Midline brain structures in teenagers with first-presentation borderline personality disorder
Abstract
Brain morphologic changes have been reported in borderline personality disorder (BPD), but it remains largely unknown whether BPD is associated with midline brain abnormalities. We used magnetic resonance imaging to investigate the length of the adhesio interthalamica (AI) and cavum septum pellucidum (CSP) as well as third ventricular volume in 20 teenagers with first-presentation BPD and 20 healthy controls. While the CSP length did not differ between the groups, the AI was significantly shorter in BPD patients than in controls. Furthermore, the BPD patients had a significantly larger third ventricle than controls. These preliminary findings suggest that ongoing neuroimaging studies should further evaluate a potential involvement of midline brain structures in the pathogenesis of BPD.
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Other research found no relationship between NSSI and OFC, midline structures, or STG.
“Other research found no relationship with the OFC (66), midline structures (67), or STG (68).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [67]
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- Authors
- Takahashi, T., Chanen, A. M., Wood, S. J., Walterfang, M., Harding, I. H., Yücel, M., Nakamura, K., McGorry, P. D., Suzuki, M., Velakoulis, D., & Pantelis, C.
- Affiliations
- The University of Melbourne (AU)
- University of Toyama (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Takahashi, Tsutomu
- ORCID
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 33
- Issue
- 5
- Pages
- 842-846
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2002934811
- Cited by
- 33
- References
- 39
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- borderline personality disorder, cavum septum pellucidum, third ventricle, adolescents, brain structure, neuroimaging
- MeSH terms
- Adolescent, Age Factors, Borderline Personality Disorder, Humans, Magnetic Resonance Imaging, Psychiatric Status Rating Scales, Septum Pellucidum, Thalamus, Third Ventricle, Young Adult
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