Cited by 106Treatment of Major DepressionStress Responses and CortisolHistone Deacetylase Inhibitors Research

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Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression

Iga, Jun-ichi, Ueno, Shu-ichi, Yamauchi, Ken, Numata, Shusuke, Kinouchi, Sawako, Tayoshi-Shibuya, Sumiko, Song, Hongwei, Ohmori, Tetsuro·2007·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2006.12.014

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Abstract

Background Gene expressions of the peripheral leukocytes in depressive patients might reflect the systemic dysfunction of major depression. We determined mRNA expression levels of Histone deacetylase 5 (HDAC5) gene and cyclic AMP response element-binding protein 1 (CREB) gene in the leukocyte of depressive patients. HDAC5 and CREB are reported to be important targets of antidepressants, the latter being located in the downstream of the former in lymphocyte calcium signaling.Methods 25 patients with major depression and 25 age- and sex-matched healthy controls were included in this study. Twenty patients were able to be followed up until the 8 week-treatment. The mRNA levels were determined by a quantitative RT-PCR method.Result Levels of HDAC5 and CREB mRNA were significantly higher in drug-free depressive patients than those of controls and the higher mRNA levels decreased to control levels after 8-week paroxetine treatment. There were positive correlation between levels of HDAC5 and CREB.Conclusion Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression.

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Epigenetic, neuroplasticity, and adrenergic targets associated with major depression in immune cellsPreprint
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Authors: Iga, J.-I., Ueno, S.-I., Yamauchi, K., Numata, S., Kinouchi, S., Tayoshi-Shibuya, S., Song, H., & Ohmori, T.
Affiliations: Tokushima University (JP)
ORCID: Iga, Jun-ichi
Yamauchi, Ken
Numata, Shusuke
Song, Hongwei
Ohmori, Tetsuro
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2007-04
Volume: 31
Issue: 3
Pages: 628-632
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2006.12.014
OpenAlex: W2051089184
Cited by: 105
References: 27
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 2
FWCI: 1.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology (16390325)
Ministry of Health, Labour and Welfare (H16-002)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Keywords: major depressive disorder, HDAC5, CREB, peripheral blood leukocytes, gene expression, paroxetine, antidepressant response, systemic dysfunction, antidepressant targets
MeSH terms: Adult, Aged, Depressive Disorder, Major, Major Depressive Disorder, Female, Gene Expression Regulation, Histone Deacetylases, Humans, Leukocytes, Male, Middle Aged, RNA, Messenger, Case-Control Studies, Paroxetine, Statistics, Nonparametric, Reverse Transcriptase Polymerase Chain Reaction, CREB-Binding Protein

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Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression

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