The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression
Abstract
Background Gene expressions of the peripheral leukocytes in depressive patients might reflect the systemic dysfunction of major depression. We determined mRNA expression levels of Histone deacetylase 5 (HDAC5) gene and cyclic AMP response element-binding protein 1 (CREB) gene in the leukocyte of depressive patients. HDAC5 and CREB are reported to be important targets of antidepressants, the latter being located in the downstream of the former in lymphocyte calcium signaling.Methods 25 patients with major depression and 25 age- and sex-matched healthy controls were included in this study. Twenty patients were able to be followed up until the 8 week-treatment. The mRNA levels were determined by a quantitative RT-PCR method.Result Levels of HDAC5 and CREB mRNA were significantly higher in drug-free depressive patients than those of controls and the higher mRNA levels decreased to control levels after 8-week paroxetine treatment. There were positive correlation between levels of HDAC5 and CREB.Conclusion Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression.
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“Antidepressant treatment caused higher peripheral HDAC5 expression to decrease to control levels after about eight weeks of treatment.160”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [160]
In the citing paper
“Higher levels of HDAC4 and HDAC5 were found in depressed patients.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [86]
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Cites
Wilamowska (2010) · doi:10.1001/archpsyc.1988.01800320058007 · Cited by 2,115
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
McKinsey, T. A., Zhang, C., Lu, J., & Olson, E. N. (2000) · Nature · doi:10.1038/35040593 · Cited by 1,051
Regulation of transcription factors by neuronal activity
West, A. E., Griffith, E. C., & Greenberg, M. E. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn987 · Cited by 610
cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment
Thome, J., Sakai, N., Shin, K.-H., Steffen, C., Zhang, Y.-J., Impey, S., Storm, D. R., & Duman, R. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04030.2000 · Cited by 509
Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509
The Role of CREB in Depression and Antidepressant Treatment
Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365
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- Irie, 2000, Phase I clinical study of paroxetine HCl (Study 3): pharmacokinetics after single oral administration of paroxetine HCl 10, 20 and 40 mg to healthy adult male volunteers, Jpn Pharmacol Ther, 28, 47
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Hu, T., Yan, L., Huang, C., Zhang, H., Guo, Y., Zhang, W. X., & Jiang, C. (2026) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2026-0033
Chapter 4. Inflammation and Epigenetics
(2025) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550930.lg04
Epigenetic processes in depressive and anxiety disorders
Breton, É., Booij, L., & Nemoda, Z. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19043-8.00032-3
Metadata
- Authors
- Iga, J.-I., Ueno, S.-I., Yamauchi, K., Numata, S., Kinouchi, S., Tayoshi-Shibuya, S., Song, H., & Ohmori, T.
- Affiliations
- Tokushima University (JP)
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 31
- Issue
- 3
- Pages
- 628-632
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2051089184
- Cited by
- 105
- References
- 27
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (16390325)
- Ministry of Health, Labour and Welfare (H16-002)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- major depressive disorder, HDAC5, CREB, peripheral blood leukocytes, gene expression, paroxetine, antidepressant response, systemic dysfunction, antidepressant targets
- MeSH terms
- Adult, Aged, Depressive Disorder, Major, Major Depressive Disorder, Female, Gene Expression Regulation, Histone Deacetylases, Humans, Leukocytes, Male, Middle Aged, RNA, Messenger, Case-Control Studies, Paroxetine, Statistics, Nonparametric, Reverse Transcriptase Polymerase Chain Reaction, CREB-Binding Protein
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