmentation and regeneration during the mitotic cycle of the cell. During this process, Golgi-resident proteins are released to the cytosol and interact with other signaling molecules to regulate various cellular processes. Acyl-coenzyme A binding domain containing 3 protein (ACBD3) is a Golgi protein involved in several signaling events. ACBD3 protein was previously known as peripheral-type benzodiazepine receptor and cAMP-dependent protein kinase associated protein 7 (PAP7), Golgi complex-associated protein of 60kDa (GCP60), Golgi complex-associated protein 1 (GOCAP1), and Golgi phosphoprotein 1 (GOLPH1). In this review, we present the gene ontology of ACBD3, its relations to other Acyl-coenzyme A binding domain containing (ACBD) proteins, and its biological function in steroidogenesis, apoptosis, neurogenesis, and embryogenesis. We also discuss the role of ACBD3 in asymmetric cell division and cancer. New findings about ACBD3 may help understand this newly characterized signaling molecule and stimulate further research into its role in molecular endocrinology, neurology, and stem cell biology.
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“ACBD5 is one of the seven members of the mammalian acyl-CoA binding domain-containing protein (ACBP) family characterized by an N-terminal acyl-CoA binding domain (ACBD) (15).”
From Deficiency of a Retinal Dystrophy Protein, Acyl-CoA Binding Domain-containing 5 (ACBD5), Impairs Peroxisomal β-Oxidation of Very-long-chain Fatty Acids (2017) · cites this paper as [15]
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Metadata
- Authors
- Fan, J., Liu, J., Culty, M., & Papadopoulos, V.
- Affiliations
- McGill University Health Centre (CA)
- Georgetown University Medical Center (US)
- Corresponding author
- Papadopoulos, Vassilios
- Venue
- Progress in Lipid Research
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 49
- Issue
- 3
- Pages
- 218-234
- ISSN
- 0163-7827 (ISSN-L)
- PMC
- PMC2873055
- OpenAlex
- W2054877611
- Cited by
- 142
- References
- 110
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 9 · 2023: 1 · 2022: 9 · 2021: 19 · 2020: 12 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 21 · 2014: 8 · 2013: 5 · 2012: 11
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Lipid Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37031, R01HD037031)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- ACBD3, Golgi apparatus, steroidogenesis, apoptosis, neurogenesis, embryonic development, asymmetric cell division, cancer, molecular endocrinology, neurology, stem cell biology
- MeSH terms
- Golgi Apparatus, Humans, Membrane Proteins, Signal Transduction, Apoptosis, Protein Structure, Tertiary, Embryonic Development, Adaptor Proteins, Signal Transducing, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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