The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression
Abstract
Background Gene expressions of the peripheral leukocytes in depressive patients might reflect the systemic dysfunction of major depression. We determined mRNA expression levels of Histone deacetylase 5 (HDAC5) gene and cyclic AMP response element-binding protein 1 (CREB) gene in the leukocyte of depressive patients. HDAC5 and CREB are reported to be important targets of antidepressants, the latter being located in the downstream of the former in lymphocyte calcium signaling.Methods 25 patients with major depression and 25 age- and sex-matched healthy controls were included in this study. Twenty patients were able to be followed up until the 8 week-treatment. The mRNA levels were determined by a quantitative RT-PCR method.Result Levels of HDAC5 and CREB mRNA were significantly higher in drug-free depressive patients than those of controls and the higher mRNA levels decreased to control levels after 8-week paroxetine treatment. There were positive correlation between levels of HDAC5 and CREB.Conclusion Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression.
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“Antidepressant treatment caused higher peripheral HDAC5 expression to decrease to control levels after about eight weeks of treatment.160”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [160]
In the citing paper
“Higher levels of HDAC4 and HDAC5 were found in depressed patients.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [86]
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Metadata
- Authors
- Iga, J.-I., Ueno, S.-I., Yamauchi, K., Numata, S., Kinouchi, S., Tayoshi-Shibuya, S., Song, H., & Ohmori, T.
- Affiliations
- Tokushima University (JP)
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 31
- Issue
- 3
- Pages
- 628-632
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2051089184
- Cited by
- 105
- References
- 27
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (16390325)
- Ministry of Health, Labour and Welfare (H16-002)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- major depressive disorder, HDAC5, CREB, peripheral blood leukocytes, gene expression, paroxetine, antidepressant response, systemic dysfunction, antidepressant targets
- MeSH terms
- Adult, Aged, Depressive Disorder, Major, Major Depressive Disorder, Female, Gene Expression Regulation, Histone Deacetylases, Humans, Leukocytes, Male, Middle Aged, RNA, Messenger, Case-Control Studies, Paroxetine, Statistics, Nonparametric, Reverse Transcriptase Polymerase Chain Reaction, CREB-Binding Protein
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