The DOI matches its Crossref record; 298 of the 303 references it cites were found in a registry or an index.
On the origin of proteins in human drusen: The meet, greet and stick hypothesis
Open accessAbstract
Retinal drusen formation is not only a clinical hallmark for the development of age-related macular degeneration (AMD) but also for other disorders, such as Alzheimer's disease and renal diseases. The initiation and growth of drusen is poorly understood. Attention has focused on lipids and minerals, but relatively little is known about the origin of drusen-associated proteins and how they are retained in the space between the basal lamina of the retinal pigment epithelium and the inner collagenous layer space (sub-RPE-BL space). While some authors suggested that drusen proteins are mainly derived from cellular debris from processed photoreceptor outer segments and the RPE, others suggest a choroidal cell or blood origin. Here, we reviewed and supplemented the existing literature on the molecular composition of the retina/choroid complex, to gain a more complete understanding of the sources of proteins in drusen. These "drusenomics" studies showed that a considerable proportion of currently identified drusen proteins is uniquely originating from the blood. A smaller, but still large fraction of drusen proteins comes from both blood and/or RPE. Only a small proportion of drusen proteins is uniquely derived from the photoreceptors or choroid. We next evaluated how drusen components may "meet, greet and stick" to each other and/or to structures like hydroxyapatite spherules to form macroscopic deposits in the sub-RPE-BL space. Finally, we discuss implications of our findings with respect to the previously proposed homology between drusenogenesis in AMD and plaque formation in atherosclerosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“drusen, a hallmark of AMD containing systemic proteins, have been suggested to result from pathological transport of visual cycle by-products across the capillary wall or BrM [219].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [219]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lang, G. E., Vaiser, A., Snyder, W. B., & Lynn, J. R. (2007) · Developments in ophthalmology · doi:10.1159/isbn.978-3-318-01439-6 · Cited by 5,607
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492
Minimum information about a microarray experiment (MIAME)-toward standards for microarray data
Brazma, A., Hingamp, P., Quackenbush, J., Sherlock, G., Spellman, P., Stoeckert, C., Aach, J., Ansorge, W., Ball, C. A., Causton, H. C., et al. (2001) · Nature Genetics · doi:10.1038/ng1201-365 · Cited by 4,109
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Complement factor H polymorphism and age-related macular degeneration
Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424
Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961
Bird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T. V. M., Klaver, C. C. W., Klein, B. E. K., Klein, R., et al. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80092-x · Cited by 1,926
Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3448 · Cited by 1,544
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413
Cited by
Sorted by citations
Central serous chorioretinopathy: Towards an evidence-based treatment guideline
van Rijssen, T. J., van Dijk, E. H. C., Yzer, S., Ohno‐Matsui, K., KEUNEN, J. E. E., Schlingemann, R. O., Sivaprasad, S., Querques, G., Downes, S. M., Fauser, S., et al. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.07.003 · Cited by 489
Self-citationFields, M. A., Priore, L. V. D., Adelman, R. A., & Rizzolo, L. J. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100803 · Cited by 179
Retinal Degeneration and Alzheimer’s Disease: An Evolving Link
Ashok, A., Singh, N., Chaudhary, S., Bellamkonda, V., Kritikos, A. E., Wise, A. S., Rana, N. A., McDonald, D., & Ayyagari, R. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197290 · Cited by 164
Schnichels, S., Paquet‐Durand, F., Löscher, M., Tsai, T., Hurst, J., Joachim, S. C., & Klettner, A. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100880 · Cited by 152
Central serous chorioretinopathy: An evidence-based treatment guideline
Feenstra, H. M. A., van Dijk, E. H. C., Cheung, C. M. G., Ohno‐Matsui, K., Lai, T. Y. Y., Koizumi, H., Larsen, M., Querques, G., Downes, S. M., Yzer, S., et al. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101236 · Cited by 141
Self-citationDynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life
Lewandowski, D., Sander, C. L., Tworak, A., Gao, F., Xu, Q., & Skowronska‐Krawczyk, D. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101037 · Cited by 111
Role of Mitochondria in Retinal Pigment Epithelial Aging and Degeneration
Tong, Y., Zhang, Z., & Wang, S. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.926627 · Cited by 102
Yumnamcha, T., Devi, T. S., & Pukhrambam, L. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01065 · Cited by 91
Flores‐Bellver, M., Mighty, J., Aparicio‐Domingo, S., Li, K. V., Shi, C., Zhou, J., Cobb, H., McGrath, P. S., Michelis, G., Lenhart, P., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12165 · Cited by 89
Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula
van Dijk, E. H. C., & Boon, C. J. F. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100955 · Cited by 88
Self-citationThe retinal pigmentation pathway in human albinism: Not so black and white
Bakker, R., Wagstaff, E. L., Kruijt, C. C., Emri, E., van Karnebeek, C., Hoffmann, M. B., Brooks, B. P., Boon, C. J. F., Montoliu, L., van Genderen, M. M., et al. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101091 · Cited by 88
Self-citationBrinks, J., van Dijk, E. H. C., Klaassen, I., Schlingemann, R. O., Kiełbasa, S. M., Emri, E., Quax, P. H. A., Bergen, A. A. B., Meijer, O. C., & Boon, C. J. F. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100994 · Cited by 82
Self-citationAging of the eye: Lessons from cataracts and age-related macular degeneration
Cvekl, A., & Vijg, J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102407 · Cited by 77
Implications of genetic variation in the complement system in age-related macular degeneration
de Jong, S., Gagliardi, G., Garanto, A., de Breuk, A., Lechanteur, Y. T. E., Katti, S., van den Heuvel, L. P., Volokhina, E. B., & den Hollander, A. I. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100952 · Cited by 71
La Cunza, N., Tan, L. X., Thamban, T., Germer, C. J., Rathnasamy, G., Toops, K. A., & Lakkaraju, A. (2021) · JCI Insight · doi:10.1172/jci.insight.142254 · Cited by 65
Dyslipidemia in age-related macular degeneration
Lin, J. B., Halawa, O. A., Husain, D., Miller, J. W., & Vavvas, D. G. (2022) · Eye · doi:10.1038/s41433-021-01780-y · Cited by 67
Matrix Metalloproteinases in Age-Related Macular Degeneration (AMD)
García‐Onrubia, L., Valentín-Bravo, F. J., Coco, R. M., González‐Sarmiento, R., Jimeno, J. C. P., Usategui‐Martín, R., & Pastor‐Idoate, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165934 · Cited by 54
New insights into the role of autophagy in retinal and eye diseases.
Villarejo-Zori, B., Jiménez-Loygorri, J. I., Zapata-Muñoz, J., Bell, K., & Boya, P. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101038 · Cited by 50
Sun, Y., Li, F., Liu, Y., Qiao, D., Yao, X., Liu, G., Li, D., Xiao, C., Wang, T., & Chi, W. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101263 · Cited by 54
Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44
Suzumura, A., Terao, R., & Kaneko, H. (2020) · Antioxidants · doi:10.3390/antiox9100920 · Cited by 44
Eye on the horizon: The metabolic landscape of the RPE in aging and disease
Hansman, D., Du, J., Casson, R. J., & Peet, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101306 · Cited by 50
Bruch’s membrane pathology: A mechanistic perspective
Murali, A., Krishnakumar, S., Subramanian, A., & Parameswaran, S. (2020) · European Journal of Ophthalmology · doi:10.1177/1120672120919337 · Cited by 41
Zebrafish and inherited photoreceptor disease: Models and insights
Noel, N. C. L., Allison, W. T., MacDonald, I. M., & Hocking, J. C. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101096 · Cited by 34
Koster, C., van den Hurk, K., ten Brink, J. B., Lewallen, C. F., Stanzel, B. V., Bharti, K., & Bergen, A. A. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23062918 · Cited by 34
Self-citationA Systematic Review on Transplantation Studies of the Retinal Pigment Epithelium in Animal Models
Koster, C., Wever, K. E., Wagstaff, E. L., van den Hurk, K., Hooijmans, C. R., & Bergen, A. A. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082719 · Cited by 33
Self-citationMcHarg, S., Booth, L., Perveen, R., Riba‐Garcia, I., Brace, N., Bayatti, N., Sergouniotis, P. I., Phillips, A. M., Day, A. J., Black, G. C. M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118510119 · Cited by 32
Quercetin protect cigarette smoke extracts induced inflammation and apoptosis in RPE cells
Zhu, Q., Liu, M., He, Y., & Yang, B. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1608217 · Cited by 32
Late‐onset retinal degeneration pathology due to mutations in CTRP5 is mediated through HTRA1
Chekuri, A., Zientara‐Rytter, K., Soto‐Hermida, A., Borooah, S., Voronchikhina, M., Biswas, P., Kumar, V., Goodsell, D. S., Hayward, C., Shaw, P. X., et al. (2019) · Aging Cell · doi:10.1111/acel.13011 · Cited by 30
Zhang, Q., Liu, Z., Li, J., & Liu, G. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s288419 · Cited by 32
Jabbehdari, S., Oganov, A. C., Rezagholi, F., Mohammadi, S., Harandi, H., Yazdanpanah, G., & Arévalo, J. F. (2023) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2023.11.003 · Cited by 30
Innate Immunity in Age-Related Macular Degeneration
Zhang, Y., & Wong, W. T. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-66014-7_5 · Cited by 27
Shin, K., Kent, J. E., Singh, C., Fujimoto, L. M., Yu, J., Tian, Y., Im, W., & Marassi, F. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007699117 · Cited by 26
Noel, N. C. L., Nadolski, N. J., Hocking, J. C., MacDonald, I. M., & Allison, W. T. (2020) · Cells · doi:10.3390/cells9102214 · Cited by 25
Cillà, S. D., Farruggio, S., Cocomazzi, G., Mary, D., Alkabes, M., Rossetti, L. M., Vujosevic, S., & Grossini, E. (2020) · Cellular Physiology and Biochemistry · doi:10.33594/000000212 · Cited by 21
A G-Protein Coupled Receptor and Macular Degeneration
Figueroa, A. G., & McKay, B. S. (2020) · Cells · doi:10.3390/cells9040910 · Cited by 21
Benefits of plant carotenoids against age-related macular degeneration
Nguyen, D. M., Thrimawithana, T. R., Piva, T. J., Grando, D., & Huynh, T. T. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105597 · Cited by 20
Circadian clocks, retinogenesis and ocular health in vertebrates: new molecular insights
Béry, A., Bagchi, U., Bergen, A. A. B., & Felder‐Schmittbuhl, M. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.02.001 · Cited by 22
Self-citationMechanobiological implications of age-related remodelling in the outer retina
Piskova, T., Kozyrina, A. N., & Russo, J. D. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213343 · Cited by 18
Bruch's Membrane Calcification in Pseudoxanthoma Elasticum
Risseeuw, S., Pilgrim, M. G., Bertazzo, S., Brown, C. N., Csincsik, L., Fearn, S., Thompson, R. B., Bergen, A. A. B., ten Brink, J. B., Körtvely, E., et al. (2023) · Ophthalmology Science · doi:10.1016/j.xops.2023.100416 · Cited by 17
Self-citationThe Placental Growth Factor Pathway and Its Potential Role in Macular Degenerative Disease
Cunningham, F., Bergen, T. V., Canning, P., Lengyel, I., Feyen, J. H. M., & Stitt, A. W. (2019) · Current Eye Research · doi:10.1080/02713683.2019.1614197 · Cited by 18
Self-citationBiasella, F., Strunz, T., Kiel, C., Weber, B. H. F., & Friedrich, U. (2022) · Cells · doi:10.3390/cells11111766 · Cited by 17
Kiruthika, M., & Malathi, G. (2024) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2024.104454 · Cited by 16
Systemic Metabolomics in a Framework of Genetics and Lifestyle in Age-Related Macular Degeneration
Thee, E. F., Acar, İ. E., Colijn, J. M., Meester‐Smoor, M. A., Verzijden, T., Baart, S. J., Jarboui, M. A., Fauser, S., Hoyng, C. B., Ueffing, M., et al. (2023) · Metabolites · doi:10.3390/metabo13060701 · Cited by 15
Yeh, W.-J., Chien, P.-T., Wen, Y.-T., & Wu, C. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110142 · Cited by 16
Menero‐Valdés, P., Lores‐Padín, A., Fernández, B., Quarles, C. D., García, M., González‐Iglesias, H., & Pereiro, R. (2022) · Talanta · doi:10.1016/j.talanta.2022.123974 · Cited by 14
Pinelli, R., Biagioni, F., Limanaqi, F., Bertelli, M., Scaffidi, E., Polzella, M., Busceti, C. L., & Fornai, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155563 · Cited by 16
Markers and mechanisms of death in Drosophila
Tower, J. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1292040 · Cited by 15
Fructosamine-3-Kinase as a Potential Treatment Option for Age-Related Macular Degeneration
Bruyne, S. D., den Broecke, C. V., Vrielinck, H., Khelifi, S., Wever, O. D., Bracke, K. R., Huizing, M. T., Boston, N., Himpe, J., Speeckaert, M. M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092869 · Cited by 13
Pinelli, R., Ferrucci, M., Biagioni, F., Bumah, V. V., Scaffidi, E., Puglisi‐Allegra, S., & Fornai, F. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230705103839 · Cited by 12
Molins, B., Rodríguez, A., Llorenç, V., & Adán, A. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01789 · Cited by 12
Age-Related Macular Degeneration and Its Association With Neurodegenerative Disorders
Mody, S., & Joshi, A. (2023) · Cureus · doi:10.7759/cureus.34920 · Cited by 13
den Haan, J., de Ruyter, F. J. H., Lochocki, B., Kroon, M. A. G. M., Kemper, E. M., Teunissen, C. E., van Berckel, B. N. M., Scheltens, P., Hoozemans, J. J. M., van de Kreeke, A., et al. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12347 · Cited by 11
Pilgrim, M. G., Marouf, S., Fearn, S., Csincsik, L., Körtvely, E., Knowles, J. C., Malek, G., Thompson, R. B., & Lengyel, I. (2021) · Ophthalmology Science · doi:10.1016/j.xops.2021.100053 · Cited by 11
Self-citationGopinath, T., Shin, K., Tian, Y., Im, W., Struppe, J. O., Perrone, B., Hassan, A., & Marassi, F. M. (2024) · Journal of Structural Biology · doi:10.1016/j.jsb.2024.108061 · Cited by 10
PATHWAYS TO GEOGRAPHIC ATROPHY IN NONNEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Spaide, R. F. (2024) · Retina · doi:10.1097/iae.0000000000004242 · Cited by 9
Wang, Y., Lv, Z., Chen, Y., Cen, X., Zhang, H., & Chen, D. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.052015 · Cited by 9
Gao, Y., Wang, R., Mou, K., Zhang, Y., Xu, H., Liu, Y., Yang, F., Gao, Y., Wang, X., Li, B., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01551-3 · Cited by 9
Age-related macular degeneration
James, L. M. (2024) · Nursing · doi:10.1097/nsg.0000000000000079 · Cited by 9
Peterson, K. M., Mishra, S., Asaki, E., Powell, J. I., He, Y., Berger, A. E., Rajapakse, D., & Wistow, G. J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0293383 · Cited by 8
Vision on gyrate atrophy: why treat the eye?
Bergen, A. A. B., Buijs, M. J., ten Asbroek, A. L. M. A., Balfoort, B. M., Boon, C. J. F., Diederen, R. M. H., Ferdinandusse, S., Ferreira, E. A., Schultink, P., Timmer, C., et al. (2023) · EMBO Molecular Medicine · doi:10.1038/s44321-023-00001-1 · Cited by 8
Self-citationEarly onset drusen and RPE dysfunction in a patient with NLRP3-AID
Li, B., Yang, Z., Zhao, X., Chen, Y., Li, D., Zhang, L., Min, H., Yu, W., & Shen, M. (2022) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2022.2113804 · Cited by 7
Altered zinc homeostasis in a primary cell culture model of the retinal pigment epithelium
Álvarez-Barrios, A., Álvarez, L., Artime, E., García, M., Lengyel, I., Pereiro, R., & González‐Iglesias, H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1124987 · Cited by 8
Self-citationKlee, K., Storti, F., Maggi, J., Todorova, V., Karademir, D., Berger, W., Samardzija, M., & Grimm, C. (2020) · Genes · doi:10.3390/genes11010111 · Cited by 6
Ranjan, R., Kayastha, A. M., & Sinha, N. (2020) · Biophysical Chemistry · doi:10.1016/j.bpc.2020.106430 · Cited by 7
Dohl, J., Burns, G., & Singh, M. K. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02165-2 · Cited by 7
Wang, K., Hsieh, M., Chien, H., Lee, C., Yeh, C., Huang, J., & Yang, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18010301 · Cited by 6
Calcium-induced environmental adaptability of the blood protein vitronectin
Tian, Y., Shin, K., Aleshin, A. E., Im, W., & Marassi, F. M. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.08.044 · Cited by 6
Advances in eye-brain axis: Anatomy, immunity, and association with visual dysfunction
Zhang, S., Fan, Z., & Ji, D. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102925 · Cited by 5
Louer, E., Lorés‐Motta, L., Ion, A. M., den Hollander, A. I., & Deen, P. M. T. (2019) · RNA Biology · doi:10.1080/15476286.2019.1643100 · Cited by 5
Are macular drusen in midlife a marker of accelerated biological ageing?
Wilson, G., Cheyne, K. R., Ramrakha, S., Ambler, A. P., Tan, G. S. W., Caspi, A., Williams, B., Sugden, K., Houts, R., Niederer, R. L., et al. (2021) · Clinical and Experimental Optometry · doi:10.1080/08164622.2021.2012428 · Cited by 4
Molins, B., Mesquida, M., & Adán, A. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101097 · Cited by 5
RetractedVision on gyrate atrophy: why treat the liver?
Boffa, I., & Brunetti‐Pierri, N. (2023) · EMBO Molecular Medicine · doi:10.1038/s44321-023-00002-0 · Cited by 4
Anvesh, K., Hariharan, S., Reshmi, B. M., Xu, Q., Lu, J., Kukreja, V., & Krishnamoorthy, M. (2025) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2025.112316 · Cited by 3
Overview and definition of age-related macular degeneration
Li, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822061-0.00004-9 · Cited by 2
Emri, E., Cappa, O., Kelly, C., Körtvely, E., SanGiovanni, J. P., McKay, B. S., Bergen, A. A. B., Simpson, D. A. C., & Lengyel, I. (2023) · Cells · doi:10.3390/cells12050773 · Cited by 3
Self-citationKropp, M., Mohit, M., Leroy-Ciocanea, C. I., Schwerm, L., Harmening, N., Bascuas, T., Clerck, E. E. B. D., Kreis, A., Pajic, B., Johnen, S., et al. (2023) · Antioxidants · doi:10.3390/antiox12061211 · Cited by 3
Álvarez-Barrios, A., Álvarez, L., Pereiro, R., & González‐Iglesias, H. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-04880-8 · Cited by 3
Ma, D. J., Oh, B., Bak, E., Kim, J.-S., Lee, J., & Choi, H. J. (2024) · Biomedicines · doi:10.3390/biomedicines12122681 · Cited by 2
Cioanca, A. V., Natoli, R., & Wooff, Y. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-27681-1_14 · Cited by 2
Mapanao, J. R., & Lozano, P. L. (2024) · International Conference on Computer Communication and the Internet (ICCCI) · doi:10.1109/iccci62159.2024.10674599 · Cited by 2
Goyanes, E., Leyva, S., Herrero, P., de Moura, J., Novo, J., & Ortega, M. (2024) · Procedia Computer Science · doi:10.1016/j.procs.2024.09.529 · Cited by 2
Tan, R. Y. Y., Drazyk, A. M., Urankar, K., Bailey, C., Gräf, S., Markus, H. S., & Giffin, N. (2021) · Practical Neurology · doi:10.1136/practneurol-2021-003058 · Cited by 1
Ranjan, R., Kayastha, A. M., & Sinha, N. (2021) · The Protein Journal · doi:10.1007/s10930-021-10026-5 · Cited by 1
Sever, Ö., & Mercan, R. (2020) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-2001-36 · Cited by 1
Goyanes, E., Leyva, S., Herrero, P., de Moura, J., Novo, J., & Ortega, M. (2025) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2025.108476 · Cited by 1
Neovascular age‐related macular degeneration without drusen
Sirks, M. J., van Dijk, E. H. C., Ghalayini, H., Bazdar, S., Yu, W., Yzer, S., Ciriano, J. P. M., Schlingemann, R. O., Diederen, R. M. H., & Boon, C. J. F. (2025) · Acta Ophthalmologica · doi:10.1111/aos.70010 · Cited by 1
Self-citationAn Unexpected Role for GPR143 in Retinal HomeostasisPreprint
Tung, D., Congrove, N. R., Figueroa, A. G., Bliss, R. M., Zvavamwe, T., & McKay, B. S. (2023) · Preprints.org · doi:10.20944/preprints202301.0094.v1 · Cited by 1
APOE Impacts Lipid Trafficking in Retinal Pigment Epithelium CellsPreprint
Richards, S. E. V., Demirs, J. T., Jose, S., Fan, L., Xu, Y., Esterberg, R., Huang, C. L., Wilson, C. W., Saint‐Geniez, M., & Liao, S.-M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.30.596647 · Cited by 1
The metabolite receptor SUCNR1 in oxidative stress-induced age-related macular degenerationPreprint
Louer, E., Deen, P. M. T., & den Hollander, A. I. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.24.962779
Diagnosis of age-related macular degeneration
Li, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822061-0.00012-8
Pathogenesis of age-related macular degeneration
Li, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822061-0.00002-5
“TOOTH AGENESIS: A REVIEW OF MOLECULAR BASES”
Luciani, F., Papa, E., Costantini, R., Condò, R., & Calabrese, L. (2021) · Indian Journal Of Applied Research · doi:10.36106/ijar/1216293
A 2,7-dichlorofluorescein derivative to monitor microcalcifications
Tholen, P., Brown, C. N., Keil, C., Bayır, A., Zeng, H.-H., Haase, H., Thompson, R. B., Lengyel, I., & Yücesan, G. (2022) · Molecular Systems Design & Engineering · doi:10.1039/d2me00185c
Self-citationGonzález‐Zamora, J. (2023) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · doi:10.15581/10171/69537
Noel, N. C. L., Breitenbach, E., & MacDonald, R. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.23.683644
Circadian regulation of the retinal pigment epithelium–photoreceptor complex
Milićević, N. (2020) · theses.fr (ABES) · doi:10.70675/2a3b679cz473bz4c14zb33az700581cd794a
Biological rhythms in retinal development
Bagchi, U. (2022) · theses.fr (ABES) · doi:10.70675/f3adc3caz635bz4f0ezbd7az684aff912e21
Smeller, L., Ördögh, D., Burcsár, S., Balog, A., Szalay, L., Tóth‐Molnár, E., & Sohár, N. (2026) · PLoS ONE · doi:10.1371/journal.pone.0346705
Kurzawa‐Akanbi, M., Haggarty, J. H., Hansohn, C., Patel, M. T., Cree, A. J., Teo, P., Armstrong, M., Coles, N., Platt, M., Griffiths, H., et al. (2026) · Journal of Extracellular Biology · doi:10.1002/jex2.70178
Metadata
- Authors
- Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P. J., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J., & Lengyel, I.
- Affiliations
- Netherlands Institute for Neuroscience (NL)
- University of St Andrews (GB)
- Amsterdam UMC Location University of Amsterdam (NL)
- University College London (GB)
- Helmholtz Munich (DE)
- Leiden University Medical Center (NL)
- Queen's University Belfast (GB)
- Corresponding author
- Bergen, Arthur A.
- ORCID
- Venue
- Progress in Retinal and Eye Research
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 70
- Pages
- 55-84
- ISSN
- 1350-9462 (ISSN-L)
- OpenAlex
- W2905434803
- Cited by
- 101
- References
- 303
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 17 · 2023: 18 · 2022: 15 · 2021: 17 · 2020: 18 · 2019: 7
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Progress in Retinal and Eye Research (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion, other-oa)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- de Algemene Nederlandse Vereniging ter Voorkoming van Blindheid (ANVVB)
- de Stichting Blinden-Penning
- de Gelderse Blinden Stichting
- de Landelijke Stichting voor Blinden en Slechtzienden (LSBS)
- Stichting Oogfonds Nederland
- Stichting MD Fonds
- Stichting Retina Nederland Fonds
- Uitzicht (2011-6, 2014-7)
- de Rotterdamse Stichting Blindenbelangen (RSB)
- de Haagse Stichting Blindenhulp
- Stichting Lijf en Leven
- Stichting voor Ooglijders
- ZonMW (446001002)
- Bill Brown Charitable Trust
- Moorfields Eye Hospital Special Trustees
- Fight for Sight
- European Union’s Horizon 2020 research and innovation programme (634479)
- Bright Focus Foundation (M2015370)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- retinal drusen, age-related macular degeneration, retinal pigment epithelium, photoreceptor outer segments, choroid, drusen formation, Alzheimer's disease, kidney disease
- MeSH terms
- Eye Proteins, Humans, Retinal Drusen, Bruch Membrane, Proteome, Proteomics, Retinal Pigment Epithelium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
