Cited by 761Retinal Development and DisordersRetinal Diseases and TreatmentsGlaucoma and retinal disorders

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Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects

Bringmann, Andreas, Iandiev, Ianors, Pannicke, Thomas, Wurm, Antje, Hollborn, Margrit, Wiedemann, Peter, Osborne, Neville N., Reichenbach, Andreas·2009·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2009.07.001

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Abstract

Müller cells are active players in normal retinal function and in virtually all forms of retinal injury and disease. Reactive Müller cells protect the tissue from further damage and preserve tissue function by the release of antioxidants and neurotrophic factors, and may contribute to retinal regeneration by the generation of neural progenitor/stem cells. However, Müller cell gliosis can also contribute to neurodegeneration and impedes regenerative processes in the retinal tissue by the formation of glial scars. This article provides an overview of the neuroprotective and detrimental effects of Müller cell gliosis, with accounts on the cellular signal transduction mechanisms and factors which are implicated in Müller cell-mediated neuroprotection, immunomodulation, regulation of Müller cell proliferation, upregulation of intermediate filaments, glial scar formation, and the generation of neural progenitor/stem cells. A proper understanding of the signaling mechanisms implicated in gliotic alterations of Müller cells is essential for the development of efficient therapeutic strategies that increase the supportive/protective and decrease the destructive roles of gliosis.

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Background
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See all 761

Authors: Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A.
Affiliations: University Hospital Leipzig (DE)
Leipzig University (DE)
University of Oxford (GB)
Corresponding author: Bringmann, Andreas
ORCID: Bringmann, Andreas
Pannicke, Thomas
Wiedemann, Peter
Osborne, Neville N.
Reichenbach, Andreas
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2009-11
Volume: 28
Issue: 6
Pages: 423-451
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2009.07.001
OpenAlex: W2080816502
Cited by: 761
References: 543
Citations by year: 2026: 46 · 2025: 55 · 2024: 66 · 2023: 53 · 2022: 53 · 2021: 64 · 2020: 61 · 2019: 44 · 2018: 42 · 2017: 40 · 2016: 39 · 2015: 37 · 2014: 37 · 2013: 40 · 2012: 33
FWCI: 2.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Retinal and Eye Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Keywords: Müller cells, gliosis, retinal damage, neuroprotection, glial scar formation, retinal regeneration, neural progenitor cells, retinal stem cells, signal transduction, intermediate filaments, immunomodulation, neurodegeneration
MeSH terms: Animals, Gliosis, Humans, Neuroglia, Retinal Diseases, Signal Transduction, Up-Regulation, Neuroprotective Agents

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Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects

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