The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.
TNF-α as a molecular target in bipolar disorder
Abstract
The pathophysiology of bipolar disorder (BD) is poorly understood. An emerging body of evidence points to impairments in neuroplasticity, cell resilience and neuronal survival as the main neuropathological correlates of BD. It has been suggested that inflammatory cytokines, particularly TNF-alpha may play a critical role in this process. In the present review we examine the evidence suggesting that TNF-alpha regulates apoptotic cascades which may be related to neuronal and glial loss in BD. Current evidence suggests that an increase in serum levels of TNF-alpha takes place during manic and depressive episodes. The present article reviews the therapeutic implications of TNF-alpha signaling pathways involvement in the pathophysiology of BD.
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In the citing paper
“TNF-α antagonists, such as adalimumab, etanercept, and infliximab, have been used as therapeutic agents for rheumatic diseases, and are currently being used in clinical trials to treat the depressive episodes of patients with bipolar disorder[64].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [64]
In the citing paper
“Current evidence suggests that TNF-α regulates apoptotic cascades that may be associated with neuronal and glial loss in bipolar disorder.”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [64]
Citations
Cites
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235
Mood disorders in the medically ill: scientific review and recommendations
Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.001 · Cited by 1,071
Mortality of patients with mood disorders: follow-up over 34–38 years
Angst, F., Stassen, H. H., Clayton, P. J., & Angst, J. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00377-9 · Cited by 881
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822
Cytokines and the Brain: Implications for Clinical Psychiatry
Kronfol, Z., & Remick, D. G. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.683 · Cited by 784
Depressive disorders and immunity: 20 years of progress and discovery
Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659
Functional outcome in bipolar disorder: the role of clinical and cognitive factors
Martínez‐Arán, A., Vieta, E., Torrent, C., Sánchez‐Moreno, J., Goikolea, J. M., Salamero, M., Malhi, G. S., González-Pinto, A. M., Daban, C., Alvarez-Grandi, S. A., et al. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00327.x · Cited by 615
Roles for NF-κB in nerve cell survival, plasticity, and disease
Mattson, M. P., & Meffert, M. K. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401837 · Cited by 612
Research works printed but not linked: 2
- Balakumar, 2006, Anti-tumor necrosis factor-α in heart failure: future directions, Pharmacol Toxicol, 99, 391
- Kim, 2003, Association Study of Tumor Necrosis Factor-Alpha Gene Polymorphism in schizophrenia and bipolar disorder, J Korean Neuropsychiatr Assoc, 42, 559
Cited by
Sorted by citations
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178
Self-citationAggarwal, B. B., Gupta, S. C., & Kim, J. H. (2012) · Blood · doi:10.1182/blood-2011-04-325225 · Cited by 877
Kauer‐Sant’Anna, M., Kapczinski, F. P., Andreazza, A. C., Bond, D. J., Lam, R. W. M., Young, L. T., & Yatham, L. N. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009310 · Cited by 442
Self-citationRao, J. S., Harry, G. J., Rapoport, S. I., & Kim, H. W. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.47 · Cited by 432
Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
Brietzke, E., Stertz, L., Fernandes, B. S., Kauer-Sant’Anna, M., Mascarenhas, M., Escosteguy Vargas, A., Chies, J. A., & Kapczinski, F. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.12.001 · Cited by 423
Self-citation
Metadata
- Authors
- Brietzke, E., & Kapczinski, F.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Kapczinski, Flávio
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 32
- Issue
- 6
- Pages
- 1355-1361
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2003038736
- Cited by
- 163
- References
- 58
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 15 · 2014: 16 · 2013: 18 · 2012: 8
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- TNF-α, bipolar disorder, neuroinflammation, inflammatory cytokines, apoptosis, neuroplasticity, neuronal survival, manic and depressive episodes, serum TNF-α levels, therapeutic target
- MeSH terms
- Animals, Bipolar Disorder, Cell Survival, Cognition Disorders, Humans, Tumor Necrosis Factor-alpha, Cytokines, NF-kappa B, Apoptosis, Antimanic Agents, Mood Disorders
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