The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids
Open accessAbstract
“K2” and “Spice” drugs (collectively hereafter referred to as Spice) represent a relatively new class of designer drugs that have recently emerged as popular alternatives to marijuana, otherwise characterized as “legal highs”. These drugs are readily available on the Internet and sold in many head shops and convenience stores under the disguise of innocuous products like herbal blends, incense, or air fresheners. Although package labels indicate “not for human consumption”, the number of intoxicated people presenting to emergency departments is dramatically increasing. The lack of validated and standardized human testing procedures and an endless supply of potential drugs of abuse are primary reasons why researchers find it difficult to fully characterize clinical consequences associated with Spice. While the exact chemical composition and toxicology of Spice remains to be determined, there is mounting evidence identifying several synthetic cannabinoids as causative agents responsible for psychoactive and adverse physical effects. This review provides updates of the legal status of common synthetic cannabinoids detected in Spice and analytical procedures used to test Spice products and human specimens collected under a variety of clinical circumstances. The pharmacological and toxicological consequences of synthetic cannabinoid abuse are also reviewed to provide a future perspective on potential short- and long-term implications.
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Cites
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Cited by
Gone to Pot – A Review of the Association between Cannabis and Psychosis
Radhakrishnan, R., Wilkinson, S. T., & D’Souza, D. C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00054 · Cited by 310
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Self-citationThe adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects
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Novel halogenated derivates of JWH-018: behavioral and binding studies in mice
Vigolo, A., Ossato, A., Trapella, C., Vincenzi, F., Rimondo, C., Seri, C., Varani, K., Serpelloni, G., & Marti, M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.008 · Cited by 91
Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms
DeVuono, M. V., & Parker, L. A. (2020) · Cannabis & Cannabinoid Research · doi:10.1089/can.2019.0059 · Cited by 87
Metadata
- Authors
- Seely, K. A., Lapoint, J., Moran, J. H., & Fattore, L.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 39
- Issue
- 2
- Pages
- 234-243
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2110036909
- Cited by
- 465
- References
- 106
- FWCI
- 62.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Seely, K. A., Lapoint, J., Moran, J. H., & Fattore, L. (2012). Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids. Progress in Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/j.pnpbp.2012.04.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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