High prevalence of the hepatitis C virus infection among the inpatients of schizophrenia and psychoactive substance abuse in Japan
Abstract
Prevalence of anti-HCV antibody in 1193 hospitalized patients (848 males and 345 females) in psychiatric department was investigated. Overall prevalence ratio was 9.1%, indicating significantly higher than that of healthy blood donors. In the classification of ICD-10, the prevalence of the inpatients diagnosed in schizophrenia group and psychoactive substance use group accounted for 6.2% and 13.8%, respectively. However, adequate reasons such as sanitary issues were not found to account for the high prevalence. Only the age of the patients could account for the high prevalence in the schizophrenic group. In the psychoactive substance abuse group, the sanitary issues might be a major cause of the very high prevalence of anti-HCV antibody, while other factors such as dysfunction of the immune system might be considered to account for it.
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Across different continents, rates of hepatitis virus infection are markedly elevated in persons with SMI compared to the general population.
“Across different continents, markedly elevated rates of hepatitis virus infection have been reported in persons with SMI compared to the general population (364,396-403).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [403]
In the largest study to date, prevalence rates of hepatitis B virus (23.4%) and hepatitis C virus (19.6%) in SMI patients were approximately 5 and 11 times the overall estimated population rates for these infections.
“The largest study to date found prevalence rates of hepatitis B virus (23.4%) and hepatitis C virus (19.6%) in SMI patients to be approximately 5 and 11 times the overall estimated population rates for these infections.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [403]
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- Authors
- Nakamura, Y., Koh, M., Miyoshi, E., Ida, O., Morikawa, M., Tokuyama, A., Nagano, T., Honda, Y., Iida, J., Yamamoto, K., Minami, N., Kasahara, A., Hirai, M., Hayashi, N., & Kishimoto, T.
- Affiliations
- Nara Medical University (JP)
- The University of Osaka (JP)
- Akitsu Kounoike Hospital (JP)
- Corresponding author
- Nakamura, Yu
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 28
- Issue
- 3
- Pages
- 591-597
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2081427335
- Cited by
- 32
- References
- 21
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- hepatitis C virus, anti-HCV antibody prevalence, schizophrenia, psychoactive substance abuse, psychiatric inpatients, psychiatric hospitalization, age as risk factor, hospital sanitation, immune dysfunction
- MeSH terms
- Adult, Age Factors, Alcoholism, Blood Donors, Female, Hepatitis C, Humans, Inpatients, Japan, Male, Schizophrenia, Sex Characteristics, Hepatitis C Antibodies, Substance-Related Disorders, Amphetamine-Related Disorders
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