Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression
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Background: Hippocampal volume reduction has been reported inconsistently in people with major depression. Aims: To evaluate the interrelationships between hippocampal volumes, memory and key clinical, vascular and genetic risk factors. Method: Totals of 66 people with depression and 20 control participants underwent magnetic resonance imaging and clinical assessment. Measures of depression severity, psychomotor retardation, verbal and visual memory and vascular and specific genetic risk factors were collected. Results: Reduced hippocampal volumes occurred in older people with depression, those with both early-onset and late-onset disorders and those with the melancholic subtype. Reduced hippocampal volumes were associated with deficits in visual and verbal memory performance. Conclusions: Although reduced hippocampal volumes are most pronounced in late-onset depression, older people with early-onset disorders also display volume changes and memory loss. No clear vascular or genetic risk factors explain these findings. Hippocampal volume changes may explain how depression emerges as a risk factor to dementia.
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Hippocampal volume loss in depressed patients correlates with memory dysfunction.
“Hippocampal volume loss in depressed patients is correlated with memory dysfunction [81].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [81]
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Self-citation
- Authors
- Hickie, I., Naismith, S., Ward, P. B., Turner, K., Scott, E., Mitchell, P., Wilhelm, K., & Parker, G.
- Affiliations
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Corresponding author
- Hickie, Ian
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2005-03
- Volume
- 186
- Issue
- 3
- Pages
- 197-202
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2171092546
- Cited by
- 437
- References
- 33
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 15 · 2023: 12 · 2022: 16 · 2021: 45 · 2020: 12 · 2019: 19 · 2018: 24 · 2017: 18 · 2016: 22 · 2015: 22 · 2014: 24 · 2013: 22 · 2012: 24
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- hippocampal volume, major depressive disorder, early-onset depression, late-onset depression, memory impairment, verbal memory, visual memory, endogenous depression, vascular risk factors, genetic risk factors, dementia risk
- MeSH terms
- Adult, Aged, Aged, 80 and over, Apolipoproteins E, Atrophy, Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Psychiatric Status Rating Scales, Psychomotor Performance, Risk Factors, Age of Onset, Genetic Predisposition to Disease, Diagnostic and Statistical Manual of Mental Disorders, Methylenetetrahydrofolate Reductase (NADPH2)
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