Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress

The Pathobiology of Diabetic Complications

Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339 · see citing works

Method for the measurement of antioxidant activity in human fluids

Koraćević, D., Koracevic, G., Djordjevic, V., Andrejevic, S., & Cosic, V. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.5.356 · Cited by 1,986 · see citing works

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

Yakes, F. M., & Van Houten, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.514 · Cited by 1,854 · see citing works

A central role for inflammation in the pathogenesis of diabetic retinopathy

Joussen, A. M., Poulaki, V., Le, M. L., Koizumi, K., Esser, C., Janicki, H., Schraermeyer, U., Kociok, N., Fauser, S., Kirchhof, B., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-1476fje · Cited by 1,178 · see citing works

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction

Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863 · see citing works

Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology

Li, J.-M., & Shah, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2004 · Cited by 773 · see citing works

Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration

Liang, F.-Q., & Godley, B. F. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00023-x · Cited by 557 · see citing works

The missing link: A single unifying mechanism for diabetic complications

Nishikawa, T., Edelstein, D., & Brownlee, M. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.07705.x · Cited by 512 · see citing works

Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

Green, K., Brand, M. D., & Murphy, M. P. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s110 · Cited by 490 · see citing works

Mitochondrial regulation of apoptotic cell death

Orrenius, S. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.017 · Cited by 482 · see citing works

Role of mitochondrial DNA in toxic responses to oxidative stress

Houten, B. V., Woshner, V. M., & Santos, J. H. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.03.002 · Cited by 455 · see citing works

Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia

Kowluru, R. A., Tang, J., & Kern, T. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1938 · Cited by 436 · see citing works

Hyperglycemia increases mitochondrial superoxide in retina and retinal cells

Du, Y., Miller, C. M., & Kern, T. S. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.08.018 · Cited by 355 · see citing works

How Does the Eye Breathe?

Schmidt, M., Giessl, A., Laufs, T., Hankeln, T., Wolfrum, U., & Burmester, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209909200 · Cited by 316 · see citing works

Diabetes-Induced Mitochondrial Dysfunction in the Retina

Kowluru, R. A., & Abbas, S. N. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-0353 · Cited by 288 · see citing works

Vascular Damage in a Mouse Model of Diabetic Retinopathy: Relation to Neuronal and Glial Changes

Feit-Leichman, R., Kinouchi, R., Takeda, M., Fan, Z., Mohr, S., Kern, T. S., & Chen, D. F. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1361 · Cited by 280 · see citing works

Diabetic Retinopathy: Mitochondrial Dysfunction and Retinal Capillary Cell Death

Kowluru, R. A. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1581 · Cited by 235 · see citing works

Effect of Long-Term Administration of α-Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats

Kowluru, R. A., & Odenbach, S. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3233 · Cited by 227 · see citing works

Bax Is Increased in the Retina of Diabetic Subjects and Is Associated with Pericyte Apoptosis in Vivo and in Vitro

Podestà, F., Romeo, G. R., Liu, W., Krajewski, S., Reed, J. C., Gerhardinger, C., & Lorenzi, M. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64970-x · Cited by 216 · see citing works

Evaluation of Urinary 8-Hydroxydeoxy-Guanosine as a Novel Biomarker of Macrovascular Complications in Type 2 Diabetes

Nishikawa, T., Sasahara, T., Kiritoshi, S., Sonoda, K., Senokuchi, T., Matsuo, T., Kukidome, D., Wake, N., Matsumura, T., Miyamura, N., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1507 · Cited by 190 · see citing works

Role of Mitochondrial Superoxide Dismutase in the Development of Diabetic Retinopathy

Kowluru, R. A., Atasi, L. K., & Ho, Y.-S. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1276 · Cited by 185 · see citing works

Abnormalities of Retinal Metabolism in Diabetes or Experimental Galactosemia. IV. Antioxidant Defense System

Kowluru, R. A., Kern, T. S., & Engerman, R. L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00347-4 · Cited by 170 · see citing works

Overexpression of Cu2+/Zn2+ Superoxide Dismutase Protects Against Early Diabetic Glomerular Injury in Transgenic Mice

Craven, P. A., Melhem, M. F., Phillips, S. L., & DeRubertis, F. R. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2114 · Cited by 157 · see citing works

Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats

Mustata, G. T., Rosca, M. G., Biemel, K. M., Reihl, O., Smith, M. A., VISWANATHAN, A., Strauch, C., Du, Y., Tang, J., Kern, T. S., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.2.517 · Cited by 136 · see citing works

Transgenic Models for the Study of Lung Antioxidant Defense: Enhanced Manganese-containing Superoxide Dismutase Activity Gives Partial Protection to B6C3 Hybrid Mice Exposed to Hyperoxia

Ho, Y., Vincent, R., Dey, M. S., Slot, J. W., & Crapo, J. D. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.18.4.2959 · Cited by 132 · see citing works

Attenuation of Renal Injury in db/db Mice Overexpressing Superoxide Dismutase

DeRubertis, F. R., Craven, P. A., Melhem, M. F., & Salah, E. (2004) · Diabetes · doi:10.2337/diabetes.53.3.762 · Cited by 127 · see citing works

Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients

Xu, G., Yao, Q., Weng, Q., Su, B. L., Zhang, X., & Xiong, J. (2004) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2004.04.016 · Cited by 121 · see citing works

Abnormalities of Retinal Metabolism in Diabetes or Experimental Galactosemia. III. Effects of Antioxidants

Kowluru, R. A., Kern, T. S., Engerman, R. L., & Armstrong, D. (1996) · Diabetes · doi:10.2337/diab.45.9.1233 · Cited by 115 · see citing works

Heme oxygenase in diabetes-induced oxidative stress in the heart

Farhangkhoee, H. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2003.09.007 · Cited by 112 · see citing works

Reversal of hyperglycemia and diabetic nephropathy

Kowluru, R. A., Abbas, S. N., & Odenbach, S. (2004) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2004.03.002 · Cited by 98 · see citing works

Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium

Reddy, V. N., Kasahara, E., Hiraoka, M., Lu, L., & Ho, Y. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.04.005 · Cited by 93 · see citing works

Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione.

Kern, T. S., Kowluru, R. A., & Engerman, R. L. (1994) · PubMed · Cited by 91 · see citing works

Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve

Coppey, L. J., Gellett, J. S., Davidson, E. P., Dunlap, J. A., Lund, D. D., Salvemini, D., & Yorek, M. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704216 · Cited by 91 · see citing works

Importance of complete DNA digestion in minimizing variability of 8-oxo-dG analyses

Huang, X., Powell, J., Mooney, L. A., Li, C., & Frenkel, K. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00681-5 · Cited by 76 · see citing works

Zinc might protect oxidative changes in the retina and pancreas at the early stage of diabetic rats

Moustafa, S. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.05.014 · Cited by 71 · see citing works

Disulphide formation on mitochondrial protein thiols.

Hurd, T., Filipovska, A., Costa, N. J., Dahm, C., & Murphy, M. P. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331390 · Cited by 70 · see citing works

Glutathione Depletion in a Midbrain-Derived Immortalized Dopaminergic Cell Line Results in Limited Tyrosine Nitration of Mitochondrial Complex I Subunits: Implications for Parkinson's Disease

Bharath, S., & Andersen, J. K. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.900 · Cited by 64 · see citing works

Prevention of mitochondrial dysfunction in post‐traumatic mouse brain by superoxide dismutase

Xiong, Y., Shie, F., Zhang, J., Lee, C.-P., & Ho, Y. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03412.x · Cited by 61 · see citing works

Role for Poly(ADP-ribose) Polymerase Activation in Diabetic Nephropathy, Neuropathy and Retinopathy

Obrosova, I. G., & Julius, U. (2005) · Current Vascular Pharmacology · doi:10.2174/1570161054368634 · Cited by 58 · see citing works

APOPTOTIC AN IN AN IN VITRO MODEL OF NEURONAL OXIDATIVE STRESS

Ratan, R. R., & Baraban, J. M. (1995) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1995.tb02006.x · Cited by 55 · see citing works

Disulphide formation on mitochondrial protein thiols

Filipovska, A., Hurd, T. R., Costa, N. J., Dahm, C. C., & Murphy, M. P. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051390 · Cited by 32 · see citing works

Mitochondrial Glutathione and Chemically Induced Stress Including Ethanol

Reed, D. J. (2004) · Drug Metabolism Reviews · doi:10.1081/dmr-200033449 · Cited by 31 · see citing works

Effect of genetic polymorphisms of MnSOD and MPO on the relationship between PAH exposure and oxidative DNA damage

Park, S. Y., Lee, K., Kang, D., Lee, K.-H., Ha, E., & Hong, Y. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.06.022 · Cited by 25 · see citing works

Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxidants

Kowluru, A., Kern, T. S., Engerman, R. L., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.9.1233 · Cited by 25 · see citing works

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

Oxidative stress and diabetic complications

Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works

Inflammation in diabetic retinopathy

Tang, J. C. O., & Kern, T. S. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.05.002 · Cited by 1,118 · see citing works

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Brand, M. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.001 · Cited by 1,063 · see citing works

Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances

Xu, X., Pang, Y., & Fan, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02253-4 · Cited by 939 · see citing works

Oxidative Stress and Diabetic Retinopathy

Kowluru, R. A., & Chan, P.-S. (2007) · Journal of Diabetes Research · doi:10.1155/2007/43603 · Cited by 749 · see citing works

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742 · see citing works

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

Li, L., & Yang, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7580707 · Cited by 660 · see citing works

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications

Lei, X. G., Zhu, J., Cheng, W.-H., Bao, Y., Ho, Y.-S., Reddi, A. R., Holmgren, A., & Arnér, E. S. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00010.2014 · Cited by 437 · see citing works

Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy

Kowluru, R. A., Kowluru, A., Mishra, M., & Kumar, B. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.05.001 · Cited by 334 · see citing works

Oxidative Damage in the Retinal Mitochondria of Diabetic Mice: Possible Protection by Superoxide Dismutase

Kanwar, M., Chan, P.-S., Kern, T. S., & Kowluru, R. A. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.06-1280 · Cited by 333 · see citing works

Effects of curcumin on retinal oxidative stress and inflammation in diabetes

Kowluru, R. A., & Kanwar, M. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-8 · Cited by 327 · see citing works

Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives

Madsen-Bouterse, S. A., & Kowluru, R. (2008) · Reviews in Endocrine & Metabolic Disorders · doi:10.1007/s11154-008-9090-4 · Cited by 313 · see citing works

International Journal of Collaborative Research on Internal Medicine & Public Health

Valdivia, J. R. M. (2021) · Journal of Womens Health Issues and Care · Cited by 300 · see citing works

Mitochondrial DNA damage and its potential role in retinal degeneration

Jarrett, S. G., Lin, H., Godley, B. F., & Boulton, M. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.09.001 · Cited by 276 · see citing works

Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets

Safi, S. Z., Qvist, R., Kumar, S., Batumalaie, K., & Ismail, I. S. (2014) · BioMed Research International · doi:10.1155/2014/801269 · Cited by 257 · see citing works

Transcription Factor Nrf2-Mediated Antioxidant Defense System in the Development of Diabetic Retinopathy

Zhong, Q. P. W., Mishra, M., & Kowluru, R. A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-11598 · Cited by 222 · see citing works

The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications

Zhang, Z., Huang, Q., Zhao, D., Lian, F., Li, X., & Qi, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1112363 · Cited by 221 · see citing works

NRF2 plays a protective role in diabetic retinopathy in mice

Xu, Z., Wei, Y., Gong, J., Cho, H., Park, J. K., Sung, E.-R., Hu, H., Wu, L., Eberhart, C. G., Handa, J. T., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3093-8 · Cited by 211 · see citing works

Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy

Zhong, Q. P. W., & Kowluru, R. A. (2011) · Diabetes · doi:10.2337/db10-0133 · Cited by 210 · see citing works

AGEs and Diabetic Retinopathy

Stitt, A. W. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5881 · Cited by 208 · see citing works

Prevention of diabetic nephropathy in Ins2+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ

Chacko, B. K., Reily, C., Srivastava, A., Johnson, M. S., Ye, Y., Ulasova, E., Agarwal, A., Zinn, K. R., Murphy, M. P., Kalyanaraman, B., et al. (2010) · Biochemical Journal · doi:10.1042/bj20100308 · Cited by 204 · see citing works

Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9

Kowluru, R. A., Zhong, Q. P. W., & dos Santos, J. M. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.681043 · Cited by 190 · see citing works

Mitochondrial Dysfunction in Retinal Diseases

Barot, M., Gokulgandhi, M. R., & Mitra, A. K. (2011) · Current Eye Research · doi:10.3109/02713683.2011.607536 · Cited by 183 · see citing works

Oxidative Stress‐Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy

Li, C., Miao, X., Li, F., Wang, S., Liu, Q., Wang, Y., & Sun, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9702820 · Cited by 184 · see citing works

Antioxidant Compounds from Propolis Collected in Anhui, China

Yang, H., Dong, Y., Du, H.-J., Shi, H., Peng, Y., & Li, X. (2011) · Molecules · doi:10.3390/molecules16043444 · Cited by 174 · see citing works

Oxidative Damage of Mitochondrial Proteins Contributes to Fruit Senescence: A Redox Proteomics Analysis

Qin, G., Meng, X., Wang, Q., & Tian, S. (2009) · Journal of Proteome Research · doi:10.1021/pr801046m · Cited by 167 · see citing works

Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase

Madsen‐Bouterse, S. A., Zhong, Q. P. W., Mohammad, G., Ho, Y.-S., & Kowluru, R. A. (2010) · Free Radical Research · doi:10.3109/10715760903494168 · Cited by 161 · see citing works

Mitochondrial biogenesis and the development of diabetic retinopathy

dos Santos, J. M., Tewari, S., Goldberg, A. F. X., & Kowluru, R. A. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.017 · Cited by 153 · see citing works

Ischemic Retinopathies: Oxidative Stress and Inflammation

Rivera, J. C., Dabouz, R., Noueihed, B., Omri, S., Tahiri, H., & Chemtob, S. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3940241 · Cited by 152 · see citing works

Beneficial Effect of Zeaxanthin on Retinal Metabolic Abnormalities in Diabetic Rats

Kowluru, R. A., Menon, B., & Gierhart, D. L. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0764 · Cited by 148 · see citing works

Epigenetic Modification of Sod2 in the Development of Diabetic Retinopathy and in the Metabolic Memory: Role of Histone Methylation

Zhong, Q. P. W., & Kowluru, R. A. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10854 · Cited by 143 · see citing works

Alterations to the Blood–Retinal Barrier in Diabetes: Cytokines and Reactive Oxygen Species

Frey, T., & Antonetti, D. A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3906 · Cited by 137 · see citing works

Hypoxia-Induced Oxidative Stress in Ischemic Retinopathy

Li, S.-Y., Fu, Z., & Lo, A. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/426769 · Cited by 136 · see citing works

Hesperidin Prevents Retinal and Plasma Abnormalities in Streptozotocin-Induced Diabetic Rats

Shi, X., Liao, S., Mi, H., Guo, C.-R., Qi, D., Li, F., Zhang, C.-F., & Yang, Z. (2012) · Molecules · doi:10.3390/molecules171112868 · Cited by 133 · see citing works

Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy

Kowluru, R. A., dos Santos, J. M., & Zhong, Q. P. W. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14383 · Cited by 131 · see citing works

Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy

Zheng, L. (2009) · Frontiers in bioscience · doi:10.2741/3505 · Cited by 130 · see citing works

Riding the tiger – physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123 · see citing works

Cerium oxide and platinum nanoparticles protect cells from oxidant-mediated apoptosis

Clark, A. J., Zhu, A., Sun, K., & Petty, H. R. (2011) · Journal of Nanoparticle Research · doi:10.1007/s11051-011-0544-3 · Cited by 122 · see citing works

Dietary resveratrol administration increases MnSOD expression and activity in mouse brain

Robb, E. L., Winkelmolen, L., Visanji, N. P., Brotchie, J. M., & Stuart, J. A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.028 · Cited by 116 · see citing works

Oxidative Stress, Glucose Metabolism, and the Prevention of Type 2 Diabetes: Pathophysiological Insights

Shah, S., Iqbal, M., Karam, J., Salifu, M., & McFarlane, S. I. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1629 · Cited by 115 · see citing works

The Role of HIF1α-PFKFB3 Pathway in Diabetic Retinopathy

Min, J., Zeng, T., Roux, M., Lazar, D., Chen, L., & Tudzarova, S. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab362 · Cited by 115 · see citing works

Metabolic Memory Phenomenon and Accumulation of Peroxynitrite in Retinal Capillaries

Kowluru, R. A., Kanwar, M., & Kennedy, A. (2007) · Journal of Diabetes Research · doi:10.1155/2007/21976 · Cited by 114 · see citing works

Low-Intensity Far-Red Light Inhibits Early Lesions That Contribute to Diabetic Retinopathy: In Vivo and In Vitro

Tang, J. C. O., Du, Y., Lee, C. A., Talahalli, R. R., Eells, J. T., & Kern, T. S. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11018 · Cited by 112 · see citing works

The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications

Dal-Ros, S., & Sigrist, S. (2016) · Diseases · doi:10.3390/diseases4030024 · Cited by 112 · see citing works

Diabetic Retinopathy, Superoxide Damage and Antioxidants

dos Santos, J. M., Mohammad, G., Zhong, Q. P. W., & Kowluru, R. A. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111794480507 · Cited by 110 · see citing works

Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats

Kamboj, S. S., & Sandhir, R. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.09.014 · Cited by 108 · see citing works

Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy

Kanwar, M., & Kowluru, R. A. (2008) · Diabetes · doi:10.2337/db08-1025 · Cited by 108 · see citing works

Epigenetic Modifications and Diabetic Retinopathy

Kowluru, R. A., dos Santos, J. M., & Mishra, M. (2013) · BioMed Research International · doi:10.1155/2013/635284 · Cited by 107 · see citing works

The mitochondrial manganese superoxide dismutase gene in Chinese shrimp Fenneropenaeus chinensis: Cloning, distribution and expression

Zhang, Q., Li, F., Wang, B., Zhang, J., Liu, Y., Zhou, Q., & Xiang, J. (2006) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2006.08.005 · Cited by 107 · see citing works

Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells

Munusamy, S., & MacMillan-Crow, L. A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.022 · Cited by 106 · see citing works

The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients

Escribano‐López, I., Díaz‐Morales, N., Rovira‐Llopis, S., Marañón, A., Orden, S., Álvarez, Á., Bañuls, C., Rocha, M., Murphy, M. P., Hernández‐Mijares, A., et al. (2016) · Redox Biology · doi:10.1016/j.redox.2016.10.017 · Cited by 107 · see citing works

Oxidative stress and the development of diabetic retinopathy: Contributory role of matrix metalloproteinase-2

Kowluru, R. A., & Kanwar, M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.03.024 · Cited by 105 · see citing works

Mitochondrial protein tyrosine nitration

Castro, L., Demicheli, V., Tórtora, V., & Radí, R. (2010) · Free Radical Research · doi:10.3109/10715762.2010.516254 · Cited by 100 · see citing works

The Importance of Mitochondria in Age-Related and Inherited Eye Disorders

Jarrett, S. G., Lewin, A. S., & Boulton, M. E. (2010) · Ophthalmic Research · doi:10.1159/000316480 · Cited by 98 · see citing works

Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction

Mohammad, G., & Kowluru, R. A. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.89 · Cited by 97 · see citing works

Damaged Mitochondrial DNA Replication System and the Development of Diabetic Retinopathy

Tewari, S., dos Santos, J. M., & Kowluru, R. A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4333 · Cited by 93 · see citing works

Hyperglycemia Induces Oxidative Stress and Impairs Axonal Transport Rates in Mice

Sharma, R. G., Buras, E. D., Terashima, T., Serrano, F., Massaad, C. A., Hu, L., Bitner, B. R., Inoue, T., Chan, L., & Pautler, R. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013463 · Cited by 90 · see citing works

Overexpression of SOD in retina: Need for increase in H2O2-detoxifying enzyme in same cellular compartment

Usui, S., Oveson, B. C., Iwase, T., Lu, L., Lee, S. Y., Jo, Y.-J., Wu, Z., Choi, E.-Y., Samulski, R. J., & Campochiaro, P. A. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.010 · Cited by 90 · see citing works

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop

Giacco, F., Du, X., Carratù, A. C., Gerfen, G. J., D’Apolito, M., Giardino, I., Rasola, A., Marin, O., Divakaruni, A. S., Murphy, A. N., et al. (2015) · Diabetes · doi:10.2337/db15-0084 · Cited by 87 · see citing works

Epigenetic changes in diabetes

Keating, S. T., & El‐Osta, A. (2013) · Clinical Genetics · doi:10.1111/cge.12121 · Cited by 86 · see citing works

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension

Itani, H. A., Dikalova, A., McMaster, W. G., Nazarewicz, R. R., Bikineyeva, A. T., Harrison, D. G., & Dikalov, S. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.07085 · Cited by 86 · see citing works

Oxygen delivery, consumption, and conversion to reactive oxygen species in experimental models of diabetic retinopathy

Eshaq, R. S., Wright, W. S., & Harris, N. R. (2014) · Redox Biology · doi:10.1016/j.redox.2014.04.006 · Cited by 85 · see citing works

Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension

Adesina, S. E., Kang, B., Bijli, K. M., Ma, J., Cheng, J., Murphy, T. C., Hart, C. M., & Sutliff, R. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.042 · Cited by 84 · see citing works

Oxidative Stress and Its Regulation in Diabetic Retinopathy

Haydinger, C. D., Oliver, G. F., Ashander, L. M., & Smith, J. R. (2023) · Antioxidants · doi:10.3390/antiox12081649 · Cited by 87 · see citing works

Retinal Ion Regulation in a Mouse Model of Diabetic Retinopathy: Natural History and the Effect of Cu/Zn Superoxide Dismutase Overexpression

Berkowitz, B. A., Gradianu, M., Bissig, D., Kern, T. S., & Roberts, R. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2918 · Cited by 77 · see citing works

Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism

Mahmoud, A. M., El-Twab, S. M. A., & Abdel-Reheim, E. S. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1214-0 · Cited by 77 · see citing works

Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction

Dou, G., Sreekumar, P. G., Spee, C. K., He, S., Ryan, S. J., Kannan, R., & Hinton, D. R. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.042 · Cited by 76 · see citing works

Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers

Al‐Shabrawey, M., & Smith, S. B. (2010) · The EPMA Journal · doi:10.1007/s13167-010-0002-9 · Cited by 67 · see citing works

Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia

Hung, M., Tipoe, G. L., Poon, A. M. S., Reiter, R. J., & Fung, M. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00514.x · Cited by 67 · see citing works

Catalase Therapy Corrects Oxidative Stress-Induced Pathophysiology in Incipient Diabetic Retinopathy

Giordano, C. R., Roberts, R. A., Krentz, K. A., Bissig, D., Talreja, D., Kumar, A., Terlecky, S. R., & Berkowitz, B. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-16194 · Cited by 66 · see citing works

Oxidative and Nitrative Stress in Opisthorchis viverrini–Infected Hamsters: An Indirect Effect after Praziquantel Treatment

Pinlaor, S., Prakobwong, S., Hiraku, Y., Kaewsamut, B., Dechakhamphu, S., Boonmars, T., Sithithaworn, P., Pinlaor, P., Ma, N., Yongvanit, P., et al. (2008) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2008.78.564 · Cited by 65 · see citing works

Vitamin D3 ameliorates nitrogen mustard‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway

Dong, X., He, Y., Feng, Y., Zhao, Y., Cheng, J. S., Xiao, J., Yu, W., Zhao, J., Sai, Y., Dan, G., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.312 · Cited by 61 · see citing works

DNA Methylation—a Potential Source of Mitochondria DNA Base Mismatch in the Development of Diabetic Retinopathy

Mishra, M., & Kowluru, R. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1086-9 · Cited by 64 · see citing works

Therapeutic implications of curcumin in the prevention of diabetic retinopathy via modulation of anti-oxidant activity and genetic pathways.

Aldebasi, Y. H., Aly, S. M., & Rahmani, A. H. (2013) · Europe PMC (PubMed Central) · Cited by 62 · see citing works

Vitreous Mediators in Retinal Hypoxic Diseases

dell’Omo, R., Semeraro, F., Bamonte, G., Cifariello, F., Romano, M. R., & Costagliola, C. (2013) · Mediators of Inflammation · doi:10.1155/2013/935301 · Cited by 64 · see citing works

Genetic Polymorphisms in Genes Encoding Antioxidant Enzymes Are Associated With Diabetic Retinopathy in Type 1 Diabetes

Hovnik, T., Dolžan, V., Bratina, N., Podkrajšek, K. T., & Battelino, T. (2009) · Diabetes Care · doi:10.2337/dc09-0852 · Cited by 61 · see citing works

GSTT1 Null Genotype Is a Risk Factor for Diabetic Retinopathy in Caucasians with Type 2 Diabetes, whereas GSTM1 Null Genotype Might Confer Protection against Retinopathy

Cilenšek, I., Mankoč, S., Petrovič, M. G., & Petrovič, D. (2012) · Disease Markers · doi:10.1155/2012/675628 · Cited by 61 · see citing works

Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy

Uno, K., Prow, T. W., Bhutto, I. A., Yerrapureddy, A., McLeod, D. S., Yamamoto, M. P., Reddy, S. P., & Lutty, G. A. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2009.12.012 · Cited by 60 · see citing works

Combined vitamins (C and E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats

Hamden, K., Boujbiha, M. A., Masmoudi, H., Ayadi, F. M., Jamoussi, K., & Elfeki, A. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.02.001 · Cited by 59 · see citing works

Reversible retinal vessel closure from VEGF-induced leukocyte plugging

Liu, Y., Shen, J., Fortmann, S. D., Wang, J., Vestweber, D., & Campochiaro, P. A. (2017) · JCI Insight · doi:10.1172/jci.insight.95530 · Cited by 57 · see citing works

Effect of N‐acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats

Tsai, G., Cui, J. Z., Syed, H., Xia, Z., Özerdem, U., McNeill, J. H., & Matsubara, J. A. (2009) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2009.02000.x · Cited by 51 · see citing works

An Hypothesis to Account for the Renewal of Outer Segments in Rod and Cone Photoreceptor Cells: Renewal as a Surrogate Antioxidant

Winkler, B. S. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-1785 · Cited by 50 · see citing works

The Mitochondria-Targeted Antioxidant MitoQ Modulates Mitochondrial Function and Endoplasmic Reticulum Stress in Pancreatic β Cells Exposed to Hyperglycaemia

Escribano‐López, I., Bañuls, C., Díaz‐Morales, N., Iannantuoni, F., Rovira‐Llopis, S., Gomis, R., Rocha, M., Hernández‐Mijares, A., Murphy, M. P., & Víctor, V. M. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000013 · Cited by 49 · see citing works

Effects of N-Acetylcysteine on Nicotinamide Dinucleotide Phosphate Oxidase Activation and Antioxidant Status in Heart, Lung, Liver and Kidney in Streptozotocin-Induced Diabetic Rats

Lei, S., Liu, Y., Liu, H., Yu, H., Wang, H., & Xia, Z. (2012) · Yonsei Medical Journal · doi:10.3349/ymj.2012.53.2.294 · Cited by 48 · see citing works

Diabetic retinopathy: reversibility of epigenetic modifications and new therapeutic targets

Zhang, X., Zhao, L., Hambly, B. D., Bao, S., & Wang, K. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0167-1 · Cited by 47 · see citing works

Resilience to diabetic retinopathy

Serikbaeva, A., Li, Y., Ma, S., Yi, D., & Kazlauskas, A. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101271 · Cited by 45 · see citing works

Antioxidants in the Prevention and Treatment of Diabetic Retinopathy – A Review

Baptista-Silva, S., da Costa, J. P. O., Pintado, M., Ferreira, D. D. C., & Sarmento, B. F. C. C. (2010) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000111 · Cited by 45 · see citing works

Leukocytes regulate retinal capillary degeneration in the diabetic mouse via generation of leukotrienes

Talahalli, R. R., Zarini, S., Tang, J., Li, G., Murphy, R. C., Kern, T. S., & Gubitosi‐Klug, R. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0112025 · Cited by 45 · see citing works

Fatty acid induced metabolic memory involves alterations in renal histone H3K36me2 and H3K27me3

Kumar, S., Pamulapati, H., & Tikoo, K. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.019 · Cited by 46 · see citing works

Involvement of oxidative stress and mitochondrial dysfunction in the osmotic swelling of retinal glial cells from diabetic rats

Krügel, K., Wurm, A., Pannicke, T., Hollborn, M., Karl, A., Wiedemann, P., Reichenbach, A., Kohen, L., & Bringmann, A. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.11.007 · Cited by 43 · see citing works

Role of macular xanthophylls in prevention of common neovascular retinopathies: Retinopathy of prematurity and diabetic retinopathy

Gong, X., & Rubin, L. P. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.02.004 · Cited by 44 · see citing works

Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients

García‐Ramírez, M., Francisco, G., García‐Arumí, E., Hernández, C., Martínez, R., Andreu, A. L., & Simó, R. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.10.011 · Cited by 43 · see citing works

The stilbenes resveratrol, pterostilbene and piceid affect growth and stress resistance in mammalian cells via a mechanism requiring estrogen receptor beta and the induction of Mn-superoxide dismutase.

Robb, E. L., & Stuart, J. (2014) · Phytochemistry · doi:10.1016/j.phytochem.2013.11.019 · Cited by 41 · see citing works

REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice

Miller, W. P., Toro, A. L., Barber, A. J., & Dennis, M. D. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-26606 · Cited by 42 · see citing works

Effects of antioxidant gene therapy on retinal neurons and oxidative stress in a model of retinal ischemia/reperfusion

Liu, Y., Tang, L., & Chen, B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.013 · Cited by 41 · see citing works

Delivery of Antioxidant Enzyme Genes to Protect against Ischemia/Reperfusion-Induced Injury to Retinal Microvasculature

Chen, B., Caballero, S., Seo, S., Grant, M. B., & Lewin, A. S. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3633 · Cited by 40 · see citing works

Chromatin Modifications Associated with Diabetes

Keating, S. T., & El‐Osta, A. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9380-9 · Cited by 40 · see citing works

Impairment of mitochondrial respiratory chain activity in aortic endothelial cells induced by glycated low-density lipoprotein

Sangle, G. V., Chowdhury, S. R., Xie, X., Stelmack, G. L., Halayko, A. J., & Shen, G. X. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.017 · Cited by 40 · see citing works

Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase

Madsen‐Bouterse, S. A., Zhong, Q. P. W., Mohammad, G., Ho, Y.-S., & Kowluru, R. A. (2010) · Free Radical Research · doi:10.3109/10715760903494168 · Cited by 161 · see citing works

Role of Mitochondrial Superoxide Dismutase in the Development of Diabetic Retinopathy

Kowluru, R. A., Atasi, L. K., & Ho, Y.-S. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1276 · Cited by 185 · see citing works

Oxidative Damage in the Retinal Mitochondria of Diabetic Mice: Possible Protection by Superoxide Dismutase

Kanwar, M., Chan, P.-S., Kern, T. S., & Kowluru, R. A. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.06-1280 · Cited by 333 · see citing works

Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice

Goto, H., Nishikawa, T., Sonoda, K., Kondo, T., Kukidome, D., Fujisawa, K., Yamashiro, T., Motoshima, H., Matsumura, T., Tsuruzoe, K., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.041 · Cited by 44 · see citing works

Effects of melatonin on expression of manganese superoxide dismutase and cuproznic superoxide dismutase in retina in early diabetic rats

Mao-nia, Z. (2010) · Zhonghua shiyan yanke zazhi