Anterior cingulate volume in adolescents with first-presentation borderline personality disorder
Abstract
Reports of volumetric abnormalities in the anterior cingulate cortex (ACC) in adults with established borderline personality disorder (BPD) are inconsistent, and it is not known whether such abnormalities are present early in the disorder. We aimed to investigate ACC volume in a first-presentation teenage BPD sample with minimal exposure to treatment. Fifteen female BPD patients and 15 healthy female control participants underwent magnetic resonance imaging (MRI) scanning. ACC volumes were estimated using a reliable method that accounts for inter-individual variation in sulcal morphology, and measurements were compared between the two groups. Analysis of variance revealed a decrease in volume of the left ACC in BPD patients compared with control participants. This volumetric change was correlated with parasuicidal behavior and impulsivity. A measure of ACC volume asymmetry was also correlated with fear of abandonment symptoms. Our results suggest that ACC volumetric abnormalities early in the course of BPD might be related to clinical correlates of the disorder. Longitudinal studies are needed to examine the nature of this abnormality over the course of the disorder.
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Reduced anterior cingulate cortex volume is associated with STB and NSSI in youth.
“there is reduced anterior cingulate cortex volume related to STB and NSSI.”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [69]
Among adolescents with BPD, more lifetime parasuicidal behaviors in the past 6 months associates with smaller left ACC volume, consistent with findings comparing past-year self-injurers and healthy youth.
“Among adolescents with BPD, a greater number of lifetime parasuicidal behaviors in the past 6 months associates with smaller left ACC volume (69), consistent with findings comparing past-year self-injurers and healthy youth (64).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [69]
NSSI research reveals ACC structural alterations and disruptions in amygdala and ACC connectivity, which contribute to hyperarousal and reduced impulse control, central features of NSSI.
“By contrast, NSSI research reveals ACC structural alterations (64, 69) as well as disruptions in amygdala and ACC connectivity (96), which contributes to hyperarousal and reduced impulse control—central features of NSSI (110, 111).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [69]
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- Authors
- Whittle, S., Chanen, A. M., Fornito, A., McGorry, P. D., Pantelis, C., & Yücel, M.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Yücel, Murat
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 172
- Issue
- 2
- Pages
- 155-160
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2023217661
- Cited by
- 105
- References
- 56
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 11 · 2013: 10 · 2012: 11
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- borderline personality disorder, anterior cingulate cortex, brain volume, adolescents, initial presentation, parasuicide, impulsivity, fear of abandonment, hemispheric lateralization, sulcal morphology, neuroanatomical correlates
- MeSH terms
- Adolescent, Age Factors, Atrophy, Borderline Personality Disorder, Brain, Brain Mapping, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Limbic System, Magnetic Resonance Imaging, Young Adult
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