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Resting state functional connectivity and treatment response in late-life depression
Open accessAbstract
Indices of functional connectivity in the default mode network (DMN) are promising neural markers of treatment response in late-life depression. We examined the differences in DMN functional connectivity between treatment-responsive and treatment-resistant depressed older adults. Forty-seven depressed older adults underwent MRI scanning pre- and post-pharmacotherapy. Forty-six never depressed older adults underwent MR scanning as comparison subjects. Treatment response was defined as achieving a Hamilton Depression Rating Scale of 10 or less post-treatment. We analyzed resting state functional connectivity using the posterior cingulate cortex as the seed region-of-interest. The resulting correlation maps were employed to investigate between-group differences. Additionally we examined the association between white matter hyperintensity burden and functional connectivity results. Comparison of pre- and post-treatment scans of depressed participants revealed greater post-treatment functional connectivity in the frontal precentral gyrus. Relative to treatment-responsive participants, treatment-resistant participants had increased functional connectivity in the left striatum. When adjusting for white matter hyperintensity burden, the observed differences lost significance for the PCC-prefrontal functional connectivity, but not for the PCC-striatum functional connectivity. The post-treatment "frontalization" of the DMN connectivity suggests a normalizing effect of antidepressant treatment. Moreover, our study confirms the central role of white matter lesions in disrupting brain functional connectivity.
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“The results of studies examining the impact of ADM initiation on connectivity are heterogeneous28–39.”
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Metadata
- Authors
- Andreescu, C., Tudorascu, D. L., Butters, M. A., Tamburo, E., Patel, M., Price, J., Karp, J. F., Reynolds, C. F., & Aizenstein, H.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Andreescu, Carmen
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 214
- Issue
- 3
- Pages
- 313-321
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3865521
- OpenAlex
- W2037229172
- Cited by
- 153
- References
- 61
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 34 · 2020: 11 · 2019: 14 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 4 · 2013: 1
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000005, KL2TR000146)
- National Institute on Aging (P01AG025204, RF1AG025516, R01AG033575, AG033575, R37AG025516)
- National Institute of Mental Health (P30MH090333, MH-071944, P30 MH90333, R01MH076079, R01MH080240, P30MH071944, MH080240, MH086686, K23MH086686)
- National Institute of Neurological Disorders and Stroke (R21NS060184)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- geriatric depression, resting-state functional connectivity, default mode network, treatment response, treatment-resistant depression, antidepressant treatment, posterior cingulate cortex, white matter hyperintensities, striatum, prefrontal cortex, older adults, neural markers
- MeSH terms
- Adult, Aged, Antidepressive Agents, Brain, Brain Mapping, Depressive Disorder, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Rest, Case-Control Studies, Treatment Outcome, Neostriatum, Age of Onset
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