Pharmacokinetic aspects of retinal drug delivery

Understanding biophysicochemical interactions at the nano–bio interface

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

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Regulated portals of entry into the cell

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Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles

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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

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The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

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Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

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Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

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Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

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Peptidomimetics Therapeutics for Retinal Disease

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Screening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular applications

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Stability of monoclonal antibodies after simulated subcutaneous administration

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High‐Efficiency Ocular Delivery of Brain‐Derived Neurotrophic Factor and Oligomycin for Neuroprotection in Glaucoma

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Thermoresponsive Hydrogels with Tunable Viscoelasticity for Extended Ocular Drug Delivery

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Recent advances and future challenges in nanosystems for ocular drug delivery

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mTORC1 Signaling and Negative Lens-Induced Axial Elongation

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Ag2S Biocompatible Ensembles as Dual OCT Contrast Agents and NIR Ocular Imaging Probes

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Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure

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Blood retinal barrier and ocular pharmacokinetics: Considerations for the development of oncology drugs

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5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery

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Neonatal ocular prophylaxis in the United States: is it still necessary?

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Advances in Drug Delivery and Biomaterials: Facts and Vision

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Comment on “Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5‐Associated Liposomes”: Topical Liposomal Bevacizumab Results in Negligible Retinal Concentrations

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Investigations Into Bioenergetic Neuroprotection of Cone Photoreceptors: Relevance to Retinitis Pigmentosa

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Ex-Vivo Trans-Corneal and Trans-Scleral Diffusion Studies with Ocular Formulations of Glutathione as an Antioxidant Treatment for Ocular Diseases

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Emerging opportunities for C3 inhibition in the eye

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The Role of Natural Products in Diabetic Retinopathy

Zhao, Y., Chen, Y., & Yan, N. (2024) · Biomedicines · doi:10.3390/biomedicines12061138 · Cited by 12

Intravitreal Metformin Protects Against Choroidal Neovascularization and Light-Induced Retinal Degeneration

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Repurposing verteporfin and hyaluronic acid gel for ocular surface treatment to prevent corneal scarring

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Toward successful retinal drug delivery after intravitreal injection: Current strategies to overcome the inner limiting membrane

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Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants

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Head and Neck 3D Bioprinting—A Review on Recent Advancements in Soft Tissue 3D Bioprinting and Medical Applications

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Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye

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Hotspots and trends in ophthalmology in recent 5 years: Bibliometric analysis in 2017–2021

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Improved Melatonin Delivery by a Size-Controlled Polydopamine Nanoformulation Attenuates Preclinical Diabetic Retinopathy

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Aqueous humour concentrations of PEDF and Erythropoietin are not influenced by subthreshold micropulse laser treatment of diabetic macular edema

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Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing

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Biperiden Challenge Model in Healthy Elderly as Proof‐of‐Pharmacology Tool: A Randomized, Placebo‐Controlled Trial

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Cyclodextrin‐Assisted Delivery of Azobenzene Photoswitches for Uniform and Long‐Term Restoration of Light Responses in Degenerated Retinas of Blind Mice

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Attenuation of Experimental Autoimmune Uveitis in Lewis Rats by Betaine

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Extracellular vesicles as a potential therapeutic for age-related macular degeneration

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7.1 T MRI and T2 mapping of the human and porcine vitreous body post mortem

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Inhibition of VCP preserves retinal structure and function in autosomal dominant retinal degenerationPreprint

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The learning curve of murine subretinal injection among clinically trained ophthalmic surgeons

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Polysaccharide-based injectable hydrogels for targeted drug delivery: advances and challenges

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JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice

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In-depth comparison of Anc80L65 and AAV9 retinal targeting and characterization of cross-reactivity to multiple AAV serotypes in humans

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Long‐Acting Microparticle Formulation of Griseofulvin for Ocular Neovascularization Therapy

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The significance of chemical transfection/transduction enhancers in promoting the viral vectors-assisted gene delivery approaches: A focus on potentials for inherited retinal diseases

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Catalytic neural stem cell exosomes for multi-stage targeting and synergistical therapy of retinal ischemia-reperfusion injury

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Delivery of therapeutics for deep-seated ocular conditions – status quo

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Non-invasive multimodal imaging of Diabetic Retinopathy: A survey on treatment methods and Nanotheranostics

Sadasivam, R., Packirisamy, G., Shakya, S., & Goswami, M. (2021) · Nanotheranostics · doi:10.7150/ntno.56015 · Cited by 10

Technological Advances in a Therapy of Primary Open-Angle Glaucoma: Insights into Current Nanotechnologies

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The Potential of Lisosan G as a Possible Treatment for Glaucoma

Amato, R., Rossino, M. G., Cammalleri, M., Timperio, A. M., Fanelli, G., Monte, M. D., Pucci, L., & Casini, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.719951 · Cited by 10

Nanomaterials and Nanotechnology in Medicine

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Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2

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Drug-Loaded Polymeric Particulated Systems for Ophthalmic Drugs Release

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Discovery and Potential Utility of a Novel Non-Invasive Ocular Delivery Platform

Wang, W., & Snider, N. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092344 · Cited by 8

Clinical Correlation of Retinal Fluid Fluctuation Represented by Fluctuation Index in Wet Age-Related Macular Degeneration: TOWER Study Report 2

Chantarasorn, Y., Ruamviboonsuk, P., Thoongsuwan, S., Vongkulsiri, S., Kungwanpongpun, P., & Hanutsaha, P. (2023) · Translational Vision Science & Technology · doi:10.1167/tvst.12.10.2 · Cited by 9

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Valtari, A., Posio, S., Toropainen, E., Balla, A., Puranen, J., Sadeghi, A., Ruponen, M., Ranta, V., Vellonen, K., Urtti, A. O., et al. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114260 · Cited by 9

Co-delivery of antioxidants and siRNA-VEGF: promising treatment for age-related macular degeneration

Dias, M. F., da Cruz-Cazarim, E. L. C., Pittella, F., Baião, A., Pacheco, C., Sarmento, B. F. C. C., & Fialho, S. L. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01772-x · Cited by 9

Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease

Karjosukarso, D. W., Bukkems, F., Duijkers, L., Tomkiewicz, T. Z., Kiefmann, J. F., Sarlea, A. S., Bervoets, S., Vázquez-Domínguez, I., Molday, L. L., Molday, R. S., et al. (2025) · Communications Medicine · doi:10.1038/s43856-024-00712-7 · Cited by 9

Delivery of Fenofibrate to Ocular Tissues using 2-Hydroxypropyl-β-cyclodextrin-Based Micelles

Klahan, B., O’Reilly, N. J., Sigurðsson, H. H., Chauhan, A., Mering, S., & Fitzhenry, L. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125417 · Cited by 9

Nanovesicular Drug Delivery Systems for Rare Ocular Diseases: Advances, Challenges, and Future Directions

Sultana, S., Yusuf, M., & Sharma, V. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03159-8 · Cited by 10

Emerging drug delivery strategies for glaucoma therapy: focus on nanoparticles and stimuli-responsive systems

Kundu, S., Kumari, G., & Srinivasarao, D. A. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00068h · Cited by 11

Hyaluronic acid methacryloyl-based co-delivery system for aflibercept and miR-21-3p antagomir: a dual-therapeutic approach for diabetic retinopathy

Ni, X.-S., Zhao, Y., Zhu, J., Liu, Y., Zhang, Z., Zhang, H., Liu, Q., Jiang, Q., Gao, S., & Yan, B. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114077 · Cited by 9

Combination Antioxidant/NSAID Therapies and Oral/Topical Ocular Delivery Modes for Prevention of Oxygen-Induced Retinopathy in a Rat Model

Beharry, K. D. A., Cai, C. L., Siddiqui, F., D’Agrosa, C., Zangaladze, A., Mustafa, G., Qadri, A., Duggan, T. J., & Aranda, J. V. (2020) · Nutrients · doi:10.3390/nu12071980 · Cited by 10

Ocular Versus Oral Propranolol for Prevention and/or Treatment of Oxygen-Induced Retinopathy in a Rat Model

Qadri, A., Cai, C. L., Deslouches, K., Siddiqui, F., Aranda, J. V., & Beharry, K. D. A. (2021) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2020.0092 · Cited by 9

Glial contribution to cyclodextrin-mediated reversal of cholesterol accumulation in murine NPC1-deficient neurons in vivo

Barthelemy, A., Demais, V., Stancu, I., Vasile, E., Houben, T., Reber, M., Pallottini, V., Perraut, M., Reibel, S., & Pfrieger, F. W. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105469 · Cited by 8

Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model

Bergen, T. V., Hu, T., Little, K., Groef, L. D., Moons, L., Stitt, A. W., Vermassen, E., & Feyen, J. H. M. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.13.18 · Cited by 9

Systemic C‐peptide supplementation ameliorates retinal neurodegeneration by inhibiting VEGF ‐induced pathological events in diabetes

Lee, A.-J., Moon, C., Lee, Y., Jeon, H., Park, W. S., & Ha, K. (2023) · The FASEB Journal · doi:10.1096/fj.202201390rr · Cited by 9

Novel therapeutic perspectives for wet age-related macular degeneration: RGD-modified liposomes loaded with 2-deoxy-D-glucose as a promising nanomedicine

Chen, X., Liu, S., Chen, M., Ni, N., Zhou, R., Wang, Y., Xu, Y., Wang, Y., Gao, H., Zhang, D., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116776 · Cited by 9

Role of Blood Retinal Barrier in Drug Absorption

Tyagi, A., Sharma, P. K., & Malviya, R. (2018) · Pharmaceutica Analytica Acta · doi:10.4172/2153-2435.1000585 · Cited by 9

Retinal and choroidal cancers: Blood-retinal barriers considerations in ocular chemotherapy

Matet, A., Béhar‐Cohen, F., Cassoux, N., Declèves, X., & Cisternino, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816434-1.00010-3 · Cited by 9

Transport and fate of aflibercept in VEGF-A165-challenged retinal endothelial cells

Deissler, H. L., Sommer, K., Lang, G. K., & Lang, G. E. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108156 · Cited by 9

Quantification of Drugs in Distinctly Separated Ocular Substructures of Albino and Pigmented Rats

Rimpelä, A., Garneau, M., Kroker, K. S., Schönberger, T., Runge, F. E., & Sauer, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121174 · Cited by 9

Ocular drug delivery systems

Nayak, K., Choudhari, M. V., Bagul, S., Chavan, T. A., & Misra, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819838-4.00006-7 · Cited by 10

Assessment of Suprachoroidal Injection of Triamcinolone Acetonide in Cases of Diabetic Macular Edema

Yousef, M. S., Elhafez, Y. A., & Farag, M. (2021) · International Journal of Medical Arts · doi:10.21608/ijma.2021.55079.1230 · Cited by 10

Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis

Delgado‐Tirado, S., González-Buendía, L., An, M. B., Amarnani, D., Isaacs-Bernal, D., Whitmore, H. A. B., Arévalo-Alquichire, S., Leyton-Cifuentes, D., Ruiz‐Moreno, J. M., Arboleda‐Velásquez, J. F., et al. (2022) · Ophthalmology Science · doi:10.1016/j.xops.2022.100163 · Cited by 9

A sustainable approach for the stability study of psychotropic substances using vitreous humor and liver as alternative matrices

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Enhanced immune responses to vaccine antigens in the corneal stroma

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