Serotonin 5-HT2A receptor polymorphisms are associated with irritability and aggression in conduct disorder
Open accessAbstract
In childhood and adolescence, overt antisocial and aggressive manifestations are typically diagnosed as conduct disorder (CD). Given that the emerging research has pointed to the influence of 5-HT 2A receptors in the ontogeny of aggression, we aimed to analyze the association of its genetic polymorphisms with CD. The study included 228 male adolescent subjects (120 with and 108 without CD). CD was diagnosed according to Structured Clinical Interview for DSM-IV criteria, while evaluations of aggressive/dissociative behaviors were performed using psychometric questionnaires including the PCL-YV, OAS-M, KADS, and CBCL. Platelet 5-HT concentration was determined by spectrophotofluorometry. Genotyping of 5-HT 2A receptor polymorphisms rs2070040, rs9534511, rs4142900, rs9534512 was performed using TaqMan SNP Genotyping Assays. Subjective irritability, physical aggression toward others, and antisocial behavior were strongly associated with the G allele of rs2070040 and rs4142900, and the C allele of rs9534511 and rs9534512. A significantly increased platelet 5-HT concentration in CD subjects, compared to controls, was lost after the correction according to the smoking status. Our results indicate an association of the studied HTR2A polymorphisms and their haplotypes with irritability and impulsivity traits, which may contribute to the aggressive and antisocial behavior in male adolescents with CD.
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Archer, N. P., Wilkinson, A. V., Ranjit, N., Wang, J., Zhao, H., Swann, A. C., & Shete, S. S. (2014) · Brain and Behavior · doi:10.1002/brb3.236 · Cited by 6 · see citing works
Langevin, S., Mascheretti, S., Côté, S. M., Vitaro, F., Boivin, M., Turecki, G., Tremblay, R. E., & Ouellet‐Morin, I. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.251 · Cited by 6 · see citing works
Podobnik, J., Perković, M. N., Erjavec, G. N., Ćurković, K. D., Ćurković, M., Kovač, V., Štrac, D. Š., Cusek, M., Bortolato, M., & Pivac, N. (2020) · Biomolecules · doi:10.3390/biom10111555 · Cited by 5 · see citing works
Self-citationGolub, T. L., Uzun, S., Mimica, N., Kozumplik, O., Kalinić, D., Petrović, Z. K., Grošić, P. F., & Pivac, N. (2021) · Stress · doi:10.1080/10253890.2021.1920918 · Cited by 5 · see citing works
Self-citationLin, C., Hu, Z., Yan, Z., Li, W., Chen, Y., Zhao, J., Zhang, L.-Q., Zhao, B., Zhong, W., & Du, F. (2015) · PubMed Central · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33 · see citing works
Cheng, N., Ma, H., Zhang, K., Zhang, C., & Geng, D. (2023) · Medicina · doi:10.3390/medicina59030503 · Cited by 17 · see citing works
- Authors
- Nedic Erjavec, G., Tudor, L., Nikolac Perkovic, M., Podobnik, J., Dodig Curkovic, K., Curkovic, M., Svob Strac, D., Cusek, M., Bortolato, M., & Pivac, N.
- Affiliations
- Ruđer Bošković Institute (HR)
- Children's Hospital Zagreb (HR)
- University of Utah (US)
- Corresponding author
- Bortolato, Marco
- Pivac, Nela
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 117
- Pages
- 110542
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W4220813185
- Cited by
- 18
- References
- 98
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 2
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- fulir.irb.hr
- Licence
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- 5-HT2A receptor, conduct disorder, irritability, aggression, antisocial behavior, platelet serotonin, adolescent boys, genetic association, haplotypes, impulsivity, smoking
- MeSH terms
- Adolescent, Aggression, Blood Platelets, Humans, Male, Polymorphism, Genetic, Conduct Disorder, Receptor, Serotonin, 5-HT2A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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