Pharmacokinetic aspects of retinal drug delivery

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Regulated portals of entry into the cell

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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles

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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

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Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

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Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

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Photodisruption of the Inner Limiting Membrane: Exploring ICG Loaded Nanoparticles as Photosensitizers

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Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies

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Binding of Small Molecule Drugs to Porcine Vitreous Humor

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Intravitreal therapeutic nanoparticles for age-related macular degeneration: Design principles, progress and opportunities

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Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases

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Investigating Ex Vivo Animal Models to Test the Performance of Intravitreal Liposomal Drug Delivery Systems

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Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor

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Age-related ocular conditions: Current treatments and role of cyclodextrin-based nanotherapies

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Host cell proteins induce inflammation and immunogenicity as adjuvants in an integrated analysis of in vivo and in vitro assay systems

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Topical Ophthalmic Liposomes Dual-Modified with Penetratin and Hyaluronic Acid for the Noninvasive Treatment of Neovascular Age-Related Macular Degeneration

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FluoroGold‐Labeled Organotypic Retinal Explant Culture for Neurotoxicity Screening Studies

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AAV2 and AAV9 tropism and transgene expression in the mouse eye and major tissues after intravitreal and subretinal delivery

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Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery

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Ophthalmic delivery of hydrophilic drugs through drug-loaded oleogels

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Retinal neuroprotection by controlled release of a VCP inhibitor from self-assembled nanoparticles

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Ocular Fluid Mechanics and Drug Delivery: A Review of Mathematical and Computational Models

Bhandari, A. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03141-6 · Cited by 23

Six-month effective treatment of corneal graft rejection

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Lutein loaded double-layered polymer nanocarrier modulate H2O2 and CoCl2 induced oxidative and hypoxia damage and angiogenic markers in ARPE-19 cells

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Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells

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Turning the screw even further to increase microparticle retention and ocular bioavailability of associated drugs: The bioadhesion goal

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3D cell-laden polymers to release bioactive products in the eye

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Hydrogel-Based Therapy for Age-Related Macular Degeneration: Current Innovations, Impediments, and Future Perspectives

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Ocular and systemic pharmacokinetics of BI-X, a nanobody targeting VEGF and Ang-2, after intravitreal dosing in cynomolgus monkeys – Evidence for half-life extension by albumin

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The effects of aging on the mechanical properties of the vitreous

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Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

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A single intravenous injection of cyclosporin A–loaded lipid nanocapsules prevents retinopathy of prematurity

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Topical Treatment for Retinal Degenerative Pathologies: A Systematic Review

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A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic

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Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier

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Recent theranostic paradigms for the management of Age-related macular degeneration

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Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells

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Novel treatments for age-related macular degeneration: a review of clinical advances in sustained Drug delivery systems

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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.

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TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

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Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice

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Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

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A novel, liposome-loaded, injectable hydrogel for enhanced treatment of choroidal neovascularization by sub-tenon's injection

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Drug Diffusion Along an Intact Mammalian Cochlea

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Ophthalmic Nanosystems with Antioxidants for the Prevention and Treatment of Eye Diseases

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Design of the ocular coil, a new device for non-invasive drug delivery

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Targeted drug delivery vehicles mediated by nanocarriers and aptamers for posterior eye disease therapeutics: barriers, recent advances and potential opportunities

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Elimination of “lag” and “burst” phases in drug release profiles of melt-extruded, PLGA-based intravitreal implants

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Laser-Activated Drug Implant for Controlled Release to the Posterior Segment of the Eye

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Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials

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Generation of Human Patient iPSC-derived Retinal Organoids to Model Retinitis Pigmentosa

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Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues

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Tailoring surface properties of liposomes for dexamethasone intraocular administration

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Ocular permeability, intraocular biodistribution of lipid nanocapsule formulation intended for retinal drug delivery

Christensen, G., Urimi, D., Lorenzo‐Soler, L., Schipper, N. G. M., & Paquet‐Durand, F. (2023) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2023.04.012 · Cited by 18

Potential in exosome-based targeted nano-drugs and delivery vehicles for posterior ocular disease treatment: from barriers to therapeutic application

Peng, X., Zhang, T., Liu, R., & Jin, X. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04798-w · Cited by 18

Novel Drug Delivery Methods and Approaches for the Treatment of Retinal Diseases

Ham, Y., Mehta, H., Kang‐Mieler, J. J., Mieler, W. F., & Chang, A. (2023) · Asia-Pacific Journal of Ophthalmology · doi:10.1097/apo.0000000000000623 · Cited by 18

Retinoblastoma: An update on genetic origin, classification, conventional to next-generation treatment strategies

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Müller cells and choriocapillaris in the pathogenesis of geographic atrophy secondary to age-related macular degeneration

Pilotto, E., Midena, E., Longhin, E., Parrozzani, R., Frisina, R., & Frizziero, L. (2019) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-019-04289-z · Cited by 18

Confocal Raman spectroscopy: Evaluation of a non-invasive technique for the detection of topically applied ketorolac tromethamine in vitro and in vivo

Bertens, C. J. F., Zhang, S., Erckens, R. J., van den Biggelaar, F. J. H. M., Berendschot, T. T. J. M., Webers, C. A. B., Nuijts, R. M. M. A., & Gijs, M. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118641 · Cited by 17

The Present and Future of Mitochondrial-Based Therapeutics for Eye Disease

Ji, M. H., Kreymerman, A., Belle, K. C., Ghiam, B. K., Muscat, S. P., Mahajan, V. B., Enns, G. M., Mercola, M. A., & Wood, E. H. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.8.4 · Cited by 18

Brain and Retinal Organoids for Disease Modeling: The Importance of In Vitro Blood–Brain and Retinal Barriers Studies

Martinelli, I., Tayebati, S. K., Tomassoni, D., Nittari, G., Roy, P., & Amenta, F. (2022) · Cells · doi:10.3390/cells11071120 · Cited by 17

Intravitreal Application: Physicochemical Properties of Drugs Dissolved in Silicone Oils of Different Density in Comparison to the Porcine Vitreous Body

Hammer, M., Schickhardt, S. K., Merz, P., Khoramnia, R., Scheuerle, A. F., Mier, W., Uhl, P., & Auffarth, G. U. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071364 · Cited by 17

Long‐Acting Ocular Injectables: Are We Looking In The Right Direction?

Dang, M., & Shoichet, M. S. (2023) · Advanced Science · doi:10.1002/advs.202306463 · Cited by 17

Nanoparticle-based optical interfaces for retinal neuromodulation: a review

Stoddart, P. R., Begeng, J. M., Tong, W., Ibbotson, M. R., & Kameneva, T. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1360870 · Cited by 18

Injectable Dendrimer Hydrogel Delivers Melphalan in Both Conjugated and Free Forms for Retinoblastoma

Cooper, R. C., Wang, J., & Yang, H. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00597 · Cited by 17

Functional and Structural Effects of Erythropoietin Subconjunctival Administration in Glaucomatous Animals

Resende, A. P., Rosolen, S. G., Nunes, T. P., Bráz, B. S., & Delgado, E. (2018) · Biomedicine Hub · doi:10.1159/000488970 · Cited by 17

Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands

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A technical protocol for an experimental ex vivo model using arterially perfused porcine eyes

Rousou, C., Hoogenboom, P., van Overdam, K. A., Storm, G., Dorrestijn, J., & Mastrobattista, E. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.02.003 · Cited by 17

Comparative Analysis of Morphological and Release Profiles in Ocular Implants of Acetazolamide Prepared by Electrospinning

Morais, M., Coimbra, P., & Pina, M. E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020260 · Cited by 17

New Method for Efficient siRNA Delivery in Retina Explants: Reverse Magnetofection

Bassetto, M., Sen, M., Poulhès, F., Arango‐González, B., Bonvin, E., Sapet, C., Ueffing, M., & Zelphati, O. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00132 · Cited by 17

Pullulan Based Bioconjugates for Ocular Dexamethasone Delivery

Kicková, E., Salmaso, S., Mastrotto, F., Caliceti, P., & Urtti, A. O. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060791 · Cited by 17

Hyaluronic Acid–Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics

Famili, A., Crowell, S. R., Loyet, K. M., Mandikian, D., Boswell, C. A., Cain, D., Chan, J., Comps‐Agrar, L., Kamath, A. V., & Rajagopal, K. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00475 · Cited by 17

Preclinical PET Study of Intravitreal Injections.

Fernández‐Ferreiro, A., Luaces-Rodríguez, A., Aguiar, P., Pardo‐Montero, J., González‐Barcia, M., García-Varela, L., Herranz, M., Silva‐Rodríguez, J., Gil‐Martínez, M., Bermúdez, M. A., et al. (2017) · PubMed · doi:10.1167/iovs.17-21812 · Cited by 17

Endogenous Fungal Endophthalmitis: A Single-Center Retrospective Study and Review of the Literature

Burton, E., Reddy, V., & Venkat, A. (2024) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2024.01.018 · Cited by 16

Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data

Lamminsalo, M., Urtti, A. O., & Ranta, V. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109162 · Cited by 16

Sirolimus loaded chitosan functionalized PLGA nanoparticles protect against sodium iodate-induced retinal degeneration

Suri, R., Nag, T. C., Mehra, N., Neupane, Y. R., Shafi, S., Sharma, D., Sharma, K., Sultana, Y., & Kohli, K. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104369 · Cited by 16

Quantitative intravitreal pharmacokinetics in mouse as a step towards inter-species translation

Puranen, J., Ranta, V., Ruponen, M., Urtti, A. O., & Sadeghi, A. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109638 · Cited by 17

Development of a Resveratrol Nanoformulation for the Treatment of Diabetic Retinopathy

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Latest advances in hydrogel therapy for ocular diseases

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