The DOI matches its Crossref record; 328 of the 332 references it cites were found in a registry or an index.
Protective effects and mechanisms of sirtuins in the nervous system
Open accessAbstract
Silent information regulator two proteins (sirtuins or SIRTs) are a group of histone deacetylases whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD(+)). They suppress genome-wide transcription, yet upregulate a select set of proteins related to energy metabolism and pro-survival mechanisms, and therefore play a key role in the longevity effects elicited by calorie restriction. Recently, a neuroprotective effect of sirtuins has been reported for both acute and chronic neurological diseases. The focus of this review is to summarize the latest progress regarding the protective effects of sirtuins, with a focus on SIRT1. We first introduce the distribution of sirtuins in the brain and how their expression and activity are regulated. We then highlight their protective effects against common neurological disorders, such as cerebral ischemia, axonal injury, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. Finally, we analyze the mechanisms underlying sirtuin-mediated neuroprotection, centering on their non-histone substrates such as DNA repair enzymes, protein kinases, transcription factors, and coactivators. Collectively, the information compiled here will serve as a comprehensive reference for the actions of sirtuins in the nervous system to date, and will hopefully help to design further experimental research and expand sirtuins as therapeutic targets in the future.
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“SIRT1 transcription decreases in the aged brain,121 worsening pathological protein aggregation and neuron loss and sharply increasing the risk of neurodegenerative diseases.122,123”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [122]
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3 retracted
RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
Dönmez, G., Wang, D., Cohen, D. E., & Guarente, L. (2010) · Cell · doi:10.1016/j.cell.2010.06.020 · Cited by 443
RetractedSirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
Shulga, N., Wilson‐Smith, R., & Pastorino, J. G. (2010) · Journal of Cell Science · doi:10.1242/jcs.061846 · Cited by 165
RetractedCytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70
Sawada, M., Hayes, P. L., & Matsuyama, S. (2003) · Nature Cell Biology · doi:10.1038/ncb955 · Cited by 162
RetractedMicroRNAs: Target Recognition and Regulatory Functions
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Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
Cited by
Sorted by citations
Luen Tang, B. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2318 · Cited by 740
SIRT1 and SIRT2: emerging targets in neurodegeneration
Dönmez, G., & Outeiro, T. F. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302451 · Cited by 419
Role of NAD+ in regulating cellular and metabolic signaling pathways
Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K. A., Haris, M., Reddy, R. D., Patay, Z. J., Baur, J. A., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101195 · Cited by 413
Mitochondrial function in hypoxic ischemic injury and influence of aging
Ham, P. B., & Raju, R. P. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.006 · Cited by 374
Cho, S.-H., Chen, J. A., Sayed, F., Ward, M. E., Gao, F., Nguyen, T. A., Krabbe, G., Sohn, P. D., Lo, I., Minami, S., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2939-14.2015 · Cited by 275
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Metadata
- Authors
- Zhang, F., Wang, S., Gan, L., Vosler, P. S., Gao, Y., Zigmond, M. J., & Chen, J.
- Affiliations
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Corresponding author
- Zhang, Feng
- Chen, Jun
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 95
- Issue
- 3
- Pages
- 373-395
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC3242010
- OpenAlex
- W2067554187
- Cited by
- 211
- References
- 332
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 7 · 2023: 5 · 2022: 24 · 2021: 18 · 2020: 21 · 2019: 13 · 2018: 13 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 19 · 2013: 17 · 2012: 9
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 45048, NS43802, R01NS062157, NS 36736, R01NS070825, R01NS056118, R01NS045048, R01NS043802, R01NS036736, NS62157)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- sirtuins, SIRT1, neuroprotection, histone deacetylase, NAD+, neurological disorders, cerebral ischemia, axonal injury, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, DNA repair, protein kinases, transcription factors, transcriptional coactivator, therapeutic target
- MeSH terms
- Animals, Brain Chemistry, Cell Nucleus, Cytosol, Gene Expression Regulation, Histone Deacetylases, Humans, Longevity, Mitochondria, Nervous System Physiological Phenomena, Neuroprotective Agents, Neurodegenerative Diseases, Caloric Restriction, Sirtuins, Sirtuin 1
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