Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545 · see citing works

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

Kosik, K. S., Joachim, C. L., & Selkoe, D. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4044 · Cited by 1,462 · see citing works

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

Brunn, G. J., Hudson, C. C., Sekulić, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., & Abraham, R. T. (1997) · Science · doi:10.1126/science.277.5322.99 · Cited by 967 · see citing works

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayPreprint

Gingras, A., Kennedy, S. G., O'Leary, M., Sonenberg, N., & Hay, N. (1998) · Genes & Development · doi:10.1101/gad.12.4.502 · Cited by 885 · see citing works

Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

Wang, X.-M., Li, W., Williams, M. R., Terada, N., Alessi, D., & Proud, C. G. (2001) · EMBO Journal · doi:10.1093/emboj/20.16.4370 · Cited by 862 · see citing works

Regulation of eIF-4E BP1 Phosphorylation by mTOR

Hara, K., Yonezawa, K., Kozlowski, M. T., Sugimoto, T., Andrabi, K. I., Weng, Q.-P., Kasuga, M., Nishimoto, I., & Avruch, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26457 · Cited by 529 · see citing works

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer’s disease pathology

Griffin, R. J., Moloney, A., Kelliher, M., Johnston, J. A., Ravid, R., Dockery, P., O'Connor, R., & O'Neill, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02949.x · Cited by 459 · see citing works

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00011 · Cited by 459 · see citing works

Distribution, Levels, and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain

PEI, J.-J., TANAKA, T., TUNG, Y.-C., BRAAK, E., IQBAL, K., & GRUNDKE-IQBAL, I. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199701000-00007 · Cited by 371 · see citing works

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions*

Peterson, R., Beal, P., Comb, M., & Schreiber, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7416 · Cited by 355 · see citing works

One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1

Nukina, N., & Ihara, Y. (1986) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a135625 · Cited by 338 · see citing works

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

An, W.-L., Cowburn, R. F., Li, L., Braak, H., Alafuzoff, I., Iqbal, K., Iqbal, I.-G., Winblad, B., & Pei, J.-J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63687-5 · Cited by 312 · see citing works

Brain Levels of Microtubule‐Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno‐Slot‐Blot Assay for Nanograms of the Protein

Khatoon, S., Grundke, I., & Iqbal, K. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09432.x · Cited by 304 · see citing works

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer’s disease

Pei, J.-J., Braak, H., An, W.-L., Winblad, B., Cowburn, R. F., Iqbal, K., & Grundke-Iqbal, I. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00488-6 · Cited by 247 · see citing works

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70 s6k

von Manteuffel, S. R., Dennis, P. B., Pullen, N., Gingras, A., Sonenberg, N., & Thomas, G. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5426 · Cited by 234 · see citing works

The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites

Herbert, T. P., Tee, A. R., & Proud, C. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110367200 · Cited by 181 · see citing works

Role of protein kinase B in Alzheimer's neurofibrillary pathology

Pei, J.-J., Khatoon, S., An, W., Nordlinder, M., Tanaka, T., Braak, H., Tsujio, I., Takeda, M., Alafuzoff, I. I., Winblad, B. G., et al. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0657-y · Cited by 165 · see citing works

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (2001) · Journal of Alzheimer's Disease · doi:10.3233/jad-2001-3107 · Cited by 165 · see citing works

Mechanism of zinc‐induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH‐SY5Y neuroblastoma cells

An, W., Björkdahl, C., Liu, R., Cowburn, R. F., Winblad, B. G., & Pei, J.-J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02948.x · Cited by 106 · see citing works

Functional studies of Alzheimer's disease tau protein

Lu, Q., & Jg, W. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00508.1993 · Cited by 96 · see citing works

Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain

Li, X., An, W.-L., Alafuzoff, I., Soininen, H., Winblad, B., & Pei, J.-J. (2004) · NeuroReport · doi:10.1097/00001756-200410050-00019 · Cited by 84 · see citing works

Expression of tau mRNA and soluble tau isoforms in affected and non‐affected brain areas in Alzheimer's disease

Boutajangout, A., Boom, A., Leroy, K., & Brion, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.011 · Cited by 77 · see citing works

In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs: species differences and relative preservation in Alzheimer's disease

Mah, V. H., Eskin, T. A., Kazee, A. M., Lapham, L. W., & Higgins, G. A. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90071-i · Cited by 43 · see citing works

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597 · see citing works

mTOR signaling: At the crossroads of plasticity, memory and disease

Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128 · see citing works

Tau-targeting therapies for Alzheimer disease

Congdon, E. E., & Sigurdsson, E. M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0013-z · Cited by 1,113 · see citing works

Current development of mTOR inhibitors as anticancer agents

Faivre, S. J., Kroemer, G., & Raymond, É. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2062 · Cited by 998 · see citing works

The Neurology of mTOR

Lipton, J. O., & Şahin, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.034 · Cited by 732 · see citing works

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 671 · see citing works

Autophagy failure in Alzheimer's disease—locating the primary defect

Nixon, R. A., & Yang, D. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.021 · Cited by 634 · see citing works

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

Um, J. W., Kaufman, A. C., Kostylev, M., Heiss, J. K., Stagi, M., Takahashi, H., Kerrisk, M. E., Vortmeyer, A., Wisniewski, T., Koleske, A. J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.036 · Cited by 572 · see citing works

Targeting mammalian target of rapamycin (mTOR) for health and diseases

Tsang, C. K., Qi, H., Liu, L. F., & Zheng, X. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.12.008 · Cited by 403 · see citing works

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

Ghosh, H. S., McBurney, M., & Robbins, P. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009199 · Cited by 397 · see citing works

Molecular neurobiology of mTOR

Switon, K., Kotulska, K., Janusz, A., Zmorzyńska, J., & Jaworski, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.017 · Cited by 389 · see citing works

The mTOR signalling cascade: paving new roads to cure neurological disease

Crino, P. B. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.81 · Cited by 368 · see citing works

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

Bordi, M., Berg, M. J., Mohan, P. S., Peterhoff, C. M., Alldred, M. J., Che, S., Ginsberg, S. D., & Nixon, R. A. (2016) · Autophagy · doi:10.1080/15548627.2016.1239003 · Cited by 353 · see citing works

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive impairment and late‐stage AD

Tramutola, A., Triplett, J. C., Di Domenico, F., Niedowicz, D. M., Murphy, M. P., Coccia, R., Perluigi, M., & Butterfield, D. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13037 · Cited by 347 · see citing works

Role of mTOR in physiology and pathology of the nervous system

Swiech, L., Perycz, M., Malik, A., & Jaworski, J. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.08.015 · Cited by 338 · see citing works

mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy

Perluigi, M., Di Domenico, F., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.014 · Cited by 339 · see citing works

Synaptic changes in Alzheimer’s disease and its models

Pozueta, J., Lefort, R., & Shelanski, M. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.050 · Cited by 305 · see citing works

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

Neill, C. O. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.025 · Cited by 292 · see citing works

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Querfurth, H., & Lee, H.-K. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00428-5 · Cited by 288 · see citing works

Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease

Akhtar, A., & Sah, S. P. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104707 · Cited by 286 · see citing works

Oxidative stress and β-amyloid protein in Alzheimer’s disease

Cai, Z., Zhao, B., & Ratka, A. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8155-9 · Cited by 279 · see citing works

Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes

Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 275 · see citing works

The role of mTOR signaling in Alzheimer disease

Oddo, S. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s310 · Cited by 235 · see citing works

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

Rosner, M., & Hengstschläger, M. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn192 · Cited by 233 · see citing works

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

Yarchoan, M. M., Toledo, J. B., Lee, E. B., Arvanitakis, Z., Kazi, H., Han, L.-Y., Louneva, N., Lee, V. M. ‐., Kim, S. F., Trojanowski, J. Q., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1328-5 · Cited by 208 · see citing works

Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses

Won, H., Mah, W., & Kim, E. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00019 · Cited by 204 · see citing works

Autophagy and Its Normal and Pathogenic States in the Brain

Yamamoto, A., & Yue, Z. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014149 · Cited by 204 · see citing works

Regulation of mRNA Translation in Neurons—A Matter of Life and Death

Kapur, M., Monaghan, C. E., & Ackerman, S. L. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.057 · Cited by 200 · see citing works

mTOR‐dependent signalling in Alzheimer's disease

Pei, J., & Hugon, J. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00509.x · Cited by 190 · see citing works

Amino acid catabolism in Alzheimer’s disease brain: Friend or foe?

Griffin, J. W. D., & Bradshaw, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5472792 · Cited by 185 · see citing works

The mTOR pathway and its role in human genetic diseases

ROSNER, M., Hanneder, M., Siegel, N., Valli, A., Fuchs, C., & HENGSTSCHLAGER, M. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.06.001 · Cited by 182 · see citing works

Impaired insulin signalling and allostatic load in Alzheimer disease

Felice, F. G. D., Gonçalves, R. A., & Ferreira, S. T. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00558-9 · Cited by 180 · see citing works

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

Bhaskar, K., Miller, M., Chludzinski, A., Herrup, K., Zagorski, M., & Lamb, B. T. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-14 · Cited by 177 · see citing works

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases

Wong, M. (2013) · Biomedical Journal · doi:10.4103/2319-4170.110365 · Cited by 169 · see citing works

Activation of mTOR: a culprit of Alzheimer’s disease?

Cai, Z., Zhou, Y., Xiao, M., Yan, L.-J., & He, W. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75717 · Cited by 161 · see citing works

A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer’s Disease

Santos, R. X., Correia, S., Wang, X.-L., Perry, G., Smith, M. A., Moreira, P., & Zhu, X.-W. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100666 · Cited by 157 · see citing works

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

Perluigi, M., Pupo, G., Tramutola, A., Cini, C., Coccia, R., Barone, E., Head, E., Butterfield, D. A., & Di Domenico, F. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.007 · Cited by 155 · see citing works

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer’s Disease

Colacurcio, D. J., Pensalfini, A., Jiang, Y., & Nixon, R. A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.001 · Cited by 167 · see citing works

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

Silva, T., Reis, J., Teixeira, J., & Borges, F. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.03.008 · Cited by 157 · see citing works

Mammalian Target of Rapamycin: Hitting the Bull′s‐Eye for Neurological Disorders

Chong, Z. Z., Shang, Y., Zhang, L., Wang, S., & Maiese, K. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.6.14787 · Cited by 149 · see citing works

Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine

Ding, M.-R., Qu, Y.-J., Hu, B., & An, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113208 · Cited by 144 · see citing works

Tuberous Sclerosis Complex: Neurological, Renal and Pulmonary Manifestations

Franz, D. N., Bissler, J. J., & McCormack, F. X. (2010) · Neuropediatrics · doi:10.1055/s-0030-1269906 · Cited by 139 · see citing works

Decreased RNA, and Increased RNA Oxidation, in Ribosomes from Early Alzheimer’s Disease

Ding, Q., Markesbery, W. R., Cecarini, V., & Keller, J. N. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9071-5 · Cited by 140 · see citing works

Validation of anti-aging drugs by treating age-related diseases

Blagosklonny, M. V. (2009) · Aging · doi:10.18632/aging.100034 · Cited by 140 · see citing works

Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease

Ferrari-Souza, J., Ferreira, P., Bellaver, B., Tissot, C., Wang, Y., Leffa, D., Brum, W., Benedet, A., Ashton, N., de Bastiani, M. D., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01716-2 · Cited by 126 · see citing works

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

John, J. S. (2007) · Frontiers in bioscience · doi:10.2741/2714 · Cited by 134 · see citing works

Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

Cai, Z., Zhao, B., Li, K., Zhang, L., Li, C., Quazi, S. H., & Tan, Y. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23011 · Cited by 134 · see citing works

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

Silva, D. F., Selfridge, J. E., Lu, J., E, L., Roy, N., Hutfles, L., Burns, J. M., Michaelis, E. K., Yan, S., Cardoso, S. M., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt247 · Cited by 133 · see citing works

and Alzheimer's disease

Brioni, J. D., Esbenshade, T. A., Garrison, T. R., Bitner, S. R., & Cowart, M. (2010) · Cited by 125 · see citing works

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

Tang, Z., Bereczki, E., Zhang, H., Wang, S., Li, C., Ji, X., Branca, R. M., Lehtiö, J., Guan, Z., Filipčík, P., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.435123 · Cited by 124 · see citing works

Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology

Silva, J. M., Rodrigues, S., Sampaio‐Marques, B., Gomes, P., Neves‐Carvalho, A., Dioli, C., Soares‐Cunha, C., Mazuik, B. F., Takashima, A., Ludovico, P., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0217-1 · Cited by 123 · see citing works

Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles

Funk, K. E., Mrak, R. E., & Kuret, J. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01135.x · Cited by 123 · see citing works

mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder

Marzia Perluigi, A., Domenico, F. D., Barone, E., & Butterfield, D. A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.04.025 · Cited by 121 · see citing works

TOR on the brain

Garelick, M. G., & Kennedy, B. K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.030 · Cited by 119 · see citing works

The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy

Xu, T., Liu, J., Li, X.-R., Yu, Y., Luo, X., Zheng, X., Cheng, Y. G., Yu, P.-Q., & Liu, Y. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02390-1 · Cited by 122 · see citing works

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

Chong, Z. Z., Shang, Y. C., Wang, S., & Maiese, K. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.08.001 · Cited by 119 · see citing works

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

Thellung, S., Corsaro, A., Nizzari, M., Barbieri, F., & Florio, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040901 · Cited by 105 · see citing works

Therapeutic targeting of the mTOR ‐signalling pathway in cancer: benefits and limitations

Moschetta, M., Reale, A., Marasco, C., Vacca, A., & Carratù, M. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12749 · Cited by 116 · see citing works

Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions

Pandit, R., Leinenga, G., & Götz, J. (2019) · Theranostics · doi:10.7150/thno.34388 · Cited by 115 · see citing works

The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics

Di Domenico, F., Barone, E., Perluigi, M., & Butterfield, D. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6759 · Cited by 114 · see citing works

mTor mediates tau localization and secretion: implication for Alzheimer’s disease

Tang, Z., Ioja, E., Bereczki, E., Hultenby, K., Li, C., Guan, Z., Winblad, B., & Pei, J.-J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.03.003 · Cited by 112 · see citing works

Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development

Mueed, Z., Tandon, P., Maurya, S. K., Deval, R., Kamal, M. A., & Poddar, N. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01017 · Cited by 111 · see citing works

Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases

Ciregia, F., Urbani, A., & Palmisano, G. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00276 · Cited by 110 · see citing works

Insulin signaling and its application

Thi Kim Chung, L. E., Dao, X. D., Nguyen, D. V., Luu, D. H., Bui, T. M. H., Le, T. H., Nguyen, H. T., Le, N. T., Hosaka, T., & Nguyen, T. T. T. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1226655 · Cited by 120 · see citing works

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

Ryskalin, L., Limanaqi, F., Frati, A., Busceti, C. L., & Fornai, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082226 · Cited by 105 · see citing works

Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer’s disease

Nalls, M. A., Guerreiro, R. J., Simón‐Sánchez, J., Brás, J., Traynor, B. J., Gibbs, J. R., Launer, L. J., Hardy, J., & Singleton, A. (2009) · Neurogenetics · doi:10.1007/s10048-009-0182-4 · Cited by 102 · see citing works

Amyloid‐β interrupts the PI3K‐Akt‐mTOR signaling pathway that could be involved in brain‐derived neurotrophic factor‐induced Arc expression in rat cortical neurons

Chen, T., Wang, D., & Chen, S. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22057 · Cited by 98 · see citing works

Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Lachance, V., Wang, Q., Sweet, E., Choi, I., Cai, C.-Z., Zhuang, X.-X., Zhang, Y., Jiang, J. L., Blitzer, R. D., Bozdagi-Gunal, O., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0342-4 · Cited by 96 · see citing works

Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors

Xu, T., Sun, D., Chen, Y., & Ouyang, L. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112391 · Cited by 96 · see citing works

Frontier of Epilepsy Research - mTOR signaling pathway

Cho, C. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.5.032 · Cited by 92 · see citing works

The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis

Russo, E., Citraro, R., Constanti, A., & Sarro, G. D. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8314-5 · Cited by 90 · see citing works

Rapamycin, Autophagy, and Alzheimer's Disease.

Cai, Z., & Yan, L. (2013) · PubMed · Cited by 91 · see citing works

Effects of AMP-activated protein kinase (AMPK) signaling and essential amino acids on mammalian target of rapamycin (mTOR) signaling and protein synthesis rates in mammary cells

Appuhamy, J. A. D. R. N., Nayananjalie, W. A. D., England, E. M., Gerrard, D. E., Akers, R. M., & Hanigan, M. D. (2013) · Journal of Dairy Science · doi:10.3168/jds.2013-7189 · Cited by 91 · see citing works

DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application

Huang, M., & Chen, S. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102114 · Cited by 87 · see citing works

Activated mTOR and PKR Kinases in Lymphocytes Correlate with Memory and Cognitive Decline in Alzheimer’s Disease

Paccalin, M., Pain-Barc, S., Pluchon, C., Paul, C., Besson, M.-N., Carret-Rebillat, A.-S., Rioux-Bilan, A., Gil, R., & Hugon, J. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000095562 · Cited by 96 · see citing works

Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer’s Disease-like Neurotoxicity

Wang, T., Xie, C.-W., Yu, P., Fang, F., Zhu, J., Cheng, J., Gu, A., Wang, J., & Xiao, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-07544-7 · Cited by 83 · see citing works

TRPM7 and its role in neurodegenerative diseases

Sun, Y., Sukumaran, P., Schaar, A., & Singh, B. B. (2015) · Channels · doi:10.1080/19336950.2015.1075675 · Cited by 82 · see citing works

PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

Xiong, X., Xie, R., Zhang, H., Gu, L., Xie, W., Cheng, M., Jian, Z., Kovacina, K. S., & Zhao, H. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.02.006 · Cited by 82 · see citing works

Functions and Regulation of Translation Elongation Factors

Xu, B., Liu, L., & Song, G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.816398 · Cited by 79 · see citing works

Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?

Puglielli, L. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.01.010 · Cited by 80 · see citing works

Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn

Xu, J.-T., Zhao, X., Yaster, M., & Tao, Y.-X. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.010 · Cited by 80 · see citing works

Orexin receptors exert a neuroprotective effect in Alzheimer’s disease (AD) via heterodimerization with GPR103

Davies, J., Chen, J., Pink, R. C., Carter, D., Saunders, N. J. S. G., Sotiriadis, G., Bai, B., Pan, Y., Howlett, D. R., Payne, A. M., et al. (2015) · Scientific Reports · doi:10.1038/srep12584 · Cited by 78 · see citing works

Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease

Yates, S. C., Zafar, A., Hubbard, P., Nagy, S., Durant, S., Bicknell, R., Wilcock, G., Christie, S., Esiri, M. M., Smith, A. D., et al. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-3 · Cited by 76 · see citing works

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Zhang, Z., Wang, X., Zhang, D., Liu, Y., & Lin, L. (2019) · Aging · doi:10.18632/aging.101759 · Cited by 75 · see citing works

p70 S6 Kinase and Tau in Alzheimer's Disease

Pei, J.-J., Björkdahl, C., Zhang, H., Zhou, X., & Winblad, B. G. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14405 · Cited by 75 · see citing works

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response

Jan, A., Jansonius, B., Delaidelli, A., Somasekharan, S. P., Bhanshali, F., Vandal, M., Negri, G. L., Moerman, D. G., Mackenzie, I. R., Calon, F., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1634-1 · Cited by 73 · see citing works

Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

Gureev, A. P., Popov, V. N., & Starkov, A. A. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113285 · Cited by 73 · see citing works

Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease

Żekanowski, C., & Wojda, U. (2009) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2009-1748 · Cited by 73 · see citing works

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

Lourenco, M. V., Ferreira, S. T., & Felice, F. G. D. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.003 · Cited by 71 · see citing works

Linking pathways in the developing and aging brain with neurodegeneration

Kovács, G. G., Adle‐Biassette, H., Milenković, I., Cipriani, S., van Scheppingen, J., & Aronica, E. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.03.045 · Cited by 67 · see citing works

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.

Tramutola, A., Lanzillotta, C., & Di Domenico, F. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1244482 · Cited by 69 · see citing works

GLP-1 Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight

Monti, G., Moreira, D. G., Richner, M., Mutsaers, H. A. M., Ferreira, N., & Jan, A. (2022) · Cells · doi:10.3390/cells11132023 · Cited by 69 · see citing works

Leucine and histidine independently regulate milk protein synthesis in bovine mammary epithelial cells via mTOR signaling pathway

Gao, H., Hu, H., Zheng, N., & Wang, J. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400337 · Cited by 69 · see citing works

Trilateral association of autophagy, mTOR and Alzheimer’s disease: Potential pathway in the development for Alzheimer’s disease therapy

Subramanian, A., Tamilanban, T., Alsayari, A., Ramachawolran, G., Wong, L. S., Sekar, M., Gan, S. H., Subramaniyan, V., Chinni, S. V., Rani, N. N. I. M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1094351 · Cited by 67 · see citing works

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

Jan, A., Jansonius, B., Delaidelli, A., Bhanshali, F., An, Y. A., Ferreira, N., Smits, L. M., Negri, G. L., Schwamborn, J. C., Jensen, P. H., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0554-9 · Cited by 66 · see citing works

mTOR Hyperactivation in Down Syndrome Hippocampus Appears Early During Development

Iyer, A. M., van Scheppingen, J., Milenkovic, I., Anink, J. J., Adle-Biassette, H., Kovacs, G. G., & Aronica, E. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000083 · Cited by 69 · see citing works

Biphasic Activation of the mTOR Pathway in the Gustatory Cortex Is Correlated with and Necessary for Taste Learning

Belelovsky, K., Kaphzan, H., Elkobi, A., & Rosenblum, K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3809-08.2009 · Cited by 66 · see citing works

Rapamycin suppresses brain aging in senescence-accelerated OXYS rats

Kolosova, N. G., Vitovtov, A. O., Muraleva, N. A., Евгеньевич, А. А., Stefanova, N. A., & Blagosklonny, M. V. (2013) · Aging · doi:10.18632/aging.100573 · Cited by 65 · see citing works

Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain

Li, X., An, W.-L., Alafuzoff, I., Soininen, H., Winblad, B., & Pei, J.-J. (2004) · NeuroReport · doi:10.1097/00001756-200410050-00019 · Cited by 84 · see citing works

The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer Disease

Tang, Z. (2014) · Figshare

P3‐133: Role of mTOR in tau translation and phosphorylation in SH‐SY5Y cell

Tang, Z., Zhang, H., Wang, S., Winblad, B. G., & Pei, J. J. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.1573

Neuropathological associations between translational control and Alzheimer's disease

Chauvet, M. G., Ferreira, D. C., Isaac, A. R., Ferreira, S. T., & Lourenco, M. V. (2025) · Alzheimer s & Dementia · doi:10.1002/alz70855_097357

P3–096: Kinases mTOR and PKR controlling translation in Alzheimer's disease potential biomarkers?

Paccalin, M., Barc, S. P., Paquet, C., Pluchon, C., Bilan, A. R., Gil, R., & Hugon, J. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1363 · Cited by 1 · see citing works