The Neurobiology of Impulsive Aggression
Open accessAbstract
This selective review provides a model of the neurobiology of impulsive aggression from a cognitive neuroscience perspective. It is argued that prototypical cases of impulsive aggression, those associated with anger, involve the recruitment of the acute threat response system structures; that is, the amygdala, hypothalamus, and periaqueductal gray. It is argued that whether the recruitment of these structures results in impulsive aggression or not reflects the functional roles of ventromedial frontal cortex and dorsomedial frontal and anterior insula cortex in response selection. It is also argued that impulsive aggression may occur because of impaired decision making. The aggression may not be accompanied by anger, but it will reflect disrupted evaluation of the rewards/benefits of the action.
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The insula mediates states of anger, aggression, and social emotion.
“In addition, the insula has also been reported to mediate the states of anger, aggression, and social emotion [62,[67][68][69].”
From The Insular Cortex: An Interface Between Sensation, Emotion and Cognition (2024) · cites this paper as [68]
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Reduced neural responsiveness to looming stimuli is associated with increased aggression
Blair, J., Zhang, R., Bashford‐Largo, J., Bajaj, S., Mathur, A., Ringle, J. L., Schwartz, A., Elowsky, J., Dobbertin, M. D., Blair, K. S., et al. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab058 · Cited by 9 · see citing works
Neurobiological Bases of Alcohol Consumption After Social Stress
Miczek, K. A., DiLeo, A., Newman, E. L., Akdilek, N., & Covington, H. E. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_273 · Cited by 10 · see citing works
- Authors
- Blair, R. J. R.
- Affiliations
- National Institutes of Health
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2016-02
- Volume
- 26
- Issue
- 1
- Pages
- 4-9
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- PMC
- PMC4779272
- OpenAlex
- W2245990605
- Cited by
- 235
- References
- 71
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 29 · 2023: 31 · 2022: 20 · 2021: 36 · 2020: 28 · 2019: 15 · 2018: 13 · 2017: 9 · 2016: 5 · 2013: 1
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (1-ZIA-MH002860, 1‑ZIA‑MH002860‑08, ZIAMH002860)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
- Keywords
- impulsive aggression, neurobiology of aggression, amygdala, hypothalamus, periaqueductal gray, ventromedial prefrontal cortex, dorsomedial prefrontal cortex, anterior insula, response selection, decision-making, reward evaluation, anger
- MeSH terms
- Aggression, Brain, Humans, Impulsive Behavior, Neurobiology
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