Roles of UVA radiation and DNA damage responses in melanoma pathogenesis
Open accessAbstract
The growing incidence of melanoma is a serious public health issue that merits a thorough understanding of potential causative risk factors, which includes exposure to ultraviolet radiation (UVR). Though UVR has been classified as a complete carcinogen and has long been recognized for its ability to damage genomic DNA through both direct and indirect means, the precise mechanisms by which the UVA and UVB components of UVR contribute to the pathogenesis of melanoma have not been clearly defined. In this review, we therefore highlight recent studies that have addressed roles for UVA radiation in the generation of DNA damage and in modulating the subsequent cellular responses to DNA damage in melanocytes, which are the cell type that gives rise to melanoma. Recent research suggests that UVA not only contributes to the direct formation of DNA lesions but also impairs the removal of UV photoproducts from genomic DNA through oxidation and damage to DNA repair proteins. Moreover, the melanocyte microenvironment within the epidermis of the skin is also expected to impact melanomagenesis, and we therefore discuss several paracrine signaling pathways that have been shown to impact the DNA damage response in UV‐irradiated melanocytes. Lastly, we examine how alterations to the immune microenvironment by UVA‐associated DNA damage responses may contribute to melanoma development. Thus, there appear to be multiple avenues by which UVA may elevate the risk of melanoma. Protective strategies against excess exposure to UVA wavelengths of light therefore have the potential to decrease the incidence of melanoma. Environ. Mol. Mutagen. 59:438–460, 2018. © 2018 Wiley Periodicals, Inc.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The findings are consistent with other studies that indicate that UV-A radiation may contribute to the development of melanoma.
“Nevertheless, the findings are consistent with the other studies that indicate that UV-A radiation may contribute to the development of melanoma [252], and highlight the need for sun protection that covers both UV-A and UV-B radiation.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
RETRACTED: PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage
Jarrett, S. G., Horrell, E. M. W., Christian, P. A., Vanover, J. C., Boulanger, M. C., Zou, Y., & D’Orazio, J. A. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.030 · Cited by 85 · see citing works
RetractedRetracted: AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair
Jarrett, S. G., Wolf Horrell, E. M., & D'Orazio, J. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw871 · Cited by 23 · see citing works
RetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · see citing works
Oxidative DNA damage: mechanisms, mutation, and disease
Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245 · see citing works
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,637 · see citing works
A landscape of driver mutations in melanoma
Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J.-P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.024 · Cited by 2,610 · see citing works
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224 · see citing works
A role for sunlight in skin-cancer – UV-induced p53 mutations in squamous-cell carcinoma
Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., McKenna, G. J., Baden, H. P., Halperin, A. J., & Pontén, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10124 · Cited by 1,959 · see citing works
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Blackford, A. N., & Jackson, S. P. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.015 · Cited by 1,953 · see citing works
ATR: an essential regulator of genome integrity
Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Chang, H. H. Y., Pannunzio, N. R., Adachi, N., & Lieber, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.48 · Cited by 1,757 · see citing works
Defective repair replication of DNA in xeroderma pigmentosum
CLEAVER, J. E. (1968) · Nature · doi:10.1038/218652a0 · Cited by 1,729 · see citing works
Skin cancers after organ transplantation
Euvrard, S., Kanitakis, J., & Claudy, A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022137 · Cited by 1,575 · see citing works
Wold, M. S. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.61 · Cited by 1,445 · see citing works
Understanding nucleotide excision repair and its roles in cancer and ageing
Marteijn, J. A., Lans, H., Vermeulen, W., & Hoeijmakers, J. H. J. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3822 · Cited by 1,192 · see citing works
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Krauthammer, M., Kong, Y., Ha, B. H., Evans, P., Bacchiocchi, A., McCusker, J. P., Cheng, E., Davis, M. J., Goh, G., Choi, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2359 · Cited by 1,191 · see citing works
ATM Activation by Oxidative Stress
Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079 · see citing works
Hosoda, K., Hammer, R. E., Richardson, J. A., Baynash, A. G., Cheung, J. C., Giaid, A., & Yanagisawa, M. (1994) · Cell · doi:10.1016/0092-8674(94)90017-5 · Cited by 1,004 · see citing works
Valverde, P., Healy, E., Jackson, I., Rees, J. L., & Thody, A. J. (1995) · Nature Genetics · doi:10.1038/ng1195-328 · Cited by 999 · see citing works
ATR and ATRIP: Partners in Checkpoint Signaling
Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works
Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J., Emoto, N., Hammer, R., & Yanagisawa, M. (1994) · Cell · doi:10.1016/0092-8674(94)90018-3 · Cited by 974 · see citing works
Ultraviolet radiation-mediated damage to cellular DNA
Cadet, J., Sage, E., & Douki, T. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.09.012 · Cited by 932 · see citing works
Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme.
Xanthoudakis, S., Miao, G. G., Wang, F., Pan, Y., & Curran, T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05411.x · Cited by 913 · see citing works
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
Toledo, L. I., Altmeyer, M., Rask, M.-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J., & Lukas, J. (2013) · Cell · doi:10.1016/j.cell.2013.10.043 · Cited by 911 · see citing works
The pathogenesis of melanoma induced by ultraviolet radiation
Gilchrest, B. A., Eller, M. S., Geller, A. C., & Yaar, M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401707 · Cited by 876 · see citing works
Nucleotide Excision Repair in EukaryotesPreprint
Schärer, O. D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012609 · Cited by 801 · see citing works
Reduced melanoma after regular sunscreen use: randomized trial follow-up
Green, A. C., Williams, G. M., Logan, V., & Strutton, G. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.7078 · Cited by 799 · see citing works
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794 · see citing works
Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes & Development · doi:10.1101/gad.1301205 · Cited by 767 · see citing works
McGill, G. G., Horstmann, M. A., Widlund, H. R., Du, J., Motyckova, G., Nishimura, E. K., Lin, Y., Ramaswamy, S., Avery, W., Ding, H., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00762-6 · Cited by 760 · see citing works
Melanoma genome sequencing reveals frequent PREX2 mutations
Berger, M. F., Hodis, E., Heffernan, T. P., Deribe, Y. L., Lawrence, M. S., Protopopov, A., Ivanova, E., Watson, I. R., Nickerson, E., Ghosh, P., et al. (2012) · Nature · doi:10.1038/nature11071 · Cited by 756 · see citing works
The control of DNA repair by the cell cycle
Hustedt, N., & Durocher, D. (2017) · Nature Cell Biology · doi:10.1038/ncb3452 · Cited by 738 · see citing works
Epidemiology of Melanoma and Nonmelanoma Skin Cancer—The Role of Sunlight
Leiter, U., & Garbe, C. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77574-6_8 · Cited by 720 · see citing works
Wavelengths effective in induction of malignant melanoma.
Setlow, R. B., Grist, E., Thompson, K. H., & Woodhead, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6666 · Cited by 718 · see citing works
Sources and measurement of ultraviolet radiation
Diffey, B. L. (2002) · Methods · doi:10.1016/s1046-2023(02)00204-9 · Cited by 704 · see citing works
Mouret, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604213103 · Cited by 684 · see citing works
Central role of p53 in the suntan response and pathologic hyperpigmentation
Cui, R., Widlund, H. R., Feige, E., Lin, J. Y., Wilensky, D. L., Igras, V. E., D'Orazio, J., Fung, C. Y., Schanbacher, C. F., Granter, S. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.045 · Cited by 657 · see citing works
Kraemer, K. H. (1994) · Archives of Dermatology · doi:10.1001/archderm.130.8.1018 · Cited by 571 · see citing works
Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma
Lens, M. B., & Dawes, M. G. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.05708.x · Cited by 570 · see citing works
A dynamic model for replication protein A (RPA) function in DNA processing pathways
Fanning, E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl550 · Cited by 565 · see citing works
Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure
Premi, S., Wallisch, S., Mano, C. M., Weiner, A. B., Bacchiocchi, A., Wakamatsu, K., Bechara, E. J. H., Halaban, R., Douki, T., & Brash, D. E. (2015) · Science · doi:10.1126/science.1256022 · Cited by 550 · cited 4× · see citing works
“However, UVA has also long been recognized for its indirect effects on DNA damage formation through the excitation of vari- ous cellular photosensitizers, such as flavin, melanin, riboflavin, and porphyrins [Wondrak et al., 2006; Premi et al., 2015].”
BackgroundInfluentialInitiating Cellular Stress Responses
Bakkenist, C. J., & Kastan, M. B. (2004) · Cell · doi:10.1016/j.cell.2004.06.023 · Cited by 544 · see citing works
Bastian, B. C., LeBoit, P. E., Hamm, H., Bröcker, E.-B., & Pinkel, D. (1998) · PubMed · Cited by 513 · see citing works
Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice.
Kripke, M. L., Cox, P. A., Alas, L., & Yarosh, D. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7516 · Cited by 507 · see citing works
Frederico, L. A., Kunkel, T. A., & Shaw, B. R. (1990) · Biochemistry · doi:10.1021/bi00462a015 · Cited by 498 · see citing works
Peyrin‐Biroulet, L., Khosrotehrani, K., Carrat, F., Bouvier, A., Chevaux, J., Simon, T., Carbonnel, F., Colombel, J., Dupas, J., Godeberge, P., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.050 · Cited by 489 · see citing works
UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
Pfeifer, G. P., & Besaratinia, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05144j · Cited by 473 · see citing works
Paull, T. T. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034335 · Cited by 458 · see citing works
Signalling by insulin and IGF receptors: supporting acts and new players
Siddle, K. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0022 · Cited by 456 · see citing works
Douki, T., Reynaud-Angelin, A., Cadet, J., & Sage, E. (2003) · Biochemistry · doi:10.1021/bi034593c · Cited by 452 · see citing works
PI 3-kinase related kinases: ?big? players in stress-induced signaling pathways
Abraham, R. T. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.002 · Cited by 445 · see citing works
Huang, J. C., Svoboda, D. L., Reardon, J. T., & Sancar, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3664 · Cited by 437 · see citing works
Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
Cleaver, J. E., Lam, E. T., & Revet, I. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2663 · Cited by 428 · cited 2× · see citing works
“The importance of NER to human disease [Cleaver et al., 2009; Marteijn et al., 2014], including UV-induced melanoma, can be observed in patients with the disease XP [Cleaver, 1968], who have a mutation in one of seven different “XP” genes that prevents NER and elevates melanoma and nonmelanoma skin cancer risk by seve…”
BackgroundATM functions at the peroxisome to induce pexophagy in response to ROS
Zhang, J., Tripathi, D. N., Ji, J., Alexander, A., Kim, J., Powell, R. T., Dere, R., Tait-Mulder, J., Lee, J., Paull, T. T., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3230 · Cited by 426 · see citing works
Melanocytes as Instigators and Victims of Oxidative Stress
Denat, L., Kadekaro, A. L., Marrot, L., Leachman, S., & Abdel-Malek, Z. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.65 · Cited by 414 · see citing works
Wondrak, G. T., Jacobson, M. K., & Jacobson, E. L. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b504573h · Cited by 411 · see citing works
Epidemiology of invasive cutaneous melanoma
MacKie, R. M., Hauschild, A., & Eggermont, A. M. M. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp252 · Cited by 405 · see citing works
Sunlight and skin cancer: another link revealed
Kraemer, K. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.11 · Cited by 403 · see citing works
<scp>UV</scp> Signature Mutations
Brash, D. E. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12377 · Cited by 401 · see citing works
FISHER, M. S., & Kripke, M. L. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.4.1688 · Cited by 400 · see citing works
Neonatal sunburn and melanoma in mice
Noonan, F. P., Recio, J. A., Takayama, H., Duray, P. H., Anver, M. R., Rush, W. L., Fabo, E. C. D., & Merlino, G. T. (2001) · Nature · doi:10.1038/35095108 · Cited by 390 · see citing works
Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes
Imokawa, G., Yada, Y., & Miyagishi, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35817-4 · Cited by 385 · see citing works
Dungrawala, H., Rose, K. L., Bhat, K. P., Mohni, K. N., Glick, G. G., Couch, F. B., & Cortez, D. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.030 · Cited by 376 · see citing works
Zou, Y., Liu, Y., Wu, X., & Shell, S. M. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20622 · Cited by 364 · see citing works
Mechanisms of Ultraviolet Light‐Induced Pigmentation
Gilchrest, B. A., Park, H., Eller, M. S., & Yaar, M. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb02988.x · Cited by 364 · see citing works
Marti, T. M., Hefner, E., Feeney, L., Natale, V., & Cleaver, J. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603779103 · Cited by 359 · see citing works
The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.
Xanthoudakis, S., Miao, G. G., & Curran, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.23 · Cited by 355 · see citing works
Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
D'Orazio, J. A., Nobuhisa, T., Cui, R., Arya, M., Spry, M., Wakamatsu, K., Igras, V., Kunisada, T., Granter, S. R., Nishimura, E. K., et al. (2006) · Nature · doi:10.1038/nature05098 · Cited by 350 · see citing works
Reardon, J. T., & Sancar, A. (2005) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(04)79004-2 · Cited by 350 · see citing works
Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment
Noonan, F. P., Zaidi, M. R., Wolnicka-Glubisz, A., Anver, M. R., Bahn, J., Wielgus, A., Cadet, J., Douki, T., Mouret, S., Tucker, M. A., et al. (2012) · Nature Communications · doi:10.1038/ncomms1893 · Cited by 331 · see citing works
Effects of Aging and Chronic Sun Exposure on Melanocytes in Human Skin
Gilchrest, B. A., Blog, F. B., & Szabo, G. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12581580 · Cited by 328 · see citing works
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
Davis, A. J., Chen, B. P. C., & Chen, D. J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.02.020 · Cited by 320 · see citing works
Circadian clock control of the cellular response to DNA damage
Sancar, A., Lindsey‐Boltz, L. A., Kang, T., Reardon, J. T., Lee, J. H., & Öztürk, N. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.03.017 · Cited by 317 · see citing works
ATR signalling: more than meeting at the fork
Nam, E. A., & Cortez, D. (2011) · Biochemical Journal · doi:10.1042/bj20102162 · Cited by 316 · see citing works
Freeman, S. E., Hacham, H., Gange, R. W., Maytum, D. J., Sutherland, J. C., & Sutherland, B. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5605 · Cited by 311 · see citing works
Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup>
Cadet, J., Mouret, S., Ravanat, J., & Douki, T. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01200.x · Cited by 300 · see citing works
Skin β-Endorphin Mediates Addiction to UV Light
Fell, G. L., Robinson, K. C., Mao, J., Woolf, C. J., & Fisher, D. E. (2014) · Cell · doi:10.1016/j.cell.2014.04.032 · Cited by 299 · see citing works
Broad-Spectrum Sunscreen Use and the Development of New Nevi in White Children
Gallagher, R. P., Rivers, J. K., Lee, T. K., Bajdik, C. D., McLean, D. I., & Coldman, A. J. (2000) · JAMA · doi:10.1001/jama.283.22.2955 · Cited by 294 · see citing works
Nucleotide excision repair is impaired by binding of transcription factors to DNA
Sabarinathan, R., Mularoni, L., Deu-Pons, J., González-Pérez, A., & López-Bigas, N. (2016) · Nature · doi:10.1038/nature17661 · Cited by 290 · see citing works
Jette, N., & Lees‐Miller, S. P. (2014) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2014.12.003 · Cited by 285 · see citing works
Ultraviolet B but not Ultraviolet A Radiation Initiates Melanoma
De Fabo, E. C., Noonan, F. P., Fears, T., & Merlino, G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1454 · Cited by 279 · see citing works
Melanocortin 1 Receptor: Structure, Function, and Regulation
Horrell, E. M. W., Boulanger, M. C., & D'Orazio, J. A. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00095 · Cited by 272 · see citing works
Effects of endothelins on signal transduction and proliferation in human melanocytes.
Yada, Y., Higuchi, K., & Imokawa, G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55277-7 · Cited by 270 · see citing works
Kadekaro, A. L., Kavanagh, R., Kanto, H., Terzieva, S., Hauser, J., Kobayashi, N., Schwemberger, S., Cornelius, J., Babcock, G., Shertzer, H. G., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4535 · Cited by 259 · see citing works
Mechanisms of Skin Tanning in Different Racial/Ethnic Groups in Response to Ultraviolet Radiation
Tadokoro, T., Yamaguchi, Y., Batzer, J., Coelho, S. G., Zmudzka, B. Z., Miller, S. A., Wolber, R., Beer, J. Z., & Hearing, V. J. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23760.x · Cited by 257 · see citing works
A role for ultraviolet A in solar mutagenesis.
Drobetsky, E. A., Turcotte, J., & Châteauneuf, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.2350 · Cited by 255 · see citing works
TERT Promoter Mutation Status as an Independent Prognostic Factor in Cutaneous Melanoma
Griewank, K., Murali, R., Puig‐Butillé, J. A., Schilling, B., Livingstone, E., Potrony, M., Carrera, C., Schimming, T. T., Möller, I., Schwamborn, M., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju246 · Cited by 254 · see citing works
Geyfman, M., Kumar, V., Liu, Q., Ruiz, R., Gordon, W., Espitia, F., Cam, E., Millar, S. E., Smyth, P., Ihler, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209592109 · Cited by 252 · see citing works
The core spliceosome as target and effector of non-canonical ATM signalling
Tresini, M., Warmerdam, D. O., Kolovos, P., Snijder, L., Vrouwe, M. G., Demmers, J. A. A., van IJcken, W. F. J., Grosveld, F. G., Medema, R. H., Hoeijmakers, J. H. J., et al. (2015) · Nature · doi:10.1038/nature14512 · Cited by 252 · see citing works
Kang, T.-H., Lindsey-Boltz, L. A., Reardon, J. T., & Sancar, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915085107 · Cited by 250 · see citing works
Distribution and Repair of Bipyrimidine Photoproducts in Solar UV-irradiated Mammalian Cells
Perdiz, D., Gróf, P., Mezzina, M., Nikaido, O., Moustacchi, E., & Sage, E. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61437-7 · Cited by 248 · see citing works
Coordination of DNA single strand break repair
Abbotts, R., & Wilson, D. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.039 · Cited by 240 · see citing works
Control of skin cancer by the circadian rhythm
Gaddameedhi, S., Selby, C. P., Kaufmann, W. K., Smart, R. C., & Sancar, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115249108 · Cited by 234 · see citing works
Fears, T. R., Scotto, J., & Schneiderman, M. A. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112400 · Cited by 228 · see citing works
Böhm, M., Wolff, I., Scholzen, T. E., Robinson, S. J., Healy, E., Luger, T. A., Schwarz, T., & Schwarz, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m406334200 · Cited by 228 · see citing works
Role of melanin as a scavenger of active oxygen species
BUSTAMANTE, J., BREDESTON, L., MALANGA, G., & MORDOH, J. (1993) · Pigment Cell Research · doi:10.1111/j.1600-0749.1993.tb00612.x · Cited by 222 · see citing works
Melanoma and use of sunscreens: An EORTC case‐control study in germany, belgium and france
Autier, P., Doré, J., Schifflers, E., Cesarini, J., Bollaerts, A., Kölmel, K. F., Gefeller, O., Liabeuf, A., Lejeune, F. J., Liénard, D., et al. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910610602 · Cited by 218 · see citing works
Hanasoge, S., & Ljungman, M. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm157 · Cited by 216 · see citing works
Use of Tanning Beds and Incidence of Skin Cancer
Zhang, M., Qureshi, A. A., Geller, A. C., Frazier, A. L., Hunter, D. J., & Han, J. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.3652 · Cited by 214 · see citing works
The Chemical Toxicology of 2-Deoxyribose Oxidation in DNA
Dedon, P. C. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700283c · Cited by 213 · see citing works
Circadian oscillation of nucleotide excision repair in mammalian brain
Kang, T., Reardon, J. T., Kemp, M. G., & Sancar, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812638106 · Cited by 205 · see citing works
Self-citationShort- and Long-Wave UV Light (UVB and UVA) Induce Similar Mutations in Human Skin Cells
Kappes, U. P., Luo, D., Potter, M., Schulmeister, K., & Rünger, T. M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700093 · Cited by 200 · see citing works
Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes
Perera, D. S., Poulos, R. C., Shah, A., Beck, D., Pimanda, J. E., & Wong, J. W. H. (2016) · Nature · doi:10.1038/nature17437 · Cited by 199 · see citing works
Takayama, H., LaRochelle, W. J., Anver, M. R., Bockman, D. E., & Merlino, G. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5866 · Cited by 195 · see citing works
Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein
Tang, J. Y., & Chu, G. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00052-6 · Cited by 195 · see citing works
The Genomic Landscape of Childhood and Adolescent Melanoma
Lu, C., Zhang, J., Nagahawatte, P., Easton, J. B., Lee, S., Liu, Z., Ding, L., Wyczalkowski, M. A., Valentine, M. L., Navid, F., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.425 · Cited by 187 · see citing works
García‐Borrón, J. C., Abdel‐Malek, Z., & Jiménez‐Cervantes, C. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12257 · Cited by 187 · see citing works
Epidermal Growth Factor and Insulin-Like Growth Factor I Enhance Keratinocyte Migration
Ando, Y., & Jensen, P. J. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12472297 · Cited by 186 · see citing works
Dynamic maps of UV damage formation and repair for the human genome
Hu, J., Adebalı, O., Adar, S., & Sancar, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706522114 · Cited by 181 · see citing works
Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling
Lin, K., Kumar, V., Geyfman, M., Chudova, D. I., Ihler, A., Smyth, P., Paus, R., Takahashi, J. S., & D, B. A. M. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000573 · Cited by 178 · see citing works
Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs
Zhou, X., Sun, X., Cooper, K. L., Wang, F., Liu, K. J., & Hudson, L. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.232926 · Cited by 177 · see citing works
Plikus, M. V., Spyk, E. N. V., Pham, K., Geyfman, M., Kumar, V., Takahashi, J. S., & D, B. A. M. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414563537 · Cited by 176 · see citing works
Preferential binding of ATR protein to UV-damaged DNA
Ünsal-Kaçmaz, K., Makhov, A. M., Griffith, J. D., & Sancar, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102167799 · Cited by 176 · see citing works
The genomic landscape of cutaneous melanoma
Zhang, T., Dutton‐Regester, K., Brown, K. M., & Hayward, N. K. (2016) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12459 · Cited by 173 · see citing works
Circadian Clock, Cancer, and Chemotherapy
Sancar, A., Lindsey-Boltz, L. A., Gaddameedhi, S., Selby, C. P., Ye, R., Chiou, Y.-Y., Kemp, M. G., Hu, J., Lee, J. H., & Ozturk, N. (2015) · Biochemistry · doi:10.1021/bi5007354 · Cited by 170 · see citing works
Self-citationUnravelling UVA-induced mutagenesis
Sage, E., Girard, P.-M., & Francesconi, S. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05219e · Cited by 167 · cited 2× · see citing works
“These so-called “UV signature” mutations were first observed in 1964 [Howard and Tess- man, 1964] in viral DNA and have since been observed in both naked DNA and DNA isolated from cultured cells and skin following UV exposure and in skin cancers [Brash et al., 1991; Sage et al., 2012; Brash, 2015].”
BackgroundLewis, D. A., Travers, J. B., Somani, A.-K., & Spandau, D. F. (2009) · Oncogene · doi:10.1038/onc.2009.440 · Cited by 166 · see citing works
Self-citationKelley, M. R., Georgiadis, M. M., & Fishel, M. L. (2011) · Current Molecular Pharmacology · doi:10.2174/1874467211205010036 · Cited by 165 · see citing works
Redox Regulation of Human OGG1 Activity in Response to Cellular Oxidative Stress
Bravard, A., Vacher, M., Gouget, B., Coutant, A., de Boisferon, F. H., Marsin, S., Chevillard, S., & Radicella, J. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00624-06 · Cited by 165 · see citing works
The ATM-dependent DNA Damage Signaling PathwayPreprint
Kitagawa, R., & Kastan, M. B. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.002 · Cited by 164 · see citing works
Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution
Mao, P., Smerdon, M. J., Roberts, S. A., & Wyrick, J. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606667113 · Cited by 164 · see citing works
Protein oxidation, UVA and human DNA repair
Karran, P., & Brem, R. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.024 · Cited by 163 · see citing works
α‐MSH activates immediate defense responses to UV‐induced oxidative stress in human melanocytes
Song, X., Mosby, N., Yang, J., Xu, A., Abdel‐Malek, Z., & Kadekaro, A. L. (2009) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2009.00615.x · Cited by 163 · see citing works
Boiteux, S., Coste, F., & Castaing, B. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.042 · Cited by 161 · see citing works
Barreca, A., Luca, M. D., Monte, P. D., Bondanza, S., Damonte, G., Cariola, G., Marco, E. D., Giordano, G., Cancedda, R., & Minuto, F. M. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041510207 · Cited by 157 · see citing works
Azathioprine treatment photosensitizes human skin to ultraviolet A radiation
Perrett, C. M., Walker, S. L., O’Donovan, P., Warwick, J., Harwood, C. A., Karran, P., & McGregor, J. M. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08610.x · Cited by 152 · see citing works
Ding, W. Q., Liu, W., Cooper, K. L., Qin, X.-J., Bergo, P. L. D. S., Hudson, L. G., & Liu, K. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805566200 · Cited by 148 · see citing works
Courdavault, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2004) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.07.011 · Cited by 145 · see citing works
Rodeck, U., Herlyn, M., Menssen, H. D., Furlanetto, R. W., & Koprowski, H. (1987) · International Journal of Cancer · doi:10.1002/ijc.2910400520 · Cited by 143 · see citing works
Kadekaro, A. L., Kanto, H., Kavanagh, R. J., & ABDEL‐MALEK, Z. A. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03200.x · Cited by 140 · see citing works
Base Excision Repair and its Role in Maintaining Genome Stability
Baute, J., & Depicker, A. (2008) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230802309905 · Cited by 139 · see citing works
Matsumoto, M., Yaginuma, K., Igarashi, A., Imura, M., Hasegawa, M., Iwabuchi, K., Date, T., Mori, T., Ishizaki, K., Yamashita, K., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.03391 · Cited by 138 · see citing works
Guy, G. P., Ekwueme, D. U., Tangka, F. K. L., & Richardson, L. C. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.07.031 · Cited by 137 · see citing works
Cultured Human Keratinocytes Synthesize and Secrete Endothelin-1
Yohn, J. J., Morelli, J. G., Walchak, S. J., Rundell, K., Norris, D. A., & Zamora, M. R. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12349932 · Cited by 136 · see citing works
The Melanocortin‐1 Receptor is a Key Regulator of Human Cutaneous Pigmentation
ABDEL‐MALEK, Z. A., Scott, M., Suzuki, I., Tada, A., Im, S., Lamoreux, L., Ito, S., Barsh, G. S., & Hearing, V. J. (2000) · Pigment Cell Research · doi:10.1034/j.1600-0749.13.s8.28.x · Cited by 136 · see citing works
Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA
Brem, R., Guven, M., & Karran, P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.488 · Cited by 136 · see citing works
Kunisada, M., Sakumi, K., Tominaga, Y., Budiyanto, A., Ueda, M., Ichihashi, M., Nakabeppu, Y., & Nishigori, C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0724 · Cited by 135 · see citing works
Melanoma in Immunosuppressed Patients
Kubica, A. W., & Brewer, J. D. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.04.018 · Cited by 134 · see citing works
de Laat, A. (1997) · Carcinogenesis · doi:10.1093/carcin/18.5.1013 · Cited by 133 · see citing works
Kadekaro, A. L., Leachman, S., Kavanagh, R. J., Swope, V., Cassidy, P., Supp, D., Sartor, M., Schwemberger, S., Babcock, G., Wakamatsu, K., et al. (2010) · The FASEB Journal · doi:10.1096/fj.10-158485 · Cited by 130 · see citing works
Solar UV Radiation-Induced DNA Bipyrimidine Photoproducts: Formation and Mechanistic Insights
Cadet, J., Grand, A., & Douki, T. (2014) · Topics in current chemistry · doi:10.1007/128_2014_553 · Cited by 130 · see citing works
Robinson, S. N., Zens, M. S., Perry, A. E., Spencer, S. K., Duell, E. J., & Karagas, M. R. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.33 · Cited by 130 · see citing works
Peng, W., & Shaw, B. R. (1996) · Biochemistry · doi:10.1021/bi960001x · Cited by 128 · see citing works
Hauser, J. E., Kadekaro, A. L., Kavanagh, R. J., Wakamatsu, K., Terzieva, S., Schwemberger, S., Babcock, G., Rao, M. B., Ito, S., & Abdel‐Malek, Z. A. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00315.x · Cited by 128 · see citing works
Kang, T.-H., Reardon, J. T., & Sancar, A. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1318 · Cited by 124 · see citing works
Sun exposure and skin cancer, and the puzzle of cutaneous melanoma
Armstrong, B. K., & Cust, A. E. (2017) · Cancer Epidemiology · doi:10.1016/j.canep.2017.04.004 · Cited by 123 · see citing works
Kadekaro, A. L., Chen, J., Yang, J., Chen, S., Jameson, J., Swope, V. B., Cheng, T., Kadakia, M., & Abdel-Malek, Z. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0436 · Cited by 122 · see citing works
Giannattasio, M., Follonier, C., Tourrière, H., Puddu, F., Lazzaro, F., Pasero, P., Lopes, M., Plevani, P., & Muzi-Falconi, M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.004 · Cited by 121 · see citing works
UV stalled replication forks restart by re-priming in human fibroblasts
Elvers, I., Johansson, F., Groth, P., Erixon, K., & Helleday, T. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr420 · Cited by 120 · see citing works
Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts
Wang, H.-T., Choi, B., & Tang, M.-S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005244107 · Cited by 119 · see citing works
Kvam, E., & Tyrrell, R. M. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00653.x · Cited by 118 · see citing works
Young, A. R., Potten, C. S., Nikaido, O., Parsons, P. G., Boenders, J., Ramsden, J. M., & Chadwick, C. A. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00435.x · Cited by 117 · see citing works
An action spectrum for ultraviolet radiation-induced immunosuppression in humans
Damian, D. L., Matthews, Y. J., Phan, T. A., & Halliday, G. M. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10161.x · Cited by 115 · see citing works
Lewis, D. A., Yi, Q., Travers, J. B., & Spandau, D. F. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1041 · Cited by 115 · see citing works
Self-citationRPA and ATR link transcriptional stress to p53
Derheimer, F. A., O’Hagan, H. M., Krueger, H., Hanasoge, S., Paulsen, M. T., & Ljungman, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705317104 · Cited by 114 · see citing works
DNA nucleotide excision repair-dependent signaling to checkpoint activation
Marini, F., Nardo, T., Giannattasio, M., Minuzzo, M., Stefanini, M., Plevani, P., & Falconi, M. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605446103 · Cited by 114 · see citing works
The Intra-S Checkpoint Responses to DNA Damage
Iyer, D., & Rhind, N. (2017) · Genes · doi:10.3390/genes8020074 · Cited by 113 · see citing works
Melanoma in Solid Organ Transplant Recipients
Zwald, F. O., Christensonb, L. J., Billingsley, E. M., Zeitouni, N. C., Ratner, D., Bordeaux, J. S., Patel, M. J., Brown, M. D., Proby, C. M., Euvrard, S., et al. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03078.x · Cited by 110 · see citing works
The Melanocyte and the Epidermal Melanin Unit: An Expanded Concept
Nordlund, J. J. (2007) · Dermatologic Clinics · doi:10.1016/j.det.2007.04.001 · Cited by 109 · see citing works
Enninga, I. C., Groenendijk, R. T. L., Filon, A. R., van Zeeland, A. A., & Simons, J. W. I. M. (1986) · Carcinogenesis · doi:10.1093/carcin/7.11.1829 · Cited by 109 · see citing works
DNA base excision repair: a mechanism of trinucleotide repeat expansion
Liu, Y., & Wilson, S. H. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.12.002 · Cited by 108 · see citing works
Human skin keratinocytes, melanocytes, and fibroblasts contain distinct circadian clock machineries
Sandu, C., Dumas, M., Malan, A., Sambakhe, D., Marteau, C., Nizard, C., Schnebert, S., Perrier, É., Challet, É., Pévet, P., et al. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1026-1 · Cited by 107 · see citing works
Nucleotide Excision Repair in Human Cells
Hu, J., Choi, J.-H., Gaddameedhi, S., Kemp, M. G., Reardon, J. T., & Sancar, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482257 · Cited by 104 · see citing works
Self-citationTime-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage
Wang, H., Spyk, E. N. V., Liu, Q., Geyfman, M., Salmans, M., Kumar, V., Ihler, A., Li, N., Takahashi, J. S., & D, B. A. M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.022 · Cited by 104 · see citing works
国定, 充. (2006) · Medical Entomology and Zoology · Cited by 103 · see citing works
Biological Rhythms in the Skin
Matsui, M. S., Pelle, E., Dong, K. K., & Pernodet, N. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060801 · Cited by 102 · see citing works
Damian, D. L., Barnetson, R. S., & Halliday, G. M. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00610.x · Cited by 101 · see citing works
APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress
Willis, J., Patel, Y., Lentz, B. L., & Yan, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301445110 · Cited by 100 · see citing works
Vrouwe, M. G., Pines, A., Overmeer, R. M., Hanada, K., & Mullenders, L. H. F. (2011) · Journal of Cell Science · doi:10.1242/jcs.075325 · Cited by 100 · see citing works
Maglio, D. H. G., Paz, M. L., & Leoni, J. (2016) · BioMed Research International · doi:10.1155/2016/1934518 · Cited by 100 · see citing works
Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair
Kemp, M. G., Reardon, J. T., Lindsey‐Boltz, L. A., & Sancar, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374447 · Cited by 99 · see citing works
Self-citationRegulation of damage recognition in mammalian global genomic nucleotide excision repair
Sugasawa, K. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.08.004 · Cited by 99 · see citing works
Miyauchi‐Hashimoto, H., Tanaka, K., & Horio, T. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12363295 · Cited by 97 · see citing works
The Peripheral Clock Regulates Human Pigmentation
Hardman, J. A., Tobin, D. J., Haslam, I. S., Farjo, N. P., Farjo, B., Al‐Nuaimi, Y., Grimaldi, B., & Paus, R. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.442 · Cited by 96 · see citing works
Tu, Y., Dammann, R., & Pfeifer, G. P. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2176 · Cited by 95 · see citing works
Swope, V. B., Jameson, J., McFarland, K. L., Supp, D. M., Miller, W. E., McGraw, D. W., Patel, M. A., Nix, M. A., Millhauser, G. L., Babcock, G. F., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.135 · Cited by 94 · see citing works
The specificity of UVA-induced DNA damage in human melanocytes
Mouret, S., Forestier, A., & Douki, T. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05185g · Cited by 94 · see citing works
UVA photosensitization of thiopurines and skin cancer in organ transplant recipients
Attard, N. R., & Karran, P. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05194f · Cited by 94 · see citing works
Mitogen- and Ultraviolet-B-Induced Signaling Pathways in Normal Human Melanocytes
Tada, A., Pereira, E., Beitner‐Johnson, D., Kavanagh, R. J., & ABDEL‐MALEK, Z. A. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01694.x · Cited by 93 · see citing works
Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis.
Recio, J. A., Noonan, F. P., Takayama, H., Anver, M. R., Duray, P. H., Rush, W. L., Lindner, G., Fabo, E. C. D., DePinho, R. A., & Merlino, G. T. (2002) · PubMed · Cited by 91 · see citing works
Auclair, Y., Rouget, R., Affar, E. B., & Drobetsky, E. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801585105 · Cited by 91 · see citing works
Reactive oxygen‐mediated damage to a human DNA replication and repair protein
Montaner, B., O'Donovan, P., Reelfs, O., Perrett, C. M., Zhang, X., Xu, Y., Ren, X., Macpherson, P., Frith, D., & Karran, P. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401084 · Cited by 88 · see citing works
Noonan, F. P., Dudek, J., Merlino, G. T., & Fabo, E. C. D. (2003) · Pigment Cell Research · doi:10.1034/j.1600-0749.2003.00014.x · Cited by 87 · see citing works
ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage
Göhler, T., Sabbioneda, S., Green, C., & Lehmann, A. R. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008076 · Cited by 87 · see citing works
Shell, S. M., Li, Z., Shkriabai, N., Kvaratskhelia, M., Brosey, C., Serrano, M. A., Chazin, W. J., Musich, P. R., & Zou, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000745 · Cited by 86 · see citing works
Identification of the altered bases in mutated single-stranded DNA
Howard, B. D., & Tessman, I. (1964) · Journal of Molecular Biology · doi:10.1016/s0022-2836(64)80214-x · Cited by 85 · see citing works
Smith, P. J., & Paterson, M. C. (1982) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1982.tb04383.x · Cited by 83 · see citing works
Abdel‐Malek, Z. A., Ruwe, A., Kavanagh‐Starner, R., Kadekaro, A. L., Swope, V., Haskell‐Luevano, C., Koikov, L., & Knittel, J. J. (2009) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2009.00598.x · Cited by 83 · see citing works
Kamath‐Loeb, A. S., Hizi, A., Kasai, H., & Loeb, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5892 · Cited by 83 · see citing works
Reduced dimer excision in bacteria following near ultraviolet (365 nm) radiation
Tyrrell, R. M., & Webb, R. B. (1973) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(73)90238-8 · Cited by 82 · see citing works
High resolution mapping of modified DNA nucleobases using excision repair enzymesPreprint
Bryan, D. S., Ransom, M., Adane, B., York, K. T., & Hesselberth, J. R. (2014) · Genome Research · doi:10.1101/gr.174052.114 · Cited by 82 · see citing works
Cdc45 is limiting for replication initiation in humans
Köhler, C., Koalick, D., Fabricius, A., Parplys, A. C., Borgmann, K., Pospiech, H., & Große, F. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1152424 · Cited by 82 · see citing works
Mechanisms Underlying the Suppression of Established Immune Responses by Ultraviolet Radiation
Nghiem, D. X., Kazimi, N., Mitchell, D. L., Vink, A. A., Ananthaswamy, H. N., Kripke, M. L., & Ullrich, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01845.x · Cited by 81 · see citing works
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin
Gaddameedhi, S., Selby, C. P., Kemp, M. G., Ye, R., & Sancar, A. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.508 · Cited by 80 · see citing works
Self-citationSystematic review of melanoma incidence and prognosis in solid organ transplant recipients
Dahlke, E. J., Murray, C., Kitchen, J., & Chan, A. (2014) · Transplantation Research · doi:10.1186/2047-1440-3-10 · Cited by 80 · see citing works
Redox regulation of AP-1: a link between transcription factor signaling and DNA repair.
Xanthoudakis, S., & Curran, T. (1996) · PubMed · Cited by 80 · see citing works
Flagged first, then by citations
3 of the 321 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Brash DE 2015 UV signature mutations Photochem Photobiol 91 15 26 25354245 PMC4294947
- Garcia-Borron JC Abdel-Malek Z Jimenez-Cervantes C 2014 MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation Pigment Cell Melanoma Res 27 699 720 24807163 PMC4150834
Cited by
Sorted by citations
Targeting the ERK Signaling Pathway in Melanoma
Savoia, P., Fava, P., Casoni, F., & Cremona, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061483 · Cited by 188 · see citing works
Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances
Strashilov, S. A., & Yordanov, A. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126395 · Cited by 169 · see citing works
Kim, D. J., Iwasaki, A., Chien, A. L.-L., & Kang, S. (2022) · JCI Insight · doi:10.1172/jci.insight.156344 · Cited by 166 · see citing works
Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development
Yu, W., Tu, Y., Long, Z., Liu, J., Kong, D., Peng, J., Wu, H., Zheng, G., Zhao, J., Chen, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2606928 · Cited by 161 · see citing works
Photoelectrochemical biosensing platforms for tumor marker detection
Shi, J., Chen, Z., Zhao, C.-Q., Shen, M., Li, H., Zhang, S., & Zhang, Z. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214675 · Cited by 139 · see citing works
Lee, J. H., Kim, H., Hwang, J., Chung, J., Jang, T., Seo, D. G., Gao, Y., Lee, J., Park, H., Lee, S., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c03110 · Cited by 124 · see citing works
Koklesová, L., Líšková, A., Samec, M., Qaradakhi, T., Zulli, A., Šmejkal, K., Kajo, K., Jakubı́ková, J., Behzadi, P., Péč, M. J., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00210-5 · Cited by 94 · see citing works
UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
Vechtomova, Y. L., Telegina, T. A., Buglak, A. A., & Kritsky, M. (2021) · Biomedicines · doi:10.3390/biomedicines9111564 · Cited by 92 · see citing works
DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy
de Almeida, L. C., Calil, F. A., Machado‐Neto, J. A., & Costa-Lotufo, L. V. (2020) · Cancer Genetics · doi:10.1016/j.cancergen.2020.12.002 · Cited by 86 · see citing works
Sexton, R. E., Mpilla, G., Kim, S. H., Philip, P. A., & Azmi, A. S. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.02.004 · Cited by 70 · see citing works
Relevance of Vitamin D in Melanoma Development, Progression and Therapy
Brożyna, A. A., Hoffman, R. M., & Slominski, A. T. (2019) · Anticancer Research · doi:10.21873/anticanres.13976 · Cited by 61 · see citing works
Ultraviolet A light effectively reduces bacteria and viruses including coronavirus
Rezaie, A. R., Leite, G. G. S., MELMED, G. Y., Mathur, R., Villanueva-Millán, M. J., Parodi, G., Sin, J., Germano, J. D. F., Morales, W., Weitsman, S. R., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236199 · Cited by 59 · see citing works
Spectral transmission of solar radiation by plastic and glass materials
Serrano, M., & Moreno‐Piraján, J. C. (2020) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2020.111894 · Cited by 55 · see citing works
Rager, T., Eckburg, A., Patel, M., Qiu, R., Gantiwala, S., Dovalovsky, K., Fan, K. D., Lam, K., Roesler, C., Rastogi, A., et al. (2022) · Cancers · doi:10.3390/cancers14153779 · Cited by 52 · see citing works
Slip versus Slop: A Head-to-Head Comparison of UV-Protective Clothing to Sunscreen
Berry, E., Bezecny, J. A., Acton, M., Sulmonetti, T. P., Anderson, D. M., Beckham, H. W., Durr, R. A., Chiba, T., Beem, J., Brash, D. E., et al. (2022) · Cancers · doi:10.3390/cancers14030542 · Cited by 49 · see citing works
Sarkar, S., & Gaddameedhi, S. (2020) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22370 · Cited by 46 · see citing works
DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer
Zhivagui, M., Hoda, A., Valenzuela, N., Yeh, Y.-Y., Dai, J., He, Y., Nandi, S. P., Otlu, B., Houten, B. V., & Alexandrov, L. B. (2023) · Nature Communications · doi:10.1038/s41467-023-35876-8 · Cited by 45 · see citing works
A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer
Dachani, S. R., Kaleem, M., Mujtaba, M. A., Mahajan, N. M., Ali, S. A., Almutairy, A. F., Mahmood, D., Anwer, M. K., Ali, M. D., & Kumar, S. (2024) · ACS Omega · doi:10.1021/acsomega.3c09780 · Cited by 44 · see citing works
Esposito, C. L., & Kirilov, P. (2021) · Gels · doi:10.3390/gels7030097 · Cited by 41 · see citing works
Mendoza, D. J., Maliha, M., Raghuwanshi, V. S., Browne, C., Mouterde, L. M. M., Simon, G. P., Allais, F., & Garnier, G. (2021) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100126 · Cited by 37 · see citing works
Ultraviolet A radiation exposure and melanoma: a review
Fadadu, R. P., & Wei, M. L. (2022) · Melanoma Research · doi:10.1097/cmr.0000000000000857 · Cited by 39 · see citing works
Ultraviolet radiation and cutaneous melanoma: a historical perspective
Autier, P., & Doré, J. (2020) · Melanoma research · doi:10.1097/cmr.0000000000000609 · Cited by 33 · see citing works
Kumar, P. V. A., Dakup, P., Sarkar, S., Modasia, J. B., Motzner, M. S., & Gaddameedhi, S. (2019) · PubMed Central · Cited by 33 · see citing works
Advances in targeted therapy and immunotherapy for melanoma (Review)
Qin, Z., & Zheng, M. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12115 · Cited by 35 · see citing works
Douki, T. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13278 · Cited by 32 · see citing works
The physiological effect of polystyrene nanoplastic particles on fish and human fibroblasts
Peng, M., Félix, R. C., Canário, A. V. M., & Power, D. M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.169979 · Cited by 30 · see citing works
Red light stimulates vasodilation through extracellular vesicle trafficking
Weihrauch, D., Keszler, Á., Lindemer, B. J., Krolikowski, J. G., & Lohr, N. L. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112212 · Cited by 29 · see citing works
Neale, P. J., Hylander, S., Banaszak, A. T., Häder, D.-P., Rose, K. C., Vione, D., Wängberg, S.-Å., Jansen, M. A. K., Busquets, R., Andersen, M. P. S., et al. (2025) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-025-00687-x · Cited by 32 · see citing works
“Nevertheless, the findings are consistent with the other studies that indicate that UV-A radiation may contribute to the development of melanoma [252], and highlight the need for sun protection that covers both UV-A and UV-B radiation.”
The influence of various endocrine disruptors on the reproductive system
Czarnywojtek, A., Borowska, M., Dyrka, K., Moskal, J., Kościński, J., Krela‐Kaźmierczak, I., Lewandowska, A. M., Hjeily, B. A., Gut, P., Hoffmann, K., et al. (2023) · Endokrynologia Polska · doi:10.5603/ep.a2023.0034 · Cited by 30 · see citing works
Mechanisms of ultraviolet‐induced melasma formation: A review
Yang, J., Zeng, J., & Lu, J. (2022) · The Journal of Dermatology · doi:10.1111/1346-8138.16542 · Cited by 28 · see citing works
New trends on personalized sunscreens
Gracia‐Cazaña, T., Aguilera, J. M., Navarro‐Bielsa, A., González, S., Lim, H. W., & Gilaberte, Y. (2024) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12967 · Cited by 29 · see citing works
Ma, Y., Li, C., Su, W.-P., Sun, Z., Gao, S., Xie, W. D., Zhang, B., & Sui, L. (2025) · Antioxidants · doi:10.3390/antiox14050577 · Cited by 27 · see citing works
Parisi, A. V., Igoe, D. P., Downs, N. J., Turner, J. F., Amar, A., & Jebar, M. A. A. (2021) · Remote Sensing · doi:10.3390/rs13040752 · Cited by 27 · see citing works
Oxidative-Stress-Sensitive microRNAs in UV-Promoted Development of Melanoma
Pecorelli, A., & Valacchi, G. (2022) · Cancers · doi:10.3390/cancers14133224 · Cited by 26 · see citing works
Chimeric antigen receptor T-cell therapy for melanoma
Razavi, A., Keshavarz-Fathi, M., Pawelek, J., & Rezaei, N. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1880895 · Cited by 25 · see citing works
Melanoma–role of the environment and genetics
Cust, A. E., Mishra, K., & Berwick, M. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00411g · Cited by 25 · see citing works
Bellei, B., Migliano, E., & Picardo, M. (2020) · Cancers · doi:10.3390/cancers12113400 · Cited by 24 · see citing works
Circadian Rhythm of NER and ATR Pathways
Kang, T. (2021) · Biomolecules · doi:10.3390/biom11050715 · Cited by 24 · see citing works
do Prado, A. H., Araújo, V. H. S., Eloy, J. O., Fonseca‐Santos, B., Pereira-da-Silva, M. A., Peccinini, R. G., & Chorilli, M. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-019-1547-0 · Cited by 24 · see citing works
Etiologies of Melanoma Development and Prevention Measures: A Review of the Current Evidence
Djavid, A. R., Stonesifer, C. J., Fullerton, B. T., Wang, S. W., Tartaro, M. A., Kwinta, B. D., Grimes, J. M., Geskin, L. J., & Saenger, Y. M. (2021) · Cancers · doi:10.3390/cancers13194914 · Cited by 24 · see citing works
Skin Photodamage and Melanomagenesis: A Comprehensive Review
Manganelli, M., Stabile, G., Scharf, C., Brunetti, A. P., Paolino, G., Giuffrida, R., Bigotto, G. D., Damiano, G., Mercuri, S. R., Sallustio, F., et al. (2025) · Cancers · doi:10.3390/cancers17111784 · Cited by 23 · see citing works
UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma
Bowman, R. L., Hennessey, R. C., Tallman, D., Weiss, T. J., Crawford, E. R., Murphy, B., Webb, A., Zhang, S., Perle, K. M. D. L., Burd, C. J., et al. (2021) · Life Science Alliance · doi:10.26508/lsa.202101135 · Cited by 24 · see citing works
Yaagoubi, O. M. E., Oularbi, L., Bouyahya, A., Samaki, H., Antri, S. E., & Aboudkhil, S. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1978785 · Cited by 22 · see citing works
Łuczaj, W., Dobrzyńska, I., & Skrzydlewska, E. (2023) · Scientific Reports · doi:10.1038/s41598-023-43363-9 · Cited by 22 · see citing works
Circular Rnas: New Genetic Tools in Melanoma
Hallajzadeh, J., Amirani, E., Mirzaei, H., Shafabakhsh, R., Mirhashemi, S. M., Sharifi, M., Yousefi, B., Mansournia, M. A., & Asemi, Z. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2019-0567 · Cited by 22 · see citing works
Gene expression and immune infiltration in melanoma patients with different mutation burden
Wang, L., Fu, C. S., Liu, R., Shi, L., Zhao, G., & Yan, Z. (2021) · BMC Cancer · doi:10.1186/s12885-021-08083-1 · Cited by 22 · see citing works
Goyer, B., Pereira, U., Magne, B., Larouche, D., Kearns‐Turcotte, S., Rochette, P. J., Martin, L., & Germain, L. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2959 · Cited by 23 · see citing works
Thy, L. T. M., Thanh, L. N. P., Đạt, N. T., & Dat, N. M. (2025) · Results in Surfaces and Interfaces · doi:10.1016/j.rsurfi.2025.100580 · Cited by 19 · see citing works
Lapides, R. A., Saravi, B., Mueller, A., Evers, M., Maul, L. V., Németh, I. B., Navarini, A. A., Manstein, D., & Roider, E. (2023) · Cancers · doi:10.3390/cancers15245868 · Cited by 19 · see citing works
Sun, Y., Hsu, C., Ling, T., Liu, L., Lin, T.-C., Jakfar, S., Young, I.-C., & Lin, F. (2020) · Biofabrication · doi:10.1088/1758-5090/ab78ee · Cited by 19 · see citing works
Shen, Y., Ha, W., Zeng, W., Queen, D., & Liu, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-61807-4 · Cited by 19 · see citing works
Lohan, S. B., Ivanov, D., Schüler, N., Berger, B., Zastrow, L., Lademann, J. M., & Meinke, M. C. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.319 · Cited by 19 · see citing works
Monolithically integrated neuromorphic electronic skin for biomimetic radiation shielding
Lee, J. M., Cho, S. W., Jo, C., Yang, S. H., Kim, J., Kim, D.-Y., Jo, J., Park, J. S., Kim, Y., & Park, S. K. (2024) · Science Advances · doi:10.1126/sciadv.adp9885 · Cited by 16 · see citing works
Strategies to make human skin models based on cellular senescence for ageing research
Shakel, Z., Lima, S. A. C., & Reis, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102430 · Cited by 16 · see citing works
Promotion of Melanoma Cell Proliferation by Cyclic Straining through Regulatory Morphogenesis
Huang, S., Chen, Z., Hou, X., Han, K., Xu, B., Zhang, M., Ding, S., Wang, Y.-T., & Yang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911884 · Cited by 14 · see citing works
Role of antioxidants in neutralizing oxidative stress
Bajaj, S., Singh, S., & Sharma, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18951-7.00020-7 · Cited by 14 · see citing works
Shen, Y., Chan, G., Xie, M. H., Zeng, W., & Liu, L. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy168 · Cited by 12 · see citing works
Yao, W., Qi, Y., Cao, L., Ren, L., Jiang, L., Kong, X., & Gao, W. (2024) · Applied Energy · doi:10.1016/j.apenergy.2023.122581 · Cited by 13 · see citing works
Turn the light on photosensitivity
Kurz, B., Ivanova, I., Bäumler, W., & Berneburg, M. (2021) · Journal of Photochemistry and Photobiology · doi:10.1016/j.jpap.2021.100071 · Cited by 13 · see citing works
Robinson, J. K., Durst, D. A., Gray, E., Kwasny, M., Heo, S. Y., Banks, A. R., & Rogers, J. A. (2020) · Archives of Dermatological Research · doi:10.1007/s00403-020-02163-1 · Cited by 13 · see citing works
Damage Induced to DNA and Its Constituents by 0–3 eV UV Photoelectrons†
Liu, C., Zheng, Y., & Sanche, L. (2021) · Photochemistry and Photobiology · doi:10.1111/php.13559 · Cited by 13 · see citing works
DNA damage modulates sleep drive in basal cnidarians with divergent chronotypes
Aguillon, R., Harduf, A., Sagi, D., Simon‐Blecher, N., Levy, O., & Appelbaum, L. (2026) · Nature Communications · doi:10.1038/s41467-025-67400-5 · Cited by 12 · see citing works
Du, J., Du, Y., Chen, L., & Liu, H. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119547 · Cited by 12 · see citing works
Li, H., Cao, X., Chen, X., Yi, X., Xia, J., Chen, J., & Yang, L. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10452 · Cited by 12 · see citing works
The Impact of Sunlight on Skin Aging
Kaddurah, H., Braunberger, T. L., Vellaichamy, G., Nahhas, A. F., Lim, H. W., & Hamzavi, I. H. (2018) · Current Geriatrics Reports · doi:10.1007/s13670-018-0262-0 · Cited by 11 · see citing works
Zhao, Z., Feng, X., Wu, H., Chen, S., Ma, C., Guan, Z., Lei, L., Tang, K., Chen, X., Dong, Y. Q., et al. (2024) · Translational Lung Cancer Research · doi:10.21037/tlcr-24-490 · Cited by 11 · see citing works
Impressive merits of Nanocellulose driving sustainable beauty
Wang, X., Zhong, C., Zhong, Y., Fan, Z., Liu, Z., Xu, P., Deng, X., Guo, J., Sawant, T. R., Zhou, M., et al. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123270 · Cited by 11 · see citing works
Allahyari, E., Carraturo, F., Risi, A. D., Nappo, A., Morelli, M., Cajora, A., & Guida, M. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119224 · Cited by 11 · see citing works
Yao, W., Kong, X., Xu, J., Jiang, L., Tian, W., & Gao, W. (2023) · Journal of Building Engineering · doi:10.1016/j.jobe.2023.107291 · Cited by 10 · see citing works
Quantum Sensing Unravels Antioxidant Efficacy Within PCL/Matrigel Skin Equivalents
Wu, X., Koch, M., Martinez, F. P. P., Schirhagl, R., & Włodarczyk‐Biegun, M. K. (2024) · Small · doi:10.1002/smll.202403729 · Cited by 10 · see citing works
DNA modifications: Biomarkers for the exposome?
Möller, C., Virzi, J., Chang, Y.-J., Keidel, A., Chao, M., Hu, C., & Cooke, M. S. (2024) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2024.104449 · Cited by 9 · see citing works
Fiore, P. D., Russo, I., Monico, A. D., Tartaglia, J., Ferrazzi, B., Mazza, M., Cavallin, F., Tropea, S., Buja, A., Cappellesso, R., et al. (2022) · Life · doi:10.3390/life12050745 · Cited by 9 · see citing works
Influence of cosmetic formulations on the skin's circadian clock
Hettwer, S., Gyenge, E. B., & Obermayer, B. (2020) · International Journal of Cosmetic Science · doi:10.1111/ics.12623 · Cited by 8 · see citing works
In Vitro Antiproliferative Effect of Cannabis Extract PHEC-66 on Melanoma Cell Lines
Bachari, A., Nassar, N., Telukutla, S. R., Zomer, R., Dekiwadia, C. D., Piva, T. J., & Mantri, N. L. (2023) · Cells · doi:10.3390/cells12202450 · Cited by 8 · see citing works
The potential cutaneous benefits of edible bird’s nest
Wang, J. R., Patel, P., Mineroff, J., & Jagdeo, J. R. (2024) · Archives of Dermatological Research · doi:10.1007/s00403-024-02824-5 · Cited by 7 · see citing works
Lovisolo, F., Carton, F., Gino, S., Migliario, M., & Renò, F. (2021) · Lasers in Medical Science · doi:10.1007/s10103-021-03285-2 · Cited by 7 · see citing works
Physicochemical and biological impacts of light stress on adeno-associated virus serotype 6
Takino, R., Yamaguchi, Y., Maruno, T., Ramadhani, E., Furukawa, M., Torisu, T., & Uchiyama, S. (2024) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2024.101362 · Cited by 6 · see citing works
Refining mutanome-based individualised immunotherapy of melanoma using artificial intelligence
Zakariya, F., Salem, F. K., Alamrain, A. A., Sanker, V., Abdelazeem, Z. G., Hosameldin, M., Tan, J. K., Howard, R., Huang, H. Y. R., & Awuah, W. A. (2024) · European journal of medical research · doi:10.1186/s40001-023-01625-2 · Cited by 6 · see citing works
Masuda, S., Makioka‐Itaya, Y., 伊地知哲生, & Tsukahara, T. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.21-54 · Cited by 6 · see citing works
Factors Influencing Effects of Low-dose Radiation Exposure
Mothersill, C. E., Seymour, C. B., Cocchetto, A. M., & Williams, D. (2024) · Health Physics · doi:10.1097/hp.0000000000001816 · Cited by 6 · see citing works
Moi, S., Shekh, S., Reddy, K. K. A., Dhurjad, P., Sonti, R., & Gowd, K. H. (2022) · Photochemistry and Photobiology · doi:10.1111/php.13691 · Cited by 5 · see citing works
Lentigo maligna part I: Epidemiology, risk factors, and diagnosis
Gupta, S., Shaughnessy, M., Rashid, S., Stagner, A. M., Fewkes, J. L., Marghoob, A. A., & Tsao, H. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2024.09.065 · Cited by 6 · see citing works
Tonolli, P. N., Marie, S. K. N., Oba‐Shinjo, S. M., de Assis, L. V. M., & Baptista, M. S. (2025) · Photochemistry and Photobiology · doi:10.1111/php.14095 · Cited by 5 · see citing works
Rana, S., Fatima, N., Yaqoob, S., Hameed, A., Mirza, M. R., Jabeen, A., & Iqbal, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-25515-5 · Cited by 5 · see citing works
Nurla, L.-A., Wafi, G., Tătar, R., Dorobanțu, A. M., Chivu, M., Popa, L. G., Giurcăneanu, C., & Orzan, O. A. (2024) · Medicina · doi:10.3390/medicina60010187 · Cited by 5 · see citing works
An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage
Agrez, M., Rybchyn, M. S., Silva, W. G. M. D., Mason, R. S., Chandler, C., Piva, T. J., Thurecht, K. J., Fletcher, N. L., Liu, F., Subramaniam, G., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38890-4 · Cited by 5 · see citing works
Art of prevention: The importance of melanoma surveillance
Goddard, L., Ivey, L. A., & Hirokane, J. (2020) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2020.01.003 · Cited by 5 · see citing works
Berry Fruit Extracts as Topical Cosmeceuticals for Skin Health Applications: A Systematic Review
Azevedo, F. S., Pires, A. R., Lila, M. A., Valacchi, G., Hoskin, R. T., Sarandy, M. M., Novaes, R. D., & Gonçalves, R. V. (2025) · Cosmetics · doi:10.3390/cosmetics12030087 · Cited by 4 · see citing works
Melanin-Driven Delayed CPD Formation Is Independent of Melanin Biosynthesis Pathway
Yadav, V. K., Srivastava, J., Venkatachalam, A., Tantak, M. P., Lawrence, N. J., Fisher, D. E., Lawrence, H. R., & Premi, S. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.09.011 · Cited by 4 · see citing works
Liu, E., Bai, S. X., Huang, Y., Pang, Y., Zhang, X., Zeng, J., & Guo, J. (2025) · Current Treatment Options in Oncology · doi:10.1007/s11864-025-01356-y · Cited by 4 · see citing works
Hemin with Peroxidase Activity Can Inhibit the Oxidative Damage Induced by Ultraviolet A
Hui, W., Yang, Z., Fang, K., Wu, M., Mu, W., Zhao, C., Xue, D., Zhu, T., Li, X., Gao, M., et al. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44060183 · Cited by 4 · see citing works
Acosta, S., Canclini, L., Marizcurrena, J. J., Castro‐Sowinski, S., & Hernández, P. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.104001 · Cited by 5 · see citing works
Barbosa, E. C., Bucar, E. E. C., JUBÉ, G. R., SILVEIRA, L. B., SILVA, N. C. D., FARIA, P. C. C., Ramos, P., Moraes, V. R. Y., & BARROS, J. O. B. (2023) · Revista do Colégio Brasileiro de Cirurgiões · doi:10.1590/0100-6991e-20233490-en · Cited by 4 · see citing works
Plant-Derived bioactive compounds as Skin Photo protection Agents Authors
Ahmad, S., Shabbir, A., Tareen, N., Ahmad, S., & Chohan, M. A. (2022) · International Journal of Natural Medicine and Health Sciences · doi:10.52461/ijnms.v1i2.866 · Cited by 4 · see citing works
Lara-Vega, I., Maximiliano, C. L., & López, A. V. (2023) · Bulletin du Cancer · doi:10.1016/j.bulcan.2023.05.002 · Cited by 4 · see citing works
Liang, L., Mai, S., Mai, G., Chen, Y., & Liu, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.882431 · Cited by 4 · see citing works
Fatima, N., Yaqoob, S., Rana, S., Hameed, A., Mirza, M. R., & Jabeen, A. (2024) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2024.112841 · Cited by 3 · see citing works
Mokrzynski, K. T., Wojtala, M., Sułkowski, M., Ito, S., Wakamatsu, K., Żądło, A. C., Majka, M., Sarna, T., & Sarna, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094119 · Cited by 3 · see citing works
Impact of Mechanical and Architectural Signals in the Tumor Microenvironment on Melanoma
Khan, Z. M., Rossello-Martinez, A., & Mak, M. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501759 · Cited by 4 · see citing works
Patil, A. K. A., Mannur, V. S., & Koli, R. (2025) · Next Nanotechnology · doi:10.1016/j.nxnano.2025.100317 · Cited by 3 · see citing works
- Authors
- Khan, A. Q., Travers, J. B., & Kemp, M. G.
- Affiliations
- Wright State University (US)
- Corresponding author
- Kemp, Michael G.
- Venue
- Environmental and Molecular Mutagenesis
- Publisher
- Wiley
- Published
- 2018-02-21
- Volume
- 59
- Issue
- 5
- Pages
- 438-460
- ISSN
- 0893-6692 (ISSN-L)
- 1098-2280
- PMC
- PMC6031472
- OpenAlex
- W2792144160
- Cited by
- 152
- References
- 321
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 25 · 2023: 22 · 2022: 20 · 2021: 23 · 2020: 20 · 2019: 7 · 2018: 5
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Environmental and Molecular Mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG048946)
- National Institute of Environmental Health Sciences (ES020866)
- U.S. Department of Veterans Affairs (1101CX000809)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- melanoma, UVA, UV-B radiation, DNA damage response, melanocytes, UV photoproducts, DNA repair proteins, oxidative DNA damage, paracrine signaling, tumor immune microenvironment, melanomagenesis
- MeSH terms
- DNA Damage, DNA Repair, Humans, Melanocytes, Melanoma, Neoplasms, Radiation-Induced, Skin, Skin Neoplasms, Ultraviolet Rays, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review