Cited by 153Functional Brain Connectivity StudiesTreatment of Major DepressionTranscranial Magnetic Stimulation Studies

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Resting state functional connectivity and treatment response in late-life depression

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Andreescu, Carmen, Tudorascu, Dana L., Butters, Meryl A., Tamburo, Erica, Patel, Meenal, Price, Julie, Karp, Jordan F., Reynolds, Charles F., Aizenstein, Howard·2013·Psychiatry Research: Neuroimaging

DOI 10.1016/j.pscychresns.2013.08.007PMC PMC3865521

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Abstract

Indices of functional connectivity in the default mode network (DMN) are promising neural markers of treatment response in late-life depression. We examined the differences in DMN functional connectivity between treatment-responsive and treatment-resistant depressed older adults. Forty-seven depressed older adults underwent MRI scanning pre- and post-pharmacotherapy. Forty-six never depressed older adults underwent MR scanning as comparison subjects. Treatment response was defined as achieving a Hamilton Depression Rating Scale of 10 or less post-treatment. We analyzed resting state functional connectivity using the posterior cingulate cortex as the seed region-of-interest. The resulting correlation maps were employed to investigate between-group differences. Additionally we examined the association between white matter hyperintensity burden and functional connectivity results. Comparison of pre- and post-treatment scans of depressed participants revealed greater post-treatment functional connectivity in the frontal precentral gyrus. Relative to treatment-responsive participants, treatment-resistant participants had increased functional connectivity in the left striatum. When adjusting for white matter hyperintensity burden, the observed differences lost significance for the PCC-prefrontal functional connectivity, but not for the PCC-striatum functional connectivity. The post-treatment "frontalization" of the DMN connectivity suggests a normalizing effect of antidepressant treatment. Moreover, our study confirms the central role of white matter lesions in disrupting brain functional connectivity.

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Authors: Andreescu, C., Tudorascu, D. L., Butters, M. A., Tamburo, E., Patel, M., Price, J., Karp, J. F., Reynolds, C. F., & Aizenstein, H.
Affiliations: University of Pittsburgh (US)
Corresponding author: Andreescu, Carmen
ORCID: Andreescu, Carmen
Tudorascu, Dana L.
Butters, Meryl A.
Price, Julie
Karp, Jordan F.
Reynolds, Charles F.
Aizenstein, Howard
Venue: Psychiatry Research: Neuroimaging
Publisher: Elsevier BV
Published: 2013-12
Volume: 214
Issue: 3
Pages: 313-321
ISSN: 0925-4927 (ISSN-L)
DOI: 10.1016/j.pscychresns.2013.08.007
PMC: PMC3865521
OpenAlex: W2037229172
Cited by: 153
References: 61
Citations by year: 2026: 7 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 34 · 2020: 11 · 2019: 14 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 4 · 2013: 1
FWCI: 5.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Psychiatry Research Neuroimaging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000005, KL2TR000146)
National Institute on Aging (P01AG025204, RF1AG025516, R01AG033575, AG033575, R37AG025516)
National Institute of Mental Health (P30MH090333, MH-071944, P30 MH90333, R01MH076079, R01MH080240, P30MH071944, MH080240, MH086686, K23MH086686)
National Institute of Neurological Disorders and Stroke (R21NS060184)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: geriatric depression, resting-state functional connectivity, default mode network, treatment response, treatment-resistant depression, antidepressant treatment, posterior cingulate cortex, white matter hyperintensities, striatum, prefrontal cortex, older adults, neural markers
MeSH terms: Adult, Aged, Antidepressive Agents, Brain, Brain Mapping, Depressive Disorder, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Rest, Case-Control Studies, Treatment Outcome, Neostriatum, Age of Onset

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Resting state functional connectivity and treatment response in late-life depression

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