Dyslipidemia management for primary prevention of cardiovascular events: Best in-clinic practices
Open accessAbstract
Dyslipidemia is a fundamental risk factor for cardiovascular diseases (CVDs) and can worsen the prognosis, if unaddressed. Lipid guidelines are still evolving as dyslipidemia is affecting newer patient subsets. However, these guidelines are governed by regional demographics and ethnic data. Primary care practitioners (PCPs) are the first to offer treatment, and hence placed early in the healthcare continuum. PCPs shoulder a huge responsibility in early detection of dyslipidemia for primary prevention of future cardiovascular (CV) events. Therefore, as members of Cardiovascular RISk Prevention (CRISP) in Asia network, the authors intend to align and shape-up the daily clinical practice workflow for PCPs and have a goal-directed strategy for managing dyslipidemia. This paper reviews the major international lipid guidelines, namely the American and European guidelines, and the regional guidelines from Indonesia, Malaysia, Philippines, Thailand, and Vietnam to identify their commonalities and heterogeneities. The authors, with a mutual consensus, have put forth, best in-clinic practices for screening, risk assessment, diagnosis, treatment, and management of dyslipidemia, particularly to reduce the overall risk of CV events, especially in the Asian context. The authors feel that PCPs should be encouraged to work in congruence with patients to decide on best possible therapy, which would be a holistic approach, rather than pursuing a "one-size-fits-all" approach. Since dyslipidemia is a dynamic field, accumulation of high-quality evidence and cross-validation studies in the future are warranted to develop best in-clinic practices at a global level.
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Given that dyslipidemia is a key component of metabolic syndrome, and cardiovascular outcomes are of the utmost importance in managing such patients, a combination approach may yield better results than GLP-1RA monotherapy.
“Given that dyslipidemia is a key component of metabolic syndrome, and cardiovascular outcomes are of the utmost importance in managing such patients, a combination approach may yield better results than GLP-1RA monotherapy in this aspect30.”
From Efficacy and safety of GLP-1 receptor agonists on weight management and metabolic parameters in PCOS women: a meta-analysis of randomized controlled trials (2025) · cites this paper as [30]
The Introduction describes dyslipidemia as a major modifiable cardiovascular risk factor, and the section on managing patients with co-morbidities discusses lipid management and cardiovascular risk screening in metabolic syndrome (page numbers unavailable). The paper discusses adding non-statin drugs to statins, but does not address whether a combination approach improves cardiovascular outcomes compared with GLP-1RA monotherapy. (LLM, conf=0.86)
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Lin, S., Deng, Y., Huang, J., Li, M., Sooranna, S. R., Qin, M., & Tan, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-99622-4 · Cited by 35 · see citing works
“Given that dyslipidemia is a key component of metabolic syndrome, and cardiovascular outcomes are of the utmost importance in managing such patients, a combination approach may yield better results than GLP-1RA monotherapy in this aspect 30 .”
- Authors
- Thongtang, N., Sukmawan, R., Llanes, E. J. B., & Lee, Z.-V.
- Affiliations
- Siriraj Hospital (TH)
- University of Indonesia (ID)
- Philippine General Hospital (PH)
- University Malaya Medical Centre (MY)
- Corresponding author
- Thongtang, Nuntakorn
- Venue
- Preventive Medicine Reports
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 27
- Pages
- 101819
- ISSN
- 2211-3355 (ISSN-L)
- PMC
- PMC9152805
- OpenAlex
- W4229052466
- Cited by
- 61
- References
- 74
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 27 · 2023: 7 · 2022: 2
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Preventive Medicine Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- dyslipidemia, cardiovascular risk reduction, primary prevention, primary care, lipid screening, cardiovascular risk assessment, dyslipidemia diagnosis, dyslipidemia management, client-centered therapy, clinical guidelines
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