Cited by 211Sirtuins and Resveratrol in MedicineNuclear Receptors and SignalingNeuroprotection in Cerebral Ischemia

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Protective effects and mechanisms of sirtuins in the nervous system

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Zhang, Feng, Wang, Suping, Gan, Li, Vosler, Peter S., Gao, Yanqin, Zigmond, Michael J., Chen, Jun·2011·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2011.09.001PMC PMC3242010

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Abstract

Silent information regulator two proteins (sirtuins or SIRTs) are a group of histone deacetylases whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD(+)). They suppress genome-wide transcription, yet upregulate a select set of proteins related to energy metabolism and pro-survival mechanisms, and therefore play a key role in the longevity effects elicited by calorie restriction. Recently, a neuroprotective effect of sirtuins has been reported for both acute and chronic neurological diseases. The focus of this review is to summarize the latest progress regarding the protective effects of sirtuins, with a focus on SIRT1. We first introduce the distribution of sirtuins in the brain and how their expression and activity are regulated. We then highlight their protective effects against common neurological disorders, such as cerebral ischemia, axonal injury, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. Finally, we analyze the mechanisms underlying sirtuin-mediated neuroprotection, centering on their non-histone substrates such as DNA repair enzymes, protein kinases, transcription factors, and coactivators. Collectively, the information compiled here will serve as a comprehensive reference for the actions of sirtuins in the nervous system to date, and will hopefully help to design further experimental research and expand sirtuins as therapeutic targets in the future.

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Authors: Zhang, F., Wang, S., Gan, L., Vosler, P. S., Gao, Y., Zigmond, M. J., & Chen, J.
Affiliations: University of Pittsburgh (US)
University of California, San Francisco (US)
Corresponding author: Zhang, Feng
Chen, Jun
ORCID: Zhang, Feng
Wang, Suping
Gan, Li
Vosler, Peter S.
Gao, Yanqin
Chen, Jun
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2011-11
Volume: 95
Issue: 3
Pages: 373-395
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2011.09.001
PMC: PMC3242010
OpenAlex: W2067554187
Cited by: 211
References: 332
Citations by year: 2026: 8 · 2025: 13 · 2024: 7 · 2023: 5 · 2022: 24 · 2021: 18 · 2020: 21 · 2019: 13 · 2018: 13 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 19 · 2013: 17 · 2012: 9
FWCI: 1.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS 45048, NS43802, R01NS062157, NS 36736, R01NS070825, R01NS056118, R01NS045048, R01NS043802, R01NS036736, NS62157)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: sirtuins, SIRT1, neuroprotection, histone deacetylase, NAD+, neurological disorders, cerebral ischemia, axonal injury, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, DNA repair, protein kinases, transcription factors, transcriptional coactivator, therapeutic target
MeSH terms: Animals, Brain Chemistry, Cell Nucleus, Cytosol, Gene Expression Regulation, Histone Deacetylases, Humans, Longevity, Mitochondria, Nervous System Physiological Phenomena, Neuroprotective Agents, Neurodegenerative Diseases, Caloric Restriction, Sirtuins, Sirtuin 1

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Protective effects and mechanisms of sirtuins in the nervous system

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