Cited by 163Bipolar Disorder and TreatmentTryptophan and brain disordersTreatment of Major Depression

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TNF-α as a molecular target in bipolar disorder

Brietzke, Elisa, Kapczinski, Flávio·2008·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2008.01.006

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Abstract

The pathophysiology of bipolar disorder (BD) is poorly understood. An emerging body of evidence points to impairments in neuroplasticity, cell resilience and neuronal survival as the main neuropathological correlates of BD. It has been suggested that inflammatory cytokines, particularly TNF-alpha may play a critical role in this process. In the present review we examine the evidence suggesting that TNF-alpha regulates apoptotic cascades which may be related to neuronal and glial loss in BD. Current evidence suggests that an increase in serum levels of TNF-alpha takes place during manic and depressive episodes. The present article reviews the therapeutic implications of TNF-alpha signaling pathways involvement in the pathophysiology of BD.

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Authors: Brietzke, E., & Kapczinski, F.
Affiliations: Universidade Federal do Rio Grande do Sul (BR)
Corresponding author: Kapczinski, Flávio
ORCID: Brietzke, Elisa
Kapczinski, Flávio
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-08
Volume: 32
Issue: 6
Pages: 1355-1361
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2008.01.006
OpenAlex: W2003038736
Cited by: 163
References: 58
Citations by year: 2026: 3 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 15 · 2014: 16 · 2013: 18 · 2012: 8
FWCI: 1.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: TNF-α, bipolar disorder, neuroinflammation, inflammatory cytokines, apoptosis, neuroplasticity, neuronal survival, manic and depressive episodes, serum TNF-α levels, therapeutic target
MeSH terms: Animals, Bipolar Disorder, Cell Survival, Cognition Disorders, Humans, Tumor Necrosis Factor-alpha, Cytokines, NF-kappa B, Apoptosis, Antimanic Agents, Mood Disorders

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TNF-α as a molecular target in bipolar disorder

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