GFAP in health and disease

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

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Oxidative Stress, Caloric Restriction, and Aging

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Localization of neuronal and glial glutamate transporters

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Glial Fibrillary Acidic Protein: GFAP-Thirty-One Years (1969–2000)

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Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

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Cloning and expression of a rat brain L-glutamate transporter

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An acidic protein isolated from fibrous astrocytes

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

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Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

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Astrocytic response to cerebral ischemia is influenced by sex differences and impaired by aging

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Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury

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Novel Luteolin-Loaded Chitosan Decorated Nanoparticles for Brain-Targeting Delivery in a Sporadic Alzheimer’s Disease Mouse Model: Focus on Antioxidant, Anti-Inflammatory, and Amyloidogenic Pathways

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Astrocyte-Mediated Neuroinflammation in Neurological Conditions

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Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness

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Serum GFAP and NfL as disease severity and prognostic biomarkers in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder

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Immunocytochemical and Ultrastructural Evidence of Glial Cells and Hyalocytes in Internal Limiting Membrane Specimens of Idiopathic Macular Holes

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MicroRNA Signature of Traumatic Brain Injury: From the Biomarker Discovery to the Point-of-Care

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Astrocitos en las enfermedades neurodegenerativas (I): función y caracterización molecular

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Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

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Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids

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The cells involved in the pathological process of diabetic retinopathy

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Increased GFAP concentrations in the cerebrospinal fluid of patients with unipolar depression

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The Diversity of Intermediate Filaments in Astrocytes

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Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective

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Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition

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Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice

Rocha, S. M., Bantle, C. M., Aboellail, T., Chatterjee, D., Smeyne, R. J., & Tjalkens, R. B. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105685 · Cited by 87

Glial fibrillary acidic protein in Alzheimer’s disease: a narrative review

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Omega‐3 fatty acids deficiency aggravates glutamatergic synapse and astroglial aging in the rat hippocampal CA 1

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Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

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Beyond Expectations

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Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition

Lang, D. G., Schott, B. H., van Ham, M., Morton, L., Kulikovskaja, L., Herrera‐Molina, R., Pielot, R., Klawonn, F., Montag, D., Jänsch, L., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1242-1 · Cited by 77

Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease

Calderón-Peláez, M.-A., Velandia-Romero, M. L., Bastidas-Legarda, L. Y., Beltrán, E. O., Camacho-Ortega, S. J., & Castellanos, J. E. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01435 · Cited by 84

Astrocytic TDP-43 Pathology in Alexander Disease

Walker, A. K., Daniels, C. M. L., Goldman, J. E., Trojanowski, J. Q., Lee, V. M. ‐., & Messing, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0248-14.2014 · Cited by 81

Early Maternal Deprivation Induces Microglial Activation, Alters Glial Fibrillary Acidic Protein Immunoreactivity and Indoleamine 2,3-Dioxygenase during the Development of Offspring Rats

Réus, G. Z., da Silva, R. H., de Moura, A. B., Presa, J. F., Abelaira, H. M., Abatti, M. R., Vieira, A. A. D. S., Pescador, B., Michels, M., Ignácio, Z. M., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1161-2 · Cited by 82

Extracellular Vesicle-Mediated Bilateral Communication between Glioblastoma and Astrocytes

Nieland, L., Morsett, L. M., Broekman, M. L. D., Breakefield, X. O., & Abels, E. R. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.014 · Cited by 77

High Glucose Alters Retinal Astrocytes Phenotype through Increased Production of Inflammatory Cytokines and Oxidative Stress

Shin, E. S., Huang, Q., Gürel, Z., Sorenson, C. M., & Sheibani, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103148 · Cited by 79

Memory and Learning Dysfunction Following Copper Toxicity: Biochemical and Immunohistochemical Basis

Kalita, J., Kumar, V., Misra, U. K., & Bora, H. K. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0619-y · Cited by 77

Avobenzone and nanoplastics affect the development of zebrafish nervous system and retinal system and inhibit their locomotor behavior

Liu, Y., Wang, Y., Li, N., & Jiang, S. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.150681 · Cited by 83

Distinct pathological patterns in relapsing–remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate

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Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls

Ayyadevara, S., Balasubramaniam, M., Parcon, P. A., Barger, S. W., Griffin, W. S. T., Alla, R., Tackett, A. J., Mackintosh, S. G., Petricoin, E. F., Zhou, W., et al. (2016) · Aging Cell · doi:10.1111/acel.12501 · Cited by 77

Evidence of an association between brain cellular injury and cognitive decline after non-cardiac surgery

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Disease‐modifying effects of ganglioside GM1 in Huntington's disease models

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Age-dependent changes at the blood-brain barrier. A Comparative structural and functional study in young adult and middle aged rats

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The Astrocyte-Targeted Therapy by Bushi for the Neuropathic Pain in Mice

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Distinct progenitor behavior underlying neocortical gliogenesis related to tumorigenesis

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Astrocytes in neurodegenerative diseases (I): function and molecular description

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Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease

Olajide, O. J., Suvanto, M. E., & Chapman, C. A. (2021) · Biology Open · doi:10.1242/bio.056796 · Cited by 77

Modulation of Synaptic Plasticity by Exercise Training as a Basis for Ischemic Stroke Rehabilitation

Nie, J., & Yang, X. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0348-1 · Cited by 73

Repeated transcranial low‐level laser therapy for traumatic brain injury in mice: biphasic dose response and long‐term treatment outcome

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Nanomicellar formulation of coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model: potential use as an adjuvant treatment in Parkinson's disease

Sikorska, M., Lanthier, P., Miller, H., Beyers, M., Sodja, C., Zurakowski, B., Gangaraju, S., Pandey, S., & Sandhu, J. K. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.032 · Cited by 70

The Emerging Role of the Interplay Among Astrocytes, Microglia, and Neurons in the Hippocampus in Health and Disease

Lana, D., Ugolini, F., Nosi, D., Wenk, G. L., & Giovannini, M. G. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.651973 · Cited by 73

Low Glucose Utilization and Neurodegenerative Changes Caused by Sodium Fluoride Exposure in Rat’s Developmental Brain

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Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid

Kozela, E., Juknat, A., & Vogel, Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081669 · Cited by 74

Astrocyte plasticity induced by emotional stress: A new partner in psychiatric physiopathology?

Bender, C. L., Calfa, G. D., & Molina, V. A. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.005 · Cited by 70

CUMS and dexamethasone induce depression‐like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation

Wu, J., Li, J., Chhetri, G., Muhammad, U., Chen, Y., Li, X., Chen, J., & Wang, Z. (2021) · General Psychiatry · doi:10.1136/gpsych-2021-100529 · Cited by 70

Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging

van Vliet, E. A., & Marchi, N. (2022) · Epilepsia · doi:10.1111/epi.17210 · Cited by 69

The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches

O’Brien, E. R., Howarth, C., & Sibson, N. R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00040 · Cited by 71

Histone acetylation in astrocytes suppresses GFAP and stimulates a re-organization of the intermediate filament network

Kanski, R., Sneeboer, M. A. M., van Bodegraven, E. J., Sluijs, J. A., Kropff, W., Vermunt, M. W., Creyghton, M. P., Filippis, L. D., Vescovi, A. L., Aronica, E., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.145912 · Cited by 68

Treadmill Exercise Induces Hippocampal Astroglial Alterations in Rats

Bernardi, C. L., Tramontina, A. C., Nardin, P., Biasibetti, R., Costa, A. P., Vizuete, A. F. K., Batassini, C., Tortorelli, L. S., Wartchow, K. M., Dutra, M. F., et al. (2013) · Neural Plasticity · doi:10.1155/2013/709732 · Cited by 68

White matter disease and cognitive impairment in FMR1 premutation carriers

Filley, C. M., Brown, M. S., Onderko, K., Ray, M., Bennett, R. E., Berry‐Kravis, E., & Grigsby, J. (2015) · Neurology · doi:10.1212/wnl.0000000000001612 · Cited by 67

The neuron-astrocyte-microglia triad involvement in neuroinflammaging mechanisms in the CA3 hippocampus of memory-impaired aged rats

Lana, D., Iovino, L., Nosi, D., Wenk, G. L., & Giovannini, M. G. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.011 · Cited by 68

Artemether Activation of AMPK/GSK3 β (ser9)/Nrf2 Signaling Confers Neuroprotection towards β- Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model

Li, S., Zhao, X., Lazarovici, P., & Zheng, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1862437 · Cited by 67

Isolation of endothelial cells, pericytes and astrocytes from mouse brain

Bernard-Patrzynski, F., Lécuyer, M., Puscas, I., Boukhatem, I., Charabati, M., Bourbonnière, L., Ramassamy, C., Leclair, G., Prat, A., & Roullin, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226302 · Cited by 64

Effect of Electrical Stimulation Conditions on Neural Stem Cells Differentiation on Cross-Linked PEDOT:PSS Films

Sordini, L., Garrudo, F. F. F., Rodrigues, C. A. V., Linhardt, R. J., Cabral, J. M. S., Ferreira, F. C., & Morgado, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.591838 · Cited by 66

Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury

Hori, D., Ono, M., Rappold, T. E., Conte, J. V., Shah, A. S., Cameron, D. E., Adachi, H., Everett, A. D., & Hogue, C. W. J. (2015) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2015.03.036 · Cited by 66

Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion

Hase, Y., Craggs, L., Hase, M., Stevenson, W., Slade, J. Y., Lopez, D., Mehta, R., Chen, A., Liang, D., Oakley, A. E., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0850-5 · Cited by 68

Morphometric analysis of astrocytes in brainstem respiratory regions

Sheikhbahaei, S., Morris, B., Collina, J., Anjum, S., Znati, S. A., Gamarra, J., Zhang, R., Gourine, A., & Smith, J. (2018) · The Journal of comparative neurology · doi:10.1002/cne.24472 · Cited by 62

A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice

Nandar, W., Neely, E. B., Unger, E., & Connor, J. R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.009 · Cited by 64

The Wistar-Kyoto rat model of endogenous depression: a tool for exploring treatment resistance with an urgent need to focus on sex differences

Millard, S. J., Weston-Green, K., & Newell, K. A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109908 · Cited by 62

Characterization of Antibodies that Detect Human GFAP after Traumatic Brain Injury

Zoltewicz, J. S., Scharf, D., Yang, B., Chawla, A., Newsom, K. J., & Fang, L. (2012) · Biomarker Insights · doi:10.4137/bmi.s9873 · Cited by 65

Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies

Asai-Coakwell, M., March, L. D., Dai, X. H., DuVal, M. G., López, I., French, C. R., Famulski, J. K., Baere, E. B. W. D., Francis, P. J., Sundaresan, P., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds560 · Cited by 68

Ferroptosis is Involved in Hypoxic-ischemic Brain Damage in Neonatal Rats

Lin, W., Zhang, T., Zheng, J., Zhou, Y., Lin, Z., & Fu, X. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.02.013 · Cited by 64

Caffeine triggers behavioral and neurochemical alterations in adolescent rats

Ardais, A. P., Borges, M. F., da Rocha, A. S., Sallaberry, C., Cunha, R. A., & Porciúncula, L. O. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.003 · Cited by 64

Developments in scalable strategies for detecting early markers of cognitive decline

Whelan, R., Barbey, F. M., Cominetti, M. R., Gillan, C. M., & Rosická, A. M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02237-w · Cited by 69

The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain

McGinnis, A., & Ji, R. (2023) · Cells · doi:10.3390/cells12060965 · Cited by 67

Stereological Analysis of Neuron, Glial and Endothelial Cell Numbers in the Human Amygdaloid Complex

García‐Amado, M., & Prensa, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038692 · Cited by 65

Disorders of Astrocytes: Alexander Disease as a Model

Olabarria, M., & Goldman, J. E. (2017) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100218 · Cited by 63

Affective Immunology: The Crosstalk Between Microglia and Astrocytes Plays Key Role?

Yang, L., Zhou, Y., Jia, H., Qi, Y., Tu, S., & Shao, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01818 · Cited by 69

Astroglial activation: Current concepts and future directions

Edison, P. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13678 · Cited by 67

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Bustos, F., Segarra-Fas, A., Nardocci, G., Cassidy, A., Antico, O., Davidson, L., Brandenburg, L., Macartney, T., Toth, R. L., Hastie, C. J., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.09.025 · Cited by 58

GFAPδ Expression in Glia of the Developmental and Adolescent Mouse Brain

Mamber, C., Kamphuis, W., Haring, N. L., Peprah, N., Middeldorp, J., & Hol, E. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052659 · Cited by 61

Type III intermediate filaments as targets and effectors of electrophiles and oxidants

Viedma-Poyatos, Á., Pajares, M. A., & Pérez‐Sala, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101582 · Cited by 58

Chemobrain in rats: Behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration

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A Brain-Targeted Approach to Ameliorate Memory Disorders in a Sporadic Alzheimer’s Disease Mouse Model via Intranasal Luteolin-Loaded Nanobilosomes

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