Regulation of HMG-CoA reductase in mammals and yeast

A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703

Regulation of the mevalonate pathway

Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530417 · Cited by 1,927

Structural mechanism for statin inhibition of HMG-CoA reductase

Istvan, E. S., & Deisenhofer, J. (2001) · Science · doi:10.1126/science.1059344 · Cited by 1,644

Protein Sensors for Membrane Sterols

Goldstein, J. L., DeBose-Boyd, R. A., & Brown, M. S. (2006) · Cell · doi:10.1016/j.cell.2005.12.022 · Cited by 1,517

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

Hardie, D. G., Carling, D., & Carlson, M. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.821 · Cited by 1,440

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232

Crucial Step in Cholesterol Homeostasis

Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., & Brown, M. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00872-3 · Cited by 987

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

Endo, A., KURODA, M., & Tsujita, Y. (1976) · The Journal of Antibiotics · doi:10.7164/antibiotics.29.1346 · Cited by 954

Targeting fungal lipid synthesis for antifungal drug development and potentiation of contemporary antifungals

Gutierrez-Perez, C., & Cramer, R. A. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00093-4 · Cited by 35

Overexpression of Key Sterol Pathway Enzymes in Two Model Marine Diatoms Alters Sterol Profiles in Phaeodactylum tricornutum

Jaramillo-Madrid, A. C., Abbriano, R. M., Ashworth, J., Fabris, M., Pernice, M., & Ralph, P. J. (2020) · Pharmaceuticals · doi:10.3390/ph13120481 · Cited by 30

Engineering of Yarrowia lipolytica for terpenoid production

Arnesen, J. A., & Borodina, I. (2022) · Metabolic Engineering Communications · doi:10.1016/j.mec.2022.e00213 · Cited by 30

Regulation of lipid metabolism: a tale of two yeasts

Raychaudhuri, S., Young, B. P., Espenshade, P. J., & Loewen, C. J. R. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.05.006 · Cited by 28

Transcription of the three HMG-CoA reductase genes of Mucor circinelloides

Nagy, G., Farkas, A., Csernetics, Á., Bencsik, O., Szekeres, A., Nyilasi, I., Vágvölgyi, C., & Papp, T. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-93 · Cited by 28

Effects of an Enriched Extract of Paeoniflorin, a Monoterpene Glycoside used in Chinese Herbal Medicine, on Cholesterol Metabolism in a Hyperlipidemic Rat Model

Hu, H., Zhu, Q., Su, J., Wu, Y., Zhu, Y., Wang, Y., Fang, H., Pang, M.-X., Li, B., Chen, S., et al. (2017) · Medical Science Monitor · doi:10.12659/msm.905544 · Cited by 28

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue

Grunwald, S. A., Popp, O., Haafke, S., Jedraszczak, N., Grieben, U. I., Saar, K., Patone, G., Kreß, W., Steinhagen‐Thiessen, E., Dittmar, G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-58668-2 · Cited by 29

Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis

Chevallier, V., Schoof, E. M., Malphettes, L., Andersen, M. R., & Workman, C. T. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27495 · Cited by 27

Roles of Spicy Foods and Their Bioactive Compounds in Management of Hypercholesterolemia

Zhao, Y., & Chen, Z. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02975 · Cited by 27

Short-Chain Fatty Acid Production and Functional Aspects on Host Metabolism

Tungland, B. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814649-1.00002-8 · Cited by 29

Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice

Karanth, S., Tran, V. M., Kuberan, B., & Schlegel, A. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.013425 · Cited by 25

The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level

Goldman, A. R., Bitler, B. G., Schug, Z. T., Conejo-Garcia, J. R., Zhang, R., & Speicher, D. W. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.062539 · Cited by 26

Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins

Mao, S., Ren, J., Xu, Y. H., Lin, J., Pan, C., Meng, Y., & Xu, N. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175033 · Cited by 26

A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action

Haywood, J., Breese, K. J., Zhang, J., Waters, M. T., Bond, C. S., Stubbs, K. A., & Mylne, J. S. (2022) · Nature Communications · doi:10.1038/s41467-022-33185-0 · Cited by 27

Anti-obesity effects of olivetol in adult zebrafish model induced by short-term high-fat diet

Reshma, A., Tamilanban, T., Chitra, V., Subramaniyan, V., Gupta, G., Fuloria, N. K., Sekar, M., Fuloria, S., Sahu, R., Narayanan, J., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-44462-3 · Cited by 26

Biosynthesis of ergosterol as a relevant molecular target of metal-based antiparasitic and antifungal compounds

Scalese, G., Mosquillo, M. F., Pérez‐Díaz, L., & Gambino, D. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215608 · Cited by 24

Regulatory mechanism of mineral-balanced deep sea water on hypocholesterolemic effects in HepG2 hepatic cells

Lee, K., Kwon, Y., Kim, S., Moon, D.-S., Kim, H.-J., & Nam, K. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.046 · Cited by 23

Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Qian, L., Scott, N. A., Capell-Hattam, I. M., Draper, E. A., Fenton, N. M., Luu, W., Sharpe, L. J., & Brown, A. J. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100362 · Cited by 23

Chemical approaches to inhibitors of isoprenoid biosynthesis: targeting farnesyl and geranylgeranyl pyrophosphate synthases

Merino, P., Maiuolo, L., Delso, I., Algieri, V., Nino, A. D., & Tejero, T. (2017) · RSC Advances · doi:10.1039/c6ra28316k · Cited by 23

The UPRmt Protects Caenorhabditis elegans from Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway

Oks, O., Lewin, S., Goncalves, I. L., & Sapir, A. (2018) · Genetics · doi:10.1534/genetics.118.300863 · Cited by 23

Metabolism of Storage Lipids and the Role of Lipid Droplets in the Yeast Schizosaccharomyces pombe

Hapala, I., Griač, P., & Holič, R. (2020) · Lipids · doi:10.1002/lipd.12275 · Cited by 22

Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis

Usal, M., Veyrenc, S., Darracq-Ghitalla-Ciock, M., Regnault, C., Sroda, S., Fini, J., Canlet, C., Tremblay‐Franco, M., Raveton, M., & Reynaud, S. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116109 · Cited by 22

The landscape of metabolic pathway dependencies in cancer cell lines

Joly, J. H., Chew, B. T. L., & Graham, N. A. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008942 · Cited by 25

Parent-of-origin effects propagate through networks to shape metabolic traits

Macias-Velasco, J. F., Pierre, C. L. S., Wayhart, J. P., Yin, L., Spears, L., Miranda, M. A., Carson, C., Funai, K., Cheverud, J. M., Semenkovich, C. F., et al. (2022) · eLife · doi:10.7554/elife.72989 · Cited by 24

The 3-hydroxy-3-methylglutaryl coenzyme-A reductases from fungi: A proposal as a therapeutic target and as a study model

Andrade-Pavón, D., Sanchez‐Sandoval, E., Rosales-Acosta, B., Ibarra, J. A., Tamariz, J., Hernández-Rodríguez, C., & Villa‐Tanaca, L. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2013.10.004 · Cited by 21

Yeast Bioflavoring in Beer: Complexity Decoded and Built up Again

Nasuti, C., & Solieri, L. (2024) · Fermentation · doi:10.3390/fermentation10040183 · Cited by 21

Chronic exposure to environmentally relevant levels of simvastatin disrupts zebrafish brain gene signaling involved in energy metabolism

Barros, S., Coimbra, A. M., Alves, N., Pinheiro, M., Quintana, J. B., Santos, M. M., & Neuparth, T. (2020) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2020.1733722 · Cited by 23

Overexpression and repression of key rate‐limiting enzymes (acetyl CoA carboxylase and HMG reductase) to enhance fatty acid production from Rhodotorula mucilaginosa

Chaturvedi, S., Gupta, A. K., Bhattacharya, A., Dutta, T., Nain, L., & Khare, S. K. (2020) · Journal of Basic Microbiology · doi:10.1002/jobm.202000407 · Cited by 20

An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases

Ilias, N., Hamzah, H. B., Ismail, I. S., Mohidin, T. B. M., Idris, M. F., & Ajat, M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112207 · Cited by 22

hapE and hmg1 Mutations Are Drivers of cyp51A -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

Souza, A. C. O., Ge, W., Wiederhold, N. P., Rybak, J. M., Fortwendel, J. R., & Rogers, P. D. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.05188-22 · Cited by 20

Engineering Aspergillus nidulans for heterologous ent-kaurene and gamma-terpinene production

Bromann, K., Toivari, M. H., Viljanen, K., Ruohonen, L., & Nakari‐Setälä, T. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7517-5 · Cited by 20

Biosynthetic Approaches to Squalene Production: The Case of Yeast

Valachovič, M., & Hapala, I. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6445-1_7 · Cited by 19

Potential role of mycosterols in hyperlipidemia – A review

Das, M., & Kumar, G. S. (2020) · Steroids · doi:10.1016/j.steroids.2020.108775 · Cited by 19

Exposure of Ldlr−/− Mice to a PFAS Mixture and Outcomes Related to Circulating Lipids, Bile Acid Excretion, and the Intestinal Transporter ASBT

Roth, K., Yang, Z., Agarwal, M., Birbeck, J. A., Westrick, J. A., Lydic, T. A., Gurdziel, K., & Petriello, M. C. (2024) · Environmental Health Perspectives · doi:10.1289/ehp14339 · Cited by 20

Versatile filamentous fungal host highly-producing heterologous natural products developed by genome editing-mediated engineering of multiple metabolic pathways

Saito, N., Katayama, T., Minami, A., Oikawa, H., & Maruyama, J. (2024) · Communications Biology · doi:10.1038/s42003-024-06958-0 · Cited by 18

Review: Endoplasmic Reticulum-Associated Degradation (ERAD)-Dependent Control of (Tri)terpenoid Metabolism in Plants

Erffelinck, M., & Goossens, A. (2018) · Planta Medica · doi:10.1055/a-0635-8369 · Cited by 19

Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

Cirigliano, A., Amelina, A., Biferali, B., Macone, A., Mozzetta, C., Bianchi, M. M., Mori, M., Botta, B., Pick, E., Negri, R., et al. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1687461 · Cited by 14

Transcriptomics Reveals the Mevalonate and Cholesterol Pathways Blocking as Part of the Bacterial Cyclodipeptides Cytotoxic Effects in HeLa Cells of Human Cervix Adenocarcinoma

Lázaro-Mixteco, P. E., González-Coronel, J. M., Hernández-Padilla, L., Alcantar, L. M., Martínez-Carranza, E., López‐Bucio, J. S., Guevara-García, Á. A., & Campos‐García, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.790537 · Cited by 17

Nitrogen Sources Affect the Long-Chain Polyunsaturated Fatty Acids Content in Thraustochytrium sp. RT2316-16

Valdebenito, D., Urrutia, S., Leyton, A., Yusuf Chisti, B., Asenjo, J. A., & Shene, C. (2022) · Marine Drugs · doi:10.3390/md21010015 · Cited by 17

Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells

Piccarducci, R., Giacomelli, C., Bertilacchi, M. S., Benito-Martínez, A., Giorgi, N. D., Daniele, S., Signore, G., Rocchiccioli, S., Vilar, M., Marchetti, L., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166793 · Cited by 19

Common aspects in the engineering of yeasts for fatty acid- and isoprene-based products

Arhar, S., & Natter, K. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.08.009 · Cited by 17

Gain and loss of a transcription factor that regulates late trichothecene biosynthetic pathway genes in Fusarium

Brown, D. W., Villani, A., Susca, A., Moretti, A., Hao, G., Kim, H.-S., Proctor, R. H., & McCormick, S. P. (2019) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2019.103317 · Cited by 17

Mediterranean, vegetarian and vegan diets as practical outtakes of EAS and ACC/AHA recommendations for lowering lipid profile

Wojda, A., Janczy, A., & Małgorzewicz, S. (2021) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5515 · Cited by 17

Eicosapentaenoic Acid‐Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease

Liu, Y., Shi, D., Tian, Y., Liu, Y., Zhan, Q., Xu, J., Wang, J., & Xue, C. (2016) · Lipids · doi:10.1007/s11745-016-4222-1 · Cited by 17

Krill Oil Inhibits Cholesterol Synthesis and Stimulated Cholesterol Excretion in Hypercholesterolemic Rats

Kim, O., Yun, J. M., Kim, D., Park, S., Lee, C., Go, E. B., Kim, J. S., Park, S. Y., & Lee, J. (2022) · Marine Drugs · doi:10.3390/md20100609 · Cited by 16

Control of Cholesterol Metabolism Using a Systems Approach

Formanowicz, D., Radom, M., Rybarczyk, A., Tanaś, K., & Formanowicz, P. (2022) · Biology · doi:10.3390/biology11030430 · Cited by 18

Molecular Effects of Diphenyl Diselenide on Cholesterol and Glucose Cell Metabolism

da Rocha, J. T., Trapani, L., Segatto, M., Rosa, P. L., Nogueira, C. W., Zeni, G. R., & Pallottini, V. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320350007 · Cited by 16

The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-α-bisabolene production

Adamczyk, P., Hwang, H. J., Chang, T.-H., Gao, Y., Baidoo, E. E. K., Kim, J., Webb‐Robertson, B., Flores, J. E., Quijano, K. C., Burnet, M., et al. (2025) · Metabolic Engineering · doi:10.1016/j.ymben.2025.02.014 · Cited by 15

Phospholipid Biosynthesis: An Unforeseen Modulator of Nuclear Metabolism

Qiu, H., & Ye, C. (2025) · Biology of the Cell · doi:10.1111/boc.70002 · Cited by 18

Multilevel interactions between native and ectopic isoprenoid pathways affect global metabolism in rice

Pérez, L., Alves, R., Pérez-Fons, L., Albacete, A. A., Farré, G., Soto, E., Vilaprinyó, E., Martínez‐Andújar, C., Basallo, O., Fraser, P. D., et al. (2022) · Transgenic Research · doi:10.1007/s11248-022-00299-6 · Cited by 15

p140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells

Centonze, G., Natalini, D., Grasso, S., Morellato, A., Salemme, V., Piccolantonio, A., D’Attanasio, G., Savino, A., Bianciotto, O. T., Fragomeni, M., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06357-z · Cited by 15

Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase from Candida glabrata by α-asarone-based synthetic compounds as antifungal agents

Andrade-Pavón, D., Ortiz-Álvarez, J., Sanchez‐Sandoval, E., Tamariz, J., Hernández, G., Ibarra, J. A., & Villa‐Tanaca, L. (2019) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2019.01.008 · Cited by 13

Overproduction of mycotoxin biosynthetic enzymes triggers Fusarium toxisome-shaped structure formation via endoplasmic reticulum remodeling

Wang, M., Wu, N., Wang, H., Liu, C., Chen, Q., Xu, T., Chen, Y., Zhao, Y. F., & Ma, Z. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1011913 · Cited by 14

Nanomedicine-based drug delivery strategies for the treatment of atherosclerosis

Lin, Y., Lin, R., Lin, H.-B., & Shen, S. (2024) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2024.100189 · Cited by 14

An Insight Into Structure, Function, and Expression Analysis of 3-Hydroxy-3-Methylglutaryl-CoA Reductase of Cymbopogon winterianus

Devi, K., Patar, L., Modi, M. K., & Sen, P. (2017) · Bioinformatics and Biology Insights · doi:10.1177/1177932217701735 · Cited by 14

Effects of Phenanthrene Exposure on Cholesterol Homeostasis and Cardiotoxicity in Zebrafish Embryos

McGruer, V., Tanabe, P., Vliet, S. M. F., Dasgupta, S., Qian, L., Volz, D. C., & Schlenk, D. (2021) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5002 · Cited by 14

Cholesterol Biosynthesis and Trafficking in Cortisol-Producing Lesions of the Adrenal Cortex

London, E., Wassif, C. A., Horvath, A., Tatsi, C., Angelousi, A. G., Karageorgiadis, A. S., Porter, F. D., & Stratakis, C. A. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2212 · Cited by 15

Recombinant 3-Hydroxy 3-Methyl Glutaryl-CoA Reductase from Candida glabrata (Rec-CgHMGR) Obtained by Heterologous Expression, as a Novel Therapeutic Target Model for Testing Synthetic Drugs

Andrade-Pavón, D., Cuevas‐Hernández, R. I., Trujillo-Ferrara, J. G., Hernández, G., Ibarra, J. A., & Villa‐Tanaca, L. (2017) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-017-2412-9 · Cited by 12

BAI1 acts as a tumor suppressor in lung cancer A549 cells by inducing metabolic reprogramming via the SCD1/HMGCR module

Liu, L., Chai, L., Ran, J., Yang, Y., & Zhang, L. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa036 · Cited by 15

Pinto Beans (Phaseolus vulgaris L.) Lower Non-HDL Cholesterol in Hamsters Fed a Diet Rich in Saturated Fat and Act on Genes Involved in Cholesterol Homeostasis

Nguyen, A. T., Althwab, S. A., Qiu, H., Zbasnik, R., Urrea, C. A., Carr, T. P., & Schlegel, V. L. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz044 · Cited by 13

Retinal cholesterol metabolism is perturbated in response to experimental glaucoma in the rat

Léger-Charnay, E., Gambert, S., Martine, L., Dubus, É., Maire, M., Buteau, B., Morala, T., Gigot, V., Bron, A. M., Brétillon, L., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264787 · Cited by 13

The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease

Akadam-Teker, B., Kurnaz, Ö., Coşkunpınar, E. M., Aday, A. D., Küçükhüseyin, Ö., Çakmak, H. A., Teker, E., Buğra, Z., Öztürk, O., & Yılmaz, H. (2013) · Gene · doi:10.1016/j.gene.2013.07.056 · Cited by 13

Heterologous Microarray Analysis of Transcriptome Alterations inMus spretusMice Living in an Industrial Settlement

Abril, N., Ruiz-Laguna, J., García-Sevillano, M. Á., Mata, A. M., Gómez‐Ariza, J. L., & Pueyo, C. (2014) · Environmental Science & Technology · doi:10.1021/es4053973 · Cited by 13

Emergence of W272C Substitution in Hmg1 in a Triazole-Resistant Isolate of Aspergillus fumigatus from a Chinese Patient with Chronic Cavitary Pulmonary Aspergillosis

Liang, T., Yang, X., Li, R., Yang, E., Wang, Q., Osherov, N., Chen, W., Wan, Z., & Liu, W. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00263-21 · Cited by 13

Secondary Metabolism for Isoprenoid-based Biofuels

Kang, A., & Lee, T. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-444-63475-7.00002-9 · Cited by 13

Is 24(S)-hydroxycholesterol a potent modulator of cholesterol metabolism in Müller cells? An in vitro study about neuron to glia communication in the retina

Léger-Charnay, E., Masson, E., Morala, T., Martine, L., Buteau, B., Leclère, L., Brétillon, L., & Gambert, S. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107857 · Cited by 12

The anti-lipidemic drug simvastatin modifies epigenetic biomarkers in the amphipod Gammarus locusta

Alves, N., Neuparth, T., Barros, S., & Santos, M. M. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111849 · Cited by 15

Investigating microRNAs to Explain the Link between Cholesterol Metabolism and NAFLD in Humans: A Systematic Review

Konings, M. C. J. M., Baumgartner, S., Mensink, R. P., & Plat, J. (2022) · Nutrients · doi:10.3390/nu14234946 · Cited by 12

Streptomyces albidoflavus Q antifungal metabolites inhibit the ergosterol biosynthesis pathway and yeast growth in fluconazole-resistant Candida glabrata : phylogenomic and metabolomic analyses

Bautista-Crescencio, C., Casimiro-Ramos, A., Fragoso-Vázquez, M. J., Correa‐Basurto, J., Olano, C., Hernández, G., & Villa‐Tanaca, L. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01271-23 · Cited by 27

Dietary Cholesterol Exacerbates Statin-Induced Hepatic Toxicity in Syrian Golden Hamsters and in Patients in an Observational Cohort Study

Yu, Q., Ma, X., Wang, Y., Shi, H., An, J., Wang, Y., Dong, Z., Lu, Y., Ge, J., Liu, C., et al. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07060-3 · Cited by 11

Extra‐virgin olive oil ameliorates high‐fat diet‐induced seminal and testicular disorders by modulating the cholesterol pathway

Funes, A. K., Avena, M. V., Ibáñez, J. E., Simón, L., Ituarte, L. M. E., Colombo, R., Roldán, A., Conte, M. I., Monclus, M. A., Boarelli, P. V., et al. (2023) · Andrology · doi:10.1111/andr.13398 · Cited by 11

PLAG1 expression and target genes in the hypothalamo-pituitary system in male mice

Juma, A. R., Hall, N. E., Wong, J., Gasperoni, J. G., Watanabe, Y., Sahota, A., Damdimopoulou, P., Grommen, S. V. H., & Groef, B. D. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.07.009 · Cited by 11

Cholesterol-lowering effect of Aralia elata (Miq.) Seem via the activation of SREBP-2 and the LDL receptor

Hwang, K., Hwang, Y.-J., & Song, J. (2017) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2017.06.007 · Cited by 11

Cyclodextrins Increase Triterpene Production in Solanum lycopersicum Cell Cultures by Activating Biosynthetic Genes

Sabater‐Jara, A. B., Marín-Marín, M. J., Almagro, L., & Pedreño, M. A. (2022) · Plants · doi:10.3390/plants11202782 · Cited by 10

Comparative Analysis of the Characteristics of Triterpenoid Transcriptome from Different Strains of Wolfiporia cocos

GuiPing, Z., Li, Z., & Zhao, Z. Q. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153703 · Cited by 9

Microbial metabolites inhibiting sterol biosynthesis: Their chemical diversity and characteristics of the mechanism of action

Trenin, A. S. (2013) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162013060095 · Cited by 10

Determination of 3-Hydroxy-3-methylglutaryl CoA Reductase Activity in Plants

Campos, N., Arró, M., Ferrer, A., & Boronat, A. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0606-2_3 · Cited by 10

High soluble endoglin levels regulate cholesterol homeostasis and bile acids turnover in the liver of transgenic mice

Doleželová, E., Igreja, I. C., Prašnická, A., Hroch, M., Hyšpler, R., Tichá, A., Laštůvková, H., Cermanová, J., Pericacho, M., Víšek, J., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116643 · Cited by 10

Loose Morphology and High Dynamism of OSER Structures Induced by the Membrane Domain of HMG-CoA Reductase

Grados-Torrez, R. E., López‐Iglesias, C., Ferrer, J. C., & Campos, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179132 · Cited by 10

Thoughts on Quorum Sensing and Fungal Dimorphism

Nickerson, K. W., Atkin, A. L., Hargarten, J. C., Pathirana, R. U., & Hasim, S. (2012) · Springer eBooks · doi:10.1007/978-94-007-4264-2_12 · Cited by 10

Kinetic characterization of an oxidative, cooperative HMG-CoA reductase from Burkholderia cenocepacia

Schwarz, B. H., Driver, J., Peacock, R. B., Dembinski, H. E., Corson, M. H., Gordon, S. S., & Watson, J. M. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.11.015 · Cited by 9

Spatial sterol metabolism unveiled by stimulated Raman imaging

Zhang, Y., Zhou, Y., Fang, W., Zhu, H., Ye, C., Zhang, D., & Lee, H. J. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2023.1166313 · Cited by 9

Differentially expressed microRNAs in Huh-7 cells expressing HCV core genotypes 3a or 1b: Potential functions and downstream pathways

Gu, Y., Xu, Y., Jiang, L., Cao, X., Liu, F., Li, H., Zhang, L., Li, Z., Li, J., Ye, J., et al. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.991 · Cited by 9

Electroconvulsive seizures induce autophagy by activating the AMPK signaling pathway in the rat frontal cortex

Kim, S. H., Yu, H. S., Park, S., Park, H. G., Ahn, Y. M., Kang, U. G., & Kim, Y. S. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz055 · Cited by 9

Current advances in the biotechnological synthesis of betulinic acid: new findings and practical applications

Wu, Y., Yuan, Z., & Rao, Y. (2022) · Systems Microbiology and Biomanufacturing · doi:10.1007/s43393-022-00111-w · Cited by 9

Metabolic Engineering Strategies to Convert Carbohydrates to Aviation Range Hydrocarbons

Bergman, A., & Siewers, V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804568-8.00007-x · Cited by 10

Genome-Wide Identification and Characterization of the HMGR Gene Family in Taraxacum kok-saghyz Provide Insights into Its Regulation in Response to Ethylene and Methyl Jsamonate Treatments

Du, P., He, H., Wang, J., Wang, L., Meng, Z., Jin, X., Zhang, L., Wang, F., Li, H., & Xie, Q. (2024) · Plants · doi:10.3390/plants13182646 · Cited by 9

Integrative Transcriptomic and Target Metabolite Analysis as a New Tool for Designing Metabolic Engineering in Yeast

Lopez-Barbera, A., Abasolo-Zabalo, N., Torrell-Galceran, H., Canela-Canela, N., & Fernández‐Arroyo, S. (2024) · Biomolecules · doi:10.3390/biom14121536 · Cited by 8

Hypolipidemic Activity of Tetracarpidium conophorum (African walnut) Seed Oil and Its Mechanism of Action

Oriakhi, K., & Uadia, P. O. (2020) · Planta Medica International Open · doi:10.1055/a-1323-0786 · Cited by 8

Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver

Thapa, K., Kadiri, J. J., Saukkonen, K., Pennanen, I., Ghimire, B. R., Cai, M., Savontaus, E., & Rinne, P. (2023) · eLife · doi:10.7554/elife.84782 · Cited by 9

Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development

Drepanos, L. M., Gans, I. M., Grendler, J., Guitar, S., Fuqua, J. H., Maki, N. J., Tilden, A. R., Graber, J. H., & Coffman, J. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-39453-3 · Cited by 9

Lipoprotein Metabolism and the Treatment of Lipid Disorders

Freeman, M. W., & Walford, G. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00041-x · Cited by 10

Simvastatin and other inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase of Ustilago maydis (Um-Hmgr) affect the viability of the fungus, its synthesis of sterols and mating

Rosales-Acosta, B., Mendieta‐Moctezuma, A., Zúñiga, C., Tamariz, J., Hernández, G., Ibarra, J. A., & Villa‐Tanaca, L. (2019) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2018.05.004 · Cited by 8

Deubiquitinase Ubp3 enhances the proteasomal degradation of key enzymes in sterol homeostasis

Lan, Q., Li, Y., Wang, F., Li, Z., Gao, Y., Hui, L., Wang, Y., Zhao, Z., Deng, Z., He, F., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100348 · Cited by 8

Epigenetic Consequences of in Utero Exposure to Rosuvastatin: Alteration of Histone Methylation Patterns in Newborn Rat Brains

Dulka, K., Szabó, M., Lajkó, N., Belecz, I., Hoyk, Z., & Gulya, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073412 · Cited by 8

Using zebrafish embryo bioassays to identify chemicals modulating the regulation of the epigenome: a case study with simvastatin

Torres, T., Barros, S., Neuparth, T., Ruivo, R., & Santos, M. M. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-23683-5 · Cited by 9

The Differential Expression of Mevalonate Pathway Genes in the Gut of the Bark Beetle Dendroctonus rhizophagus (Curculionidae: Scolytinae) Is Unrelated to the de Novo Synthesis of Terpenoid Pheromones

Sarabia, L. E., López, M. F., Obregón-Molina, G., Cano‐Ramírez, C., Martínez, G. S., & Zúñiga, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164011 · Cited by 8

In-Silico Analysis of Methoxyl Pectin Compounds from Banana Peels as HMG-CoA Reductase Inhibitor Complexes

Tapiory, A. A., Pertiwi, K. O., Fadilla, K., Reyhanditya, D., & Fatchiyah, F. (2020) · JSMARTech · doi:10.21776/ub.jsmartech.2020.001.02.5 · Cited by 8

Improved β-carotene biosynthesis and gene transcription in Blakeslea trispora with arachidonic acid

Hu, X., Sun, J., & Yuan, Q. (2012) · Biotechnology Letters · doi:10.1007/s10529-012-1015-3 · Cited by 8

Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates

Chen, J., Li, K.-X., Fan, C.-F., Yang, H., Zhang, Z.-R., Chen, Y., Chang, Q., Li, A.-H., Lin, A.-Q., Chen, X., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01539-1 · Cited by 7

Insig Regulates HMG‐CoA Reductase by a Non‐Degradative Mechanism in Fission Yeast

Burg, J. S., Bard, M., Powell, D. W., & Espenshade, P. J. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.5.a609-c

Insig Regulates HMG-CoA Reductase by Controlling Enzyme Phosphorylation in Fission Yeast

Burg, J. S., Powell, D. W., Chai, R. L., Hughes, A. L., Link, A. J., & Espenshade, P. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.004 · Cited by 53

Regulation and degradation of HMGCo-A reductase

Panda, T., & Devi, V. A. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1720-5 · Cited by 24

Glucose Controls Phosphoregulation of Hydroxymethylglutaryl Coenzyme A Reductase through the Protein Phosphatase 2A-related Phosphatase Protein, Ppe1, and Insig in Fission Yeast

Burg, J. S., & Espenshade, P. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.233452 · Cited by 9

The 3-hydroxy-3-methylglutaryl coenzyme-A reductases from fungi: A proposal as a therapeutic target and as a study model

Andrade-Pavón, D., Sanchez‐Sandoval, E., Rosales-Acosta, B., Ibarra, J. A., Tamariz, J., Hernández-Rodríguez, C., & Villa‐Tanaca, L. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2013.10.004 · Cited by 21