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Cited by 68Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

A score for predicting response to pharmacotherapy in obsessive???compulsive disorder

Denys, Damiaan, Burger, Huibert, van Megen, Harold, de Geus, Femke, Westenberg, Herman·2003·International Clinical Psychopharmacology
DOI 10.1097/00004850-200311000-00002
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Abstract

Although there have been many attempts to find predictors of therapeutic response to antidepressant treatment of obsessive-compulsive disorder (OCD), few reports have evaluated the joint predictive value of a number of clinical characteristics. This study aimed to identify clinical predictors of outcome in OCD, and to develop an easily applicable method to predict response to drug treatment. One hundred and fifty patients with primary OCD according to DSM-IV criteria were randomly assigned in a 12-week, double-blind, comparison trial with a selective serotonin reuptake inhibitor (paroxetine), and a serotonin-noradrenaline reuptake inhibitor (venlafaxine). The primary efficacy parameter was the Yale-Brown obsessive-compulsive scale (Y-BOCS) score, and response to treatment was prospectively defined as a >/= 35% decrease from the beginning. A stepwise multivariate analysis was used to identify predictors. The absence of previous therapies, moderate baseline severity of obsessive-compulsive symptoms (Y-BOCS score < 23), and low Hamilton Depressive Rating Scale scores (6-15) were found to be prognostic determinants of good response to pharmacotherapy. The prognostic ability of the prediction model to discriminate between responders and non-responders was quantified as the area under the receiver operating/operator characteristic curve (ROC area), which was 0.71 (95% confidence interval 0.63-0.8), demonstrating a reasonable discriminatory power. This study is the first to present a model that can estimate by the use of prediction rules the probability of treatment response to antidepressants in patients with OCD.

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Authors
Denys, D., Burger, H., van Megen, H., de Geus, F., & Westenberg, H.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Denys, Damiaan
ORCID
Venue
International Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-11
Volume
18
Issue
6
Pages
315-322
ISSN
0268-1315 (ISSN-L)
DOI
10.1097/00004850-200311000-00002
OpenAlex
W2019787647
Cited by
68
References
36
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
4.96
Type
journal article
Language
en
Open access
closed
Locations
  • International Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
obsessive-compulsive disorder, treatment response prediction, prognostic factors, paroxetine, venlafaxine, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, Yale-Brown Obsessive Compulsive Scale, baseline symptom severity, depression severity, prediction model
MeSH terms
Venlafaxine Hydrochloride, Adolescent, Aged, Cyclohexanols, Dose-Response Relationship, Drug, Double-Blind Method, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Predictive Value of Tests, Psychiatric Status Rating Scales, Paroxetine, Antidepressive Agents, Second-Generation

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