Retinal Macroglial Responses in Health and Disease

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works

Physiology of Microglia

Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works

Tripartite synapses: glia, the unacknowledged partner

Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529 · see citing works

Müller cells in the healthy and diseased retina

Bringmann, A., Pannicke, T., Grosche, J., Francke, M., Wiedemann, P., Skatchkov, S. N., Osborne, N. N., & Reichenbach, A. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.05.003 · Cited by 1,905 · see citing works

Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling

Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846 · see citing works

Tripartite synapses: astrocytes process and control synaptic information

Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820 · see citing works

The glial scar and central nervous system repair

Fawcett, J. W., & Asher, R. A. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00072-6 · Cited by 1,808 · see citing works

Uniquely Hominid Features of Adult Human Astrocytes

Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · see citing works

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

Burda, J. E., & Sofroniew, M. V. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.034 · Cited by 1,431 · see citing works

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.013 · Cited by 1,352 · see citing works

New roles for astrocytes: redefining the functional architecture of the brain.

Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334 · see citing works

Astrocytes are active players in cerebral innate immunity

Farina, C., Aloisi, F., & Meinl, E. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.005 · Cited by 1,304 · see citing works

Immune function of astrocytes

Dong, Y., & Benveniste, E. N. (2001) · Glia · doi:10.1002/glia.1107 · Cited by 1,296 · see citing works

Immune function of microglia

Aloisi, F. (2001) · Glia · doi:10.1002/glia.1106 · Cited by 1,281 · see citing works

Astrocyte glutamate transport: Review of properties, regulation, and physiological functions

Anderson, C. M., & Swanson, R. A. (2000) · Glia · doi:10.1002/1098-1136(200010)32:1 · Cited by 1,218 · see citing works

Glial regulation of the cerebral microvasculature

Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153 · see citing works

Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.

Pierce, E. A., Avery, R. L., Foley, E. D., Aiello, L. P., & Smith, L. E. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.905 · Cited by 1,026 · see citing works

Metabolic coupling between glia and neurons

Tsacopoulos, M., & Magistretti, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00877.1996 · Cited by 1,006 · see citing works

CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

Bezzi, P., Domercq, M., Brambilla, L., Galli, R., Schols, D., De Clercq, E., Vescovi, A., Bagetta, G., Kollias, G., Meldolesi, J., et al. (2001) · Nature Neuroscience · doi:10.1038/89490 · Cited by 964 · see citing works

Astrocyte reactivity and reactive astrogliosis: costs and benefits

Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934 · see citing works

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877 · see citing works

The tripartite synapse: roles for gliotransmission in health and disease

Halassa, M. M., Fellin, T., & Haydon, P. G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.005 · Cited by 852 · see citing works

Astrocyte dysfunction in neurological disorders: a molecular perspective

Seifert, G., Schilling, K., & Steinhäuser, C. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1870 · Cited by 798 · see citing works

Vascular endothelial growth factor in eye disease

Penn, J. S., Madan, A., Caldwell, R. B., Bartoli, M., Caldwell, R. W., & Hartnett, M. E. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.05.001 · Cited by 768 · see citing works

Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects

Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761 · see citing works

Astrocytes: a central element in neurological diseases

Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1513-1 · Cited by 755 · see citing works

Tumor Necrosis Factor-α Induces Neurotoxicity via Glutamate Release from Hemichannels of Activated Microglia in an Autocrine Manner

Takeuchi, H., Jin, S., Wang, J., Zhang, G., Kawanokuchi, J., Kuno, R., Sonobe, Y., Mizuno, T., & Suzumura, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600504200 · Cited by 749 · see citing works

Intercellular signaling in glial cells: Calcium waves and oscillations in response to mechanical stimulation and glutamate

Charles, A. C., Merrill, J. E., Dirksen, E. R., & Sandersont, M. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90238-u · Cited by 736 · see citing works

New functions of Müller cells

Reichenbach, A., & Bringmann, A. (2013) · Glia · doi:10.1002/glia.22477 · Cited by 720 · see citing works

The dual role of astrocyte activation and reactive gliosis

Pekny, M., Wilhelmsson, U., & Pekna, M. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.071 · Cited by 666 · see citing works

CNS energy metabolism as related to function

Ames, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00038-2 · Cited by 663 · see citing works

Discussion

Unknown (1998) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(97)00012-8 · Cited by 570 · see citing works

The optic nerve head in glaucoma: role of astrocytes in tissue remodeling

Hernandez, M. R. (2000) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(99)00017-8 · Cited by 565 · see citing works

The stem cell potential of glia: lessons from reactive gliosis

Robel, S., Berninger, B., & Götz, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2978 · Cited by 546 · see citing works

Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats.

Quigley, H. A., McKinnon, S. J., Zack, D. J., Pease, M. E., Kerrigan, L. A., Kerrigan, D., & Mitchell, R. S. (2000) · PubMed · Cited by 491 · see citing works

Müller cell changes in human diabetic retinopathy.

Mizutani, M., Gerhardinger, C., & Lorenzi, M. (1998) · Diabetes · doi:10.2337/diabetes.47.3.445 · Cited by 481 · see citing works

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

Howell, G. R., Macalinao, D. G., Sousa, G. L., Walden, M., Soto, I., Kneeland, S. C., Barbay, J. M., King, B. L., Marchant, J. K., Hibbs, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44646 · Cited by 473 · see citing works

Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group.

Lieth, E., Barber, A. J., Xu, B., Dice, C., RATZ, M., Tănase, D., & Strother, J. M. (1998) · Diabetes · doi:10.2337/diabetes.47.5.815 · Cited by 468 · see citing works

Control of Müller glial cell proliferation and activation following retinal injury

Dyer, M. A., & Cepko, C. L. (2000) · Nature Neuroscience · doi:10.1038/78774 · Cited by 442 · see citing works

Astrocytes and the regulation of cerebral blood flow

Koehler, R. C., Roman, R. J., & Harder, D. R. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.11.005 · Cited by 439 · see citing works

Antioxidant defense of the brain: a role for astrocytes

Wilson, J. X. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-146 · Cited by 430 · see citing works

Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina

Poitry‐Yamate, C. L., Poitry, S., & Tsacopoulos, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05179.1995 · Cited by 410 · see citing works

Functions of Astrocytes and their Potential As Therapeutic Targets

Kimelberg, H. K., & Nedergaard, M. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.006 · Cited by 409 · see citing works

Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases

Cuenca, N., Fernández-Sánchez, L., Campello, L., Maneu, V., De la Villa, P., Lax, P., & Pinilla, I. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.07.001 · Cited by 401 · see citing works

Up-Regulation of Glial Fibrillary Acidic Protein in Response to Retinal Injury: Its Potential Role in Glial Remodeling and a Comparison to Vimentin Expression

Lewis, G. P., & Fisher, S. K. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)30005-1 · Cited by 380 · see citing works

Retinal neurodegeneration: early pathology in diabetes

Lieth, E., Gardner, T. W., Barber, A. J., & Antonetti, D. A. (2000) · Clinical and Experimental Ophthalmology · doi:10.1046/j.1442-9071.2000.00222.x · Cited by 360 · see citing works

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

González, H., Elgueta, D., Montoya, A., & Pacheco, R. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.07.012 · Cited by 352 · see citing works

Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.

Barber, A. J., Antonetti, D. A., & Gardner, T. W. (2000) · PubMed · Cited by 350 · see citing works

Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood–retinal barrier

Giebel, S. J., Menicucci, G., McGuire, P. G., & Das, A. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700251 · Cited by 326 · see citing works

Role of cholesterol in synapse formation and function

Pfrieger, F. W. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00024-5 · Cited by 325 · see citing works

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-208660 · Cited by 324 · cited 1× · see citing works

Astrocyte control of the cerebrovasculature

Gordon, G. R., Mulligan, S. J., & MacVicar, B. A. (2007) · Glia · doi:10.1002/glia.20543 · Cited by 323 · see citing works

Neuroglia in neurodegeneration

Heneka, M. T., Rodriguez, J. J., & Verkhratsky, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.004 · Cited by 303 · see citing works

Neuroglia: the 150 years after

Kettenmann, H., & Verkhratsky, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.09.003 · Cited by 300 · see citing works

Role of retinal glial cells in neurotransmitter uptake and metabolism.

Bringmann, A., Pannicke, T., Biedermann, B., Francke, M., Iandiev, I., Grosche, J., Wiedemann, P., Albrecht, J., & Reichenbach, A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.014 · Cited by 281 · see citing works

Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis

Nakazawa, T., Hisatomi, T., Nakazawa, C., Noda, K., Maruyama, K., She, H., Matsubara, A., Miyahara, S., Nakao, S., Yin, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608167104 · Cited by 272 · see citing works

The role of müller cells in the formation of the blood-retinal barrier

Tout, S., Chan‐Ling, T., Holländer, H., & Stone, J. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90473-s · Cited by 268 · see citing works

Matrix Metalloproteinases and Tumor Necrosis Factor α in Glaucomatous Optic Nerve Head

Yan, X. (2000) · Archives of Ophthalmology · doi:10.1001/archopht.118.5.666 · Cited by 266 · see citing works

Review: Role of developmental inflammation and blood–brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases

Stolp, H. B., & Dzięgielewska, K. M. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01005.x · Cited by 259 · see citing works

Hypoxia-Inducible Factor 1α in the Glaucomatous Retina and OpticNerve Head

Tezel, G. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.9.1348 · Cited by 252 · see citing works

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

Barcia, C., Ros, C., Annese, V., Gómez, A., Ros-Bernal, F., Aguado-Yera, D., Martı́nez-Pagán, M., de Pablos, V., Fernández-Villalba, E., & Herrero, M. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.17 · Cited by 242 · see citing works

Role of Muller cells in retinal degenerations

Bringmann, A. (2001) · Frontiers in bioscience · doi:10.2741/bringman · Cited by 240 · see citing works

Chronology of optic nerve head and retinal responses to elevated intraocular pressure.

Johnson, E. C., DEPPMEIER, L. M. H., Wentzien, S., Hsu, I., & Morrison, J. C. (2000) · PubMed · Cited by 230 · see citing works

Adaptive Müller Cell Responses to Microglial Activation Mediate Neuroprotection and Coordinate Inflammation in the Retina

Wang, M., Ma, W., Zhao, L., Fariss, R. N., & Wong, W. T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-173 · Cited by 228 · see citing works

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

Gallego, B. I., Salazar, J. J., de Hoz, R., Rojas, B., Ramírez, A. I., Salinas-Navarro, M., Ortín-Martínez, A., Valiente-Soriano, F. J., Avilés-Trigueros, M., Villegas-Perez, M. P., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-92 · Cited by 224 · see citing works

Effect of CNTF on retinal ganglion cell survival in experimental glaucoma

Pease, M. E., Zack, D. J., Berlinicke, C., Bloom, K., Cone, F., Wang, Y., Klein, R. L., Hauswirth, W. W., & Quigley, H. A. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-3013 · Cited by 222 · see citing works

Immunohistochemical Assessment of the Glial Mitogen-Activated Protein Kinase Activation in Glaucoma

Tezel, G., Chauhan, B. C., LeBlanc, R. P., & Wax, M. B. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1136 · Cited by 218 · see citing works

A potassium channel-linked mechanism of glial cell swelling in the postischemic retina

Pannicke, T., Iandiev, I., Uckermann, O., Biedermann, B., Kutzera, F., Wiedemann, P., Wolburg, H., Reichenbach, A., & Bringmann, A. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.04.005 · Cited by 214 · see citing works

Diabetes Alters Osmotic Swelling Characteristics and Membrane Conductance of Glial Cells in Rat Retina

Pannicke, T., Iandiev, I., Wurm, A., Uckermann, O., Hagen, F. V., Reichenbach, A., Wiedemann, P., Hammes, H., & Bringmann, A. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-1349 · Cited by 206 · see citing works

Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma

Inman, D. M., & Horner, P. J. (2007) · Glia · doi:10.1002/glia.20516 · Cited by 205 · see citing works

Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse.

Frasson, M., Picaud, S. A., Léveillard, T., Simonutti, M., Mohand‐Saïd, S., Dreyfus, H., Hicks, D., & Sabel, J. L. (1999) · PubMed · Cited by 202 · see citing works

Complement Component 1Q (C1Q) Upregulation in Retina of Murine, Primate, and Human Glaucomatous Eyes

Stasi, K., Nagel, D., Yang, X., Wang, R., Ren, L., Podos, S. M., Mittag, T. W., & Danias, J. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0830 · Cited by 201 · see citing works

Involvement of Müller glial cells in epiretinal membrane formation

Bringmann, A., & Wiedemann, P. (2009) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-009-1082-x · Cited by 197 · see citing works

Astrocytes in glaucomatous optic neuropathy

Hernandez, M. R., Miao, H., & Lukas, T. J. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)01125-4 · Cited by 193 · see citing works

An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma

Wang, X., Tay, S. S., & Ng, Y. (2000) · Experimental Brain Research · doi:10.1007/s002210000360 · Cited by 191 · see citing works

Pro-inflammatory cytokines induce the transcription factors C/EBP? and C/EBP? in astrocytes

Cardinaux, J., Allaman, I., & Magistretti, P. J. (2000) · Glia · doi:10.1002/(sici)1098-1136(20000101)29:1 · Cited by 183 · see citing works

Human Vascular Endothelial Growth Factor Protects Axotomized Retinal Ganglion CellsIn Vivoby Activating ERK-1/2 and Akt Pathways

Kılıç, Ü., Kılıç, E., Järve, A., Guo, Z., Spudich, A., Bieber, K., Barzena, U., Bassetti, C. L., Marti, H. H., & Hermann, D. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0434-06.2006 · Cited by 178 · see citing works

Attenuated Glial Reactions and Photoreceptor Degeneration after Retinal Detachment in Mice Deficient in Glial Fibrillary Acidic Protein and Vimentin

Nakazawa, T., Takeda, M., Lewis, G. P., Cho, K.-S., Jiao, J., Wilhelmsson, U., Fisher, S. K., Pekny, M., Chen, D. F., & Miller, J. W. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.06-1398 · Cited by 168 · see citing works

Targeted inactivation of dystrophin gene product Dp71: phenotypic impact in mouse retina

Dalloz, C. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg170 · Cited by 160 · see citing works

Differential expression of GFAP in early v late AMD: a quantitative analysis

Wu, K. H. C. (2003) · British Journal of Ophthalmology · doi:10.1136/bjo.87.9.1159 · Cited by 158 · see citing works

Glia in the pathogenesis of neurodegenerative diseases

Verkhratsky, A., Parpura, V., Pekna, M., Pekny, M., & Sofroniew, M. V. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140107 · Cited by 157 · see citing works

Ocular Risk Factors for Choroidal Neovascularization in Pathologic Myopia

Ikuno, Y., Jo, Y., Hamasaki, T., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3493 · Cited by 156 · see citing works

Concurrent downregulation of a glutamate transporter and receptor in glaucoma.

Naskar, R., Vorwerk, C. K., & Dreyer, E. B. (2000) · PubMed · Cited by 153 · see citing works

IFN-γ-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells

Nikcevich, K. M., Gordon, K. B., Tan, L., Hurst, S. D., Kroepfl, J. F., Gardinier, M. V., Barrett, T. A., & Miller, S. D. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.2.614 · Cited by 152 · see citing works

Friend or Foe? Resolving the Impact of Glial Responses in Glaucoma

Johnson, E. C., & Morrison, J. C. (2009) · Journal of Glaucoma · doi:10.1097/ijg.0b013e31818c6ef6 · Cited by 149 · see citing works

Transforming growth factor beta isoforms in human optic nerve heads

Peña, J., Taylor, A. W., Ricard, C. S., VIDAL, I., & Hernandez, M. R. (1999) · British Journal of Ophthalmology · doi:10.1136/bjo.83.2.209 · Cited by 147 · see citing works

α-Aminoadipate Induces Progenitor Cell Properties of Muller Glia in Adult Mice

Takeda, M., Takamiya, A., Jiao, J., Cho, K., Trevino, S. G., Matsuda, T., & Chen, D. F. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0434 · Cited by 135 · see citing works

Expression of ciliary neurotrophic factor activated by retinal Müller cells in eyes with NMDA- and kainic acid-induced neuronal death.

Honjo, M., Tanihara, H., Kido, N., Inatani, M., Okazaki, K., & Honda, Y. (2000) · PubMed · Cited by 134 · see citing works

Changes of Astrocytes in Retinal Ageing and Age-related Macular Degeneration

Ramirez, J. M., Ramirez, A. I., Salazar, J. J., de Hoz, R., & Triviño, A. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.1061 · Cited by 133 · see citing works

Cell Proliferation and Interleukin-6–Type Cytokine Signaling Are Implicated by Gene Expression Responses in Early Optic Nerve Head Injury in Rat Glaucoma

Johnson, E. C., Doser, T. A., Cepurna, W. O., Dyck, J. A., Jia, L., Guo, Y., Lambert, W. S., & Morrison, J. C. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5317 · Cited by 131 · see citing works

The role of glia in retinal vascular disease

Coorey, N. J., Shen, W., Chung, S. H., Zhu, L., & Gillies, M. C. (2012) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2012.00741.x · Cited by 130 · see citing works

Purines in the eye: Recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland

Sanderson, J., Dartt, D. A., Trinkaus‐Randall, V., Pintor, J. J., Civan, M. M., Delamere, N. A., Fletcher, E. L., Salt, T. E., Grosche, A., & Mitchell, C. H. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.08.009 · Cited by 128 · see citing works

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease

Barateiro, A. P., Brites, D. M. T. O., & Fernandes, A. M. A. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151204000636 · Cited by 128 · see citing works

The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes

Kuno, R., Yoshida, Y., Nitta, A., Nabeshima, T., Wang, J., Sonobe, Y., Kawanokuchi, J., Takeuchi, H., Mizuno, T., & Suzumura, A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.120 · Cited by 127 · see citing works

An Experimental Basis for Implicating Excitotoxicity in Glaucomatous Optic Neuropathy

Vorwerk, C. K., Gorla, M., & Dreyer, E. B. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00017-x · Cited by 125 · see citing works

Nitric Oxide Synthase Inhibition Delays Axonal Degeneration and Promotes the Survival of Axotomized Retinal Ganglion Cells

Koeberle, P. D., & Ball, A. K. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7113 · Cited by 118 · see citing works

Dual actions of nitric oxide inN-methyl-d-aspartate receptor-mediated neurotoxicity in cultured retinal neurons

Kashii, S., Mandai, M., Kikuchi, M., Honda, Y., Tamura, Y., Kaneda, K., & Akaike, A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01330-x · Cited by 110 · see citing works

Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure.

Peña, J., Agapova, O. A., Gabelt, B. T., Levin, L. A., Lucarelli, M. J., Kaufman, P. L., & Hernandez, M. R. (2001) · PubMed · Cited by 108 · see citing works

Expression profiles of nestin and synemin in reactive astrocytes and Müller cells following retinal injury: a comparison with glial fibrillar acidic protein and vimentin.

Luna, G., Lewis, G. P., Banna, C. D., Skalli, O., & Fisher, S. K. (2010) · PubMed Central · Cited by 105 · see citing works

The Pathogenesis of Glaucoma in the Interplay with the Immune System

Rieck, J. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9781 · Cited by 104 · see citing works

Phylogenetic constraints on retinal organisation and development

Reichenbach, A., & Robinson, S. R. (1995) · Progress in Retinal and Eye Research · doi:10.1016/1350-9462(95)00008-9 · Cited by 103 · see citing works

Detection of early neuron degeneration and accompanying glial responses in the visual pathway in a rat model of acute intraocular hypertension

Zhang, S., Wang, H., Lu, Q., Qing, G., Wang, N., Wang, Y., Li, S., Yang, D., & Yan, F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.029 · Cited by 99 · see citing works

The fate of Müller's glia following experimental retinal detachment: nuclear migration, cell division, and subretinal glial scar formation.

Lewis, G. P., Chapin, E. A., Luna, G., Linberg, K. A., & Fisher, S. K. (2010) · PubMed Central · Cited by 97 · see citing works

Glial cell interactions and glaucoma

Chong, R. S., & Martin, K. R. G. (2014) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000125 · Cited by 97 · see citing works

The role of Müller glia and microglia in glaucoma

Seitz, R., Ohlmann, A., & Tamm, E. R. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1666-y · Cited by 90 · see citing works

Regulation of Th1 and Th2 Lymphocyte Migration by Human Adult Brain Endothelial Cells

Biernacki, K., Prat, A., Blain, M., & Antel, J. P. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.12.1127 · Cited by 88 · see citing works

Redistribution of glutathione in the ischemic rat retina

Schütte, M., & Werner, P. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00229-8 · Cited by 85 · see citing works

Inhibition of Reactive Gliosis Attenuates Excitotoxicity-Mediated Death of Retinal Ganglion Cells

Sukka-Ganesh, B., & Chintala, S. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018305 · Cited by 82 · see citing works

Ocular inflammation alters swelling and membrane characteristics of rat Müller glial cells

Pannicke, T., Uckermann, O., Iandiev, I., et al. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.003 · Cited by 81 · see citing works

Structural Specializations of Human Retinal Glial Cells

Ramirez, J. M., Triviño, A., Ramirez, A. I., Salazar, J. J., & García-Sánchez, J. (1996) · Vision Research · doi:10.1016/0042-6989(95)00322-3 · Cited by 79 · see citing works

Long-term glial reactivity in rat retinas ipsilateral and contralateral to experimental glaucoma

Kanamori, A., Nakamura, M., Nakanishi, Y., Yamada, Y., & Negi, A. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.01.012 · Cited by 78 · see citing works

High Glucose Alters Retinal Astrocytes Phenotype through Increased Production of Inflammatory Cytokines and Oxidative Stress

Shin, E. S., Huang, Q., Gürel, Z., Sorenson, C. M., & Sheibani, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103148 · Cited by 77 · see citing works

Quantification of the Effect of Different Levels of IOP in the Astroglia of the Rat Retina Ipsilateral and Contralateral to Experimental Glaucoma

Ramirez, A. I., Salazar, J. J., de Hoz, R., Rojas, B., Gallego, B., Salinas‐Navarro, M., Alarcón-Martínez, L., Ortín-Martínez, A., Avilés‐Trigueros, M., Vidal‐Sanz, M., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5248 · Cited by 77 · see citing works

Role of glia in synapse development

Pfrieger, F. W. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00358-6 · Cited by 77 · see citing works

Differential tumor necrosis factor expression by resident retinal cells from experimental uveitis-susceptible and -resistant rat strains

de Kozak, Y., Naud, M., Bellot, J. L., et al. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90141-4 · Cited by 73 · see citing works

Muller Cell Response to Blue Light Injury of the Rat Retina

Iandiev, I., Wurm, A., Hollborn, M., Wiedemann, P., Grimm, C., Remé, C. E., Reichenbach, A., Pannicke, T., & Bringmann, A. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1723 · Cited by 73 · see citing works

Endothelin B Receptors Contribute to Retinal Ganglion Cell Loss in a Rat Model of Glaucoma

Minton, A. Z., Phatak, N., Stankowska, D. L., He, S., Ma, H.-Y., Mueller, B., Jiang, M. H., Luedtke, R. R., Yang, S., Brownlee, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043199 · Cited by 70 · see citing works

Immunohistochemical study of human retinal astroglia

Ramirez, J. M., Triviño, A., Ramirez, A. I., Salazar, J. J., & García-Sánchez, J. (1994) · Vision Research · doi:10.1016/0042-6989(94)90024-8 · Cited by 65 · see citing works

Hypoxia Inducible Factor-1α (HIF-1α) and Some HIF-1 Target Genes are Elevated in Experimental Glaucoma

Ergorul, C., Ray, A., Huang, W., Wang, D. Y., Ben, Y., Cantuti‐Castelvetri, I., & Grosskreutz, C. L. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9343-z · Cited by 64 · see citing works

Retinal vascular changes after glial disruption in rats

Shen, W., Li, S., Chung, S. H., & Gillies, M. C. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22317 · Cited by 62 · see citing works

Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina

Sarup, V., Patil, K., & Sharma, S. C. (2004) · Brain Research · doi:10.1016/j.brainres.2004.03.030 · Cited by 61 · see citing works

Requirement for Nitric Oxide in Retinal Neuronal Cell Death Induced by Activated Müller Glial Cells

Goureau, O., Régnier, F., & Courtois, Y. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722506.x · Cited by 61 · see citing works

Retinal proliferation in response to vitreous hemoglobin or iron.

Burke, J. M., & Smith, J. M. (1981) · PubMed · Cited by 60 · see citing works

Chapter 7 Astrocytes in mammalian retina

Schnitzer, J. (1988) · Progress in Retinal Research · doi:10.1016/0278-4327(88)90009-0 · Cited by 60 · see citing works

Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy

Wang, J.-J. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i5.726 · Cited by 57 · see citing works

Involvement of gp130‐associated cytokine signaling in Müller cell activation following optic nerve lesion

Kirsch, M., Trautmann, N., Ernst, M., & Hofmann, H. (2010) · Glia · doi:10.1002/glia.20961 · Cited by 57 · see citing works

Astrocyte and microglial activation in the lateral geniculate nucleus and visual cortex of glaucomatous and optic nerve transected primates.

Lam, D. Y., Jim, J., To, E. C., Rasmussen, C. A., Kaufman, P. L., & Matsubara, J. A. (2009) · Europe PMC (PubMed Central) · Cited by 57 · see citing works

Endothelin and its potential role in glaucoma

Chauhan, B. C. (2008) · Canadian Journal of Ophthalmology · doi:10.3129/i08-060 · Cited by 55 · see citing works

Gene Expression of Neurotrophins and Their High-Affinity Trk Receptors in Cultured Human Müller Cells

Oku, H., Ikeda, T., Honma, Y., Sotozono, C., Nishida, K., Nakamura, Y., Kida, T., & Kinoshita, S. (2002) · Ophthalmic Research · doi:10.1159/000048323 · Cited by 54 · see citing works

Neuroprotection in glaucoma: present and future

Shi-da, C. H. E. N., Wang, L., & Zhang, X. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20123565 · Cited by 51 · see citing works

Role of nitric oxide in retinal cell death.

Roth, S. (1997) · PubMed · Cited by 47 · see citing works

Neuroprotection by rat Müller glia against high glucose-induced neurodegeneration through a mechanism involving ERK1/2 activation

Matteucci, A., Gaddini, L., Villa, M., Varano, M., Parravano, M., Monteleone, V., Cavallo, F., Leo, L., Mallozzi, C., Malchiodi‐Albedi, F., et al. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.05.011 · Cited by 45 · see citing works

A cholesterol-enriched diet induces ultrastructural changes in retinal and macroglial rabbit cells

Triviño, A., Ramirez, A. I., Salazar, J. J., de Hoz, R., Rojas, B., Padilla, E., Tejerina, T., & Ramirez, J. M. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.12.020 · Cited by 44 · see citing works

Retinal pigment epithelium melanin granules are phagocytozed by Müller glial cells in experimental retinal detachment

Francke, M., Makarov, F. N., Kacza, J., et al. (2001) · Journal of Neurocytology · doi:10.1023/a:1011987107034 · Cited by 38 · see citing works

Modulation of immune-associated surface markers and cytokine production by murine retinal glial cells

Drescher, K. M., & Whittum‐Hudson, J. A. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00156-5 · Cited by 35 · see citing works

K+ currents fail to change in reactive retinal glial cells in a mouse model of glaucoma

Bolz, S., Schuettauf, F., Fries, J. E., Thaler, S., Reichenbach, A., & Pannicke, T. (2008) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-008-0872-x · Cited by 31 · see citing works

Confocal microscopy for astrocyte in vivo imaging: Recycle and reuse in microscopy

Pérez‐Alvarez, A., Araque, A., & Martín, E. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00051 · Cited by 30 · see citing works

Glaucoma

Tezel, G., & Wax, M. B. (2007) · KARGER eBooks · doi:10.1159/000099273 · Cited by 30 · see citing works

Increase in endothelin B receptor expression in optic nerve astrocytes in endothelin-1 induced chronic experimental optic neuropathy

Wang, X., LeVatte, T. L., Archibald, M. L., et al. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.09.009 · Cited by 29 · see citing works

Editorial (Thematic Issue: Neuroglia as a Central Element of Neurological Diseases: An Underappreciated Target for Therapeutic Intervention)

Peng, L., Parpura, V., & Verkhratsky, A. (2014) · Current Neuropharmacology · doi:10.2174/1570159x12999140829152550 · Cited by 28 · see citing works

Retinal perivascular astroglia: an immunoperoxidase study

Trivin˜o, A., Ramirez, J. M., Ramirez, A. I., et al. (1992) · Vision Research · doi:10.1016/0042-6989(92)90153-a · Cited by 27 · see citing works

Comparative study of astrocytes in human and rabbit retinae

Trivin˜o, A., Ramirez, J. M., Ramirez, A. I., et al. (1997) · Vision Research · doi:10.1016/s0042-6989(97)00021-7 · Cited by 24 · see citing works

Experimental Dispase-Induced Retinopathy Causes Up-Regulation of P2Y Receptor-Mediated Calcium Responses in Müller Glial Cells

Francke, M., Uhlmann, S., Pannicke, T., Goczalik, I., Uckermann, O., Weick, M., Härtig, W., Wiedemann, P., Reichenbach, A., & Bringmann, A. (2003) · Ophthalmic Research · doi:10.1159/000068192 · Cited by 24 · see citing works

Macroglial and retinal changes in hypercholesterolemic rabbits after normalization of cholesterol levels

Ramirez, A. I., Salazar, J. J., de Hoz, R., et al. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.07.023 · Cited by 23 · see citing works

NPY and TH innervation in human choroidal whole-mounts.

Triviño, A., de Hoz, R., Rojas, B., et al. (2005) · PubMed · doi:10.14670/hh-20.393 · Cited by 20 · see citing works

Differential tumor necrosis factor and nitric oxide production in retinal Müller glial cells from C3H/HeN and C3H/HeJ mice

Cotinet, A., Goureau, O., Thillaye-Goldenberg, B., et al. (1997) · Ocular Immunology and Inflammation · doi:10.3109/09273949709085059 · Cited by 18 · see citing works

Localization of IgG in the normal and dystrophic rat retina after laser lesions*

Chu, Y., Alder, V. A., Humphrey, M. F., et al. (1999) · Australian and New Zealand Journal of Ophthalmology · doi:10.1046/j.1440-1606.1999.00164.x · Cited by 10 · see citing works

Morphological Analyses on Retinal Glial Responses to Glaucomatous Injury Evoked by Venous Cauterization

Lee, J.-Y., Shin, J.-M., Chun, M., et al. (2014) · Han-guk hyeonmigyeong hakoeji/Applied microscopy · doi:10.9729/am.2014.44.1.21 · Cited by 5 · see citing works

Endothelin and its potential role in glaucoma

Chauhan, B. C. (2008) · Canadian Journal of Ophthalmology · doi:10.1139/i08-060 · Cited by 5 · see citing works

The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.

Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works

Long-term Retinal Function and Structure Rescue Using Capsid Mutant AAV8 Vector in the rd10 Mouse, a Model of Recessive Retinitis Pigmentosa

Pang, J., Dai, X., Boye, S. L., Barone, I., Boye, S. L., Mao, S., Everhart, D., Dinculescu, A., Liu, L., Umino, Y., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.273 · Cited by 148 · see citing works

The Severity of Retinal Degeneration in Rp1h Gene-Targeted Mice Is Dependent on Genetic Background

Liu, Q., Saveliev, A., & Pierce, E. A. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2776 · Cited by 20 · see citing works

The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa

Guadagni, V., Cerri, C., Piano, I., Novelli, E., Gargini, C., Fiorentini, C., Caleo, M., & Strettoi, E. (2016) · Scientific Reports · doi:10.1038/srep35919 · Cited by 5 · see citing works

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa

Blank, T., Goldmann, T., Koch, M., Amann, L., Schön, C., von Bonin, M., Pang, S., Prinz, M., Burnet, M. W. M., Wagner, J. E., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01930 · Cited by 52 · see citing works

Nutraceutical Molecules Slow Down Retinal Degeneration, in Tvrm4 Mice a Model of Retinitis Pigmentosa, by Genetic Modulation of Anti-oxidant Pathway

Piano, I., Corsi, F., Polini, B., & Gargini, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.868750 · Cited by 15 · see citing works