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Cited by 80Dementia and Cognitive Impairment ResearchTreatment of Major DepressionBipolar Disorder and Treatment

Age-related cognitive decline in patients with mood disorders

Gualtieri, C. Thomas, Johnson, Lynda G.·2008·Progress in Neuro-Psychopharmacology and Biological Psychiatry
DOI 10.1016/j.pnpbp.2007.12.030
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Abstract

Background The relationship between depression and dementia is complex and appreciation of its true nature is evolving. Depression is an early symptom of dementia. Recent research suggests that mood disorders, in general, may be risk factors for the development of dementia.Method This was a cross-sectional study of the effect of aging on cognition in patients with mood disorders compared to normal controls. Patients and controls were tested with a comprehensive neurocognitive test battery, CNS Vital Signs. The question at issue was the rate of aging-related cognitive decline the same or different in mood disorder patients compared to normal controls.Subjects 455 patients with mood disorders, 336 with major depression and 119 with bipolar affective disorder, age 18-86, and 1003 normal controls, age 35-90. Normal controls were age 18 or older in the CNS Vital Signs normative database. The normal subjects were healthy, on no centrally-active medication, and free of psychiatric and neurological disorders.Results Cognitive performance in the two groups run in parallel from age 18 to 45; they begin to diverge during the next decade; after age 65, mood disorder patients, as a group, decline more sharply than normal controls. The differential rate of decline was seen in the domains of memory, attention, processing speed and executive function.Conclusions There seems to be an acceleration in age-related cognitive decline in patients with depression in particular, and mood disorders in general, compared to age-matched normal controls. It is likely, then, that as people age, the ones who develop depression, or who fail to recover from early episodes of depression, include a substantial number of patients at risk for developing dementia. This is consistent with the fact that late-life depression may be an early manifestation of dementia. The data are also consistent with the idea that mood disorders are a risk factor, albeit a weak one, for the development of dementia. From a slightly different perspective, one might imagine that some pathophysiological event is shared by the mood disorders and dementing conditions.

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  • Elderly individuals with depression have accelerated cognitive decline.

    “Furthermore, elderly individuals with depression also have accelerated cognitive decline.”

    From Microglia Priming with Aging and Stress (2017) · cites this paper as Gualtieri and Johnson, 2008

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Authors
Gualtieri, C. T., & Johnson, L. G.
Corresponding author
Gualtieri, C. Thomas
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2008-05
Volume
32
Issue
4
Pages
962-967
ISSN
0278-5846 (ISSN-L)
DOI
10.1016/j.pnpbp.2007.12.030
OpenAlex
W1973257488
Cited by
80
References
39
Citations by year
2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 10
FWCI
6.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bristol-Myers Squibb
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
age-related cognitive decline, mood disorders, depression, bipolar disorder, dementia risk, geriatric depression, memory, attention, processing speed, executive function, CNS Vital Signs
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, Attention, Cognition, Cross-Sectional Studies, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Risk Factors, Mood Disorders

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