Cited by 213Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

Pharmacotherapy of Obsessive-compulsive Disorder and Obsessive-Compulsive Spectrum Disorders

Denys, Damiaan·2006·Psychiatric Clinics of North America

Abstract

This article reviews new developments of pharmacotherapy in obsessive-compulsive disorder (OCD) and OC spectrum disorders of the past five years. New developments primarily involved the ex-tension of evidence of efficacy of serotonin reuptake inhibitors(SRIs), the use of atypical antipsychotics in addition to SRIs for treatment refractory patients, the combination of pharmacotherapy with behavior therapy, and studies assessing predictors of response. Today, frontline pharmacological treatment of OCD still consists of drugs with potent serotonin reuptake inhibition proper-ties. In case of non-response, treatment options comprise adding another drug, increasing the dose, switching drugs, or changing the mode of delivery.

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Crossref · 10.1016/j.psc.2006.02.013

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Authors
Denys, D.
Affiliations
Utrecht University (NL)
Corresponding author
Denys, Damiaan
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2006-06
Volume
29
Issue
2
Pages
553-584
ISSN
0193-953X (ISSN-L)
OpenAlex
W2167273704
Cited by
213
References
142
Citations by year
2026: 4 · 2025: 9 · 2024: 18 · 2023: 10 · 2022: 15 · 2021: 16 · 2020: 15 · 2019: 7 · 2018: 9 · 2017: 11 · 2016: 2 · 2015: 16 · 2014: 12 · 2013: 9 · 2012: 4
FWCI
1.44
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
obsessive-compulsive disorder, obsessive-compulsive spectrum disorders, pharmacotherapy, serotonin reuptake inhibitors, atypical antipsychotics, treatment-refractory OCD, predictors of treatment response, drug switching, drug delivery
MeSH terms
Brain, Clomipramine, Humans, Obsessive-Compulsive Disorder, Cognitive Behavioral Therapy, Fluvoxamine, Selective Serotonin Reuptake Inhibitors, Sertraline, Positron-Emission Tomography

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