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Cited by 119PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and TherapyAlzheimer's disease research and treatments

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

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Chong, Zhao Zhong, Shang, Yan Chen, Wang, Shaohui, Maiese, Kenneth·2012·Progress in Neurobiology
DOI 10.1016/j.pneurobio.2012.08.001PMC PMC3479314
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Abstract

Neurodegenerative disorders affect a significant portion of the world's population leading to either disability or death for almost 30 million individuals worldwide. One novel therapeutic target that may offer promise for multiple disease entities that involve Alzheimer's disease, Parkinson's disease, epilepsy, trauma, stroke, and tumors of the nervous system is the mammalian target of rapamycin (mTOR). mTOR signaling is dependent upon the mTORC1 and mTORC2 complexes that are composed of mTOR and several regulatory proteins including the tuberous sclerosis complex (TSC1, hamartin/TSC2, tuberin). Through a number of integrated cell signaling pathways that involve those of mTORC1 and mTORC2 as well as more novel signaling tied to cytokines, Wnt, and forkhead, mTOR can foster stem cellular proliferation, tissue repair and longevity, and synaptic growth by modulating mechanisms that foster both apoptosis and autophagy. Yet, mTOR through its proliferative capacity may sometimes be detrimental to central nervous system recovery and even promote tumorigenesis. Further knowledge of mTOR and the critical pathways governed by this serine/threonine protein kinase can bring new light for neurodegeneration and other related diseases that currently require new and robust treatments.

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  1. Abel TW Baker SJ Fraser MM Tihan T Nelson JS Yachnis AT Bouffard JP Mena H Burger PC Eberhart CG Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway. J Neuropathol Exp Neurol 2005 64 341 349 15835270
  2. Abraham RT mTOR as a positive regulator of tumor cell responses to hypoxia. Current topics in microbiology and immunology 2004 279 299 319 14560965
  3. Acosta-Jaquez HA Keller JA Foster KG Ekim B Soliman GA Feener EP Ballif BA Fingar DC Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol Cell Biol 2009 29 4308 4324 19487463 PMC2715808
  4. Aimbetov R Chen CH Bulgakova O Abetov D Bissenbaev AK Bersimbaev RI Sarbassov DD Integrity of mTORC2 is dependent on the rictor Gly-934 site. Oncogene 2011 PMC3305845 21909137
  5. Akcakanat A Singh G Hung MC Meric-Bernstam F Rapamycin regulates the phosphorylation of rictor. Biochem Biophys Res Commun 2007 362 330 333 17707343 PMC2040311
  6. Aksu U Demirci C Ince C The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. Contrib Nephrol 2011 174 119 128 21921616
  7. Ammar HI Saba S Ammar RI Elsayed LA Ghaly WB Dhingra S Erythropoietin protects against doxorubicin-induced heart failure. Am J Physiol Heart Circ Physiol 2011 301 H2413 2421 21984540
  8. An WL Cowburn RF Li L Braak H Alafuzoff I Iqbal K Iqbal IG Winblad B Pei JJ Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am J Pathol 2003 163 591 607 12875979 PMC1868198
  9. Andreucci M Fuiano G Presta P Lucisano G Leone F Fuiano L Bisesti V Esposito P Russo D Memoli B Faga T Michael A Downregulation of cell survival signalling pathways and increased cell damage in hydrogen peroxide-treated human renal proximal tubular cells by alpha-erythropoietin. Cell Prolif 2009 42 554 561 19508320 PMC6496929
  10. Asaithambi A Kanthasamy A Saminathan H Anantharam V Kanthasamy AG Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Molecular neurodegeneration 2011 6 43 21696630 PMC3145571
  11. Astrinidis A Senapedis W Coleman TR Henske EP Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J Biol Chem 2003 278 51372 51379 14551205
  12. Baba H Sakurai M Abe K Tominaga R Autophagy-mediated stress response in motor neuron after transient ischemia in rabbits. J Vasc Surg 2009 50 381 387 19631873
  13. Bach JP Mengel D Wahle T Kautz A Balzer-Geldsetzer M Al-Abed Y Dodel R Bacher M The Role of CNI-1493 in the Function of Primary Microglia with Respect to Amyloid-beta. J Alzheimers Dis 2011 26 69 80 21593565
  14. Bailey TJ Fossum SL Fimbel SM Montgomery JE Hyde DR The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Muller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res 2010 91 601 612 20696157 PMC2962682
  15. Bains M Zaegel V Mize-Berge J Heidenreich KA IGF-I stimulates Rab7-RILP interaction during neuronal autophagy. Neurosci Lett 2010 PMC3027408 20849920
  16. Bajda M Guzior N Ignasik M Malawska B Multi-target-directed ligands in Alzheimer's disease treatment. Curr Med Chem 2011 18 4949 4975 22050745
  17. Balan V Miller GS Kaplun L Balan K Chong ZZ Li F Kaplun A VanBerkum MF Arking R Freeman DC Maiese K Tzivion G Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem 2008 283 27810 27819 18678867 PMC2562057
  18. Banach M Piskorska B Czuczwar S Borowicz K Nitric Oxide, epileptic seizures, and action of antiepileptic drugs. CNS Neurol Disord Drug Targets 2011 21999730
  19. Basile LA Ellefson D Gluzman-Poltorak Z Junes-Gill K Mar V Mendonca S Miller JD Tom J Trinh A Gallaher TK HemaMax, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates. PLoS ONE 2012 7 e30434 22383962 PMC3286478
  20. Benjamin D Colombi M Moroni C Hall MN Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov 2011 10 868 880 22037041
  21. Bhandari BK Feliers D Duraisamy S Stewart JL Gingras AC Abboud HE Choudhury GG Sonenberg N Kasinath BS Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells. Kidney Int 2001 59 866 875 11231341
  22. Bhaskar K Miller M Chludzinski A Herrup K Zagorski M Lamb BT The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Molecular neurodegeneration 2009 4 14 19291319 PMC2663563
  23. Blommaart EF Luiken JJ Blommaart PJ van Woerkom GM Meijer AJ Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 1995 270 2320 2326 7836465
  24. Boulbes D Chen CH Shaikenov T Agarwal NK Peterson TR Addona TA Keshishian H Carr SA Magnuson MA Sabatini DM Sarbassov dos D Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Mol Cancer Res 2010 8 896 906 20501647 PMC2896829
  25. Brugarolas J Lei K Hurley RL Manning BD Reiling JH Hafen E Witters LA Ellisen LW Kaelin WG Jr. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 2004 18 2893 2904 15545625 PMC534650
  26. Brunner S Huber BC Weinberger T Vallaster M Wollenweber T Gerbitz A Hacker M Franz WM Migration of bone marrow-derived cells and improved perfusion after treatment with erythropoietin in a murine model of myocardial infarction. J Cell Mol Med 2012 16 152 159 21362129 PMC3823101
  27. Bryce AH Rao R Sarkaria J Reid JM Qi Y Qin R James CD Jenkins RB Boni J Erlichman C Haluska P Phase I study of temsirolimus in combination with EKB-569 in patients with advanced solid tumors. Invest New Drugs 2011 PMC3816525 21881915
  28. Buckmaster PS Ingram EA Wen X Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J Neurosci 2009 29 8259 8269 19553465 PMC2819377
  29. Cai SL Tee AR Short JD Bergeron JM Kim J Shen J Guo R Johnson CL Kiguchi K Walker CL Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol 2006 173 279 289 16636147 PMC2063818
  30. Campos-Esparza MR Sanchez-Gomez MV Matute C Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols. Cell Calcium 2009 45 358 368 19201465
  31. Canu N Tufi R Serafino AL Amadoro G Ciotti MT Calissano P Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J Neurochem 2005 92 1228 1242 15715672
  32. Caprara C Grimm C From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease. Prog Retin Eye Res 2012 31 89 119 22108059
  33. Carayol N Vakana E Sassano A Kaur S Goussetis DJ Glaser H Druker BJ Donato NJ Altman JK Barr S Platanias LC Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc Natl Acad Sci U S A 2010 107 12469 12474 20616057 PMC2906574
  34. Carriere A Cargnello M Julien LA Gao H Bonneil E Thibault P Roux PP Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol 2008 18 1269 1277 18722121
  35. Chalhoub S Langston CE Farrelly J The use of darbepoetin to stimulate erythropoiesis in anemia of chronic kidney disease in cats: 25 cases. J Vet Intern Med 2012 26 363 369 22296687
  36. Chalkias A Xanthos T Post-cardiac arrest brain injury: pathophysiology and treatment. J Neurol Sci 2012 315 1 8 22251931
  37. Chano T Okabe H Hulette CM RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases. Brain Res 2007 1168 97 105 17706618
  38. Chen C Liu Y Zheng P mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Science signaling 2009a 2 ra75 19934433 PMC4020596
  39. Chen CH Sarbassov dos D The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2. J Biol Chem 2011 286 40386 40394 21965657 PMC3220582
  40. Chen EJ Kaiser CA LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J Cell Biol 2003 161 333 347 12719473 PMC2172900
  41. Chen J Zheng XF Brown EJ Schreiber SL Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A 1995 92 4947 4951 7539137 PMC41824
  42. Chen JX Tuo Q Liao DF Zeng H Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1/Tie-2 Signaling in Diabetes. Exp Diabetes Res 2012 2012 836759 22454630 PMC3291112
  43. Chen TJ Wang DC Chen SS Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons. J Neurosci Res 2009b 87 2297 2307 19301428
  44. Chiang GG Abraham RT Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem 2005 280 25485 25490 15899889
  45. Choi KC Kim SH Ha JY Kim ST Son JH A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem 2010 112 366 376 19878437
  46. Chong ZZ Hou J Shang YC Wang S Maiese K EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a, GSK-3beta, and beta-Catenin to Foster Vascular Integrity During Experimental Diabetes. Curr Neurovasc Res 2011a 8 103 120 21443457 PMC3084631
  47. Chong ZZ Kang JQ Maiese K Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 2002 106 2973 2979 12460881
  48. Chong ZZ Kang JQ Maiese K Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br J Pharmacol 2003a 138 1107 1118 12684267 PMC1573758
  49. Chong ZZ Kang JQ Maiese K AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9. Exp Cell Res 2004a 296 196 207 15149850
  50. Chong ZZ Li F Maiese K Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury. Histol Histopathol 2005a 20 299 315 15578447 PMC2276698
  51. Chong ZZ Li F Maiese K Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better? Curr Neurovasc Res 2005b 2 55 72 16181100 PMC2254177
  52. Chong ZZ Li F Maiese K Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Curr Neurovasc Res 2005c 2 387 399 16375720 PMC1986681
  53. Chong ZZ Li F Maiese K Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 2005d 75 207 246 15882775
  54. Chong ZZ Li F Maiese K Attempted Cell Cycle Induction in Post-Mitotic Neurons Occurs in Early and Late Apoptotic Programs Through Rb, E2F1, and Caspase 3. Curr Neurovasc Res 2006 3 25 39 16472123 PMC1986668
  55. Chong ZZ Li F Maiese K Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cell Signal 2007a 19 1150 1162 17289346 PMC1913492
  56. Chong ZZ Li F Maiese K The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection. Int J Mol Med 2007b 19 263 272 17203200 PMC1986680
  57. Chong ZZ Lin SH Kang JQ Maiese K Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res 2003b 71 659 669 12584724
  58. Chong ZZ Lin SH Kang JQ Maiese K The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival. Cell Mol Neurobiol 2003c 23 561 578 14514016 PMC11530189
  59. Chong ZZ Lin SH Li F Maiese K The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through Akt, Bad, PARP, and mitochondrial associated “anti-apoptotic” pathways. Curr Neurovasc Res 2005e 2 271 285 16181120 PMC1986682
  60. Chong ZZ Lin SH Maiese K The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential. J Cereb Blood Flow Metab 2004b 24 728 743 15241181
  61. Chong ZZ Maiese K The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. Histol Histopathol 2007 22 1251 1267 17647198 PMC2515712
  62. Chong ZZ Shang YC Hou J Maiese K Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways. Oxid Med Cell Longev 2010a 3 153 165 20716939 PMC2952099
  63. Chong ZZ Shang YC Maiese K Cardiovascular Disease and mTOR Signaling. Trends Cardiovasc Med 2011b 21 151 155 22732551 PMC3384484
  64. Chong ZZ Shang YC Wang S Maiese K SIRT1: New avenues of discovery for disorders of oxidative stress. Expert opinion on therapeutic targets 2012a 16 167 178 22233091 PMC3279588
  65. Chong ZZ Shang YC Zhang L Wang S Maiese K Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders. Oxid Med Cell Longev 2010b 3 374 391 21307646 PMC3154047
  66. Chong ZZ Wang S Shang YC Maiese K Targeting cardiovascular disease with novel SIRT1 pathways. Future Cardiol 2012b 8 89 100 22185448 PMC3254055
  67. Chung CY Park YL Song YA Myung E Kim KY Lee GH Ki HS Park KJ Cho SB Lee WS Jung YD Kim KK Joo YE Knockdown of RON Inhibits AP-1 Activity and Induces Apoptosis and Cell Cycle Arrest Through the Modulation of Akt/FoxO Signaling in Human Colorectal Cancer Cells. Dig Dis Sci 2012 57 371 380 21901254
  68. Codeluppi S Svensson CI Hefferan MP Valencia F Silldorff MD Oshiro M Marsala M Pasquale EB The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. J Neurosci 2009 29 1093 1104 19176818 PMC2682457
  69. Cota D Proulx K Smith KA Kozma SC Thomas G Woods SC Seeley RJ Hypothalamic mTOR signaling regulates food intake. Science 2006 312 927 930 16690869
  70. Curatolo P Bombardieri R Jozwiak S Tuberous sclerosis. Lancet 2008 372 657 668 18722871
  71. Curran MP Everolimus: in patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex. Paediatr Drugs 2012 14 51 60 22136276
  72. Czene S Tiback M Harms-Ringdahl M pH-dependent DNA cleavage in permeabilized human fibroblasts. Biochem J 1997 323 337 341 9163321 PMC1218324
  73. Dada S Demartines N Dormond O mTORC2 regulates PGE2-mediated endothelial cell survival and migration. Biochem Biophys Res Commun 2008 372 875 879 18539142
  74. Dan HC Adli M Baldwin AS Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. Cancer Res 2007 67 6263 6269 17616684
  75. Das J Ghosh J Manna P Sil PC Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK. Biochem Pharmacol 2011 81 891 909 21295553
  76. Dasgupta B Yi Y Chen DY Weber JD Gutmann DH Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors. Cancer Res 2005 65 2755 2760 15805275
  77. De Simone R Ajmone-Cat MA Minghetti L Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Mol Neurobiol 2004 29 197 212 15126686
  78. Deblon N Bourgoin L Veyrat-Durebex C Peyrou M Vinciguerra M Caillon A Maeder C Fournier M Montet X Rohner-Jeanrenaud F Foti M Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. Br J Pharmacol 2012 165 2325 2340 22014210 PMC3413866
  79. Dello Russo C Lisi L Tringali G Navarra P Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation. Biochem Pharmacol 2009 78 1242 1251 19576187
  80. Deruy E Gosselin K Vercamer C Martien S Bouali F Slomianny C Bertout J Bernard D Pourtier A Abbadie C MnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes. PLoS One 2010 5 e12712 20856861 PMC2939051
  81. Dibble CC Asara JM Manning BD Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 2009 29 5657 5670 19720745 PMC2772744
  82. Dormond O Madsen JC Briscoe DM The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. J Biol Chem 2007 282 23679 23686 17553806 PMC3383050
  83. Du Y Zhang X Ji H Liu H Li S Li L Probucol and atorvastatin in combination protect rat brains in MCAO model: upregulating Peroxiredoxin2, Foxo3a and Nrf2 expression. Neurosci Lett 2012 509 110 115 22233727
  84. Duan S Skaar JR Kuchay S Toschi A Kanarek N Ben-Neriah Y Pagano M mTOR Generates an Auto-Amplification Loop by Triggering the betaTrCP- and CK1alpha-Dependent Degradation of DEPTOR. Mol Cell 2011 44 317 324 22017877 PMC3212871
  85. Easley CA Ben-Yehudah A Redinger CJ Oliver SL Varum ST Eisinger VM Carlisle DL Donovan PJ Schatten GP mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells. Cellular reprogramming 2010 12 263 273 20698768 PMC2993047
  86. Echeverria V Zeitlin R Burgess S Patel S Barman A Thakur G Mamcarz M Wang L Sattelle DB Kirschner DA Mori T Leblanc RM Prabhakar R Arendash GW Cotinine Reduces Amyloid-beta Aggregation and Improves Memory in Alzheimer's Disease Mice. J Alzheimers Dis 2011 21321389
  87. Eipel C Hubschmann U Abshagen K Wagner KF Menger MD Vollmar B Erythropoietin as Additive of HTK Preservation Solution in Cold Ischemia/Reperfusion Injury of Steatotic Livers. J Surg Res 2012 173 171 179 21074785
  88. Ekim B Magnuson B Acosta-Jaquez HA Keller JA Feener EP Fingar DC mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression. Mol Cell Biol 2011 31 2787 2801 21576368 PMC3133410
  89. Erlich S Alexandrovich A Shohami E Pinkas-Kramarski R Rapamycin is a neuroprotective treatment for traumatic brain injury. Neurobiol Dis 2007 26 86 93 17270455
  90. Escobar J Pereda J Lopez-Rodas G Sastre J Redox signaling and histone acetylation in acute pancreatitis. Free Radic Biol Med 2012 52 819 837 22178977
  91. Faghiri Z Bazan NG PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Exp Eye Res 2010 90 718 725 20230819 PMC2873108
  92. Fernandez-Martos CM Gonzalez-Fernandez C Gonzalez P Maqueda A Arenas E Rodriguez FJ Differential expression of wnts after spinal cord contusion injury in adult rats. PLoS ONE 2011 6 e27000 22073235 PMC3206916
  93. Fingar DC Richardson CJ Tee AR Cheatham L Tsou C Blenis J mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 2004 24 200 216 14673156 PMC303352
  94. Floto RA Sarkar S Perlstein EO Kampmann B Schreiber SL Rubinsztein DC Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy 2007 3 620 622 17786022
  95. Floyd S Favre C Lasorsa FM Leahy M Trigiante G Stroebel P Marx A Loughran G O'Callaghan K Marobbio CM Slotboom DJ Kunji ER Palmieri F O'Connor R The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Mol Biol Cell 2007 18 3545 3555 17596519 PMC1951771
  96. Fokas E Yoshimura M Prevo R Higgins G Hackl W Maira SM Bernhard EJ McKenna WG Muschel RJ NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/Mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiat Oncol 2012 7 48 22452803 PMC3348043
  97. Frias MA Thoreen CC Jaffe JD Schroder W Sculley T Carr SA Sabatini DM mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol 2006 16 1865 1870 16919458
  98. Galan-Moya EM Le Guelte A Lima Fernandes E Thirant C Dwyer J Bidere N Couraud PO Scott MG Junier MP Chneiweiss H Gavard J Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway. EMBO Rep 2011 12 470 476 21460795 PMC3090013
  99. Gangloff YG Mueller M Dann SG Svoboda P Sticker M Spetz JF Um SH Brown EJ Cereghini S Thomas G Kozma SC Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 2004 24 9508 9516 15485918 PMC522282
  100. Gao D Inuzuka H Tan MK Fukushima H Locasale JW Liu P Wan L Zhai B Chin YR Shaik S Lyssiotis CA Gygi SP Toker A Cantley LC Asara JM Harper JW Wei W mTOR Drives Its Own Activation via SCF(betaTrCP)-Dependent Degradation of the mTOR Inhibitor DEPTOR. Mol Cell 2011 44 290 303 22017875 PMC3229299
  101. Garcia-Martinez JM Alessi DR mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 2008 416 375 385 18925875
  102. Ghosh N Ghosh R Mandal SC Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease. Free Radic Res 2011 45 888 905 21615270
  103. Gingras AC Kennedy SG O'Leary MA Sonenberg N Hay N 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 1998 12 502 513 9472019 PMC316523
  104. Glidden EJ Gray LG Vemuru S Li D Harris TE Mayo MW Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein. J Biol Chem 2012 287 581 588 22084251 PMC3249112
  105. Goffus AM Anderson GD Hoane M Sustained delivery of nicotinamide limits cortical injury and improves functional recovery following traumatic brain injury. Oxid Med Cell Longev 2010 3 145 152 20716938 PMC2952098
  106. Good DW George T Watts BA 3rd Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb. J Biol Chem 2008 283 26602 26611 18660503 PMC2546562
  107. Guertin DA Stevens DM Thoreen CC Burds AA Kalaany NY Moffat J Brown M Fitzgerald KJ Sabatini DM Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 2006 11 859 871 17141160
  108. Gulhati P Bowen KA Liu J Stevens PD Rychahou PG Chen M Lee EY Weiss HL O'Connor KL Gao T Evers BM mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 2011 71 3246 3256 21430067 PMC3085654
  109. Gumy LF Tan CL Fawcett JW The role of local protein synthesis and degradation in axon regeneration. Exp Neurol 2010 223 28 37 19520073 PMC2864402
  110. Gwinn DM Shackelford DB Egan DF Mihaylova MM Mery A Vasquez DS Turk BE Shaw RJ AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008 30 214 226 18439900 PMC2674027
  111. Han J Shi S Min L Wu T Xia W Ying W NAD(+) Treatment Induces Delayed Autophagy in Neuro2a Cells Partially by Increasing Oxidative Stress. Neurochem Res 2011 36 2270 2277 21833846
  112. Han J Wang B Xiao Z Gao Y Zhao Y Zhang J Chen B Wang X Dai J Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin. Mol Cell Neurosci 2008 39 118 124 18620060
  113. Hansel DE Platt E Orloff M Harwalker J Sethu S Hicks JL De Marzo A Steinle RE Hsi ED Theodorescu D Ching CB Eng C Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. Am J Pathol 2010 176 3062 3072 20395440 PMC2877865
  114. Hara K Maruki Y Long X Yoshino K Oshiro N Hidayat S Tokunaga C Avruch J Yonezawa K Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002 110 177 189 12150926
  115. Harrington LS Findlay GM Gray A Tolkacheva T Wigfield S Rebholz H Barnett J Leslie NR Cheng S Shepherd PR Gout I Downes CP Lamb RF The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 2004 166 213 223 15249583 PMC2172316
  116. Heitman J Movva NR Hall MN Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991 253 905 909 1715094
  117. Herbas MS Ueta YY Ishibashi K Suzuki H Expression of erythropoietic cytokines in alpha-tocopherol transfer protein knockout mice with murine malaria infection. Parasitol Res 2011 109 1243 1250 21479575
  118. Hernandez G Lal H Fidalgo M Guerrero A Zalvide J Force T Pombo CM A novel cardioprotective p38-MAPK/mTOR pathway. Exp Cell Res 2011 317 2938 2949 22001647 PMC3215777
  119. Hernandez-Negrete I Carretero-Ortega J Rosenfeldt H Hernandez-Garcia R Calderon-Salinas JV Reyes-Cruz G Gutkind JS Vazquez-Prado J P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem 2007 282 23708 23715 17565979
  120. Heublein S Kazi S Ogmundsdottir MH Attwood EV Kala S Boyd CA Wilson C Goberdhan DC Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. Oncogene 2010 29 4068 4079 20498635 PMC3018277
  121. Hofbauer GF Marcollo-Pini A Corsenca A Kistler AD French LE Wuthrich RP Serra AL The mTOR inhibitor rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis. The British journal of dermatology 2008 159 473 475 18547304
  122. Holmes GL Stafstrom CE Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia 2007 48 617 630 17386056
  123. Holz MK Blenis J Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 2005 280 26089 26093 15905173
  124. Hong JR Lin GH Lin CJ Wang WP Lee CC Lin TL Wu JL Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. Development 2004 131 5417 5427 15469976
  125. Hosokawa N Sasaki T Iemura S Natsume T Hara T Mizushima N Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy 2009 5 973 979 19597335
  126. Hou G Xue L Lu Z Fan T Tian F Xue Y An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by rapamycin and siRNA against mTOR. Cancer Lett 2007 253 236 248 17360108
  127. Hou J Chong ZZ Shang YC Maiese K Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation. Curr Neurovasc Res 2010a 7 95 112 20370652 PMC2876719
  128. Hou J Chong ZZ Shang YC Maiese K FoxO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling. Mol Cell Endocrinol 2010b 321 194 206 20211690 PMC2857725
  129. Hou J Wang S Shang YC Chong ZZ Maiese K Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress. Curr Neurovasc Res 2011 8 220 235 21722091 PMC3149772
  130. Hresko RC Mueckler M mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem 2005 280 40406 40416 16221682
  131. Hu LY Sun ZG Wen YM Cheng GZ Wang SL Zhao HB Zhang XR ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats. Neuroscience 2010 169 1046 1062 20678995
  132. Huang J Dibble CC Matsuzaki M Manning BD The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 2008 28 4104 4115 18411301 PMC2423120
  133. Huang J Wu S Wu CL Manning BD Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res 2009a 69 6107 6114 19602587 PMC2735013
  134. Huang J Zhang Y Bersenev A O'Brien WT Tong W Emerson SG Klein PS Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin Invest 2009b 119 3519 3529 19959876 PMC2786808
  135. Huang X McMahon J Huang Y Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy. Neuroscience 2012 PMC3371158 22522471
  136. Hwang SK Kim HH The functions of mTOR in ischemic diseases. BMB Rep 2011 44 506 511 21871173
  137. Hyrskyluoto A Reijonen S Kivinen J Lindholm D Korhonen L GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway. Exp Cell Res 2012 318 33 42 21925170
  138. Imai Y Gehrke S Wang HQ Takahashi R Hasegawa K Oota E Lu B Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. Embo J 2008 27 2432 2443 18701920 PMC2543051
  139. Inoki K Li Y Zhu T Wu J Guan KL TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002 4 648 657 12172553
  140. Inoki K Ouyang H Zhu T Lindvall C Wang Y Zhang X Yang Q Bennett C Harada Y Stankunas K Wang CY He X MacDougald OA You M Williams BO Guan KL TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006 126 955 968 16959574
  141. Inoki K Zhu T Guan KL TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003 115 577 590 14651849
  142. Jaber N Dou Z Chen JS Catanzaro J Jiang YP Ballou LM Selinger E Ouyang X Lin RZ Zhang J Zong WX Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A 2012 109 2003 2008 22308354 PMC3277541
  143. Jacinto E Facchinetti V Liu D Soto N Wei S Jung SY Huang Q Qin J Su B SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006 127 125 137 16962653
  144. Jacinto E Loewith R Schmidt A Lin S Ruegg MA Hall A Hall MN Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004 6 1122 1128 15467718
  145. James MF Stivison E Beauchamp R Han S Li H Wallace MR Gusella JF Stemmer-Rachamimov AO Ramesh V Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2-Deficient Target Cell Types. Mol Cancer Res 2012 22426462
  146. Janku F Wheler JJ Westin SN Moulder SL Naing A Tsimberidou AM Fu S Falchook GS Hong DS Garrido-Laguna I Luthra R Lee JJ Lu KH Kurzrock R PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 2012 30 777 782 22271473 PMC3295566
  147. Jayaram HN Kusumanchi P Yalowitz JA NMNAT Expression and its Relation to NAD Metabolism. Curr Med Chem 2011 18 1962 1972 21517776
  148. Jeong JK Moon MH Bae BC Lee YJ Seol JW Kang HS Kim JS Kang SJ Park SY Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity. Neurosci Res 2012 73 99 105 22465415
  149. Jiang YL Ning Y Ma XL Liu YY Wang Y Zhang Z Shan CX Xu YD Yin LM Yang YQ Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin. Int J Mol Med 2011 28 153 160 21567075
  150. Johannessen CM Johnson BW Williams SM Chan AW Reczek EE Lynch RC Rioth MJ McClatchey A Ryeom S Cichowski K TORC1 is essential for NF1-associated malignancies. Curr Biol 2008 18 56 62 18164202
  151. Jozwiak J Kotulska K Lojek M Galus R Jozwiak S Polnik D Wlodarski PK Fibroblasts from normal skin of a tuberous sclerosis patient show upregulation of mTOR pathway. The American Journal of dermatopathology 2009 31 68 70 19155728
  152. Julien LA Carriere A Moreau J Roux PP mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol 2010 30 908 921 19995915 PMC2815569
  153. Jung CH Jun CB Ro SH Kim YM Otto NM Cao J Kundu M Kim DH ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009 20 1992 2003 19225151 PMC2663920
  154. Kabeya Y Kamada Y Baba M Takikawa H Sasaki M Ohsumi Y Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell 2005 16 2544 2553 15743910 PMC1087256
  155. Kahn BB Alquier T Carling D Hardie DG AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005 1 15 25 16054041
  156. Kamada Y Funakoshi T Shintani T Nagano K Ohsumi M Ohsumi Y Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 2000 150 1507 1513 10995454 PMC2150712
  157. Kang JQ Chong ZZ Maiese K Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity. J Neurosci Res 2003a 74 37 51 13130504
  158. Kang JQ Chong ZZ Maiese K Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation. Mol Pharmacol 2003b 64 557 569 12920191
  159. Karlsson E Waltersson MA Bostner J Perez-Tenorio G Olsson B Hallbeck AL Stal O High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1. Genes Chromosomes Cancer 2011 50 775 787 21748818
  160. Kato S Aoyama M Kakita H Hida H Kato I Ito T Goto T Hussein MH Sawamoto K Togari H Asai K Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury. J Neurosci Res 2011 89 1566 1574 21833990
  161. Kawamoto EM Gleichmann M Yshii LM Lima Lde S Mattson MP Scavone C Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. Braz J Med Biol Res 2012 45 58 67 22124704 PMC3854138
  162. Khan MM Ahmad A Ishrat T Khan MB Hoda MN Khuwaja G Raza SS Khan A Javed H Vaibhav K Islam F Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease. Brain Res 2010 1328 139 151 20167206
  163. Kigerl KA Ankeny DP Garg SK Wei P Guan Z Lai W McTigue DM Banerjee R Popovich PG System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo. Exp Neurol 2012 233 333 341 22079587 PMC3268895
  164. Kim DH Sarbassov DD Ali SM King JE Latek RR Erdjument-Bromage H Tempst P Sabatini DM mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 110 163 175 12150925
  165. Kim DH Sarbassov DD Ali SM Latek RR Guntur KV Erdjument-Bromage H Tempst P Sabatini DM GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 11 895 904 12718876
  166. Kim H Choi J Ryu J Park SG Cho S Park BC Lee do H Activation of autophagy during glutamate-induced HT22 cell death. Biochem Biophys Res Commun 2009 388 339 344 19665009
  167. Kim J Jung Y Sun H Joseph J Mishra A Shiozawa Y Wang J Krebsbach PH Taichman RS Erythropoietin mediated bone formation is regulated by mTOR signaling. J Cell Biochem 2012 113 220 228 21898543 PMC3237787
  168. Koh PO Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway. Neurosci Lett 2008 444 74 78 18721861
  169. Koh PO Nicotinamide attenuates the decrease of astrocytic phosphoprotein PEA-15 in focal cerebral ischemic injury. J Vet Med Sci 2012 74 377 380 22067079
  170. Kook YH Ka M Um M Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP(+)) model of Parkinson's disease. Biochem Biophys Res Commun 2011 411 370 374 21741364
  171. Koren I Reem E Kimchi A DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol 2010 20 1093 1098 20537536
  172. Kovacina KS Park GY Bae SS Guzzetta AW Schaefer E Birnbaum MJ Roth RA Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem 2003 278 10189 10194 12524439
  173. Kuroyanagi H Yan J Seki N Yamanouchi Y Suzuki Y Takano T Muramatsu M Shirasawa T Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. Genomics 1998 51 76 85 9693035
  174. Kuypers NJ Hoane MR Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat. J Neurotrauma 2010 27 1275 1282 20486803 PMC2942865
  175. L'Episcopo F Tirolo C Testa N Caniglia S Morale MC Deleidi M Serapide MF Pluchino S Marchetti B Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/beta-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair. J Neurosci 2012 32 2062 2085 22323720 PMC3556384
  176. Lafay-Chebassier C Paccalin M Page G Barc-Pain S Perault-Pochat MC Gil R Pradier L Hugon J mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. J Neurochem 2005 94 215 225 15953364
  177. Lafay-Chebassier C Perault-Pochat MC Page G Rioux Bilan A Damjanac M Pain S Houeto JL Gil R Hugon J The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide. J Neurosci Res 2006 84 1323 1334 16955484
  178. Land SC Tee AR Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem 2007 282 20534 20543 17502379
  179. Lappas M Permezel M The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B(3) derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birth. The Journal of nutritional biochemistry 2011 22 1195 1201 21414766
  180. Le XF Mao W Lu Z Carter BZ Bast RC Jr. Dasatinib induces autophagic cell death in human ovarian cancer. Cancer 2010 PMC2975555 20629079
  181. Lee DF Kuo HP Chen CT Hsu JM Chou CK Wei Y Sun HL Li LY Ping B Huang WC He X Hung JY Lai CC Ding Q Su JL Yang JY Sahin AA Hortobagyi GN Tsai FJ Tsai CH Hung MC IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 2007 130 440 455 17693255
  182. Lee G Pollard HB Arispe N Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site. Peptides 2002 23 1249 1263 12128082
  183. Lee ST Chu K Park JE Jung KH Jeon D Lim JY Lee SK Kim M Roh JK Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease models. J Neurochem 2012 120 115 124 22004348
  184. Lehtinen MK Tegelberg S Schipper H Su H Zukor H Manninen O Kopra O Joensuu T Hakala P Bonni A Lehesjoki AE Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. J Neurosci 2009 29 5910 5915 19420257 PMC2694495
  185. Leuner K Hauptmann S Abdel-Kader R Scherping I Keil U Strosznajder JB Eckert A Muller WE Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease? Antioxid Redox Signal 2007 9 1659 1675 17867931
  186. Li F Chong ZZ Maiese K Vital elements of the wnt-frizzled signaling pathway in the nervous system. Curr Neurovasc Res 2005a 2 331 340 16181124 PMC2254178
  187. Li F Chong ZZ Maiese K Cell Life Versus Cell Longevity: The Mysteries Surrounding the NAD(+) Precursor Nicotinamide. Curr Med Chem 2006a 13 883 895 16611073 PMC2248696
  188. Li F Chong ZZ Maiese K Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB. Curr Neurovasc Res 2006b 3 187 201 16918383 PMC1986678
  189. Li F Chong ZZ Maiese K Winding through the WNT pathway during cellular development and demise. Histol Histopathol 2006c 21 103 124 16267791 PMC2247407
  190. Li L Kim E Yuan H Inoki K Goraksha-Hicks P Schiesher RL Neufeld TP Guan KL Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem 2010 285 19705 19709 20457610 PMC2888380
  191. Lin SH Chong ZZ Maiese K Cell cycle induction in post-mitotic neurons proceeds in concert with the initial phase of programmed cell death in rat. Neurosci Lett 2001 310 173 177 11585595
  192. Lin SH Vincent A Shaw T Maynard KI Maiese K Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death. J Cereb Blood Flow Metab 2000 20 1380 1391 10994860
  193. Liu G Detloff MR Miller KN Santi L Houle JD Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. Exp Neurol 2012 233 447 456 22123082 PMC3268901
  194. Liu K Liu C Shen L Shi J Zhang T Zhou Y Zhou L Sun X Therapeutic effects of rapamycin on MPTP-induced Parkinsonism in mice. Neurochem Int 2011 21672587
  195. Liu K Lu Y Lee JK Samara R Willenberg R Sears-Kraxberger I Tedeschi A Park KK Jin D Cai B Xu B Connolly L Steward O Zheng B He Z PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci 2010a 13 1075 1081 20694004 PMC2928871
  196. Liu T Jin H Sun QR Xu JH Hu HT The neuroprotective effects of tanshinone IIA on beta-amyloid-induced toxicity in rat cortical neurons. Neuropharmacology 2010b 59 595 604 20800073
  197. Luo S Rubinsztein DC Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ 2010 17 268 277 19713971 PMC2894406
  198. Ma J Li M Hock J Yu X Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis Type 1. J Orthop Res 2012 30 144 152 21748792
  199. Ma L Chen Z Erdjument-Bromage H Tempst P Pandolfi PP Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005 121 179 193 15851026
  200. Magri L Cambiaghi M Cominelli M Alfaro-Cervello C Cursi M Pala M Bulfone A Garcia-Verdugo JM Leocani L Minicucci F Poliani PL Galli R Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions. Cell Stem Cell 2011 9 447 462 22056141

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Cited by

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Authors
Chong, Z. Z., Shang, Y. C., Wang, S., & Maiese, K.
Affiliations
Rutgers Cancer Institute (US)
Corresponding author
Maiese, Kenneth
ORCID
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2012-11
Volume
99
Issue
2
Pages
128-148
ISSN
0301-0082 (ISSN-L)
DOI
10.1016/j.pneurobio.2012.08.001
PMC
PMC3479314
OpenAlex
W2011707975
Cited by
119
References
25
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 4 · 2016: 12 · 2015: 21 · 2014: 13 · 2013: 17 · 2012: 6
FWCI
1.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS053946)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
mTOR, neurodegenerative diseases, mTORC1, mTORC2, tuberous sclerosis complex, Alzheimer's disease, Parkinson's disease, epilepsy, stroke, brain tumors, autophagy, apoptosis, stem cell proliferation, tissue repair, synaptic growth, Wnt signaling, forkhead transcription factor, cytokines, therapeutic target
MeSH terms
Animals, Humans, Neurodegenerative Diseases, TOR Serine-Threonine Kinases

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