The DOI matches its Crossref record; 543 of the 543 references it cites were found in a registry or an index.
Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects
Abstract
Müller cells are active players in normal retinal function and in virtually all forms of retinal injury and disease. Reactive Müller cells protect the tissue from further damage and preserve tissue function by the release of antioxidants and neurotrophic factors, and may contribute to retinal regeneration by the generation of neural progenitor/stem cells. However, Müller cell gliosis can also contribute to neurodegeneration and impedes regenerative processes in the retinal tissue by the formation of glial scars. This article provides an overview of the neuroprotective and detrimental effects of Müller cell gliosis, with accounts on the cellular signal transduction mechanisms and factors which are implicated in Müller cell-mediated neuroprotection, immunomodulation, regulation of Müller cell proliferation, upregulation of intermediate filaments, glial scar formation, and the generation of neural progenitor/stem cells. A proper understanding of the signaling mechanisms implicated in gliotic alterations of Müller cells is essential for the development of efficient therapeutic strategies that increase the supportive/protective and decrease the destructive roles of gliosis.
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“MG of the mammalian retina exhibit a reactive gliotic response to injury that often causes more harm than good”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Bringmann et al., 2009
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Cites
CD44: From adhesion molecules to signalling regulators
Ponta, H., Sherman, L. S., & Herrlich, P. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1004 · Cited by 2,458
Prostanoid Receptors: Structures, Properties, and Functions
Narumiya, S., Sugimoto, Y., & Ushikubi, F. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1193 · Cited by 2,417
Müller cells in the healthy and diseased retina
Bringmann, A., Pannicke, T., Grosche, J., Francke, M., Wiedemann, P., Skatchkov, S. N., Osborne, N. N., & Reichenbach, A. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.05.003 · Cited by 1,967
Self-citationThe glial scar and central nervous system repair
Fawcett, J. W., & Asher, R. A. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00072-6 · Cited by 1,808
Astrocyte glutamate transport: Review of properties, regulation, and physiological functions
Anderson, C. M., & Swanson, R. A. (2000) · Glia · doi:10.1002/1098-1136(200010)32:1 · Cited by 1,241
Sugimoto, Y., & Narumiya, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r600038200 · Cited by 1,203
Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo
Crawford, S. E., Stellmach, V. M., Murphy-Ullrich, J. E., Ribeiro, S. M. F., Lawler, J., Hynes, R. O., Boivin, G. P., & Bouck, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81460-9 · Cited by 1,176
Retinal Stem Cells in the Adult Mammalian Eye
Tropepe, V., Coles, B. L. K., Chiasson, B. J., Horsford, D. J., Elia, A., McInnes, R. R., & van der Kooy, D. (2000) · Science · doi:10.1126/science.287.5460.2032 · Cited by 1,090
The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina
Lucas, D., & Newhouse, J. P. (1957) · Archives of Ophthalmology · doi:10.1001/archopht.1957.00940010205006 · Cited by 1,069
Banati, R. B., Gehrmann, J., Schubert, P., & Kreutzberg, G. W. (1993) · Glia · doi:10.1002/glia.440070117 · Cited by 1,032
Research works printed but not linked: 4
- Bringmann, 2003, Proliferation of retinal glial (Müller) cells: role of P2 receptors and potassium channels, Biomed. Res., 14, 38
- Elner, 1992, Intercellular adhesion molecule-1 gene expression and production by human Müller cells, Invest. Ophthalmol. Vis. Res., 33, S797
- Gao, 1995, Elevated expression of basic fibroblast growth factor during photoreceptor degeneration caused by light damage and genetic defects, Invest. Ophthalmol. Vis. Sci., 36, S203
- Kusner, 2004, Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase: a role in high glucose-induced apoptosis in retinal Müller cells, Invest. Ophthalmol. Vis. Sci., 45, 1553
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Bringmann, A., & Wiedemann, P. (2012) · Ophthalmologica · doi:10.1159/000328979 · Cited by 436
Self-citationCuenca, N., Fernández-Sánchez, L., Campello, L., Maneu, V., De la Villa, P., Lax, P., & Pinilla, I. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.07.001 · Cited by 401
HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration
Wan, J., Ramachandran, R., & Goldman, D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.020 · Cited by 262
“In general, MG of the mammalian retina exhibit a reactive gliotic response to injury that often causes more harm than good (Bringmann et al., 2009).”
BackgroundWang, M., Ma, W., Zhao, L., Fariss, R. N., & Wong, W. T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-173 · Cited by 228
Ramachandran, R., Zhao, X.-F., & Goldman, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107220108 · Cited by 206
Retinal Macroglial Responses in Health and Disease
de Hoz, R., Rojas, B., Ramírez, A. I., Salazar, J. J., Gallego, B. I., Triviño, A., & Ramírez, J. M. (2016) · BioMed Research International · doi:10.1155/2016/2954721 · Cited by 187
Wan, J., Zhao, X.-F., Vojtek, A., & Goldman, D. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.048 · Cited by 143
“anatomical features facilitate its ability to monitor and communicate with neighboring cells (Bringmann et al., 2009; Reichenbach and Bringmann, 2013).”
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Kumar, A., Pandey, R. K., Miller, L. J., Singh, P. K., & Kanwar, M. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013006618 · Cited by 99
Rhee, K. D., Nusinowitz, S., Chao, K., Yu, F., Bok, D., & Yang, X.-J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303604110 · Cited by 92
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Ryskamp, D., Redmon, S., Jo, A., & Križaj, D. (2014) · Cells · doi:10.3390/cells3030914 · Cited by 60
Groeger, G., Doonan, F., Cotter, T. G., & Donovan, M. (2012) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.12-10525 · Cited by 45
Cai, Z., Simons, D. L., Fu, X.-Y., Feng, G.-S., Wu, S. M., & Zhang, X. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05054-11 · Cited by 34
Gao, F., Li, F., Miao, Y., Xu, L.-J., Zhao, Y., Li, Q., Zhang, S.-H., Wu, J., Sun, X.-H., & Wang, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-01557-y · Cited by 34
TNFα activates MAPK and Jak-Stat pathways to promote mouse Müller cell proliferation.
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ERK1/2 pathway is activated in degenerated Rpe65-deficient mice
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Metadata
- Authors
- Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A.
- Affiliations
- University Hospital Leipzig (DE)
- Leipzig University (DE)
- University of Oxford (GB)
- Corresponding author
- Bringmann, Andreas
- Venue
- Progress in Retinal and Eye Research
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 28
- Issue
- 6
- Pages
- 423-451
- ISSN
- 1350-9462 (ISSN-L)
- OpenAlex
- W2080816502
- Cited by
- 761
- References
- 543
- Citations by year
- 2026: 46 · 2025: 55 · 2024: 66 · 2023: 53 · 2022: 53 · 2021: 64 · 2020: 61 · 2019: 44 · 2018: 42 · 2017: 40 · 2016: 39 · 2015: 37 · 2014: 37 · 2013: 40 · 2012: 33
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Retinal and Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- Müller cells, gliosis, retinal damage, neuroprotection, glial scar formation, retinal regeneration, neural progenitor cells, retinal stem cells, signal transduction, intermediate filaments, immunomodulation, neurodegeneration
- MeSH terms
- Animals, Gliosis, Humans, Neuroglia, Retinal Diseases, Signal Transduction, Up-Regulation, Neuroprotective Agents
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