Cognitive-behavioural therapy augments the effects of deep brain stimulation in obsessive-compulsive disorder
Abstract
BACKGROUND: Deep brain stimulation (DBS) is a promising new treatment for patients with treatment-refractory obsessive-compulsive disorder (OCD). However, since most DBS patients only show a partial response, the treatment still needs to be improved. In this study we hypothesized that cognitive-behavioural therapy (CBT) could optimize the post-operative management in DBS and we evaluated the efficacy of CBT as augmentation to DBS targeted at the nucleus accumbens. METHOD: A total of 16 patients with treatment-refractory OCD were treated with DBS targeted at the nucleus accumbens. After stabilization of decline in OCD symptoms, a standardized 24-week CBT treatment programme was added to DBS in an open-phase trial of 8 months. Changes in obsessive-compulsive, anxiety and depressive symptoms were evaluated using the Yale-Brown Obsessive Compulsive Scale, Hamilton Anxiety Scale and Hamilton Rating Scale for Depression. RESULTS: Following the addition of CBT to DBS, a significant decrease in obsessive-compulsive symptoms was observed, but not in anxiety and depressive symptoms. In a subsequent double-blind phase, in which stimulation was discontinued, OCD symptoms returned to baseline (relapse) and anxiety and depressive symptoms worsened (rebound) compared with baseline. CONCLUSIONS: The results of this explorative study suggest that a combined treatment of accumbens DBS and CBT may be optimal for improving obsessive-compulsive symptoms in treatment-refractory OCD. However, a subsequent randomized controlled trial is necessary to draw firm conclusions. It seems that DBS results in affective changes that may be required to enable response prevention in CBT. This may indicate that DBS and CBT act as two complementary treatments.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A recent study demonstrated combining DBS with CBT (which included ERP) resulted in reduction of OCD symptoms in a treatment-refractory sample.
“a recent study demonstrated that combining DBS with CBT (which included ERP) resulted in a reduction of OCD symptoms in a treatment-refractory sample.[70]”
From Exposure and response prevention for obsessive-compulsive disorder: A review and new directions (2019) · cites this paper as [70]
Rehabilitation and behavioral therapy have been shown to have an additive effect for patients receiving DBS for OCD.
“Rehabilitation and behavioral therapy have been shown to have an additive effect for patients receiving DBS for OCD [113].”
From Deep brain stimulation for depression. (2022) · cites this paper as [113]
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110054008 · Cited by 2,799 · see citing works
Optimizing inhibitory learning during exposure therapy
Craske, M. G., Kircanski, K., Zelikowsky, M., Mystkowski, J., Chowdhury, N., & Baker, A. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.10.003 · Cited by 1,607 · see citing works
Foa, E. B., Liebowitz, M. R., Kozak, M. J., Davies, S., Campeas, R., Franklin, M. E., Huppert, J. D., Kjernisted, K., Rowan, V., Schmidt, A. B., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.151 · Cited by 1,048 · see citing works
Subthalamic nucleus stimulation in severe obsessive-compulsive disorder
Mallet, L., Polosan, M., Jaafari, N., Baup, N., Welter, M.-L., Fontaine, D., Montcel, S. T. D., Yelnik, J., Chéreau, I., Arbus, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708514 · Cited by 965 · see citing works
Bewernick, B. H., Hurlemann, R., Matusch, A., Kayser, S., Grubert, C., Hadrysiewicz, B., Axmacher, N., Lemke, M., Cooper-Mahkorn, D., Cohen, M. X., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.013 · Cited by 865 · see citing works
Denys, D., Mantione, M., Figee, M., van den Munckhof, P., Koerselman, F., Westenberg, H., Bosch, A., & Schuurman, R. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.122 · Cited by 763 · see citing works
Deep brain stimulation for refractory obsessive-compulsive disorder
Abelson, J. L., Curtis, G. C., Sagher, O., Albucher, R. C., Harrigan, M., Taylor, S. F., Martis, B., & Giordani, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.042 · Cited by 522 · see citing works
Long-term Electrical Capsular Stimulation in Patients with Obsessive-Compulsive Disorder
Nuttin, B., Gabriëls, L. A., Cosyns, P. R., Meyerson, B. A., Andréewitch, S., Sunaert, S. G., Maes, A., Dupont, P. J., Gybels, J., Gielen, F. L. H., et al. (2003) · Neurosurgery · doi:10.1227/01.neu.0000064565.49299.9a · Cited by 482 · see citing works
Eddy, K. T., Dutra, L., Bradley, R., & Westen, D. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.08.004 · Cited by 475 · see citing works
Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder
Figee, M., Luigjes, J., Smolders, R., Valencia-Alfonso, C.-E., van Wingen, G., de Kwaasteniet, B., Mantione, M., Ooms, P., de Koning, P., Vulink, N., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3344 · Cited by 466 · see citing works
Enhanced avoidance habits in obsessive-compulsive disorder
Gillan, C. M., Morein-Zamir, S., Urcelay, G. P., Sule, A., Voon, V., Apergis-Schoute, A. M., Fineberg, N. A., Sahakian, B. J., & Robbins, T. W. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.002 · Cited by 399 · cited 2× · see citing works
“Recent research indicates that compulsivity in OCD may arise from excessive stimulus–response habit formation (Gillan et al. 2014).”
BackgroundFranklin, M. E., Abramowitz, J. S., Kozak, M. J., Levitt, J. T., & Foa, E. B. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.4.594 · Cited by 387 · see citing works
The psychological treatment of obsessive-compulsive disorder
Abramowitz, J. S. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100702 · Cited by 371 · see citing works
Goodman, W. K., Foote, K. D., Greenberg, B. D., Ricciuti, N., Bauer, R., Ward, H., Shapira, N. A., Wu, S. S., Hill, C. L., Rasmussen, S. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.028 · Cited by 362 · see citing works
Simpson, H. B., Foa, E. B., Liebowitz, M. R., Ledley, D. R., Huppert, J. D., Cahill, S., Vermes, D., Schmidt, A. B., Hembree, E., Franklin, M., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07091440 · Cited by 316 · see citing works
Huff, W., Lenartz, D., Schormann, M., Lee, S.-H., Kuhn, J., Koulousakis, A., Mai, J., Daumann, J., Maarouf, M., Klosterkötter, J., et al. (2010) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2009.11.006 · Cited by 315 · see citing works
Nakao, T., Nakagawa, A., Yoshiura, T., Nakatani, E., Nabeyama, M., Yoshizato, C., Kudoh, A., Tada, K., Yoshioka, K., Kawamoto, M., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.039 · Cited by 307 · see citing works
Trauma: prevalence, impairment, service use, and cost.
Solomon, S. D., & Davidson, J. R. T. (1997) · PubMed · Cited by 288 · see citing works
Brody, A. L., Saxena, S., Schwartz, J. M., Stoessel, P. W., Maidment, K., Phelps, M. E., & Baxter, L. R. (1998) · Psychiatry Research: Neuroimaging · doi:10.1016/s0925-4927(98)00041-9 · Cited by 285 · see citing works
Response versus remission in obsessive-compulsive disorder
Simpson, H. B., Huppert, J. D., Petkova, E., Foa, E. B., & Liebowitz, M. R. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0214 · Cited by 241 · see citing works
Pharmacotherapy of Obsessive-compulsive Disorder and Obsessive-Compulsive Spectrum Disorders
Denys, D. (2006) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.02.013 · Cited by 213 · see citing works
Self-citationde Koning, P. P., Figee, M., van den Munckhof, P., Schuurman, P. R., & Denys, D. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0200-8 · Cited by 202 · see citing works
Post-treatment effects of exposure therapy and clomipramine in obsessive–compulsive disorder
Simpson, H. B., Liebowitz, M. R., Foa, E. B., Kozak, M. J., Schmidt, A. B., Rowan, V., Petkova, E., Kjernisted, K., Huppert, J. D., Franklin, M. E., et al. (2004) · Depression and Anxiety · doi:10.1002/da.20003 · Cited by 161 · see citing works
Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear
Rodríguez-Romaguera, J., Monte, F. H. D., & Quirk, G. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200782109 · Cited by 141 · see citing works
Freyer, T., Klöppel, S., Tüscher, O., Kordon, A., Zurowski, B., Kuelz, A.-K., Speck, O., Glauche, V., & Voderholzer, U. (2011) · Psychological Medicine · doi:10.1017/s0033291710000309 · Cited by 105 · see citing works
Cognitive behaviour therapy and medication in the treatment of obsessive–compulsive disorder
O’Connor, K. P., Aardema, F., Robillard, S., Guay, S., Pélissier, M., Todorov, C., Borgeat, F., Leblanc, V., Grenier, S., & Doucet, P. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00767.x · Cited by 77 · see citing works
Protocollaire behandelingen in de ambulante geestelijke gezondheidszorg I
Keijsers, G. P. J., Minnen, A., & Hoogduin, C. A. L. (2004) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-7117-4 · Cited by 36 · see citing works
Pence, S. L., Sulkowski, M. L., Jordan, C., & Storch, E. A. (2010) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.2010.64.1.39 · Cited by 30 · see citing works
Protocollaire behandeling van patiënten met een obsessieve-compulsieve stoornis:
Verbraak, M. J. P. M., Hoogduin, C. A. L., Methorst, G., Arts, W., Hansen, A., & Keijsers, G. P. J. (2004) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-7117-4_3 · Cited by 6 · see citing works
Targets for Deep Brain Stimulation in Obsessive-Compulsive Disorder
Figee, M., Mantione, M. H. M., van den Munckhof, P., Schuurman, R., & Denys, D. A. J. P. (2010) · Psychiatric Annals · doi:10.3928/00485713-20100924-06 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Val‐Laillet, D., Aarts, E., Weber, B., Ferrari, M., Quaresima, V., Stoeckel, L. E., Alonso‐Alonso, M., Audette, M. A., Malbert, C., & Stice, E. M. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.03.016 · Cited by 443 · see citing works
Brain circuitry of compulsivity
van den Heuvel, O. A., van Wingen, G., Soriano-Mas, C., Alonso, P., Chamberlain, S. R., Nakamae, T., Denys, D., Goudriaan, A. E., & Veltman, D. J. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.005 · Cited by 374 · see citing works
Self-citationBergfeld, I. O., Mantione, M., Hoogendoorn, M. L. C., Ruhé, H. G., Notten, P., van Laarhoven, J., Visser, I., Figee, M., de Kwaasteniet, B. P., Horst, F., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0152 · Cited by 336 · see citing works
Tyagi, H., Apergis-Schoute, A. M., Akram, H., Foltynie, T., Limousin, P., Drummond, L. M., Fineberg, N. A., Matthews, K., Jahanshahi, M., Robbins, T. W., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.01.017 · Cited by 227 · see citing works
Deep brain stimulation for depression.
Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works
de Haan, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108685214 · Cited by 178 · see citing works
de Haan, S., Rietveld, E., Stokhof, M., & Denys, D. A. J. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135524 · Cited by 166 · see citing works
de Haan, S., Rietveld, E., Stokhof, M., & Denys, D. A. J. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175748 · Cited by 147 · see citing works
Exposure and response prevention for obsessive-compulsive disorder: A review and new directions
Simpson, H., & Hezel, D. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_516_18 · Cited by 137 · see citing works
“Moreover, a recent study demonstrated that combining DBS with CBT (which included ERP) resulted in a reduction of OCD symptoms in a treatment-refractory sample.[70] Indeed, DBS has been shown to enhance fear extinction,[71,72] thus highlighting its potential usefulness when paired with a treatment such as ERP.”
BackgroundEfficacy of invasive and non-invasive brain modulation interventions for addiction
Luigjes, J., Segrave, R., de Joode, N., Figee, M., & Denys, D. (2019) · Neuropsychology Review · doi:10.1007/s11065-018-9393-5 · Cited by 125 · see citing works
Mosley, P. E., Windels, F., Morris, J. S., Coyne, T. J., Marsh, R., Giorni, A., Mohan, A., Sachdev, P. S., O’Leary, E., Boschen, M. J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01307-9 · Cited by 116 · see citing works
The application of deep brain stimulation in the treatment of psychiatric disorders
Graat, I., Figee, M., & Denys, D. A. J. P. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1282439 · Cited by 106 · see citing works
Liebrand, L. C., Caan, M. W. A., Schuurman, P. R., van den Munckhof, P., Figee, M., Denys, D., & van Wingen, G. A. (2019) · Brain Stimulation · doi:10.1016/j.brs.2018.11.014 · Cited by 98 · see citing works
Self-citationToward personalized medicine in connectomic deep brain stimulation
Hollunder, B., Rajamani, N., Siddiqi, S., Finke, C., Kühn, A. A., Mayberg, H. S., Fox, M., Neudorfer, C., & Horn, A. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102211 · Cited by 89 · see citing works
Ramasubbu, R., Clark, D. L., Golding, S., Dobson, K. S., Mackie, A., Haffenden, A., & Kiss, Z. H. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30415-8 · Cited by 80 · see citing works
Graat, I., Mocking, R. J. T., Figee, M., Vulink, N. C. C., de Koning, P. P., Ooms, P., Mantione, M. H. M., van den Munckhof, P., Schuurman, R., & Denys, D. A. J. P. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.08.018 · Cited by 73 · see citing works
Huys, D., Kohl, S., Baldermann, J. C., Timmermann, L., Sturm, V., Visser-Vandewalle, V. E. R. M., & Kuhn, J. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-318996 · Cited by 71 · see citing works
Optimizing Deep Brain Stimulation Parameters in Obsessive–Compulsive Disorder
van Westen, M., Rietveld, E., Bergfeld, I. O., de Koning, P. P., Vullink, N., Ooms, P., Graat, I., Liebrand, L. C., van den Munckhof, P., Schuurman, R., et al. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13243 · Cited by 62 · see citing works
Clinical outcome and mechanisms of deep brain stimulation for obsessive-compulsive disorder
van Westen, M., Rietveld, E., Figee, M., & Denys, D. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0036-3 · Cited by 60 · see citing works
Self-citationRodríguez-Romaguera, J., Greenberg, B. D., Rasmussen, S. A., & Quirk, G. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.012 · Cited by 51 · see citing works
Martínez-Rivera, F. J., Rodríguez-Romaguera, J., Lloret-Torres, M. E., Monte, F. H. D., Quirk, G. J., & Barreto-Estrada, J. L. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.015 · Cited by 55 · see citing works
Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review
Acevedo, N., Bosanac, P., Pikoos, T. D., Rossell, S. L., & Castle, D. J. (2021) · Brain Sciences · doi:10.3390/brainsci11070948 · Cited by 55 · see citing works
Kumar, K. K., Appelboom, G., Lamsam, L. A., Caplan, A. L., Williams, N., Bhati, M. T., Stein, S. C., & Halpern, C. H. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-319318 · Cited by 54 · see citing works
Davidson, B., Giacobbe, P., George, T. P., Nestor, S. M., Rabin, J. S., Goubran, M., Nyman, A. J., Baskaran, A., Meng, Y., Pople, C. B., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01677-6 · Cited by 52 · see citing works
Deep brain stimulation modulates directional limbic connectivity in obsessive-compulsive disorder
Fridgeirsson, E. A., Figee, M., Luigjes, J., van den Munckhof, P., Schuurman, P. R., van Wingen, G., & Denys, D. (2020) · Brain · doi:10.1093/brain/awaa100 · Cited by 51 · see citing works
Self-citationClosing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity
Widge, A. S. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01643-y · Cited by 46 · see citing works
Invasive and Non-invasive Neurostimulation for OCD
Bergfeld, I. O., Dijkstra, E., Graat, I., de Koning, P. P., van den Boom, B. J. G., Arbab, T., Vulink, N. C. C., Denys, D. A. J. P., Willuhn, I., & Mocking, R. J. T. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_206 · Cited by 43 · see citing works
Kahn, L. W., Sutton, B., Winston, H. R., Abosch, A., Thompson, J. A., & Davis, R. A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.568932 · Cited by 41 · see citing works
The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap
Szechtman, H., Harvey, B. H., Woody, E. Z., & Hoffman, K. L. (2019) · Pharmacological Reviews · doi:10.1124/pr.119.017772 · Cited by 40 · see citing works
Widge, A. S., Zhang, F., Gosai, A. K., Papadimitrou, G., Wilson-Braun, P., Tsintou, M., Palanivelu, S., Noecker, A. M., McIntyre, C. C., O’Donnell, L. J., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01199-9 · Cited by 34 · see citing works
Deep brain stimulation in the treatment of obsessive-compulsive disorder: current perspectives
Tastevin, M., Spatola, G., Régis, J. M., Lançon, C., & Richieri, R. M. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s178207 · Cited by 36 · see citing works
Deep Brain Stimulation for Treatment-Refractory Mood and Obsessive-Compulsive Disorders
Widge, A. S., & Dougherty, D. D. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0049-y · Cited by 32 · see citing works
Deep Brain Stimulation for Intractable Obsessive-Compulsive Disorder: Progress and Opportunities
Goodman, W. K., Storch, E. A., Cohn, J. F., & Sheth, S. A. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20010037 · Cited by 32 · see citing works
Deep brain stimulation in obsessive-compulsive disorder: Results from meta-analysis
Cruz, S., Gutiérrez-Rojas, L., González-Domenech, P., Díaz-Atienza, F., Martínez-Ortega, J. M., & Jiménez‐Fernández, S. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114869 · Cited by 30 · see citing works
Ablative neurosurgery and deep brain stimulation for obsessive-compulsive disorder
Arumugham, S. S., Balachander, S., & Srinivas, D. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_523_18 · Cited by 30 · see citing works
Guzick, A. G., Hunt, P. J., Bijanki, K. R., Schneider, S. C., Sheth, S. A., Goodman, W. K., & Storch, E. A. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1694409 · Cited by 28 · see citing works
Progress and challenges in deep brain stimulation for obsessive-compulsive disorder
Kohl, S., & Baldermann, J. C. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.011 · Cited by 25 · see citing works
Deep brain stimulation: new possibilities for the treatment of mental disorders
Beszłej, J. A., Wieczorek, T., Kobyłko, A., Piotrowski, P., Siwicki, D., Weiser, A., Fila-Witecka, K., Rymaszewska, J., & Tabakow, P. (2019) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/103090 · Cited by 24 · see citing works
Treating OCD: what to do when first-line therapies fail
Castle, D. J., Bosanac, P., & Rossell, S. L. (2015) · Australasian Psychiatry · doi:10.1177/1039856215590027 · Cited by 23 · see citing works
Naesstr, M., Blomstedt, P. C., Hariz, M. I., & Bodlund, O. (2017) · Surgical Neurology International · doi:10.4103/sni.sni_19_17 · Cited by 23 · see citing works
Hitti, F. L., Widge, A. S., Riva‐Posse, P., Malone, D. A., Okun, M. S., Shanechi, M. M., Foote, K. D., Lisanby, S. H., Ankudowich, E., Chivukula, S., et al. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.05.011 · Cited by 21 · see citing works
Telemedical Deep Brain Stimulation: Merits and Limitations
Zhang, C., Zhang, Y., Zhan, S., Li, D., Jin, H., Denys, D. A. J. P., & Sun, B. (2018) · Stereotactic and Functional Neurosurgery · doi:10.1159/000491603 · Cited by 21 · see citing works
Recent advances in deep brain stimulation in psychiatric disorders
Clair, A.-H., Haynes, W. I. A., & Mallet, L. (2018) · F1000Research · doi:10.12688/f1000research.14187.1 · Cited by 20 · see citing works
Glannon, W. (2018) · doi:10.1093/med/9780198758853.001.0001 · Cited by 29 · see citing works
Management of obsessive-compulsive disorder comorbid with bipolar disorder
Kazhungil, F., & Mohandas, E. (2016) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.192001 · Cited by 17 · see citing works
Treatment Resistance in Obsessive-Compulsive Disorder
Middleton, R., Wheaton, M. G., Kayser, R., & Simpson, H. B. (2019) · Treatment Resistance in Psychiatry · doi:10.1007/978-981-10-4358-1_11 · Cited by 19 · see citing works
Tyagi, H., Apergis-Schoute, A. M., Akram, H., Foltynie, T., Limousin, P. D., Drummond, L. M., Fineberg, N. A., Matthews, K., Jahanshahi, M., Robbins, T. W., et al. (2022) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20105 · Cited by 16 · see citing works
Liebrand, L. C., Zhutovsky, P., Tolmeijer, E., Graat, I., Vulink, N. C. C., de Koning, P. P., Figee, M., Schuurman, P. R., van den Munckhof, P., Caan, M. W. A., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102640 · Cited by 16 · see citing works
Indian guidelines on neurosurgical interventions in psychiatric disorders
Doshi, P. K., Arumugham, S. S., Bhide, A. V., Vaishya, S., Desai, A., Singh, O. P., Math, S. B., Gautam, S., Rao, T. S. S., Mohandas, E., et al. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_536_18 · Cited by 15 · see citing works
Thomson, C. J., Segrave, R. A., Fitzgerald, P. B., Richardson, K. E., Racine, É., & Carter, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284160 · Cited by 14 · see citing works
Acevedo, N., Rossell, S. L., Castle, D. J., Groves, C., Cook, M. J., McNeill, P. M., Olver, J. S., Meyer, D., Perera, T., & Bosanac, P. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13619 · Cited by 13 · see citing works
Webler, R. D., Oathes, D. J., van Rooij, S. J. H., Gewirtz, J. C., Nahas, Z. H., Lissek, S. M., & Widge, A. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.105005 · Cited by 13 · see citing works
Snoek, A., de Haan, S., Schermer, M., & Horstkötter, D. (2019) · Neuroethics · doi:10.1007/s12152-019-09411-w · Cited by 13 · see citing works
Effective Deep Brain Stimulation for Obsessive-Compulsive Disorder Requires Clinical Expertise
van Westen, M., Rietveld, E., & Denys, D. A. J. P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02294 · Cited by 13 · see citing works
Görmezoğlu, M., van der Vlis, T. A. M. B., Schruers, K. R. J., Ackermans, L. P. C. M., Polosan, M., & Leentjens, A. F. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082383 · Cited by 13 · see citing works
Acevedo, N., Castle, D. J., Groves, C., Bosanac, P., Mosley, P. E., & Rossell, S. L. (2022) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674221100947 · Cited by 12 · see citing works
Deep brain stimulation in obsessive-compulsive disorder – case report of two patients
Beszłej, J. A., Siwicki, D., Fila-Witecka, K., Wieczorek, T., Piotrowski, P., Weiser, A., Tabakow, P., & Rymaszewska, J. (2019) · Psychiatria Polska · doi:10.12740/pp/104643 · Cited by 12 · see citing works
Deep brain stimulation and treatment-resistant obsessive-compulsive disorder: A systematic review
Vázquez-Bourgón, J., Martino, J., Peña, M. S., Infante, J., Martínez, M. Á. M., Ocón, R., Menchón, J. M., Crespo‐Facorro, B., & Vázquez-Barquero, A. (2019) · Revista de Psiquiatría y Salud Mental (English Edition) · doi:10.1016/j.rpsmen.2017.05.015 · Cited by 11 · see citing works
Vázquez-Bourgón, J., Martino, J., Peña, M. S., Infante, J., Martínez, M. Á. M., Ocón, R., Menchón, J. M., Crespo‐Facorro, B., & Vázquez-Barquero, A. (2017) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2017.05.005 · Cited by 11 · see citing works
Kilian, H. M., Schiller, B., Meyer, D. M., Heinrichs, M., & Schläpfer, T. E. (2024) · Translational Psychiatry · doi:10.1038/s41398-023-02712-y · Cited by 9 · see citing works
Abdulbaki, A., Masri, J. E., Ghazi, M., Kahl, K. G., Mocking, R. J. T., Salameh, P., Schuurman, R., Nuttin, B., & Krauss, J. K. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116651 · Cited by 7 · see citing works
Deep Brain Stimulation for Depression
Bergfeld, I. O., & Figee, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-36346-8_18 · Cited by 7 · see citing works
Graat, I., Franken, S., van Rooijen, G., de Koning, P. P., Vulink, N. C. C., de Kroo, M., Denys, D. A. J. P., & Mocking, R. J. T. (2022) · Psychological Medicine · doi:10.1017/s0033291722003130 · Cited by 7 · see citing works
A Synergistic Treatment Strategy for Severe Obsessive Compulsive Disorder
Kohl, S., Baldermann, J. C., Denys, D. A. J. P., & Kuhn, J. (2016) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12461 · Cited by 6 · see citing works
Arumugham, S. S., Srinivas, D., Narayanaswamy, J. C., Jaisoorya, T. S., Kashyap, H., Domenech, P., Palfi, S., Mallet, L., Venkatasubramanian, G., & Reddy, Y. C. J. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-047492 · Cited by 6 · see citing works
van Westen, M., Rietveld, E., van Hout, A., & Denys, D. A. J. P. (2021) · Phenomenology and the Cognitive Sciences · doi:10.1007/s11097-021-09732-3 · Cited by 6 · see citing works
Acevedo, N., Castle, D. J., & Rossell, S. L. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2306875 · Cited by 5 · see citing works
Sugiyama, K., Nozaki, T., Asakawa, T., Sameshima, T., KOIZUMI, S., Hiramatsu, H., & Namba, H. (2018) · Neurologia medico-chirurgica · doi:10.2176/nmc.st.2018-0115 · Cited by 5 · see citing works
Fanty, L., Yu, J., Chen, N., Fletcher, D. B., Hey, G. E., Okun, M. S., & Wong, J. K. (2023) · Expert Review of Medical Devices · doi:10.1080/17434440.2023.2252732 · Cited by 5 · see citing works
Psychiatric neuromodulation: the underappreciated importance of pre- and post-treatment care
Davidson, B., Li, D. Z., Meng, Y., Hamani, C., & Lipsman, N. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0851-0 · Cited by 5 · see citing works
Sheth, S. A., Provenza, N. R., Soubra, S. S., Hamre, T. A., Shofty, B., Banks, G. P., Giridharan, N., Momin, F., Vogt, G. S., McKay, S. A., et al. (2026) · medRxiv · doi:10.64898/2026.04.24.26351318 · Cited by 5 · see citing works
Deep brain stimulation in Gilles de la Tourette syndrome: killing several birds with one stone?
Hartmann, A. (2016) · F1000Research · doi:10.12688/f1000research.9521.1 · Cited by 4 · see citing works
Baldi, S., Vandenberk, E., Bors, J., Goossens, L., Cort, K. D., Ackermans, L. P. C. M., Leentjens, A. F. G., Linden, D. E. J., Duits, A., Temel, Y., et al. (2023) · Deep Brain Stimulation · doi:10.1016/j.jdbs.2023.12.003 · Cited by 4 · see citing works
Glannon, W. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198758853.003.0009 · Cited by 4 · see citing works
Zrinzo, L. U. (2024) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s407210 · Cited by 3 · see citing works
Deep brain stimulation – A primer for psychiatrists
Sharma, L. P., Ganesh, U. M., Arumugham, S. S., Srinivas, D., Venkatasubramanian, G., & Reddy, Y. C. J. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2024.104354 · Cited by 3 · see citing works
van der Vlis, T. A. M. B., & Duits, A. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13533 · Cited by 3 · see citing works
From lobotomy to connectomics: a critical review of contemporary psychosurgery
González, V., Rumià, J., Brell, M., Roset, C., de Miguel, J. D., Arboleya, S., Aguirre, I., Alegre, D., Goliney, V., & Ibáñez, J. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1785333 · Cited by 2 · see citing works
Electrical deep neuromodulation in psychiatry
Polosan, M., & Figee, M. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.06.007 · Cited by 2 · see citing works
Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation
Glewwe, N., Grissom, N. M., & Widge, A. S. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1944-24.2025 · Cited by 2 · see citing works
Stereotactic Functional Neurosurgery for Mental Health Disorders, Pain, and Epilepsy
Hyam, J. A., & Zrinzo, L. U. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-43140-8.00058-5 · Cited by 2 · see citing works
An Enactive Approach to Causes, Diagnosis, and Treatment of Psychiatric Disorders
de Haan, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108685214.009 · Cited by 2 · see citing works
Deep Brain Stimulation for Obsessive-Compulsive Disorder—Reply
Hirschtritt, M. E., Bloch, M. H., & Mathews, C. A. (2017) · JAMA · doi:10.1001/jama.2017.7873 · Cited by 2 · see citing works
Pereira de Souza, A. M. F. L., Mpavaenda, D., Banca, P., Wellsted, D., Hopkins, J., Marzuki, A. A., Lee, M., Karafylli, E., Bardsley, O., Mazoruk, S., et al. (2026) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2026.152666 · Cited by 1 · see citing works
“Some individuals drop out of ERP due to beliefs that the exposures are ‘too difficult ’ to perform [27], or that the anxiety provoked by ERP is ‘too intense ’ to bear [28,29].”
de Haan, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108685214.008 · Cited by 1 · see citing works
Cognitive Behavioral Therapy: state of the art, a review
Maia, A. C. C. D. O., Pereira, L. M. N., Nardi, A. E., & Cardoso, A. (2015) · Medical Express · doi:10.5935/medicalexpress.2015.06.01 · Cited by 1 · see citing works
Tundo, A., Salvati, L., Cieri, L., Balestrini, V., Spigno, D. D., Orazi, F., Iommi, M., & Necci, R. (2022) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2022.2054351 · Cited by 1 · see citing works
Intervening in the psychopath’s brain
Glannon, W. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198758853.003.0007 · Cited by 1 · see citing works
Acevedo, N., Castle, D. J., Bosanac, P., & Rossell, S. L. (2023) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674231184410 · Cited by 1 · see citing works
Neurobiology of deep brain stimulation for psychiatric disorders
Gadot, R., Giridharan, N., Rajesh, S. V., Provenza, N. R., Banks, G. P., Storch, E. A., Goodman, W. K., & Sheth, S. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00023-9 · Cited by 1 · see citing works
Diepe hersenstimulatie bij obsessieve-compulsieve stoornis: 10 jaar ervaring in het AMC
Bais, M. N., Figee, M., Schuurman, R., & Denys, D. A. J. P. (2015) · Neuropraxis · doi:10.1007/s12474-015-0087-y · Cited by 1 · see citing works
Treating psychiatric disorders: Less invasive and noninvasive interventions
Glannon, W. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198758853.003.0004 · Cited by 1 · see citing works
Deep Brain Stimulation for Obsessive-Compulsive Disorder
Kohl, S., & Kuhn, J. (2017) · JAMA · doi:10.1001/jama.2017.7849 · Cited by 1 · see citing works
Lawford‐Smith, H. (2015)
Disorders of consciousness, memory, and will
Glannon, W. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198758853.003.0003
Euthanasia and assisted suicide for psychiatric disorders
Glannon, W. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198758853.003.0008
Glannon, W. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198758853.003.0002
Neuromodulation: Control, identity, and justice
Glannon, W. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198758853.003.0006
Epilogue: Psychiatry, neuroscience, philosophy
Glannon, W. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198758853.003.0010
Development of brain stimulation
Crowell, A. L., Riva‐Posse, P., & Mayberg, H. S. (2020) · doi:10.1093/med/9780198713005.003.0019
- Authors
- Mantione, M., Nieman, D. H., Figee, M., & Denys, D.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Netherlands Institute for Neuroscience (NL)
- Corresponding author
- Mantione, M.
- Denys, D.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-04-25
- Volume
- 44
- Issue
- 16
- Pages
- 3515-3522
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2105399857
- Cited by
- 129
- References
- 33
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 20 · 2019: 15 · 2018: 23 · 2017: 6 · 2016: 6 · 2015: 10
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, deep brain stimulation, cognitive behavioral therapy, treatment-refractory OCD, nucleus accumbens, augmentation therapy, response prevention, symptom recurrence, anxiety and depressive symptoms
- MeSH terms
- Adult, Combined Modality Therapy, Double-Blind Method, Female, Humans, Male, Middle Aged, Netherlands, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Severity of Illness Index, Cognitive Behavioral Therapy, Treatment Outcome, Cross-Over Studies, Deep Brain Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
