Cited by 693Advanced Drug Delivery SystemsRetinal Diseases and TreatmentsOcular Infections and Treatments

The DOI matches its Crossref record; 476 of the 476 references it cites were found in a registry or an index.

Pharmacokinetic aspects of retinal drug delivery

Open access

del Amo, Eva M., Rimpelä, Anna-Kaisa, Heikkinen, Emma, Kari, Otto K., Ramsay, Eva, Lajunen, Tatu, Schmitt, Mechthild, Pelkonen, Laura, Bhattacharya, Madhushree, Richardson, Dominique, Subrizi, Astrid, Turunen, Tiina, Reinisalo, Mika, Itkonen, Jaakko, Toropainen, Elisa, Casteleijn, Marco, Kidron, Heidi, Antopolsky, Maxim, Vellonen, Kati-Sisko, Ruponen, Marika, Urtti, Arto·2017·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2016.12.001

Open this paper in CoChat — free account Open PDF

Abstract

Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to administer drugs to the retina, but this approach is applicable only in selected cases (e.g. anti-VEGF antibodies and soluble receptors). There are two basic approaches that can be adopted to improve retinal drug delivery: prolonged and/or retina targeted delivery of intravitreal drugs and use of other routes of drug administration, such as periocular, suprachoroidal, sub-retinal, systemic, or topical. Properties of the administration route, drug and delivery system determine the efficacy and safety of these approaches. Pharmacokinetic and pharmacodynamic factors determine the required dosing rates and doses that are needed for drug action. In addition, tolerability factors limit the use of many materials in ocular drug delivery. This review article provides a critical discussion of retinal drug delivery, particularly from the pharmacokinetic point of view. This article does not include an extensive review of drug delivery technologies, because they have already been reviewed several times recently. Instead, we aim to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment. This review is based on the literature and unpublished data from the authors' laboratory.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.preteyeres.2016.12.001

Cites

476 of 476 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
Wong, W. L., Su, X., Li, X., Cheung, C. M. G., Klein, R., Cheng, C., & Wong, T. Y. (2014) · The Lancet Global Health · doi:10.1016/s2214-109x(13)70145-1 · Cited by 5,545
Regulated portals of entry into the cell
Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,958
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting
Maeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495
Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology
Tenzer, S., Docter, D., Kuharev, J., Musyanovych, A., Fetz, V., Hecht, R., Schlenk, F., Fischer, D., Kiouptsi, K., Reinhardt, C., et al. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.181 · Cited by 2,283
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Maguire, A. M., Simonelli, F., Pierce, E. A., Pugh, E. N., Mingozzi, F., Bennicelli, J., Banfi, S., Marshall, K. A., Testa, F., Surace, E. M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802315 · Cited by 2,145

Flagged first, then by citations

Show all 476 references

Research works printed but not linked: 7

Barza, 1982, The effects of infection and probenecid on the transport of carbenicillin from the rabbit vitreous humor. Investig. Ophthalmol, Vis. Sci., 22, 720
Gisladottir, 2009, Diffusion characteristics of vitreous humour and saline solution follow the Stokes Einstein equation. Graefe's Arch. Clin. Exp, Ophthalmol, 247, 1677
Haselton, 1996, Modulation of retinal endothelial barrier in a perfused cell-column model of the retinal microvasculature, Investig. Ophthalmol. Vis. Sci., 37, 211
Johnson, 1984, vol. 39, 791
Szebeni, 2005, Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity, Toxicology, 216, 106, 10.1016/j.tox.2005.07.023 · DOI
Szebeni, 2011, Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention, Adv. Drug Deliv. Rev., 63, 1020, 10.1016/j.addr.2011.06.017 · DOI
U.S. Food and Drug Administration, 2013, Guidance for industry: immunogenicity assessment for therapeutic protein products, Biotechnol. Law Rep., 172

Sorted by citations

Items 601–693 of 693

Disease characterization and pre-clinical testing in canine models of the neuronal ceroid lipofuscinoses
Kick, G. R. (2021) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/88127
Comparison of Barrier Properties of Outer Blood-Retinal Barrier Models - Human Stem Cell-Based Models as a Novel Tool for Ocular Drug DiscoveryPreprint
Ruponen, M., Hellinen, L., Hongisto, H., Ramsay, E., Kaarniranta, K., Vellonen, K., & Skottman, H. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4093938
Self-citation
Tools and Data Towards Supporting Quantitative Systems Pharmacology of the Eye – An OverviewPreprint
Kuepfer, L., Fuellen, G., & Stahnke, T. (2022) · Preprints.org · doi:10.20944/preprints202203.0164.v2
Electro-diffusive transport of cationic peptide carriers in negatively charged joint environment for applications in targeted drug delivery
Vedadghavami, A. (2022) · doi:10.17760/d20449631
Response to Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”
Tamhane, M., Luu, K. T., & Attar, M. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001439
Preclinical modeling of intravitreal suspensions
Castleberry, S. A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122807
A novel sustained release therapy of combined VEGF and TNF-α inhibitors leads to pan-ocular protection for months after severe ocular traumaPreprint
Zhou, C., Lei, F., Hui, P., Wolkow, N., Dohlman, C. H., Vavvas, D. G., Chodosh, J., & Paschalis, E. I. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.14.531626
Model of an Artificial Blastula for Assessing Development Toxicity
Muzika, F., & Górecki, J. (2023) · Biomedical engineering · doi:10.5772/intechopen.110260
Treatments for diabetic retinopathy and diabetic macular edema in pipeline
Li, W., & Zhang, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-93064-2.00011-1
Fathoming biopharmaceutical tenets and characterization techniques for the plausible ophthalmic drug delivery performance
Goel, H., Dogra, N., Singla, R., & Talegaonkar, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15264-1.00006-3
Research Progress of Imaging Features of Optical Coherence Tomography in Retinal Vein Occlusion
朱, 贞. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1391983
Deciphering perivascular macrophages and microglia in the retinal ganglion cell layersPreprint
Kim, P., Jeon, J., Park, Y. S., Kim, S.-H., Kong, E., Kim, J., Yang, J. M., Lee, J., Kim, Y., & Kim, I. (2023) · Research Square · doi:10.21203/rs.3.rs-3449968/v1
Potential of Extracellular Vesicles as Therapeutics in Retinal Diseases
Bosch, S., Lajunen, T., Merivaara, A., Rilla, K. J., & Urtti, A. (2024) · Biology of extracellular matrix · doi:10.1007/978-3-031-68811-9_8
Self-citation
2-Desaza-annomontine impedes angiogenesis by inhibiting CDC2-like-kinases and β-catenin activity
Zech, T. (2024) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.87954
Mathematical Models of Retinal Drug DeliveryPreprint
Roberts, P. A., Thomas, C. N., Plaice, G. B., Roberts, J. A., Jones, M., Andrews, J. W., & Hill, L. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.17.629033
Pesticides’ Cornea Permeability—How Serious Is This Problem?
Sobańska, A. W., Sobański, A. M., & Wanat, K. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020156
Ocular pharmacokinetics of intravitreal conbercept in a rabbit model following retinal scatter laser photocoagulation
Chen, L., Liu, H., Zhang, Q., & Huang, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1534048
Is cefazolin an option for treatment of staphylococcal endogenous endophthalmitis?
Morin, A., Leguen, J., Benaboud, S., Richebé, P., Bournaud, L. F., Dedieu, D., Brézin, A. P., Charlier, C., & Canouï, É. (2025) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaf165
Nanogels in drug delivery for enhanced therapeutic efficacy
Kumar, R., Harilal, S., Singh, A. K., Vakili‐Ghartavol, R., Sheoran, S., Arora, S., & Saritha, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30016-5.00006-9
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
Vainionpää, K., Montaser, A. B., & Leinonen, H. (2025) · FEBS Letters · doi:10.1002/1873-3468.70107
Can contact lenses deliver drugs to the back of the eye?
Chauhan, A., & Kompella, U. B. (2025) · Therapeutic Delivery · doi:10.1080/20415990.2025.2539669
Novel Pharmacokinetic Bridging Strategy for Locally Acting Intravitreal Drug Products
Ji, P., Boyd, W. M., & Sahajwalla, C. G. (2025) · The AAPS Journal · doi:10.1208/s12248-025-01097-8
Mathematical Models of Topically and Intravitreally Applied Ranibizumab
Roberts, P., Thomas, C. N., Plaice, G. B., Roberts, J. A., Jones, M., Andrews, J. W., & Hill, L. J. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.11.45 · Cited by 1
BEYOND AREDS2: NEXT-GENERATION NUTRITIONAL SUPPLEMENTS FOR AGE-RELATED MACULAR DEGENERATION
Ćwiek, M., Omidi, A., Krawiec, B., Zarębski, B., Jadanowski, O., Sójka, J., Szombara, M., Mokrzyński, M., Szyszka, P., & Malec, K. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(47).2025.3710
Biomaterial-Based Drug Delivery Systems: Bridging Advances and Applications in Regenerative Medicine
Ansari, I., Yadav, S., & Prajapati, S. (2025) · Drug Metabolism and Bioanalysis · doi:10.2174/0118723128382078250818143502
Insight into vitreous biomechanics and clinical implications: A systematic reviewPreprint
Ong, L. F., Suresh, T., Son, E., Schwartz, D., & Brodie, F. L. (2025) · medRxiv · doi:10.1101/2025.09.17.25335952
Assessment of the pharmacological and safety profile of the small molecule MP-004 after topical eye drops administrationPreprint
Lara-López, A., Rodríguez-Hidalgo, M., Sarasola-Gastesi, M., González-Imaz, K., Zayas, J., Sagartzazu‐Aizpurua, M., Miranda, J. I., Espinosa, A., de Munain, A. L., Aizpurua, J. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.09.681374
Drug Delivery
Tomazoni, E., Penha, F. M., & Rodrigues, E. B. (2025) · Springer eBooks · doi:10.1007/978-3-031-29358-0_18-1
Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption
Clerck, K. D., Coster, E. D., Paoletti, L., Smedt, S. C. D., Remaut, K., & Peynshaert, K. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01987-6 · Cited by 1
Comments on “Refining the translational pathway for senotherapeutics in age-related macular degeneration: Insights on biomarkers, delivery strategies, and clinical trial design”
Aphale, P., Shekhar, H., & Dokania, S. (2025) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2025.10.002
Ocular drug delivery: Core principles and fundamental concepts
Srivastava, V., & Mehra, N. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33781-9.00018-6
Complex ophthalmic drug delivery approaches
Sharma, N., Sharma, N., Kaur, J., Raina, N., Kumar, A., & Gupta, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33781-9.00010-1
Effect of Molecular Size on Ocular Drug Distribution After Intravitreal Injection Using Computed Tomography and Mathematical Spatial Modeling
Konishi, K., Kimura, S., Minematsu, T., SHINOZAKI, A., Oishi, M., & Nagasaka, Y. (2025) · Pharmaceutical Research · doi:10.1007/s11095-025-03971-8
Additional file 1 of Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2
Grisé, K. N., Coles, B. L. K., Bautista, N. X., & van der Kooy, D. (2021) · Figshare · doi:10.6084/m9.figshare.16909578
Additional file 1 of Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation
Chan, Y.-J., Liao, P.-L., Tsai, C.-H., Cheng, Y.-W., Lin, F.-L., Ho, J.-D., Chen, C.-Y., & Li, C.-H. (2021) · Figshare · doi:10.6084/m9.figshare.13550758
Additional file 2 of Acute and continuous exposure of airborne fine particulate matter (PM2.5): diverse outer blood–retinal barrier damages and disease susceptibilities
Gu, Y., Sheng, F., Gao, M., Zhang, L., Hao, S., Chen, S., Chen, R., Xu, Y., Wu, D., Han, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26655436
Additional file 2 of Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation
Chan, Y.-J., Liao, P.-L., Tsai, C.-H., Cheng, Y.-W., Lin, F.-L., Ho, J.-D., Chen, C.-Y., & Li, C.-H. (2021) · Figshare · doi:10.6084/m9.figshare.13550761
Additional file 1 of Acute and continuous exposure of airborne fine particulate matter (PM2.5): diverse outer blood–retinal barrier damages and disease susceptibilities
Gu, Y., Sheng, F., Gao, M., Zhang, L., Hao, S., Chen, S., Chen, R., Xu, Y., Wu, D., Han, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.26655433
The Application of Animal-Derived Peptides for Glaucoma Control
Dourado, L. F. N. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1011595
Analysis of Performance Differences Between Self-Developed Fundus Surgery Image Evaluation Software and Kinovea in Ophthalmic MicrosurgeryPreprint
Xu, H., Hu, Y., Xu, Y., Yan, P., Zhong, B., & Liu, W. (2025) · Research Square · doi:10.21203/rs.3.rs-8029636/v1
Ocular metastasis in breast cancer: management of clinical case reports and a literature review
Gao, J., Cao, Q., Liu, Y., Huang, M., Li, M., & Xu, L. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2025.1605881
Monitoring Gene Expression in Retina with synthetic serum markersPreprint
Lu, J., Lee, S., Wang, M., Zheng, K., Oh, S. H., Lee, J., Soh, S., Cao, Y., Bao, X., Huang, Y., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.16.699406
Long-term suppression of retinal degeneration with anti-VEGF agents-loaded hollow mesoporous silica nanoparticles
Guo, R., Huang, Y., Zhang, X., Qin, M., Sun, H., Jin, X., Xu, J., Kang, Y., Li, K., Zhou, Y., et al. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115527
A Customizable Antibody Delivery Strategy Using Fc-Affinity Ligands
Isaacs-Bernal, D., Bahsoun, N. E.-H., Huo, L., Poda, G. I., Kozakov, D., & Shoichet, M. S. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c02112
Saccades orchestrate intraocular glucose dynamics to shape visual responses in birds
Xu, X., Xiao, T., Chen, Y., Song, L., Wu, C., Wang, Q., Zhang, T., & Yang, Y. (2026) · Nature Communications · doi:10.1038/s41467-026-70672-0
The effect of syringe design and cannula dimensions on time-force curve in intravitreal injection across different drug viscosities: area under the curve and peak injection force
Ackermann, B. C., Junker, N., Friedrich, M., Jørstad, Ø. K., Moe, M. C., Augustin, V. A., Auffarth, G. U., & Hammer, M. (2026) · International Journal of Retina and Vitreous · doi:10.1186/s40942-026-00833-2
Injected Eye, Fellow Eye and Systemic Pharmacokinetic Modeling of Intravitreally Administered Bevacizumab
Franz, M., Jairam, R. K., Ma, G., Rist, W., Fuchs, H., Kuepfer, L., Hanke, N., & Rimpelä, A. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c01877
Self-citation
Panton–Valentine leucocidin colocalized with retinal neurons cells and incited early retinal inflammation through rabbit endophthalmitis and retinal explant models
Liu, X. (2018) · theses.fr (ABES) · doi:10.70675/85bd72dez6353z441bz9566z17070f9d7ddc
Implants à base de PLGA pour la libération oculaire
Bode, C. (2019) · theses.fr (ABES) · doi:10.70675/db064711z80cez456aza9edzb4509e94b78b
Safety and Biodistribution of Topical Laquinimod, an Immunomodulator Targeting Aryl Hydrocarbon Receptor: The LION Study
Feky, D. E., Akhavanrezayat, A., Mobasserian, A., Khan, H. U., Elaraby, O., Yavari, N., Halim, M. S., Tran, A. N. T., Khatri, A., Uludağ, G., et al. (2026) · Ophthalmology Science · doi:10.1016/j.xops.2026.101186
Self-citation
Non-invasive pharmacological treatment of retinal degeneration in the Bardet-Biedl syndrome and related ciliopathies
Moreno, D. A. (2020) · doi:10.70675/8c0ccf40z399az4cfcz90bdz7f4915a9b876
Formulations de dérivés lipophénoliques, évaluation in vitro et in vivo de leur efficacité contre la dégénérescence maculaire
Vincent, M. (2022) · theses.fr (ABES) · doi:10.70675/ad0647d1z7132z4465z9e3fz19142509c761
Développement et évaluation de nouvelles formulations oculaires de spironolactone pour les segments antérieur et postérieur de l'œil
Rodrigues‐Braz, D. (2023) · theses.fr (ABES) · doi:10.70675/b5ea077fz3ec6z4238z8e5ez326aeef1629e
AI-Enabled Ocular Drug Delivery Systems for the Management of Eye Infections
Devaraj, S., & Neethirajan, G. (2026) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3487
A sequential dual-drug delivery system for multi-target inhibition of subretinal fibrosis
Zhang, Y., He, W., Wang, C., Liu, B., Wen, J., Zhao, Y. J., Zhang, Y., Liu, L., Yang, Q., Li, J., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04390-6
Targeted Delivery of Engineered Exosomes and the Advances for Their Applications in Ocular Tissue
Ju, Z., Shi, Y., Gao, L., Duan, W., & Liu, Y. (2026) · Current Eye Research · doi:10.1080/02713683.2026.2659098
Effective process for screening melanin binding affinity of small molecule drugs and new drug candidates
Vanhanen, P., Reinisalo, M., Lajunen, T., Kalinin, S., Leskinen, J., & Urtti, A. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126964
Self-citation
Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma
Raval, V., Arawindh, R., Naik, S., Jakati, S., & Venuganti, V. V. K. (2026) · Ophthalmology Science · doi:10.1016/j.xops.2026.101226
Intravitreal faricimab pharmacokinetics assessed by PET imaging in a neovascular Age-related Macular Degeneration rat model
García‐Otero, X., Cuartero‐Martínez, A., Fernández‐Robredo, P., Antas, S. G.-D., Gómez‐Lado, N., Otero-Espinar, F. J., Hernández, M., Bezunartea, J., García‐Layana, A., Recalde, S., et al. (2026) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2026.100567
Glaskörperersatzstoffe: Stand der Technik und zukünftige Perspektiven
Hammer, M., Junge, V., Junker, N., Auffarth, G. U., Szurman, P., & Schulz, A. (2026) · Die Ophthalmologie · doi:10.1007/s00347-026-02404-0
Biomaterial-based ocular drug delivery: strategies, challenges, and future perspectives
Chen, Y., Yang, J., Zhou, K., Chen, Z., & Zhang, J. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116377 · Cited by 1
Intraocular delivery of crystalline sorafenib provides sustained, potent inhibition of wet age-related macular degeneration
Lu, H., Rakoski, A. I., Ri, K., Zhou, L., Shi, L., Cho, H., Wu, S., Chen, S. S., Neill, A. N., Catazaro, J., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115120
A tear film-inspired biomimetic strategy with enhanced lubrication, anchoring, and antioxidative properties for dry eye disease
Lu, M., Lin, Y., Qi, D., Huang, B., Tian, Y., Gao, S., Tan, Z., Lin, Q., Ying, D., Liu, W. F., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.07.031
Liposomal nanocarriers in retinoblastoma: from molecular design to clinical translation
Arjmand, T. F., Shojaei, A., Mazloomi, M., & Alizadeh, E. (2026) · Cancer Nanotechnology · doi:10.1186/s12645-026-00404-y
Lithium as a Potential Neuroprotective Strategy in Glaucoma: Mechanisms and Therapeutic Perspectives
Martucci, A., Giulia, N., Adornetto, A., Aiello, F., Mancino, R., Cesareo, M., Bagetta, G., Nucci, C., Romano, E., & Russo, R. (2026) · Biomolecules · doi:10.3390/biom16071062
Hierarchical drug-releasing nanocomposite hydrogel for postoperative synergistic chemo-photothermal therapy of uveal melanoma
Guo, Z., Zhu, R., Wei, C., Wang, B., Lv, Y., Tan, J., Xiu, L., & Li, J. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103525
Eight-month sustained delivery of regorafenib from subconjunctival crystal depots for inhibition of corneal neovascularization
Jiang, S., Liu, J., Yang, H., Li, S., Meng, X., & Xia, D. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127295
From food to function: Nutraceutical-based modulation of mitochondrial, inflammatory and epigenetic networks in retinal neurodegeneration
Manjunatha, H. J., Mahalingappa, G., Varadaraju, S. R., Manjunath, S. H., Prashantha, K., Damle, A., Lee, C., & Kumar, A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103288
Visual Acuity Influences Visual Outcome in Endophthalmitis: A 10-Year Retrospective Observational Cohort Analysis
Nowosielski, Y., Erlacher, C., Maier, S., Rauchegger, T., Franchi, A., & Rehák, M. (2026) · Ophthalmology and Therapy · doi:10.1007/s40123-026-01468-0
Immunohistochemical Characterization of Intraocular Inflammation After Intravitreal Administration of Biologics to NHP and Minipigs: A Study Across Compounds
Firsching, T. C., Lenz, B. F., Neff, R., Lejeune, T., Wise, S., & Atzpodien, E.-A. (2026) · Toxicologic Pathology · doi:10.1177/01926233261469528
Natural polysaccharide microspheres for ocular drug delivery: Sources, design strategies, and therapeutic applications
Liu, S., Sun, P., Liu, X., Tan, J., Gong, Y., Chen, J., Xu, Q., Huang, Y., Yang, F., Wang, X., et al. (2026) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2026.101190
Molecular Determinants of Intravitreal Anti-VEGF Durability: Drug Architecture, Intraocular Pharmacokinetics, Target Biology and Treatment Resistance
Panos, G. D., Empeslidis, T., Amaxilati, E., Tsiropoulos, G. N., Topouzis, N., Konstas, P., Chatzimichail, E., Gatzioufas, Z., & Amoaku, W. M. K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177786
Tocopheryl polyethylene glycol 1000 succinate (TPGS-1000) in ophthalmic liposomal formulations: friend or foe?
Pierre, M., Lamaa, D., Escriou, V., & Charrueau, C. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127392
Ex Vivo Validation of the TONOVET Plus and TONOVET Pro in Cynomolgus Monkeys ( Macaca fascicularis ): Comparison of Canine and Lapine Calibration Modes
Kim, W.-T., Kang, S., Lee, J., Lee, J. Y., & Seo, K. (2026) · Veterinary Ophthalmology · doi:10.1111/vop.70265
Intra-vitreal drug delivery
Dias, M. F., Silva‐Cunha, A., & Fialho, S. L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36643-7.00005-6
Ferroptosis in retinal neurodegeneration: mechanistic vulnerability, therapeutic targeting, and translational barriers
Wu, G., Wang, S., Chen, Z., Li, J., & Li, K. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1890483
Ocular microdialysis in preclinical pharmacokinetic studies: Principles, challenges, and practical insights
Li, M., Niyangoda, S. S., Johnson, M. A., & Wang, M. Z. (2026) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2026.104506
A new omics view of retinal aging: Cell-type vulnerability, spatial niches, and disease susceptibility
Yang, L., & Li, Z. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111243
Nrf2/HO-1 signaling in retinal neurodegenerative diseases: redox homeostasis, cytoprotection, and therapeutic perspectives
Tang, Y., Yao, X., & Peng, Q. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1910230
Advanced Ophthalmic Drug Delivery in Homocystinuria Type CblC: A Translational Review of Ophthalmic Pathologies and Therapeutic Opportunities
Cuello-Rodríguez, S., Sanna, M., Lecoeuche, I., Sarmento, B., Otero-Espinar, F. J., & Díaz-Tomé, V. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18091182
Hollow Microneedles in Ophthalmology: From Drug Delivery to Integrated Biosensing
Sun, F., Xiao, C., Wang, Z., Hu, W., Peng, Z., Wong, Z. J., Tan, Z., & Cui, B. (2026) · Small · doi:10.1002/smll.75520
Carbon quantum materials for ocular nanotheranostics: Dimensionality-guided design for barrier transport, drug delivery, and therapeutic function
Akmal, M. H., Mousavi, S. M., Lai, J., & Chiang, W. (2026) · Carbon · doi:10.1016/j.carbon.2026.122153
DNA Origami Uptake in Y‐79 Retinoblastoma Cells Driven by Oligolysine Coating
Klose, A., Gounani, Z., Raik, S. V., Koivuniemi, A., Korhonen, S., Reinisalo, M., Lajunen, T., Linko, V., & Laaksonen, T. (2026) · Small Structures · doi:10.1002/sstr.70628
Self-citation
Drug Delivery
Tomazoni, E., Penha, F. M., & Rodrigues, E. B. (2026) · Springer eBooks · doi:10.1007/978-3-032-23052-2_18
Soft drugs: design principles and topical applications
Pirali, T., Accetta, A., Rautio, J., & Carzaniga, L. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-026-01535-y
A modified chitosan-based inflammation-regulating nanoplatform as a noninvasive carrier for macromolecular ophthalmic drug delivery toward synergistic AMD treatment
Zhao, H., Zhang, Q., Shen, J., Fang, Y., Lv, X., Miao, Y., Ma, B., Shuai, S., Hou, Z., Chen, L., et al. (2026) · Materials Horizons · doi:10.1039/d6mh01360k
Comparative ocular and systemic pharmacokinetics of lifitegrast delivered by an eye drop and chamber- and surface-loaded contact lenses in rabbitsPreprint
Kim, W., Jung, W., Kim, E., Kim, S., Lee, A., Kim, H. R., Choi, D. H., & Kim, T. H. (2026) · Research Square · doi:10.21203/rs.3.rs-11095677/v1
Phenylboronate hydrogel for administration route tailored dual-drug delivery to anterior and posterior ocular segments
Zhang, R. X., Wang, X., Yan, X., Yan, W. J., Wang, X.-T., Chen, Y., Deng, X., 吕维加, Guo, Y., & Yan, H. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115448
Efficacy and durability of GB10, a novel bispecific VEGF/Ang-2 neutralizing fusion protein, in ocular neovascularization models
Hao, M., 游琼英, Wei, X., & Qin, S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1974368
Possible Mechanical Stabilization of the Photoreceptor Connecting Cilium: From Molecular Scaffolds to Drug Repurposing
Weener, M. E., & Kotliar, K. E. (2026) · Cells · doi:10.3390/cells15211931
BindingDB Entry 50008251: Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure.
BindingDB (2021) · UC San Diego · doi:10.7270/q2wm1hss
BindingDB Entry 50001143: The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.
BindingDB (2020) · UC San Diego · doi:10.7270/q22f7qzm
A Mechanistic Dissection of Multifaceted Complement Attack in Age‐Related Macular Degeneration Reveals the Superiority of C3 Inhibition
Chen, Z., Wang, M., Liu, H., & Qian, F. (2026) · Advanced Science · doi:10.1002/advs.78539

Authors: del Amo, E. M., Rimpelä, A.-K., Heikkinen, E., Kari, O. K., Ramsay, E., Lajunen, T., Schmitt, M., Pelkonen, L., Bhattacharya, M., Richardson, D., Subrizi, A., Turunen, T., Reinisalo, M., Itkonen, J., Toropainen, E., Casteleijn, M., Kidron, H., Antopolsky, M., Vellonen, K.-S., Ruponen, M., & Urtti, A.
Affiliations: University of Helsinki (FI)
University of Eastern Finland (FI)
ORCID: Rimpelä, Anna-Kaisa
Heikkinen, Emma
Kari, Otto K.
Ramsay, Eva
Lajunen, Tatu
Pelkonen, Laura
Bhattacharya, Madhushree
Subrizi, Astrid
Reinisalo, Mika
Itkonen, Jaakko
Toropainen, Elisa
Casteleijn, Marco
Kidron, Heidi
Vellonen, Kati-Sisko
Ruponen, Marika
Urtti, Arto
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2017-03
Volume: 57
Pages: 134-185
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2016.12.001
OpenAlex: W2567416294
Cited by: 693
References: 476
Citations by year: 2026: 68 · 2025: 96 · 2024: 76 · 2023: 92 · 2022: 74 · 2021: 94 · 2020: 81 · 2019: 59 · 2018: 34 · 2017: 18
FWCI: 3.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Progress in Retinal and Eye Research (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion, other-oa)
UEF eRepo (University of Eastern Finland) (submittedVersion)
Työväentutkimus Vuosikirja (submittedVersion)
Funders: Sigrid Juséliuksen Säätiö (64578)
Itä-Suomen Yliopisto
Academy of Finland (263573, 263615, 268868, 272597, 283721)
Tekes (637/31/2015 TEKES)
Seventh Framework Programme
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords: retinal drug delivery, pharmacokinetics, intravitreal injection, systemic drug delivery, topical ocular drug delivery, targeted drug delivery, dosage, tolerability, ocular drug delivery systems
MeSH terms: Animals, Humans, Retina, Retinal Diseases, Tissue Distribution, Drug Delivery Systems, Angiogenesis Inhibitors, Intravitreal Injections

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pharmacokinetic aspects of retinal drug delivery

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks