Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

Beblo, Thomas; Sinnamon, Grant; Baune, Bernhard T.

doi:10.1007/s11065-011-9171-0

Cited by 128Bipolar Disorder and TreatmentNeural and Behavioral Psychology StudiesTreatment of Major Depression

Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

Beblo, Thomas, Sinnamon, Grant, Baune, Bernhard T.·2011·Neuropsychology Review

DOI 10.1007/s11065-011-9171-0

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Abstract

Neuropsychological research in patients with affective disorders shows heterogeneous results with regard to the severity and profile of cognitive impairments. In this paper we hypothesize that the investigation of clinical (subtypes, comorbidity, traumatization, personality, severity, diurnal swings, course, duration, age of onset, biased processing, rumination, motivation, experience of failure, sleep, suicidal tendencies, computer attitudes), demographic (age, education, gender) and neurobiological factors (structural and functional brain changes, glucocorticoids, medication, ECT) that are related to cognitive performance has specified the understanding of severity and profile of neuropsychological impairments. We reviewed the literature pertaining to clinical, demographic and neurobiological factors following Pubmed and PsychInfo databases using different combinations of general key-terms including "Affective Disorder," "Depression," "Mania," "Neuropsychological," "Neurobiological," "Moderator," and "Review" as well as more specific demographic, clinical and neurobiological search terms. Findings from the literature show that the consideration of these factors has improved knowledge about the severity of neuropsychological impairments in patients with affective disorders whereas the neuropsychological profile is still poorly understood. Despite limited understanding, however, the existent results provide promising suggestions for the development of treatment programs.

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Cognitive dysfunction in MDD includes psychomotor processing, declarative memory, working memory, executive functions, and attention.
“Research suggests that cognitive dysfunction in MDD includes psychomotor processing, declarative memory, working memory, executive functions, and attention.24,25”
From A Randomized Controlled Study of Efficacy and Cognitive Function Improvement of Vortioxetine and Escitalopram in Patients with Depression in Chinese Han Nationality (2024) · cites this paper as [24]
Heterogeneous demographic features, clinical compositions, and treatment assignments likely play a major role in producing the inconclusive findings reported in available studies of cognition in major depressive disorder.
“Altogether, these variables likely play a major role in producing the inconclusive findings reported in available studies [28].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [28]

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Authors: Beblo, T., Sinnamon, G., & Baune, B. T.
Affiliations: Evangelisches Krankenhaus Bielefeld (DE)
The University of Adelaide (AU)
Corresponding author: Beblo, Thomas
ORCID: Beblo, Thomas
Sinnamon, Grant
Baune, Bernhard T.
Venue: Neuropsychology Review
Publisher: Springer Science and Business Media LLC
Published: 2011-06-10
Volume: 21
Issue: 4
Pages: 337-359
ISSN: 1040-7308 (ISSN-L)
1573-6660
DOI: 10.1007/s11065-011-9171-0
OpenAlex: W2012053067
Cited by: 128
References: 219
Citations by year: 2026: 3 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 12 · 2016: 17 · 2015: 14 · 2014: 8 · 2013: 9 · 2012: 10
FWCI: 1.17
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychology Review (publishedVersion)
PubMed (publishedVersion)
ResearchOnline - JCU (James Cook University) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: mood disorders, neuropsychological deficits, cognitive impairment, depression, mania, comorbidities, trauma, personality, disease severity, diurnal variation, sleep, suicidality, rumination, motivation, glucocorticoids, electroconvulsive therapy, medication effects, demographic factors, age of onset, treatment development
MeSH terms: Bipolar Disorder, Brain, Cognition Disorders, Depressive Disorder, Humans, Neurobiology, Neuropsychological Tests, Neuropsychology, Comorbidity, Mood Disorders

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Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

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