Default-mode network connectivity and white matter burden in late-life depression
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The brain's default-mode network has been the focus of intense research. This study characterizes the default-mode network activity in late-life depression and the correlation of the default-mode network activity changes with the white-matter hyperintensities burden. We hypothesized that elderly depressed subjects would have altered default-mode network activity, which would correlate with the increased white-matter hyperintensities burden. Twelve depressed subjects (mean Hamilton Depression Rating Scale 19.8±4.1, mean age 70.5±4.9) and 12 non-depressed, comparison subjects (mean age 69±6.5) were included. Functional magnetic resonance imaging (fMRI) data were collected while subjects performed a low cognitive load, event-related task. We compared the default-mode network activity in these groups (including depressed subjects pre- and post-antidepressant treatment). We analyzed the resting connectivity patterns of the posterior cingulate cortex. Deconvolution was used to evaluate the correlation of resting-state connectivity scores with the white-matter hyperintensities burden. Compared with non-depressed elderly, depressed subjects pretreatment had decreased connectivity in the subgenual anterior cingulate cortex and increased connectivity in the dorsomedial prefrontal cortex and the orbito-frontal cortex. The abnormal connectivity was significantly correlated with the white-matter hyperintensities burden. Remitted elderly depressed subjects had improved functional connectivity compared to pretreatment, although alterations persisted in the anterior cingulate and the prefrontal cortex when remitted elderly depressed subjects were compared with non-depressed elderly. Our study provides evidence for altered default-mode network connectivity in late-life depression. The correlation between white-matter hyperintensities burden and default-mode network connectivity emphasizes the role of vascular changes in late-life depression etiopathogenesis.
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Two preliminary studies investigated the relation between white matter integrity and functional connectivity in geriatric depression, but they did not compare their data with a healthy control group.
“Furthermore, two preliminary studies investigated the relation between white matter integrity and functional connectivity in geriatric depression, but they did not compare their data with a healthy control group (27,28).”
From Relation Between Structural and Functional Connectivity in Major Depressive Disorder (2013) · cites this paper as [28]
Two preliminary studies in geriatric depression reported that decreased white matter integrity is related to functional connectivity.
“This is corroborated by two preliminary studies in geriatric depression that reported a comparable pattern that decreased white matter integrity is related to functional connectivity (27,28), although those studies did not compare patients with healthy control subjects, which is a strength of the present investigation.”
From Relation Between Structural and Functional Connectivity in Major Depressive Disorder (2013) · cites this paper as [28]
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- Authors
- Wu, M., Andreescu, C., Butters, M. A., Tamburo, R., Reynolds, C. F., & Aizenstein, H.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Andreescu, Carmen
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 194
- Issue
- 1
- Pages
- 39-46
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3189685
- OpenAlex
- W2017407197
- Cited by
- 140
- References
- 39
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 12 · 2018: 11 · 2017: 11 · 2016: 15 · 2015: 16 · 2014: 8 · 2013: 14 · 2012: 7
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- U.S. Public Health Service (K23 086686)
- National Institute of Mental Health (R01MH072947, R37MH043832, R01MH076079, R37/R01 MH43832, P30MH071944, R01MH043832, K23MH086686)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- geriatric depression, default mode network, white matter hyperintensities, resting-state functional connectivity, posterior cingulate cortex, subgenual anterior cingulate cortex, dorsomedial prefrontal cortex, orbitofrontal cortex, antidepressant response
- MeSH terms
- Aged, Brain, Brain Mapping, Depression, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Neural Pathways, Neuropsychological Tests, Oxygen, Rest, Statistics as Topic
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