Differential pattern of heart rate variability in patients with schizophrenia
Abstract
The cardiac autonomic dysfunction has been reported in patients with schizophrenia. Heart rate variability (HRV) provides non-invasive indices of cardiac autonomic modulation. This study examined whether patients with schizophrenia may show a distinctive pattern of HRV compared to healthy controls. Nine measures of time, frequency and complexity domains were extracted from 5-min resting evaluation of HRV in 30 unmedicated patients with schizophrenia and 30 age- and gender-matched controls. In addition to inferential statistics, a hierarchical clustering (HC) was used to examine difference in the interrelationships among HRV measures between the two groups. Multivariate analysis of variance revealed a significant group effect. Significantly lower sample entropy (SampEn) and a trend towards a higher ratio of low- to high frequency (LF/HF) were observed in the schizophrenia group. In the results of HC using Ward's method, SampEn co-clustered with LF/HF ratio in patients with schizophrenia compared to the separation of LF/HF ratio in healthy controls. In concert with decreased parasympathetic activity, low complexity of heart rate dynamics may reduce adaptability of cardiovascular system to changes in internal or external environment, thus increasing the risk of cardiovascular events. Diverse HRV measures combined in a multivariate fashion appear to be useful in understanding the pattern of neurocardiac modulation in patients with schizophrenia.
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Other studies have reported a trend towards a higher LF/HF ratio in schizophrenia compared with healthy control groups.
“In contrast, other studies have reported a trend towards a higher LF/HF ratio in SCZ compared to HC groups35–37.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [35]
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- Authors
- Chang, J. S., Yoo, C. S., Yi, S. H., Hong, K. H., Oh, H. S., Hwang, J. Y., Kim, S.-G., Ahn, Y. M., & Kim, Y. S.
- Affiliations
- Seoul National University Bundang Hospital (KR)
- Inje University (KR)
- Yongin Mental Hospital (KR)
- Seoul National University Hospital (KR)
- Seoul National University (KR)
- Corresponding author
- Kim, Yong Sik
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 33
- Issue
- 6
- Pages
- 991-995
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2062266966
- Cited by
- 65
- References
- 53
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Seoul National University Hospital
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- heart rate variability, schizophrenia, cardiac autonomic dysfunction, sample entropy, LF/HF ratio, parasympathetic activity, cardiovascular risk
- MeSH terms
- Adult, Electrocardiography, Female, Heart Rate, Humans, Male, Schizophrenia, Cluster Analysis, Young Adult
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