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Cited by 152Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyPsychopathy, Forensic Psychiatry, Sexual Offending

Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population

Cadoret, Remi J., Langbehn, Douglas, Caspers, Kristin, Troughton, Edward P., Yucuis, Rebecca, Sandhu, Harinder K., Philibert, Robert·2003·Comprehensive Psychiatry
DOI 10.1053/comp.2003.50018
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Abstract

Prior studies of the Iowa Adoption cohorts have demonstrated that the degree of adoptee aggressiveness and conduct disorder has a significant genetic component. Other studies have implicated the neurotransmitter serotonin or polymorphisms in the serotonin transporter gene (5HTT) as an important source of variability in "externalizing" behaviors such as aggressivity, conduct disorder, and attention deficit-hyperactivity disorders (ADHD). Following this lead, we genotyped a subgroup of adoptees (n = 87) at high risk for these kinds of disorders with respect to the serotonin-transporter-linked promoter region (5HTTLPR) polymorphism, and used ordinal logistic regression to conduct an association study. Primary analysis failed to detect a main effect between 5HTTLPR status and subscales of aggressivity, conduct disorder, or attention deficit. However, when biologic parent status and sex of proband were considered, certain interactions between 5HTTLPR and other genetic risk factors were evident. One type of interaction with the LL variant of 5HTTLPR increased externalizing behavior in individuals with antisocial biologic parentage; a second interaction with one or more 5HTTLPR short variants (SS or SL) appeared to increase externalizing behaviors in conjunction with a genetic diathesis for alcoholism. Gender of adoptee also appeared to interact with 5HTTLPR. Male individuals with the short variant were more likely to have higher symptom counts for conduct disorder, aggressivity, and ADHD. In contrast, among females, the short variant (SS, SL) was associated with lower levels of such behavior. The results support the hypothesis that gene-biological family history interactions are involved in the externalizing behaviors studied and constitute interesting findings for future replication.

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  • Male children with S/S or S/L (short) demonstrated increased aggressive behaviors while females with the SS and SL demonstrated lower levels of aggression.

    “Male children with S/S or S/L (short) demonstrated increased aggressive behaviors while females with the SS and SL demonstrated lower levels of aggression.”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as [90]

  • The initial analyses of the study on 87 adopted children from the United States of America failed to detect a main effect of 5-HTTLPR and aggressive scores.

    “Similarly, the initial analyses of the study on 87 adopted children from the United States of America further failed to detect a main effect of 5-HTTLPR and aggressive scores [90].”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as [90]

  • When the biological parent status and sex of the children were included in the analyses, the results were significant.

    “However interestingly, when the biological parent status and sex of the children were included in the analyses, the results were significant.”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as [90]

  • When the biological parent of the child was considered antisocial, adolescents, but not preadolescents, demonstrated a significant increase in aggressive behaviors with the L/L genotype.

    “Moreover, when the biological parent of the child was considered antisocial, adolescents, but not preadolescents, demonstrated a significant increase in aggressive behaviors with the L/L genotype [90].”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as [90]

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Authors
Cadoret, R. J., Langbehn, D., Caspers, K., Troughton, E. P., Yucuis, R., Sandhu, H. K., & Philibert, R.
Affiliations
University of Iowa (US)
ORCID
Venue
Comprehensive Psychiatry
Publisher
Elsevier BV
Published
2003-03
Volume
44
Issue
2
Pages
88-101
ISSN
0010-440X (ISSN-L)
DOI
10.1053/comp.2003.50018
OpenAlex
W2068113020
Cited by
152
References
60
Citations by year
2025: 2 · 2024: 4 · 2023: 3 · 2022: 3 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 11 · 2013: 8 · 2012: 3
FWCI
3.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Comprehensive Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institute on Drug Abuse (R01DA005821, DA-05821)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords
serotonin transporter, aggression, conduct disorder, attention deficits, attention deficit hyperactivity disorder, externalizing problems, gene-environment interaction, sex differences, adopted children
MeSH terms
Adolescent, Adoption, Adult, Aggression, Attention Deficit Disorder with Hyperactivity, Carrier Proteins, Child, Child, Preschool, Female, Humans, Male, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Polymorphism, Genetic, Promoter Regions, Genetic, Regression Analysis, Serotonin, Sex Factors, Conduct Disorder, Genetic Predisposition to Disease, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins

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